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Volumn 16, Issue 25, 2010, Pages 2837-2850

Nitric oxide: Target for therapeutic strategies in alzheimer's disease

Author keywords

Acetylcholinesterase; Alzheime s disease; Amyloid beta peptide; Immunotherapy; Neurodegeneration; Neuroinflammation; Nitric oxide; Nitric oxide synthase inhibitors

Indexed keywords

AMYLOID BETA PROTEIN; ANTIINFLAMMATORY AGENT; BIS 7 COGNITIN; CATALPOL; CHOLINESTERASE INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DIMEBON; DONEPEZIL; DP 55; ENZYME INHIBITOR; FLURBIPROFEN; FLURBIPROFEN 4 NITROXYBUTYL ESTER; GALANTAMINE; GEMFIBROZIL; GT 1061; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEMANTINE; MUSCARINIC AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NCX 2216; NITRIC ACID DERIVATIVE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; RESVERATROL; RETINOIC ACID; RIVASTIGMINE; TACRINE; THIOCTIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VAS 203;

EID: 77957964186     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210793176590     Document Type: Article
Times cited : (37)

References (219)
  • 1
    • 0028856460 scopus 로고
    • AnEnglish translation of Alzheimer's 1907 paper, Uber eine eigenar-tige Erkankung der Hirnrinde
    • Alzheimer A, Stelzmann RA, Schnitzlein HN, Murtagh FR. AnEnglish translation of Alzheimer's 1907 paper, Uber eine eigenar-tige Erkankung der Hirnrinde. Clin Anat 1995; 8(6): 429-31.
    • (1995) Clin Anat , vol.8 , Issue.6 , pp. 429-431
    • Alzheimer, A.1    Stelzmann, R.A.2    Schnitzlein, H.N.3    Murtagh, F.R.4
  • 2
    • 0030859067 scopus 로고    scopus 로고
    • Clinical dementia ratingtraining and reliability in multicenter studies: The Alzheimer's Dis-ease Cooperative Study experience
    • Morris JC, Ernesto C, Schafer K, et al. Clinical dementia ratingtraining and reliability in multicenter studies: the Alzheimer's Dis-ease Cooperative Study experience. Neurology 1997; 48(6): 1508-10.
    • (1997) Neurology , vol.48 , Issue.6 , pp. 1508-1510
    • Morris, J.C.1    Ernesto, C.2    Schafer, K.3
  • 3
    • 0028170818 scopus 로고
    • Cell biology of the amyloid beta-protein precursor andthe mechanism of Alzheimer's disease
    • Selkoe DJ. Cell biology of the amyloid beta-protein precursor andthe mechanism of Alzheimer's disease. Annu Rev Cell Biol 1994;10: 373-403.
    • (1994) Annu Rev Cell Biol , vol.10 , pp. 373-403
    • Selkoe, D.J.1
  • 4
    • 0031828932 scopus 로고    scopus 로고
    • Epidemiology of dementia
    • Henderson.S. Epidemiology of dementia. Ann Med Interne (Paris)1998; 149(4): 181-6.
    • (1998) Ann Med Interne (Paris) , vol.149 , Issue.4 , pp. 181-186
  • 5
    • 40449089537 scopus 로고    scopus 로고
    • Influence of pharmacogenetic factors on Alzheimer'sdisease therapeutics
    • Cacabelos R. Influence of pharmacogenetic factors on Alzheimer'sdisease therapeutics. Neurodegener Dis 2008; 5(3-4): 176-8.
    • (2008) Neurodegener Dis , vol.5 , Issue.3-4 , pp. 176-178
    • Cacabelos, R.1
  • 7
    • 0023105114 scopus 로고
    • The precursor of Alz-heimer's disease amyloid A4 protein resembles a cell-surface recep-tor
    • Kang J, Lemaire HG, Unterbeck A, et al. The precursor of Alz-heimer's disease amyloid A4 protein resembles a cell-surface recep-tor. Nature 1987; 325(6106): 733-6.
    • (1987) Nature , vol.325 , Issue.6106 , pp. 733-736
    • Kang, J.1    Lemaire, H.G.2    Unterbeck, A.3
  • 8
    • 0028106152 scopus 로고
    • Relative abundance ofAlzheimer A beta amyloid peptide variants in Alzheimer diseaseand normal aging
    • Naslund J, Schierhorn A, Hellman U, et al. Relative abundance ofAlzheimer A beta amyloid peptide variants in Alzheimer diseaseand normal aging. Proc Natl Acad Sci USA 1994; 91(18): 8378-82.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.18 , pp. 8378-8382
    • Naslund, J.1    Schierhorn, A.2    Hellman, U.3
  • 9
    • 70349123077 scopus 로고    scopus 로고
    • Depression and plasma amyloidbeta peptides in the elderly with and without the apolipoprotein E4allele
    • Sun X, Chiu CC, Liebson E, et al. Depression and plasma amyloidbeta peptides in the elderly with and without the apolipoprotein E4allele. Alzheimer Dis Assoc Disord 2009; 23(3): 238-44.
    • (2009) Alzheimer Dis Assoc Disord , vol.23 , Issue.3 , pp. 238-244
    • Sun, X.1    Chiu, C.C.2    Liebson, E.3
  • 10
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer's diseaseamyloid hypothesis: A genetic perspective
    • Tanzi RE, Bertram L. Twenty years of the Alzheimer's diseaseamyloid hypothesis: a genetic perspective. Cell 2005; 120(4): 545-55.
    • (2005) Cell , vol.120 , Issue.4 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 11
    • 46849113678 scopus 로고    scopus 로고
    • Emerging amyloid beta (Ab) peptide modulators for thetreatment of Alzheimer's disease (AD)
    • Lukiw WJ. Emerging amyloid beta (Ab) peptide modulators for thetreatment of Alzheimer's disease (AD). Expert Opin Emerg Drugs2008; 13(2): 255-71.
    • (2008) Expert Opin Emerg Drugs , vol.13 , Issue.2 , pp. 255-271
    • Lukiw, W.J.1
  • 12
    • 1542270754 scopus 로고    scopus 로고
    • Ex-pression of nitric oxide system in clinically evaluated cases of Alz-heimer's disease
    • Fernandez-Vizarra P, Fernandez AP, Castro-Blanco S, et al. Ex-pression of nitric oxide system in clinically evaluated cases of Alz-heimer's disease. Neurobiol Dis 2004; 15(2): 287-305.
    • (2004) Neurobiol Dis , vol.15 , Issue.2 , pp. 287-305
    • Fernandez-Vizarra, P.1    Fernandez, A.P.2    Castro-Blanco, S.3
  • 13
    • 47249162481 scopus 로고    scopus 로고
    • Veerhuis R,Eikelenboom P. Cyclooxygenase-1 and -2 in the different stages ofAlzheimer's disease pathology
    • Hoozemans JJ, Rozemuller JM, van Haastert ES, Veerhuis R,Eikelenboom P. Cyclooxygenase-1 and -2 in the different stages ofAlzheimer's disease pathology. Curr Pharm Des 2008; 14(14):1419-27.
    • (2008) Curr Pharm Des , vol.14 , Issue.14 , pp. 1419-1427
    • Hoozemans, J.J.1    Rozemuller, J.M.2    van Haastert, E.S.3
  • 14
    • 0036812560 scopus 로고    scopus 로고
    • From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: The role of NSAIDs andcyclooxygenase in beta-amyloidosis and clinical dementia
    • Pasinetti GM. From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: the role of NSAIDs andcyclooxygenase in beta-amyloidosis and clinical dementia. J Alz-heimers Dis 2002; 4(5): 435-45.
    • (2002) J Alz-heimers Dis , vol.4 , Issue.5 , pp. 435-445
    • Pasinetti, G.M.1
  • 15
    • 3042731174 scopus 로고    scopus 로고
    • CA1 hippocampal neuronal loss in familial Alz-heimer's disease presenilin-1 E280A mutation is related to epilepsy
    • Velez-Pardo C, Arellano JI, Cardona-Gomez P, Jimenez Del RM, Lopera F, De FJ. CA1 hippocampal neuronal loss in familial Alz-heimer's disease presenilin-1 E280A mutation is related to epilepsy.Epilepsia 2004; 45(7): 751-6.
    • (2004) Epilepsia , vol.45 , Issue.7 , pp. 751-756
    • Velez-Pardo, C.1    Arellano, J.I.2    Cardona-Gomez, P.3    Jimenez, D.R.M.4    Lopera, F.5    De, F.J.6
  • 16
    • 0032473596 scopus 로고    scopus 로고
    • Amyloid-beta peptide activates cultured astrocytes: Morphological altera-tions, cytokine induction and nitric oxide release
    • Hu J, Akama KT, Krafft GA, Chromy BA, Van Eldik LJ. Amyloid-beta peptide activates cultured astrocytes: morphological altera-tions, cytokine induction and nitric oxide release. Brain Res 1998;785(2): 195-206.
    • (1998) Brain Res , vol.785 , Issue.2 , pp. 195-206
    • Hu, J.1    Akama, K.T.2    Krafft, G.A.3    Chromy, B.A.4    van Eldik, L.J.5
  • 17
    • 0035860603 scopus 로고    scopus 로고
    • Expres-sion of endothelial and inducible NOS-isoforms is increased inAlzheimer's disease, in APP23 transgenic mice and after experi-mental brain lesion in rat: Evidence for an induction by amyloid pa-thology
    • Luth HJ, Holzer M, Gartner U, Staufenbiel M, Arendt T. Expres-sion of endothelial and inducible NOS-isoforms is increased inAlzheimer's disease, in APP23 transgenic mice and after experi-mental brain lesion in rat: evidence for an induction by amyloid pa-thology. Brain Res 2001; 913(1): 57-67.
    • (2001) Brain Res , vol.913 , Issue.1 , pp. 57-67
    • Luth, H.J.1    Holzer, M.2    Gartner, U.3    Staufenbiel, M.4    Arendt, T.5
  • 18
    • 48349085043 scopus 로고    scopus 로고
    • The amyloidprecursor protein intracellular domain (AICD) as modulator ofgene expression, apoptosis, and cytoskeletal dynamics-Relevancefor Alzheimer's disease
    • Muller T, Meyer HE, Egensperger R, Marcus K. The amyloidprecursor protein intracellular domain (AICD) as modulator ofgene expression, apoptosis, and cytoskeletal dynamics-Relevancefor Alzheimer's disease. Prog Neurobiol 2008; 85(4): 393-406.
    • (2008) Prog Neurobiol , vol.85 , Issue.4 , pp. 393-406
    • Muller, T.1    Meyer, H.E.2    Egensperger, R.3    Marcus, K.4
  • 19
    • 33747036919 scopus 로고    scopus 로고
    • Oxidative stress in Alz-heimer's disease brain: New insights from redox proteomics
    • Butterfield DA, Perluigi M, Sultana R. Oxidative stress in Alz-heimer's disease brain: new insights from redox proteomics. Eur JPharmacol 2006; 545(1): 39-50.
    • (2006) Eur JPharmacol , vol.545 , Issue.1 , pp. 39-50
    • Butterfield, D.A.1    Perluigi, M.2    Sultana, R.3
  • 20
    • 34247142905 scopus 로고    scopus 로고
    • Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitiveimpairment: Implications for the role of nitration in the progressionof Alzheimer's disease
    • Butterfield DA, Reed TT, Perluigi M, et al. Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitiveimpairment: implications for the role of nitration in the progressionof Alzheimer's disease. Brain Res 2007; 1148: 243-8.
    • (2007) Brain Res , vol.1148 , pp. 243-248
    • Butterfield, D.A.1    Reed, T.T.2    Perluigi, M.3
  • 21
    • 33947644871 scopus 로고    scopus 로고
    • Protein oxidation and lipidperoxidation in brain of subjects with Alzheimer's disease: Insightsinto mechanism of neurodegeneration from redox proteomics
    • Sultana R, Perluigi M, Butterfield DA. Protein oxidation and lipidperoxidation in brain of subjects with Alzheimer's disease: insightsinto mechanism of neurodegeneration from redox proteomics. An-tioxid Redox Signal 2006; 8(11-12): 2021-37.
    • (2006) An-tioxid Redox Signal , vol.8 , Issue.11-12 , pp. 2021-2037
    • Sultana, R.1    Perluigi, M.2    Butterfield, D.A.3
  • 22
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascadehypothesis
    • Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascadehypothesis. Science 1992; 256(5054): 184-5.
    • (1992) Science , vol.256 , Issue.5054 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 23
    • 18244389436 scopus 로고    scopus 로고
    • The role of cerebral amyloid beta accumulation in com-mon forms of Alzheimer disease
    • Gandy S. The role of cerebral amyloid beta accumulation in com-mon forms of Alzheimer disease. J Clin Invest 2005; 115(5): 1121-9.
    • (2005) J Clin Invest , vol.115 , Issue.5 , pp. 1121-1129
    • Gandy, S.1
  • 24
    • 70349147162 scopus 로고    scopus 로고
    • Genetically alteringabeta distribution from the brain to the vasculature ameliorates taupathology
    • Oddo S, Caccamo A, Cheng D, Laferla FM. Genetically alteringabeta distribution from the brain to the vasculature ameliorates taupathology. Brain Pathol 2008.
    • (2008) Brain Pathol
    • Oddo, S.1    Caccamo, A.2    Cheng, D.3    Laferla, F.M.4
  • 25
    • 1842507631 scopus 로고    scopus 로고
    • Alzheimer's disease: One disorder, too manygenes?
    • 13 Spec No
    • Bertram L, Tanzi RE. Alzheimer's disease: one disorder, too manygenes? Hum Mol Genet 2004; 13 Spec No 1: R135-41.
    • (2004) Hum Mol Genet , Issue.1
    • Bertram, L.1    Tanzi, R.E.2
  • 26
    • 1942489069 scopus 로고    scopus 로고
    • Presenilin-1-deficient neurons are nitricoxide-dependently killed by hydrogen peroxide in vitro
    • Nakajima M, Shirasawa T. Presenilin-1-deficient neurons are nitricoxide-dependently killed by hydrogen peroxide in vitro. Neurosci-ence 2004; 125(3): 563-8.
    • (2004) Neurosci-ence , vol.125 , Issue.3 , pp. 563-568
    • Nakajima, M.1    Shirasawa, T.2
  • 27
    • 0024990330 scopus 로고
    • Neurotrophic and neuro-toxic effects of amyloid beta protein: Reversal by tachykinin neu-ropeptides
    • Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neuro-toxic effects of amyloid beta protein: reversal by tachykinin neu-ropeptides. Science 1990; 250(4978): 279-82.
    • (1990) Science , vol.250 , Issue.4978 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3
  • 28
    • 33646795625 scopus 로고    scopus 로고
    • Shutting down Alzheimer's
    • Wolfe MS. Shutting down Alzheimer's. Sci Am 2006; 294(5): 72-9.
    • (2006) Sci Am , vol.294 , Issue.5 , pp. 72-79
    • Wolfe, M.S.1
  • 29
    • 51849126363 scopus 로고    scopus 로고
    • Phos-phorylated tau in neuritic plaques of APP(sw)/Tau (vlw) transgenic2846 mice and Alzheimer disease
    • Perez M, Moran MA, Ferrer I, Avila J, Gomez-Ramos P. Phos-phorylated tau in neuritic plaques of APP(sw)/Tau (vlw) transgenic2846 mice and Alzheimer disease. Acta Neuropathol 2008; 116(4): 409-18.
    • (2008) Acta Neuropathol , vol.116 , Issue.4 , pp. 409-418
    • Perez, M.1    Moran, M.A.2    Ferrer, I.3    Avila, J.4    Gomez-Ramos, P.5
  • 30
    • 41149141480 scopus 로고    scopus 로고
    • Tau kinases and phosphatases
    • Avila J. Tau kinases and phosphatases. J Cell Mol Med 2008;12(1): 258-9.
    • (2008) J Cell Mol Med , vol.12 , Issue.1 , pp. 258-259
    • Avila, J.1
  • 32
    • 29444442794 scopus 로고    scopus 로고
    • APP locus duplica-tion causes autosomal dominant early-onset Alzheimer disease withcerebral amyloid angiopathy
    • Rovelet-Lecrux A, Hannequin D, Raux G, et al. APP locus duplica-tion causes autosomal dominant early-onset Alzheimer disease withcerebral amyloid angiopathy. Nat Genet 2006; 38(1): 24-6.
    • (2006) Nat Genet , vol.38 , Issue.1 , pp. 24-26
    • Rovelet-Lecrux, A.1    Hannequin, D.2    Raux, G.3
  • 33
    • 0029087026 scopus 로고
    • Candidate gene for thechromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for thechromosome 1 familial Alzheimer's disease locus. Science 1995;269(5226): 973-7.
    • (1995) Science , vol.269 , Issue.5226 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 34
    • 0032556859 scopus 로고    scopus 로고
    • Deficiency of presenilin-1inhibits the normal cleavage of amyloid precursor protein
    • De SB, Saftig P, Craessaerts K, et al. Deficiency of presenilin-1inhibits the normal cleavage of amyloid precursor protein. Nature1998; 391(6665): 387-90.
    • (1998) Nature , vol.391 , Issue.6665 , pp. 387-390
    • de, S.B.1    Saftig, P.2    Craessaerts, K.3    Et al4
  • 35
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid-beta42(43) inbrains of mice expressing mutant presenilin 1
    • Duff K, Eckman C, Zehr C, et al. Increased amyloid-beta42(43) inbrains of mice expressing mutant presenilin 1. Nature 1996;383(6602): 710-3.
    • (1996) Nature , vol.383 , Issue.6602 , pp. 710-713
    • Duff, K.1    Eckman, C.2    Zehr, C.3
  • 36
    • 0030293676 scopus 로고    scopus 로고
    • Familial Alz-heimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
    • Borchelt DR, Thinakaran G, Eckman CB, et al. Familial Alz-heimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 1996; 17(5): 1005-13.
    • (1996) Neuron , vol.17 , Issue.5 , pp. 1005-1013
    • Borchelt, D.R.1    Thinakaran, G.2    Eckman, C.B.3
  • 37
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's dis-ease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's dis-ease: progress and problems on the road to therapeutics. Science2002; 297(5580): 353-6.
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 38
    • 33645505550 scopus 로고    scopus 로고
    • Effects of secreted oligomers of amyloid beta-protein on hippo-campal synaptic plasticity: A potent role for trimers
    • Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ.Effects of secreted oligomers of amyloid beta-protein on hippo-campal synaptic plasticity: a potent role for trimers. J Physiol 2006;572(Pt 2): 477-92.
    • (2006) J Physiol , vol.572 , Issue.Pt 2 , pp. 477-492
    • Townsend, M.1    Shankar, G.M.2    Mehta, T.3    Walsh, D.M.4    Selkoe, D.J.5
  • 39
    • 14944378094 scopus 로고    scopus 로고
    • Certain inhibitors ofsynthetic amyloid beta-peptide (Abeta) fibrillogenesis block oli-gomerization of natural Abeta and thereby rescue long-term poten-tiation
    • Walsh DM, Townsend M, Podlisny MB, et al. Certain inhibitors ofsynthetic amyloid beta-peptide (Abeta) fibrillogenesis block oli-gomerization of natural Abeta and thereby rescue long-term poten-tiation. J Neurosci 2005; 25(10): 2455-62.
    • (2005) J Neurosci , vol.25 , Issue.10 , pp. 2455-2462
    • Walsh, D.M.1    Townsend, M.2    Podlisny, M.B.3
  • 40
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimersisolated directly from Alzheimer's brains impair synaptic plasticityand memory
    • Shankar GM, Li S, Mehta TH, et al. Amyloid-beta protein dimersisolated directly from Alzheimer's brains impair synaptic plasticityand memory. Nat Med 2008; 14(8): 837-42.
    • (2008) Nat Med , vol.14 , Issue.8 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3
  • 41
    • 23044468691 scopus 로고    scopus 로고
    • The synaptic Abeta hypothesis of Alzheimer disease
    • Tanzi RE. The synaptic Abeta hypothesis of Alzheimer disease.Nat Neurosci 2005; 8(8): 977-9.
    • (2005) Nat Neurosci , vol.8 , Issue.8 , pp. 977-979
    • Tanzi, R.E.1
  • 42
  • 43
    • 0035050120 scopus 로고    scopus 로고
    • Bernardo A, jmone-Cat MA, Minghetti L. Astrocytes contribute to neuronal im-pairment in beta A toxicity increasing apoptosis in rat hippocampalneurons
    • Malchiodi-Albedi F, Domenici MR, Paradisi S, Bernardo A, jmone-Cat MA, Minghetti L. Astrocytes contribute to neuronal im-pairment in beta A toxicity increasing apoptosis in rat hippocampalneurons. Glia 2001; 34(1): 68-72.
    • (2001) Glia , vol.34 , Issue.1 , pp. 68-72
    • Malchiodi-Albedi, F.1    Domenici, M.R.2    Paradisi, S.3
  • 44
    • 23044445669 scopus 로고    scopus 로고
    • Regulation of NMDAreceptor trafficking by amyloid-beta
    • Snyder EM, Nong Y, Almeida CG, et al. Regulation of NMDAreceptor trafficking by amyloid-beta. Nat Neurosci 2005; 8(8):1051-8.
    • (2005) Nat Neurosci , vol.8 , Issue.8 , pp. 1051-1058
    • Snyder, E.M.1    Nong, Y.2    Almeida, C.G.3
  • 45
    • 34147183707 scopus 로고    scopus 로고
    • Role of the blood-brain barrier in thepathogenesis of Alzheimer's disease
    • Deane R, Zlokovic BV. Role of the blood-brain barrier in thepathogenesis of Alzheimer's disease. Curr Alzheimer Res 2007;4(2): 191-7.
    • (2007) Curr Alzheimer Res , vol.4 , Issue.2 , pp. 191-197
    • Deane, R.1    Zlokovic, B.V.2
  • 46
    • 0029670094 scopus 로고    scopus 로고
    • Beta-Amyloid-mediated vasoactivity and vascular endothelial damage
    • Thomas T, Thomas G, McLendon C, Sutton T, Mullan M., beta-Amyloid-mediated vasoactivity and vascular endothelial damage.Nature 1996; 380(6570): 168-71.
    • (1996) Nature , vol.380 , Issue.6570 , pp. 168-171
    • Thomas, T.1    Thomas, G.2    McLendon, C.3    Sutton, T.4
  • 47
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegenera-tion: Lessons from the Alzheimer's amyloid beta-peptide
    • Haass C, Selkoe DJ. Soluble protein oligomers in neurodegenera-tion: lessons from the Alzheimer's amyloid beta-peptide. Nat RevMol Cell Biol 2007; 8(2): 101-12.
    • (2007) Nat RevMol Cell Biol , vol.8 , Issue.2 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 48
    • 0034643888 scopus 로고    scopus 로고
    • The molecular and genetic basis of AD: The end ofthe beginning: The 2000 Wartenberg lecture
    • Rosenberg RN. The molecular and genetic basis of AD: the end ofthe beginning: the 2000 Wartenberg lecture. Neurology 2000;54(11): 2045-54.
    • (2000) Neurology , vol.54 , Issue.11 , pp. 2045-2054
    • Rosenberg, R.N.1
  • 49
    • 0034603525 scopus 로고    scopus 로고
    • Aberrant expression ofnitric oxide synthase III in Alzheimer's disease: Relevance to cere-bral vasculopathy and neurodegeneration
    • de la Monte SM, Lu BX, Sohn YK, et al. Aberrant expression ofnitric oxide synthase III in Alzheimer's disease: relevance to cere-bral vasculopathy and neurodegeneration. Neurobiol Aging 2000;21(2): 309-19.
    • (2000) Neurobiol Aging , vol.21 , Issue.2 , pp. 309-319
    • de la Monte, S.M.1    Lu, B.X.2    Sohn, Y.K.3
  • 50
    • 43949090196 scopus 로고    scopus 로고
    • Conformationally alteredp53: A novel Alzheimer's disease marker?
    • Lanni C, Racchi M, Mazzini G, et al. Conformationally alteredp53: a novel Alzheimer's disease marker? Mol Psychiatry 2008;13(6): 641-7.
    • (2008) Mol Psychiatry , vol.13 , Issue.6 , pp. 641-647
    • Lanni, C.1    Racchi, M.2    Mazzini, G.3
  • 51
    • 40449133643 scopus 로고    scopus 로고
    • Conformation-ally altered p53: A putative peripheral marker for Alzheimer's dis-ease
    • Uberti D, Lanni C, Racchi M, Govoni S, Memo M. Conformation-ally altered p53: a putative peripheral marker for Alzheimer's dis-ease. Neurodegener Dis 2008; 5(3-4): 209-11.
    • (2008) Neurodegener Dis , vol.5 , Issue.3-4 , pp. 209-211
    • Uberti, D.1    Lanni, C.2    Racchi, M.3    Govoni, S.4    Memo, M.5
  • 52
    • 77951046871 scopus 로고    scopus 로고
    • Highsensitivity to carcinogens in the brain of a mouse model of Alz-heimer's disease
    • Serrano J, Fernandez AP, Martinez-Murillo R, MartInez A. Highsensitivity to carcinogens in the brain of a mouse model of Alz-heimer's disease. Oncogene 2010; 29(15): 2165-71.
    • (2010) Oncogene , vol.29 , Issue.15 , pp. 2165-2171
    • Serrano, J.1    Fernandez, A.P.2    Martinez-Murillo, R.3    Martinez, A.4
  • 53
    • 0030638139 scopus 로고    scopus 로고
    • Bax protein expression is increasedin Alzheimer's brain: Correlations with DNA damage, Bcl-2 expres-sion, and brain pathology
    • Su JH, Deng G, Cotman CW. Bax protein expression is increasedin Alzheimer's brain: correlations with DNA damage, Bcl-2 expres-sion, and brain pathology. J Neuropathol Exp Neurol 1997; 56(1):86-93.
    • (1997) J Neuropathol Exp Neurol , vol.56 , Issue.1 , pp. 86-93
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 54
    • 0030831489 scopus 로고    scopus 로고
    • Correlates of p53- and Fas(CD95)-mediated apoptosis in Alzheimer's disease
    • de la Monte SM, Sohn YK, Wands JR. Correlates of p53- and Fas(CD95)-mediated apoptosis in Alzheimer's disease. J Neurol Sci11997; 152(1): 73-83.
    • (1997) J Neurol Sci1 , vol.152 , Issue.1 , pp. 73-83
    • de la Monte, S.M.1    Sohn, Y.K.2    Wands, J.R.3
  • 55
    • 0029860523 scopus 로고    scopus 로고
    • Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2and upregulates bax expression in human neurons
    • Paradis E, Douillard H, Koutroumanis M, Goodyer C, LeBlanc A.Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2and upregulates bax expression in human neurons. J Neurosci 1996; 16(23): 7533-9.
    • (1996) J Neurosci , vol.16 , Issue.23 , pp. 7533-7539
    • Paradis, E.1    Douillard, H.2    Koutroumanis, M.3    Goodyer, C.4    Leblanc, A.5
  • 56
    • 34247338555 scopus 로고    scopus 로고
    • Lovestone S,Killick R. p53 is upregulated in Alzheimer's disease and inducestau phosphorylation in HEK293a cells
    • Hooper C, Meimaridou E, Tavassoli M, Melino G, Lovestone S,Killick R. p53 is upregulated in Alzheimer's disease and inducestau phosphorylation in HEK293a cells. Neurosci Lett 2007; 418(1):34-7.
    • (2007) Neurosci Lett , vol.418 , Issue.1 , pp. 34-37
    • Hooper, C.1    Meimaridou, E.2    Tavassoli, M.3    Melino, G.4
  • 57
    • 0030962230 scopus 로고    scopus 로고
    • Attenuation of p53 expression and Baxdown-regulation during phorbol ester mediated inhibition of apop-tosis
    • Messmer UK, Brune B. Attenuation of p53 expression and Baxdown-regulation during phorbol ester mediated inhibition of apop-tosis. Br J Pharmacol 1997; 121(4): 625-34.
    • (1997) Br J Pharmacol , vol.121 , Issue.4 , pp. 625-634
    • Messmer, U.K.1    Brune, B.2
  • 58
    • 4344677000 scopus 로고    scopus 로고
    • Bacu-lovirus P35 inhibits NO-induced apoptosis in activated macro-phages by inhibiting cytochrome c release
    • Ranjan P, Shrivastava P, Singh SM, Sodhi A, Heintz NH. Bacu-lovirus P35 inhibits NO-induced apoptosis in activated macro-phages by inhibiting cytochrome c release. J Cell Sci 2004; 117(Pt14): 3031-9.
    • (2004) J Cell Sci , vol.117 , Issue.Pt14 , pp. 3031-3039
    • Ranjan, P.1    Shrivastava, P.2    Singh, S.M.3    Sodhi, A.4    Heintz, N.H.5
  • 59
    • 0347785491 scopus 로고    scopus 로고
    • Presenilin-dependentintramembrane proteolysis of CD44 leads to the liberation of its in-tracellular domain and the secretion of an Abeta-like peptide
    • Lammich S, Okochi M, Takeda M, et al. Presenilin-dependentintramembrane proteolysis of CD44 leads to the liberation of its in-tracellular domain and the secretion of an Abeta-like peptide. J BiolChem 2002; 277(47): 44754-9.
    • (2002) J BiolChem , vol.277 , Issue.47 , pp. 44754-44759
    • Lammich, S.1    Okochi, M.2    Takeda, M.3
  • 60
    • 56749163716 scopus 로고    scopus 로고
    • Notch: From neural developmentto neurological disorders
    • Lathia JD, Mattson MP, Cheng A. Notch: from neural developmentto neurological disorders. J Neurochem 2008; 107(6): 1471-81.
    • (2008) J Neurochem , vol.107 , Issue.6 , pp. 1471-1481
    • Lathia, J.D.1    Mattson, M.P.2    Cheng, A.3
  • 61
    • 0033595706 scopus 로고    scopus 로고
    • Beta-secretase cleavageof Alzheimer's amyloid precursor protein by the transmembraneaspartic protease BACE
    • Vassar R, Bennett BD, Babu-Khan S, et al. Beta-secretase cleavageof Alzheimer's amyloid precursor protein by the transmembraneaspartic protease BACE. Science 1999; 286(5440): 735-41.
    • (1999) Science , vol.286 , Issue.5440 , pp. 735-741
    • Vassar, R.1    Bennett, B.D.2    Babu-Khan, S.3
  • 62
    • 33749042749 scopus 로고    scopus 로고
    • Sorting through the cell biology of Alz-heimer's disease: Intracellular pathways to pathogenesis
    • Small SA, Gandy S. Sorting through the cell biology of Alz-heimer's disease: intracellular pathways to pathogenesis. Neuron 2006; 52(1): 15-31.
    • (2006) Neuron , vol.52 , Issue.1 , pp. 15-31
    • Small, S.A.1    Gandy, S.2
  • 63
    • 33746593662 scopus 로고    scopus 로고
    • Alzheimer's disease beta-amyloid peptides are released in association with exosomes
    • Rajendran L, Honsho M, Zahn TR, et al. Alzheimer's disease beta-amyloid peptides are released in association with exosomes. ProcNatl Acad Sci USA 2006; 103(30): 11172-7.
    • (2006) ProcNatl Acad Sci USA , vol.103 , Issue.30 , pp. 11172-11177
    • Rajendran, L.1    Honsho, M.2    Zahn, T.R.3
  • 64
    • 34247112490 scopus 로고    scopus 로고
    • Apolipoproteinreceptor 2 and X11 alpha/beta mediate apolipoprotein E-inducedendocytosis of amyloid-beta precursor protein and beta-secretase,leading to amyloid-beta production
    • He X, Cooley K, Chung CH, Dashti N, Tang J. Apolipoproteinreceptor 2 and X11 alpha/beta mediate apolipoprotein E-inducedendocytosis of amyloid-beta precursor protein and beta-secretase,leading to amyloid-beta production. J Neurosci 2007; 27(15): 4052-60.
    • (2007) J Neurosci , vol.27 , Issue.15 , pp. 4052-4060
    • He, X.1    Cooley, K.2    Chung, C.H.3    Dashti, N.4    Tang, J.5
  • 65
    • 33750731675 scopus 로고    scopus 로고
    • Mucke L. 100 years and counting: Prospects fordefeating Alzheimer's disease
    • Roberson ED, Mucke L. 100 years and counting: prospects fordefeating Alzheimer's disease. Science 2006; 314(5800): 781-4.
    • (2006) Science , vol.314 , Issue.5800 , pp. 781-784
    • Roberson, E.D.1
  • 66
    • 0036898485 scopus 로고    scopus 로고
    • Alzheimer disease gamma-secretase: A com-plex story of GxGD-type presenilin proteases
    • Haass C, Steiner H. Alzheimer disease gamma-secretase: a com-plex story of GxGD-type presenilin proteases. Trends Cell Biol 2002; 12(12): 556-62.
    • (2002) Trends Cell Biol , vol.12 , Issue.12 , pp. 556-562
    • Haass, C.1    Steiner, H.2
  • 67
    • 33947242870 scopus 로고    scopus 로고
    • When loss is gain: Reduced presenilin proteolytic func-tion leads to increased Abeta42/Abeta40. Talking Point on the roleof presenilin mutations in Alzheimer disease
    • Wolfe MS. When loss is gain: reduced presenilin proteolytic func-tion leads to increased Abeta42/Abeta40. Talking Point on the roleof presenilin mutations in Alzheimer disease. EMBO Rep 2007;8(2): 136-40.
    • (2007) EMBO Rep , vol.8 , Issue.2 , pp. 136-140
    • Wolfe, M.S.1
  • 68
    • 0034621824 scopus 로고    scopus 로고
    • Photoactivated gamma-secretaseinhibitors directed to the active site covalently label presenilin 1
    • Li YM, Xu M, Lai MT, et al. Photoactivated gamma-secretaseinhibitors directed to the active site covalently label presenilin 1.Nature 2000; 405(6787): 689-94.
    • (2000) Nature , vol.405 , Issue.6787 , pp. 689-694
    • Li, Y.M.1    Xu, M.2    Lai, M.T.3
  • 69
    • 0033780472 scopus 로고    scopus 로고
    • Transition-stateanalogue inhibitors of gamma-secretase bind directly to presenilin-1
    • Esler WP, Kimberly WT, Ostaszewski BL, et al. Transition-stateanalogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol 2000; 2(7): 428-34.
    • (2000) Nat Cell Biol , vol.2 , Issue.7 , pp. 428-434
    • Esler, W.P.1    Kimberly, W.T.2    Ostaszewski, B.L.3
  • 70
    • 0034255029 scopus 로고    scopus 로고
    • Presenilin complexes withthe C-terminal fragments of amyloid precursor protein at the sitesof amyloid beta-protein generation
    • Xia W, Ray WJ, Ostaszewski BL, et al. Presenilin complexes withthe C-terminal fragments of amyloid precursor protein at the sitesof amyloid beta-protein generation. Proc Natl Acad Sci USA 2000;97(16): 9299-304.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.16 , pp. 9299-9304
    • Xia, W.1    Ray, W.J.2    Ostaszewski, B.L.3
  • 72
    • 3343005434 scopus 로고    scopus 로고
    • PS1 activates PI3K thus inhibitingGSK-3 activity and tau overphosphorylation: Effects of FAD muta-tions
    • Baki L, Shioi J, Wen P, et al. PS1 activates PI3K thus inhibitingGSK-3 activity and tau overphosphorylation: effects of FAD muta-tions. EMBO J 2004; 23(13): 2586-96.
    • (2004) EMBO J , vol.23 , Issue.13 , pp. 2586-2596
    • Baki, L.1    Shioi, J.2    Wen, P.3
  • 73
    • 0029160069 scopus 로고
    • C-Akt in phosphatidy-linositol-3-OH kinase signal transduction
    • Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phosphatidy-linositol-3-OH kinase signal transduction. Nature 1995; 376(6541):599-602.
    • (1995) Nature , vol.376 , Issue.6541 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2    Protein, K.B.3
  • 74
    • 34447309716 scopus 로고    scopus 로고
    • Presenilin de-pendence of phospholipase C and protein kinase C signaling
    • Dehvari N, Cedazo-Minguez A, Isacsson O, et al. Presenilin de-pendence of phospholipase C and protein kinase C signaling. JNeurochem 2007; 102(3): 848-57.
    • (2007) JNeurochem , vol.102 , Issue.3 , pp. 848-857
    • Dehvari, N.1    Cedazo-Minguez, A.2    Isacsson, O.3
  • 75
    • 0038240721 scopus 로고    scopus 로고
    • Causative and suscep-tibility genes for Alzheimer's disease: A review
    • Rocchi A, Pellegrini S, Siciliano G, Murri L. Causative and suscep-tibility genes for Alzheimer's disease: a review. Brain Res Bull 2003; 61(1): 1-24.
    • (2003) Brain Res Bull , vol.61 , Issue.1 , pp. 1-24
    • Rocchi, A.1    Pellegrini, S.2    Siciliano, G.3    Murri, L.4
  • 77
    • 45249117227 scopus 로고    scopus 로고
    • Mechanism of Ca2+disruption in Alzheimer's disease by presenilin regulation of InsP3receptor channel gating
    • Cheung KH, Shineman D, Muller M, et al. Mechanism of Ca2+disruption in Alzheimer's disease by presenilin regulation of InsP3receptor channel gating. Neuron 2008; 58(6): 871-83.
    • (2008) Neuron , vol.58 , Issue.6 , pp. 871-883
    • Cheung, K.H.1    Shineman, D.2    Muller, M.3
  • 79
    • 18344380083 scopus 로고    scopus 로고
    • A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain andregulates disassembly of adherens junctions
    • Marambaud P, Shioi J, Serban G, et al. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain andregulates disassembly of adherens junctions. EMBO J 2002; 21(8):1948-56.
    • (2002) EMBO J , vol.21 , Issue.8 , pp. 1948-1956
    • Marambaud, P.1    Shioi, J.2    Serban, G.3
  • 80
    • 0036432244 scopus 로고    scopus 로고
    • The presenilins. Genome
    • reviews 3014
    • Tandon A, Fraser P. The presenilins. Genome Biol 2002; 3(11):reviews 3014.
    • (2002) Biol , vol.3 , Issue.11
    • Tandon, A.1    Fraser, P.2
  • 81
    • 0032411251 scopus 로고    scopus 로고
    • Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellularsignaling: Its significance for Alzheimer's disease
    • Dewji NN, Singer SJ. Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellularsignaling: its significance for Alzheimer's disease. Proc Natl AcadSci USA 1998; 95(25): 15055-60.
    • (1998) Proc Natl AcadSci USA , vol.95 , Issue.25 , pp. 15055-15060
    • Dewji, N.N.1    Singer, S.J.2
  • 82
    • 0036830947 scopus 로고    scopus 로고
    • Calcium dyshomeostasis and intracellular signalling inAlzheimer's disease
    • Laferla FM. Calcium dyshomeostasis and intracellular signalling inAlzheimer's disease. Nat Rev Neurosci 2002; 3(11): 862-72.
    • (2002) Nat Rev Neurosci , vol.3 , Issue.11 , pp. 862-872
    • Laferla, F.M.1
  • 83
    • 0033968306 scopus 로고    scopus 로고
    • Molecular genetics of Alzheimer's disease
    • St George-Hyslop PH. Molecular genetics of Alzheimer's disease.Biol Psychiatry 2000; 47(3): 183-199.
    • (2000) Biol Psychiatry , vol.47 , Issue.3 , pp. 183-199
    • George-Hyslop St, P.H.1
  • 84
    • 0029101491 scopus 로고
    • Familial Alzheimer'sdisease in kindreds with missense mutations in a gene on chromo-some 1 related to the Alzheimer's disease type 3 gene
    • Rogaev EI, Sherrington R, Rogaeva EA, et al. Familial Alzheimer'sdisease in kindreds with missense mutations in a gene on chromo-some 1 related to the Alzheimer's disease type 3 gene. Nature 1995;376(6543): 775-8.
    • (1995) Nature , vol.376 , Issue.6543 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3
  • 85
    • 0036023971 scopus 로고    scopus 로고
    • A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a se-vere neurogenic phenotype in zebrafish
    • Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C. A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a se-vere neurogenic phenotype in zebrafish. EMBO Rep 2002; 3(7):688-94.
    • (2002) EMBO Rep , vol.3 , Issue.7 , pp. 688-694
    • Geling, A.1    Steiner, H.2    Willem, M.3    Bally-Cuif, L.4    Haass, C.5
  • 86
    • 11144355129 scopus 로고    scopus 로고
    • Chronic treatment with thegamma-secretase inhibitor LY-411,575 inhibits beta-amyloid pep-tide production and alters lymphopoiesis and intestinal cell differ-entiation
    • Wong GT, Manfra D, Poulet FM, et al. Chronic treatment with thegamma-secretase inhibitor LY-411,575 inhibits beta-amyloid pep-tide production and alters lymphopoiesis and intestinal cell differ-entiation. J Biol Chem 2004; 279(13): 12876-82.
    • (2004) J Biol Chem , vol.279 , Issue.13 , pp. 12876-12882
    • Wong, G.T.1    Manfra, D.2    Poulet, F.M.3
  • 87
    • 0037038816 scopus 로고    scopus 로고
    • Beta-secretase (BACE) as a drug target for Alzheimer'sdisease
    • Vassar R. Beta-secretase (BACE) as a drug target for Alzheimer'sdisease. Adv Drug Deliv Rev 2002; 54(12): 1589-602.
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.12 , pp. 1589-1602
    • Vassar, R.1
  • 88
    • 34147120073 scopus 로고    scopus 로고
    • Beta-site amyloid precursorprotein cleaving enzyme 1 levels become elevated in neuronsaround amyloid plaques: Implications for Alzheimer's diseasepathogenesis
    • Zhao J, Fu Y, Yasvoina M, et al. Beta-site amyloid precursorprotein cleaving enzyme 1 levels become elevated in neuronsaround amyloid plaques: implications for Alzheimer's diseasepathogenesis. J Neurosci 2007; 27(14): 3639-49.
    • (2007) J Neurosci , vol.27 , Issue.14 , pp. 3639-3649
    • Zhao, J.1    Fu, Y.2    Yasvoina, M.3
  • 89
    • 3042798841 scopus 로고    scopus 로고
    • Beta-amyloid-mediated inhibitionof NMDA receptor-dependent long-term potentiation induction in-volves activation of microglia and stimulation of inducible nitricoxide synthase and superoxide
    • Wang Q, Rowan MJ, Anwyl R. Beta-amyloid-mediated inhibitionof NMDA receptor-dependent long-term potentiation induction in-volves activation of microglia and stimulation of inducible nitricoxide synthase and superoxide. J Neurosci 2004; 24(27): 6049-56.
    • (2004) J Neurosci , vol.24 , Issue.27 , pp. 6049-6056
    • Wang, Q.1    Rowan, M.J.2    Anwyl, R.3
  • 90
    • 39149117756 scopus 로고    scopus 로고
    • Amyloidbeta peptides and glutamatergic synaptic dysregulation
    • Parameshwaran K, Dhanasekaran M, Suppiramaniam V. Amyloidbeta peptides and glutamatergic synaptic dysregulation. Exp Neurol 2008; 210(1): 7-13.
    • (2008) Exp Neurol , vol.210 , Issue.1 , pp. 7-13
    • Parameshwaran, K.1    Dhanasekaran, M.2    Suppiramaniam, V.3
  • 91
    • 34147113790 scopus 로고    scopus 로고
    • Amyloid beta-peptideAbeta(1-42) but not Abeta(1-40) attenuates synaptic AMPA recep-tor function
    • Parameshwaran K, Sims C, Kanju P, et al. Amyloid beta-peptideAbeta(1-42) but not Abeta(1-40) attenuates synaptic AMPA recep-tor function. Synapse 2007; 61(6): 367-74.
    • (2007) Synapse , vol.61 , Issue.6 , pp. 367-374
    • Parameshwaran, K.1    Sims, C.2    Kanju, P.3
  • 93
    • 26944433799 scopus 로고    scopus 로고
    • Morphine via nitricoxide modulates beta-amyloid metabolism: A novel protectivemechanism for Alzheimer's disease
    • Pak T, Cadet P, Mantione KJ, Stefano GB. Morphine via nitricoxide modulates beta-amyloid metabolism: a novel protectivemechanism for Alzheimer's disease. Med Sci Monit 2005; 11(10):BR 357-66.
    • (2005) Med Sci Monit , vol.11 , Issue.10 , pp. 357-366
    • Pak, T.1    Cadet, P.2    Mantione, K.J.3    Stefano, G.B.4
  • 94
    • 0034836593 scopus 로고    scopus 로고
    • Riederer P,Feinstein DL, Klockgether T. Neuronal and glial coexpression ofargininosuccinate synthetase and inducible nitric oxide synthase inAlzheimer disease
    • Heneka MT, Wiesinger H, Dumitrescu-Ozimek L, Riederer P,Feinstein DL, Klockgether T. Neuronal and glial coexpression ofargininosuccinate synthetase and inducible nitric oxide synthase inAlzheimer disease. J Neuropathol Exp Neurol 2001; 60(9): 906-16.
    • (2001) J Neuropathol Exp Neurol , vol.60 , Issue.9 , pp. 906-916
    • Heneka, M.T.1    Wiesinger, H.2    Dumitrescu-Ozimek, L.3
  • 97
    • 41549095973 scopus 로고    scopus 로고
    • Cholinergic and glutamatergic altera-tions beginning at the early stages of Alzheimer disease: Participa-tion of the phospholipase A2 enzyme
    • Schaeffer EL, Gattaz WF. Cholinergic and glutamatergic altera-tions beginning at the early stages of Alzheimer disease: participa-tion of the phospholipase A2 enzyme. Psychopharmacology (Berl) 2008; 198(1): 1-27.
    • (2008) Psychopharmacology (Berl) , vol.198 , Issue.1 , pp. 1-27
    • Schaeffer, E.L.1    Gattaz, W.F.2
  • 98
    • 27744495494 scopus 로고    scopus 로고
    • Protection from Alz-heimer's-like disease in the mouse by genetic ablation of induciblenitric oxide synthase
    • Nathan C, Calingasan N, Nezezon J, et al. Protection from Alz-heimer's-like disease in the mouse by genetic ablation of induciblenitric oxide synthase. J Exp Med 2005; 202(9): 1163-9.
    • (2005) J Exp Med , vol.202 , Issue.9 , pp. 1163-1169
    • Nathan, C.1    Calingasan, N.2    Nezezon, J.3
  • 99
  • 101
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology,pathophysiology, and pharmacology
    • Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology,pathophysiology, and pharmacology. Pharmacol Rev 1991; 43(2):109-42.
    • (1991) Pharmacol Rev , vol.43 , Issue.2 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.2    Higgs, E.A.3
  • 102
    • 0035105932 scopus 로고    scopus 로고
    • Say NO to Alzheimer's disease: Theputative links between nitric oxide and dementia of the Alzheimer'stype
    • Law A, Gauthier S, Quirion R. Say NO to Alzheimer's disease: theputative links between nitric oxide and dementia of the Alzheimer'stype. Brain Res Brain Res Rev 2001; 35(1): 73-96.
    • (2001) Brain Res Brain Res Rev , vol.35 , Issue.1 , pp. 73-96
    • Law, A.1    Gauthier, S.2    Quirion, R.3
  • 103
    • 3042727914 scopus 로고    scopus 로고
    • Nitric oxide pathways in Alzheimer'sdisease and other neurodegenerative dementias
    • Togo T, Katsuse O, Iseki E. Nitric oxide pathways in Alzheimer'sdisease and other neurodegenerative dementias. Neurol Res 2004;26(5): 563-6.
    • (2004) Neurol Res , vol.26 , Issue.5 , pp. 563-566
    • Togo, T.1    Katsuse, O.2    Iseki, E.3
  • 104
    • 15044338779 scopus 로고    scopus 로고
    • Failures and successes of NMDA receptor antagonists:Molecular basis for the use of open-channel blockers like meman-tine in the treatment of acute and chronic neurologic insults
    • Lipton SA. Failures and successes of NMDA receptor antagonists:molecular basis for the use of open-channel blockers like meman-tine in the treatment of acute and chronic neurologic insults. Neu-roRx 2004; 1(1): 101-10.
    • (2004) Neu-roRx , vol.1 , Issue.1 , pp. 101-110
    • Lipton, S.A.1
  • 105
    • 0343570105 scopus 로고    scopus 로고
    • Modulation of beta-amyloid precursor pro-tein processing and tau phosphorylation by acetylcholine receptors
    • Hellstrom-Lindahl E. Modulation of beta-amyloid precursor pro-tein processing and tau phosphorylation by acetylcholine receptors.Eur J Pharmacol 2000; 393(1-3): 255-63.
    • (2000) Eur J Pharmacol , vol.393 , Issue.1-3 , pp. 255-263
    • Hellstrom-Lindahl, E.1
  • 106
    • 31544481458 scopus 로고    scopus 로고
    • KapsM. Acetylcholine esterase inhibitor donepezil improves dynamiccerebrovascular regulation in Alzheimer patients
    • Rosengarten B, Paulsen S, Molnar S, Kaschel R, Gallhofer B, KapsM. Acetylcholine esterase inhibitor donepezil improves dynamiccerebrovascular regulation in Alzheimer patients. J Neurol 2006;253(1): 58-64.
    • (2006) J Neurol , vol.253 , Issue.1 , pp. 58-64
    • Rosengarten, B.1    Paulsen, S.2    Molnar, S.3    Kaschel, R.4    Gallhofer, B.5
  • 107
    • 41049111771 scopus 로고    scopus 로고
    • Effectiveness of cholines-terase inhibitors and memantine for treating dementia: Evidence re-view for a clinical practice guideline
    • Raina P, Santaguida P, Ismaila A, et al. Effectiveness of cholines-terase inhibitors and memantine for treating dementia: evidence re-view for a clinical practice guideline. Ann Intern Med 2008;148(5): 379-97.
    • (2008) Ann Intern Med , vol.148 , Issue.5 , pp. 379-397
    • Raina, P.1    Santaguida, P.2    Ismaila, A.3
  • 108
    • 77953778864 scopus 로고    scopus 로고
    • Treatment of Alzheimer's disease: Symp-tomatic and disease-modifying approaches
    • Galimberti D, Scarpini E. Treatment of Alzheimer's disease: symp-tomatic and disease-modifying approaches. Curr Aging Sci 2010;3(1): 46-56.
    • (2010) Curr Aging Sci , vol.3 , Issue.1 , pp. 46-56
    • Galimberti, D.1    Scarpini, E.2
  • 109
    • 67651114110 scopus 로고    scopus 로고
    • Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's dis-ease, with cholinergic, antioxidant, and neuroprotective properties
    • Fernandez-Bachiller MI, Perez C, Campillo NE, et al. Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's dis-ease, with cholinergic, antioxidant, and neuroprotective properties.ChemMedChem 2009; 4(5): 828-41.
    • (2009) ChemMedChem , vol.4 , Issue.5 , pp. 828-841
    • Fernandez-Bachiller, M.I.1    Perez, C.2    Campillo, N.E.3
  • 110
    • 0032797262 scopus 로고    scopus 로고
    • Nitric oxide synthases:Targets for therapeutic strategies in neurological diseases
    • Chabrier PE, merle-Pallardy C, Auguet M. Nitric oxide synthases:targets for therapeutic strategies in neurological diseases. Cell MolLife Sci 1999; 55(8-9): 1029-35.
    • (1999) Cell MolLife Sci , vol.55 , Issue.8-9 , pp. 1029-1035
    • Chabrier, P.E.1    Merle-Pallardy, C.2    Auguet, M.3
  • 111
    • 0034883504 scopus 로고    scopus 로고
    • Neuroprotective and neurorescuingeffects of isoform-specific nitric oxide synthase inhibitors, nitricoxide scavenger, and antioxidant against beta-amyloid toxicity
    • Law A, Gauthier S, Quirion R. Neuroprotective and neurorescuingeffects of isoform-specific nitric oxide synthase inhibitors, nitricoxide scavenger, and antioxidant against beta-amyloid toxicity. BrJ Pharmacol 2001; 133(7): 1114-24.
    • (2001) BrJ Pharmacol , vol.133 , Issue.7 , pp. 1114-1124
    • Law, A.1    Gauthier, S.2    Quirion, R.3
  • 112
    • 0026569273 scopus 로고
    • Cloning and characterization ofinducible nitric oxide synthase from mouse macrophages
    • Xie QW, Cho HJ, Calaycay J, et al. Cloning and characterization ofinducible nitric oxide synthase from mouse macrophages. Science 1992; 256(5054): 225-8.
    • (1992) Science , vol.256 , Issue.5054 , pp. 225-228
    • Xie, Q.W.1    Cho, H.J.2    Calaycay, J.3
  • 113
    • 10244235267 scopus 로고    scopus 로고
    • Inducible nitric oxidesynthase in tangle-bearing neurons of patients with Alzheimer'sdisease
    • Vodovotz Y, Lucia MS, Flanders KC, et al. Inducible nitric oxidesynthase in tangle-bearing neurons of patients with Alzheimer'sdisease. J Exp Med 1996; 184(4): 1425-33.
    • (1996) J Exp Med , vol.184 , Issue.4 , pp. 1425-1433
    • Vodovotz, Y.1    Lucia, M.S.2    Flanders, K.C.3
  • 114
    • 65949085175 scopus 로고    scopus 로고
    • Calcium-sensing receptor (CaSR) in human brain'spathophysiology: Roles in late-onset Alzheimer's disease (LOAD)
    • Chiarini A, Dal P I, Marconi M, Chakravarthy B, Whitfield JF, Armato U. Calcium-sensing receptor (CaSR) in human brain'spathophysiology: roles in late-onset Alzheimer's disease (LOAD). Curr Pharm Biotechnol 2009; 10(3): 317-26.
    • (2009) Curr Pharm Biotechnol , vol.10 , Issue.3 , pp. 317-326
    • Chiarini, A.1    Dal, P.I.2    Marconi, M.3    Chakravarthy, B.4    Whitfield, J.F.5    Armato, U.6
  • 115
    • 69949108880 scopus 로고    scopus 로고
    • Nitric oxide activity andisoenzyme expression in the senescence-accelerated mouse p8model of Alzheimer's disease: Effects of anti-amyloid antibody andantisense treatments
    • Ali AK, Banks WA, Kumar VB, et al. Nitric oxide activity andisoenzyme expression in the senescence-accelerated mouse p8model of Alzheimer's disease: effects of anti-amyloid antibody andantisense treatments. J Gerontol A Biol Sci Med Sci 2009; 64(10):1025-30.
    • (2009) J Gerontol a Biol Sci Med Sci , vol.64 , Issue.10 , pp. 1025-1030
    • Ali, A.K.1    Banks, W.A.2    Kumar, V.B.3
  • 116
    • 0032707107 scopus 로고    scopus 로고
    • Inducible nitric oxidesynthase immunoreactivity in the Alzheimer disease hippocampus:Association with Hirano bodies, neurofibrillary tangles, and senileplaques
    • Lee SC, Zhao ML, Hirano A, Dickson DW. Inducible nitric oxidesynthase immunoreactivity in the Alzheimer disease hippocampus:association with Hirano bodies, neurofibrillary tangles, and senileplaques. J Neuropathol Exp Neurol 1999; 58(11): 1163-9.
    • (1999) J Neuropathol Exp Neurol , vol.58 , Issue.11 , pp. 1163-1169
    • Lee, S.C.1    Zhao, M.L.2    Hirano, A.3    Dickson, D.W.4
  • 117
    • 0035976590 scopus 로고    scopus 로고
    • Advanced glycationendproducts co-localize with inducible nitric oxide synthase inAlzheimer's disease
    • Wong A, Luth HJ, uther-Conrad W, et al. Advanced glycationendproducts co-localize with inducible nitric oxide synthase inAlzheimer's disease. Brain Res 2001; 920(1-2): 32-40.
    • (2001) Brain Res , vol.920 , Issue.1-2 , pp. 32-40
    • Wong, A.1    Luth, H.J.2    Uther-Conrad, W.3
  • 118
    • 39349105603 scopus 로고    scopus 로고
    • [The role for oxidative stress in neurode-generative diseases]
    • Shibata N, Kobayashi M. [The role for oxidative stress in neurode-generative diseases]. Brain Nerve 2008; 60(2): 157-70.
    • (2008) Brain Nerve , vol.60 , Issue.2 , pp. 157-170
    • Shibata, N.1    Kobayashi, M.2
  • 119
    • 42949152935 scopus 로고    scopus 로고
    • Association between Alzheimer'sdisease and the NOS3 gene Glu298Asp polymorphism in Chinese
    • Wang B, Tan S, Yang Z, et al. Association between Alzheimer'sdisease and the NOS3 gene Glu298Asp polymorphism in Chinese. J Mol Neurosci 2008; 34(2): 173-6.
    • (2008) J Mol Neurosci , vol.34 , Issue.2 , pp. 173-176
    • Wang, B.1    Tan, S.2    Yang, Z.3
  • 121
    • 0032948006 scopus 로고    scopus 로고
    • Peroxynitrite-induced alterationsin synaptosomal membrane proteins: Insight into oxidative stress inAlzheimer's disease
    • Koppal T, Drake J, Yatin S, et al. Peroxynitrite-induced alterationsin synaptosomal membrane proteins: insight into oxidative stress inAlzheimer's disease. J Neurochem 1999; 72(1): 310-7.
    • (1999) J Neurochem , vol.72 , Issue.1 , pp. 310-317
    • Koppal, T.1    Drake, J.2    Yatin, S.3
  • 122
    • 0037145738 scopus 로고    scopus 로고
    • Aberrant expression of NOS iso-forms in Alzheimer's disease is structurally related to nitrotyrosineformation
    • Luth HJ, Munch G, Arendt T. Aberrant expression of NOS iso-forms in Alzheimer's disease is structurally related to nitrotyrosineformation. Brain Res 2002; 953(1-2): 135-43.
    • (2002) Brain Res , vol.953 , Issue.1-2 , pp. 135-143
    • Luth, H.J.1    Munch, G.2    Arendt, T.3
  • 123
    • 4344677286 scopus 로고    scopus 로고
    • Nitricoxide in the cerebral cortex of amyloid-precursor protein (SW)Tg2576 transgenic mice
    • Rodrigo J, Fernandez-Vizarra P, Castro-Blanco S, et al. Nitricoxide in the cerebral cortex of amyloid-precursor protein (SW)Tg2576 transgenic mice. Neuroscience 2004; 128(1): 73-89.
    • (2004) Neuroscience , vol.128 , Issue.1 , pp. 73-89
    • Rodrigo, J.1    Fernandez-Vizarra, P.2    Castro-Blanco, S.3
  • 124
    • 0035105932 scopus 로고    scopus 로고
    • Say NO to Alzheimer's disease: Theputative links between nitric oxide and dementia of the Alzheimer'stype
    • Law A, Gauthier S, Quirion R. Say NO to Alzheimer's disease: theputative links between nitric oxide and dementia of the Alzheimer'stype. Brain Res Brain Res Rev 2001; 35(1): 73-96.
    • (2001) Brain Res Brain Res Rev , vol.35 , Issue.1 , pp. 73-96
    • Law, A.1    Gauthier, S.2    Quirion, R.3
  • 125
    • 25844457652 scopus 로고    scopus 로고
    • Biochemical markers and risk factors ofAlzheimer's disease
    • Flirski M, Sobow T. Biochemical markers and risk factors ofAlzheimer's disease. Curr Alzheimer Res 2005; 2(1): 47-64.
    • (2005) Curr Alzheimer Res , vol.2 , Issue.1 , pp. 47-64
    • Flirski, M.1    Sobow, T.2
  • 126
    • 0345647069 scopus 로고    scopus 로고
    • BouluRR, Plotkine M. Reduction of tyrosine nitration after N(omega)-nitro-L-arginine-methylester treatment of mice with traumatic braininjury
    • Mesenge C, Charriaut-Marlangue C, Verrecchia C, Allix M, BouluRR, Plotkine M. Reduction of tyrosine nitration after N(omega)-nitro-L-arginine-methylester treatment of mice with traumatic braininjury. Eur J Pharmacol 1998; 353(1): 53-7.
    • (1998) Eur J Pharmacol , vol.353 , Issue.1 , pp. 53-57
    • Mesenge, C.1    Charriaut-Marlangue, C.2    Verrecchia, C.3    Allix, M.4
  • 127
    • 3542996239 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor augments beta-amyloid-induced interleukin-1,interleukin-6, and nitric oxide production by microglial cells
    • Murphy GM, Jr., Yang L, Cordell B. Macrophage colony-stimulating factor augments beta-amyloid-induced interleukin-1,interleukin-6, and nitric oxide production by microglial cells. J BiolChem 1998; 273(33): 20967-71.
    • (1998) J BiolChem , vol.273 , Issue.33 , pp. 20967-20971
    • Murphy Jr., G.M.1    Yang, L.2    Cordell, B.3
  • 128
    • 77957956423 scopus 로고    scopus 로고
    • Highsensitivity to carcinogens in the brain of a mouse model of Alz-heimeŕs disease
    • In press
    • Serrano J, Fernandez AP, Martinez-Murillo R, MartInez A. Highsensitivity to carcinogens in the brain of a mouse model of Alz-heimeŕs disease. Oncogene 2009; In press.
    • (2009) Oncogene
    • Serrano, J.1    Fernandez, A.P.2    Martinez-Murillo, R.3    Martinez, A.4
  • 129
    • 0028953529 scopus 로고
    • Activation of micro-glial cells by beta-amyloid protein and interferon-gamma
    • Meda L, Cassatella MA, Szendrei GI, et al. Activation of micro-glial cells by beta-amyloid protein and interferon-gamma. Nature 1995; 374(6523): 647-50.
    • (1995) Nature , vol.374 , Issue.6523 , pp. 647-650
    • Meda, L.1    Cassatella, M.A.2    Szendrei, G.I.3
  • 130
    • 33745727518 scopus 로고    scopus 로고
    • Resveratrol inhibits inducible nitric oxide synthase and cyclooxy-genase-2 expression in beta-amyloid-treated C6 glioma cells
    • Kim YA, Lim SY, Rhee SH, Park KY, Kim CH, Choi BT et al.Resveratrol inhibits inducible nitric oxide synthase and cyclooxy-genase-2 expression in beta-amyloid-treated C6 glioma cells. Int JMol Med 2006; 17(6): 1069-75.
    • (2006) Int JMol Med , vol.17 , Issue.6 , pp. 1069-1075
    • Kim, Y.A.1    Lim, S.Y.2    Rhee, S.H.3    Park, K.Y.4    Kim, C.H.5    Choi B.T. et, al.6
  • 131
    • 4744369310 scopus 로고    scopus 로고
    • Aging-related increasein oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenicTg2576 mice with Alzheimer-like pathology
    • Apelt J, Bigl M, Wunderlich P, Schliebs R. Aging-related increasein oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenicTg2576 mice with Alzheimer-like pathology. Int J Dev Neurosci 2004; 22(7): 475-84.
    • (2004) Int J Dev Neurosci , vol.22 , Issue.7 , pp. 475-484
    • Apelt, J.1    Bigl, M.2    Wunderlich, P.3    Schliebs, R.4
  • 132
    • 0036362861 scopus 로고    scopus 로고
    • Adverse effect of a presenilin-1mutation in microglia results in enhanced nitric oxide and inflam-matory cytokine responses to immune challenge in the brain
    • Lee J, Chan SL, Mattson MP. Adverse effect of a presenilin-1mutation in microglia results in enhanced nitric oxide and inflam-matory cytokine responses to immune challenge in the brain. Neu-romolecular Med 2002; 2(1): 29-45.
    • (2002) Neu-romolecular Med , vol.2 , Issue.1 , pp. 29-45
    • Lee, J.1    Chan, S.L.2    Mattson, M.P.3
  • 133
    • 33746238205 scopus 로고    scopus 로고
    • Molecular indices of oxidative stressand mitochondrial dysfunction occur early and often progress withseverity of Alzheimer's disease
    • de la Monte SM, Wands JR. Molecular indices of oxidative stressand mitochondrial dysfunction occur early and often progress withseverity of Alzheimer's disease. J Alzheimers Dis 2006; 9(2): 167-81.
    • (2006) J Alzheimers Dis , vol.9 , Issue.2 , pp. 167-181
    • de la Monte, S.M.1    Wands, J.R.2
  • 134
    • 13844292636 scopus 로고    scopus 로고
    • Nitric oxide and neurological disorders
    • Duncan AJ, Heales SJ. Nitric oxide and neurological disorders. Mol Aspects Med 2005; 26(1-2): 67-96.
    • (2005) Mol Aspects Med , vol.26 , Issue.1-2 , pp. 67-96
    • Duncan, A.J.1    Heales, S.J.2
  • 135
    • 34249027009 scopus 로고    scopus 로고
    • Connecting TNF-alphasignaling pathways to iNOS expression in a mouse model of Alz-heimer's disease: Relevance for the behavioral and synaptic deficitsinduced by amyloid beta protein
    • Medeiros R, Prediger RD, Passos GF, et al. Connecting TNF-alphasignaling pathways to iNOS expression in a mouse model of Alz-heimer's disease: relevance for the behavioral and synaptic deficitsinduced by amyloid beta protein. J Neurosci 2007; 27(20): 5394-404.
    • (2007) J Neurosci , vol.27 , Issue.20 , pp. 5394-5404
    • Medeiros, R.1    Prediger, R.D.2    Passos, G.F.3
  • 136
    • 40949148107 scopus 로고    scopus 로고
    • Amyloid-beta(25-35) increases activity of neuronal NO-synthase in rat brain
    • Stepanichev MY, Onufriev MV, Yakovlev AA, et al. Amyloid-beta(25-35) increases activity of neuronal NO-synthase in rat brain. Neurochem Int 2008; 52(6): 1114-24.
    • (2008) Neurochem Int , vol.52 , Issue.6 , pp. 1114-1124
    • Stepanichev, M.Y.1    Onufriev, M.V.2    Yakovlev, A.A.3
  • 137
    • 0037329921 scopus 로고    scopus 로고
    • Nitric oxide syn-thase-3 overexpression causes apoptosis and impairs neuronal mi-tochondrial function: Relevance to Alzheimer's-type neurodegenera-tion
    • de la Monte SM, Chiche J, von dem BA, et al. Nitric oxide syn-thase-3 overexpression causes apoptosis and impairs neuronal mi-tochondrial function: relevance to Alzheimer's-type neurodegenera-tion. Lab Invest 2003; 83(2): 287-98.
    • (2003) Lab Invest , vol.83 , Issue.2 , pp. 287-298
    • de la Monte, S.M.1    Chiche, J.2    von dem, B.A.3
  • 138
    • 1342326751 scopus 로고    scopus 로고
    • Does nitric oxide synthasecontribute to the pathogenesis of Alzheimer's disease?: Effects ofbeta-amyloid deposition on NOS in transgenic mouse brain withAD pathology
    • Lahiri DK, Chen D, Ge YW, et al. Does nitric oxide synthasecontribute to the pathogenesis of Alzheimer's disease?: effects ofbeta-amyloid deposition on NOS in transgenic mouse brain withAD pathology. Ann N Y Acad Sci 2003; 1010: 639-42.
    • (2003) Ann N Y Acad Sci , vol.1010 , pp. 639-642
    • Lahiri, D.K.1    Chen, D.2    Ge, Y.W.3
  • 139
    • 21544467552 scopus 로고    scopus 로고
    • Van denBH. Cholinesterase inhibitors for patients with Alzheimer's disease:Systematic review of randomised clinical trials
    • Kaduszkiewicz H, Zimmermann T, Beck-Bornholdt HP, van denBH. Cholinesterase inhibitors for patients with Alzheimer's disease:systematic review of randomised clinical trials. BMJ 2005;331(7512): 321-7.
    • (2005) BMJ , vol.331 , Issue.7512 , pp. 321-327
    • Kaduszkiewicz, H.1    Zimmermann, T.2    Beck-Bornholdt, H.P.3
  • 140
    • 14844292105 scopus 로고    scopus 로고
    • Emerging prospects forthe disease-modifying treatment of Alzheimer's disease
    • Walker LC, Ibegbu CC, Todd CW, et al. Emerging prospects forthe disease-modifying treatment of Alzheimer's disease. BiochemPharmacol 2005; 69(7): 1001-8.
    • (2005) BiochemPharmacol , vol.69 , Issue.7 , pp. 1001-1008
    • Walker, L.C.1    Ibegbu, C.C.2    Todd, C.W.3
  • 141
    • 33645756861 scopus 로고    scopus 로고
    • Do cholinergictherapies have disease-modifying effects in Alzheimer's disease?
    • Sabbagh MN, Farlow MR, Relkin N, Beach TG. Do cholinergictherapies have disease-modifying effects in Alzheimer's disease? Alzheimers Dement 2006; 2(2): 118-25.
    • (2006) Alzheimers Dement , vol.2 , Issue.2 , pp. 118-125
    • Sabbagh, M.N.1    Farlow, M.R.2    Relkin, N.3    Beach, T.G.4
  • 142
    • 20844461153 scopus 로고    scopus 로고
    • Nitric oxide mimeticmolecules as therapeutic agents in Alzheimer's disease
    • Thatcher GR, Bennett BM, Reynolds JN. Nitric oxide mimeticmolecules as therapeutic agents in Alzheimer's disease. Curr Alz-heimer Res 2005; 2(2): 171-82.
    • (2005) Curr Alz-heimer Res , vol.2 , Issue.2 , pp. 171-182
    • Thatcher, G.R.1    Bennett, B.M.2    Reynolds, J.N.3
  • 143
    • 38049045075 scopus 로고    scopus 로고
    • Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer'sdisease--but how and why?
    • Das UN. Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer'sdisease--but how and why? Prostaglandins Leukot Essent Fatty Ac-ids 2008; 78(1): 11-19.
    • (2008) Prostaglandins Leukot Essent Fatty Ac-ids , vol.78 , Issue.1 , pp. 11-19
    • Das, U.N.1
  • 144
    • 33746808620 scopus 로고    scopus 로고
    • Mechanisms of neuroprotective effects of therapeuticacetylcholinesterase inhibitors used in treatment of Alzheimer'sdisease
    • Takatori Y. [Mechanisms of neuroprotective effects of therapeuticacetylcholinesterase inhibitors used in treatment of Alzheimer'sdisease]. Yakugaku Zasshi 2006;126(8): 607-16.
    • (2006) Yakugaku Zasshi , vol.126 , Issue.8 , pp. 607-616
    • Takatori, Y.1
  • 145
    • 57749094960 scopus 로고    scopus 로고
    • Novel anti-Alzheimer's dimer Bis(7)-cognitin: Cellular and molecular mechanisms of neuroprotectionthrough multiple targets
    • Li W, Mak M, Jiang H, et al. Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotectionthrough multiple targets. Neurotherapeutics 2009; 6(1): 187-201.
    • (2009) Neurotherapeutics , vol.6 , Issue.1 , pp. 187-201
    • Li, W.1    Mak, M.2    Jiang, H.3
  • 146
    • 51449084024 scopus 로고    scopus 로고
    • Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's dis-ease
    • Maczurek A, Hager K, Kenklies M, et al. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's dis-ease. Adv Drug Deliv Rev 2008; 60(13-14): 1463-70.
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.13-14 , pp. 1463-1470
    • Maczurek, A.1    Hager, K.2    Kenklies, M.3
  • 147
    • 0035936004 scopus 로고    scopus 로고
    • Nonsteroidalantiinflammatory drugs and the risk of Alzheimer's disease
    • in t, V, Ruitenberg A, Hofman A, Launer LJ, et al. Nonsteroidalantiinflammatory drugs and the risk of Alzheimer's disease. N EnglJ Med 2001; 345(21): 1515-1521.
    • (2001) N EnglJ Med , vol.345 , Issue.21 , pp. 1515-1521
    • in t, V.1    Ruitenberg, A.2    Hofman, A.3    Launer, L.J.4
  • 148
    • 0037167542 scopus 로고    scopus 로고
    • BreitnerJC. Reduced incidence of AD with NSAID but not H2 receptor an-tagonists: The Cache County Study
    • Zandi PP, Anthony JC, Hayden KM, Mehta K, Mayer L, BreitnerJC. Reduced incidence of AD with NSAID but not H2 receptor an-tagonists: the Cache County Study. Neurology 2002; 59(6): 880-6.
    • (2002) Neurology , vol.59 , Issue.6 , pp. 880-886
    • Zandi, P.P.1    Anthony, J.C.2    Hayden, K.M.3    Mehta, K.4    Mayer, L.5
  • 149
    • 0034233382 scopus 로고    scopus 로고
    • Thepervasiveness of interleukin-1 in alzheimer pathogenesis: A role forspecific polymorphisms in disease risk
    • Griffin WS, Nicoll JA, Grimaldi LM, Sheng JG, Mrak RE. Thepervasiveness of interleukin-1 in alzheimer pathogenesis: a role forspecific polymorphisms in disease risk. Exp Gerontol 2000; 35(4):481-7.
    • (2000) Exp Gerontol , vol.35 , Issue.4 , pp. 481-487
    • Griffin, W.S.1    Nicoll, J.A.2    Grimaldi, L.M.3    Sheng, J.G.4    Mrak, R.E.5
  • 150
    • 0030764732 scopus 로고    scopus 로고
    • Amyloidogenic role ofcytokine TGF-beta1 in transgenic mice and in Alzheimer's disease
    • Wyss-Coray T, Masliah E, Mallory M, et al. Amyloidogenic role ofcytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature 1997; 389(6651): 603-6.
    • (1997) Nature , vol.389 , Issue.6651 , pp. 603-606
    • Wyss-Coray, T.1    Masliah, E.2    Mallory, M.3
  • 151
    • 37349053395 scopus 로고    scopus 로고
    • Catalpol attenuates theneurotoxicity induced by beta-amyloid(1-42) in cortical neuron-gliacultures
    • Jiang B, Du J, Liu JH, Bao YM, An LJ. Catalpol attenuates theneurotoxicity induced by beta-amyloid(1-42) in cortical neuron-gliacultures. Brain Res 2008; 1188: 139-47.
    • (2008) Brain Res , vol.1188 , pp. 139-147
    • Jiang, B.1    Du, J.2    Liu, J.H.3    Bao, Y.M.4    An, L.J.5
  • 152
    • 57949087452 scopus 로고    scopus 로고
    • Molecular inflammation:Underpinnings of aging and age-related diseases
    • Chung HY, Cesari M, Anton S, et al. Molecular inflammation:underpinnings of aging and age-related diseases. Ageing Res Rev 2009; 8(1): 18-30.
    • (2009) Ageing Res Rev , vol.8 , Issue.1 , pp. 18-30
    • Chung, H.Y.1    Cesari, M.2    Anton, S.3
  • 153
  • 154
    • 16544364566 scopus 로고    scopus 로고
    • Ibuprofen and Alzheimer's disease
    • Dokmeci D. Ibuprofen and Alzheimer's disease. Folia Med(Plovdiv) 2004; 46(2): 5-10.
    • (2004) Folia Med(Plovdiv) , vol.46 , Issue.2 , pp. 5-10
    • Dokmeci, D.1
  • 155
    • 17844374592 scopus 로고    scopus 로고
    • Activity of flur-biprofen and chemically related anti-inflammatory drugs in modelsof Alzheimer's disease
    • Gasparini L, Ongini E, Wilcock D, Morgan D. Activity of flur-biprofen and chemically related anti-inflammatory drugs in modelsof Alzheimer's disease. Brain Res Brain Res Rev 2005; 48(2): 400-8.
    • (2005) Brain Res Brain Res Rev , vol.48 , Issue.2 , pp. 400-408
    • Gasparini, L.1    Ongini, E.2    Wilcock, D.3    Morgan, D.4
  • 156
    • 17144403821 scopus 로고    scopus 로고
    • Retinoic acid inhibitsexpression of TNF-alpha and iNOS in activated rat microglia
    • Dheen ST, Jun Y, Yan Z, Tay SS, Ling EA. Retinoic acid inhibitsexpression of TNF-alpha and iNOS in activated rat microglia. Glia 2005; 50(1): 21-31.
    • (2005) Glia , vol.50 , Issue.1 , pp. 21-31
    • Dheen, S.T.1    Jun, Y.2    Yan, Z.3    Tay, S.S.4    Ling, E.A.5
  • 157
    • 35748940962 scopus 로고    scopus 로고
    • Involvement of phos-phatidylinositol 3-kinase-mediated up-regulation of I kappa B al-pha in anti-inflammatory effect of gemfibrozil in microglia
    • Jana M, Jana A, Liu X, Ghosh S, Pahan K. Involvement of phos-phatidylinositol 3-kinase-mediated up-regulation of I kappa B al-pha in anti-inflammatory effect of gemfibrozil in microglia. J Im-munol 2007; 179(6): 4142-52.
    • (2007) J Im-munol , vol.179 , Issue.6 , pp. 4142-4152
    • Jana, M.1    Jana, A.2    Liu, X.3    Ghosh, S.4    Pahan, K.5
  • 158
    • 3042586648 scopus 로고    scopus 로고
    • Inflammatory mediatorand beta-amyloid (25-35)-induced ceramide generation and iNOSexpression are inhibited by vitamin
    • Ayasolla K, Khan M, Singh AK, Singh I. Inflammatory mediatorand beta-amyloid (25-35)-induced ceramide generation and iNOSexpression are inhibited by vitamin E. Free Radic Biol Med 2004;37(3): 325-38.
    • (2004) E. Free Radic Biol Med , vol.37 , Issue.3 , pp. 325-338
    • Ayasolla, K.1    Khan, M.2    Singh, A.K.3    Singh, I.4
  • 159
    • 0037387772 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1activity promotes NF-kappaB-driven transcription and microglialactivation: Implication for neurodegenerative disorders
    • Chiarugi A, Moskowitz MA. Poly(ADP-ribose) polymerase-1activity promotes NF-kappaB-driven transcription and microglialactivation: implication for neurodegenerative disorders. J Neuro-chem 2003; 85(2): 306-17.
    • (2003) J Neuro-chem , vol.85 , Issue.2 , pp. 306-317
    • Chiarugi, A.1    Moskowitz, M.A.2
  • 160
    • 0034089991 scopus 로고    scopus 로고
    • Braininflammatory reaction in an animal model of neuronal degenerationand its modulation by an anti-inflammatory drug: Implication inAlzheimer's disease
    • Scali C, Prosperi C, Vannucchi MG, Pepeu G, Casamenti F. Braininflammatory reaction in an animal model of neuronal degenerationand its modulation by an anti-inflammatory drug: implication inAlzheimer's disease. Eur J Neurosci 2000; 12(6): 1900-12.
    • (2000) Eur J Neurosci , vol.12 , Issue.6 , pp. 1900-1912
    • Scali, C.1    Prosperi, C.2    Vannucchi, M.G.3    Pepeu, G.4    Casamenti, F.5
  • 161
    • 0030610491 scopus 로고    scopus 로고
    • Involvement of phospholi-pase A2 in neurodegeneration
    • Farooqui AA, Yang HC, Horrocks L. Involvement of phospholi-pase A2 in neurodegeneration. Neurochem Int 1997; 30(6): 517-22.
    • (1997) Neurochem Int , vol.30 , Issue.6 , pp. 517-522
    • Farooqui, A.A.1    Yang, H.C.2    Horrocks, L.3
  • 162
    • 54049089921 scopus 로고    scopus 로고
    • Amyloid-beta peptide inducestemporal membrane biphasic changes in astrocytes through cytoso-lic phospholipase A2
    • Hicks JB, Lai Y, Sheng W, et al. Amyloid-beta peptide inducestemporal membrane biphasic changes in astrocytes through cytoso-lic phospholipase A2. Biochim Biophys Acta 2008; 1778(11):2512-9.
    • (2008) Biochim Biophys Acta , vol.1778 , Issue.11 , pp. 2512-2519
    • Hicks, J.B.1    Lai, Y.2    Sheng, W.3
  • 163
    • 0029657725 scopus 로고    scopus 로고
    • Cytosolicphospholipase A2 (cPLA2) immunoreactivity is elevated in Alz-heimer's disease brain
    • Stephenson DT, Lemere CA, Selkoe DJ, Clemens JA. Cytosolicphospholipase A2 (cPLA2) immunoreactivity is elevated in Alz-heimer's disease brain. Neurobiol Dis 1996; 3(1): 51-63.
    • (1996) Neurobiol Dis , vol.3 , Issue.1 , pp. 51-63
    • Stephenson, D.T.1    Lemere, C.A.2    Selkoe, D.J.3    Clemens, J.A.4
  • 164
    • 0031937355 scopus 로고    scopus 로고
    • Phospholipid-metabolizing enzymes in Alzheimer's disease: Increased lysophos-pholipid acyltransferase activity and decreased phospholipase A2activity
    • Ross BM, Moszczynska A, Erlich J, Kish SJ. Phospholipid-metabolizing enzymes in Alzheimer's disease: increased lysophos-pholipid acyltransferase activity and decreased phospholipase A2activity. J Neurochem 1998; 70(2): 786-93.
    • (1998) J Neurochem , vol.70 , Issue.2 , pp. 786-793
    • Ross, B.M.1    Moszczynska, A.2    Erlich, J.3    Kish, S.J.4
  • 165
    • 67349230279 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase: Structure, subcel-lular localization, regulation, and clinical implications
    • Zhou L, Zhu DY. Neuronal nitric oxide synthase: structure, subcel-lular localization, regulation, and clinical implications. Nitric Oxide 2009; 20(4): 223-30.
    • (2009) Nitric Oxide , vol.20 , Issue.4 , pp. 223-230
    • Zhou, L.1    Zhu, D.Y.2
  • 166
    • 0027988579 scopus 로고
    • Inhibitors of freeradical formation fail to attenuate direct beta-amyloid25-35 pep-tide-mediated neurotoxicity in rat hippocampal cultures
    • Lockhart BP, Benicourt C, Junien JL, Privat A. Inhibitors of freeradical formation fail to attenuate direct beta-amyloid25-35 pep-tide-mediated neurotoxicity in rat hippocampal cultures. J NeurosciRes 1994; 39(4): 494-505.
    • (1994) J NeurosciRes , vol.39 , Issue.4 , pp. 494-505
    • Lockhart, B.P.1    Benicourt, C.2    Junien, J.L.3    Privat, A.4
  • 167
    • 34447323271 scopus 로고    scopus 로고
    • DP-155, a lecithin derivativeof indomethacin, is a novel nonsteroidal antiinflammatory drug for analgesia and Alzheimer's disease therapy
    • Dvir E, Elman A, Simmons D, et al. DP-155, a lecithin derivativeof indomethacin, is a novel nonsteroidal antiinflammatory drug for analgesia and Alzheimer's disease therapy. CNS Drug Rev 2007;13(2): 260-77.
    • (2007) CNS Drug Rev , vol.13 , Issue.2 , pp. 260-277
    • Dvir, E.1    Elman, A.2    Simmons, D.3
  • 168
    • 28844435000 scopus 로고    scopus 로고
    • StrosznajderJB. Nitric oxide alters arachidonic acid turnover in brain cortexsynaptoneurosomes
    • Chalimoniuk M, Glowacka J, Zabielna A, Eckert A, StrosznajderJB. Nitric oxide alters arachidonic acid turnover in brain cortexsynaptoneurosomes. Neurochem Int 2006; 48(1): 1-8.
    • (2006) Neurochem Int , vol.48 , Issue.1 , pp. 1-8
    • Chalimoniuk, M.1    Glowacka, J.2    Zabielna, A.3    Eckert, A.4
  • 169
    • 28344453810 scopus 로고    scopus 로고
    • Phosphodiesterase inhibi-tion by sildenafil citrate attenuates a maze learning impairment inrats induced by nitric oxide synthase inhibition
    • Devan BD, Bowker JL, Duffy KB, et al. Phosphodiesterase inhibi-tion by sildenafil citrate attenuates a maze learning impairment inrats induced by nitric oxide synthase inhibition. Psychopharma-cology (Berl) 2006; 183(4): 439-45.
    • (2006) Psychopharma-cology (Berl) , vol.183 , Issue.4 , pp. 439-445
    • Devan, B.D.1    Bowker, J.L.2    Duffy, K.B.3
  • 170
    • 4243194585 scopus 로고    scopus 로고
    • Vardenafil: Struc-tural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5)
    • Corbin JD, Beasley A, Blount MA, Francis SH. Vardenafil: struc-tural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5). Neurochem Int 2004; 45(6):859-63.
    • (2004) Neurochem Int , vol.45 , Issue.6 , pp. 859-863
    • Corbin, J.D.1    Beasley, A.2    Blount, M.A.3    Francis, S.H.4
  • 171
    • 4344587810 scopus 로고    scopus 로고
    • In vivoreconstitution of the negative feedback in nitric oxide/cGMP sig-naling: Role of phosphodiesterase type 5 phosphorylation
    • Mullershausen F, Russwurm M, Koesling D, Friebe A. In vivoreconstitution of the negative feedback in nitric oxide/cGMP sig-naling: role of phosphodiesterase type 5 phosphorylation. Mol BiolCell 2004; 15(9): 4023-30.
    • (2004) Mol BiolCell , vol.15 , Issue.9 , pp. 4023-4030
    • Mullershausen, F.1    Russwurm, M.2    Koesling, D.3    Friebe, A.4
  • 172
    • 67649342620 scopus 로고    scopus 로고
    • Phosphodiesterase 5inhibition improves synaptic function, memory, and amyloid-betaload in an Alzheimer's disease mouse model
    • Puzzo D, Staniszewski A, Deng SX, et al. Phosphodiesterase 5inhibition improves synaptic function, memory, and amyloid-betaload in an Alzheimer's disease mouse model. J Neurosci 2009;29(25): 8075-86.
    • (2009) J Neurosci , vol.29 , Issue.25 , pp. 8075-8086
    • Puzzo, D.1    Staniszewski, A.2    Deng, S.X.3
  • 173
    • 34250778886 scopus 로고    scopus 로고
    • Parameshwaran K,Suppiramaniam V, Dhanasekaran M. Versatile effects of sildenafil:Recent pharmacological applications
    • Uthayathas S, Karuppagounder SS, Thrash BM, Parameshwaran K,Suppiramaniam V, Dhanasekaran M. Versatile effects of sildenafil:recent pharmacological applications. Pharmacol Rep 2007; 59(2):150-63.
    • (2007) Pharmacol Rep , vol.59 , Issue.2 , pp. 150-163
    • Uthayathas, S.1    Karuppagounder, S.S.2    Thrash, B.M.3
  • 174
    • 33845575859 scopus 로고    scopus 로고
    • Cyclic GMP metabolismand its role in brain physiology
    • Domek-Lopacinska K, Strosznajder JB. Cyclic GMP metabolismand its role in brain physiology. J Physiol Pharmacol 2005; 56 Suppl 2: 15-34.
    • (2005) J Physiol Pharmacol , vol.56 , Issue.SUPPL. 2 , pp. 15-34
    • Domek-Lopacinska, K.1    Strosznajder, J.B.2
  • 175
    • 0038149079 scopus 로고    scopus 로고
    • Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essentialfor spatial reference and contextual memory
    • Kleppisch T, Wolfsgruber W, Feil S, et al. Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essentialfor spatial reference and contextual memory. J Neurosci 2003;23(14): 6005-12.
    • (2003) J Neurosci , vol.23 , Issue.14 , pp. 6005-6012
    • Kleppisch, T.1    Wolfsgruber, W.2    Feil, S.3
  • 176
    • 0034114456 scopus 로고    scopus 로고
    • Cascading glia reactions:A common pathomechanism and its differentiated control by cyclicnucleotide signaling
    • Schubert P, Morino T, Miyazaki H, et al. Cascading glia reactions:a common pathomechanism and its differentiated control by cyclicnucleotide signaling. Ann N Y Acad Sci 2000; 903: 24-33.
    • (2000) Ann N Y Acad Sci , vol.903 , pp. 24-33
    • Schubert, P.1    Morino, T.2    Miyazaki, H.3
  • 178
    • 0032426667 scopus 로고    scopus 로고
    • Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitatesthe establishment of long-lasting long-term potentiation and im-proves memory
    • Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E.Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitatesthe establishment of long-lasting long-term potentiation and im-proves memory. Proc Natl Acad Sci USA 1998; 95(25): 15020-5.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.25 , pp. 15020-15025
    • Barad, M.1    Bourtchouladze, R.2    Winder, D.G.3    Golan, H.4    Kandel, E.5
  • 179
    • 85047694516 scopus 로고    scopus 로고
    • Persistent improvement in synaptic and cognitive functions in anAlzheimer mouse model after rolipram treatment
    • Gong B, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio O.Persistent improvement in synaptic and cognitive functions in anAlzheimer mouse model after rolipram treatment. J Clin Invest 2004; 114(11): 1624-34.
    • (2004) J Clin Invest , vol.114 , Issue.11 , pp. 1624-1634
    • Gong, B.1    Vitolo, O.V.2    Trinchese, F.3    Liu, S.4    Shelanski, M.5    Arancio, O.6
  • 180
    • 33750984544 scopus 로고    scopus 로고
    • Caffeine protectsAlzheimer's mice against cognitive impairment and reduces brainbeta-amyloid production
    • Arendash GW, Schleif W, Rezai-Zadeh K, et al. Caffeine protectsAlzheimer's mice against cognitive impairment and reduces brainbeta-amyloid production. Neuroscience 2006; 142(4): 941-52.
    • (2006) Neuroscience , vol.142 , Issue.4 , pp. 941-952
    • Arendash, G.W.1    Schleif, W.2    Rezai-Zadeh, K.3
  • 181
    • 33751427701 scopus 로고    scopus 로고
    • Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice
    • Dall'Igna OP, Fett P, Gomes MW, Souza DO, Cunha RA, Lara DR.Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice. Exp Neurol 2007; 203(1): 241-5.
    • (2007) Exp Neurol , vol.203 , Issue.1 , pp. 241-245
    • Dall'igna, O.P.1    Fett, P.2    Gomes, M.W.3    Souza, D.O.4    Cunha, R.A.5    Lara, D.R.6
  • 182
    • 0029127542 scopus 로고
    • The in vitro pharmacologyof ZM 241385, a potent, non-xanthine A2a selective adenosine re-ceptor antagonist
    • Poucher SM, Keddie JR, Singh P, et al. The in vitro pharmacologyof ZM 241385, a potent, non-xanthine A2a selective adenosine re-ceptor antagonist. Br J Pharmacol 1995; 115(6): 1096-102.
    • (1995) Br J Pharmacol , vol.115 , Issue.6 , pp. 1096-1102
    • Poucher, S.M.1    Keddie, J.R.2    Singh, P.3
  • 183
    • 65549132404 scopus 로고    scopus 로고
    • Pharmacological effects andbehavioral interventions on memory consolidation and reconsolida-tion
    • Baratti CM, Boccia MM, Blake MG. Pharmacological effects andbehavioral interventions on memory consolidation and reconsolida-tion. Braz J Med Biol Res 2009; 42(2): 148-54.
    • (2009) Braz J Med Biol Res , vol.42 , Issue.2 , pp. 148-154
    • Baratti, C.M.1    Boccia, M.M.2    Blake, M.G.3
  • 184
    • 0030040255 scopus 로고    scopus 로고
    • Selective pharmacological inhibition ofdistinct nitric oxide synthase isoforms
    • Southan GJ, Szabo C. Selective pharmacological inhibition ofdistinct nitric oxide synthase isoforms. Biochem Pharmacol 1996;51(4): 383-94.
    • (1996) Biochem Pharmacol , vol.51 , Issue.4 , pp. 383-394
    • Southan, G.J.1    Szabo, C.2
  • 185
    • 18944380149 scopus 로고    scopus 로고
    • Inhibition of vascular nitric oxide after ratchronic brain hypoperfusion: Spatial memory and immunocyto-chemical changes
    • de la Torre JC, Aliev G. Inhibition of vascular nitric oxide after ratchronic brain hypoperfusion: spatial memory and immunocyto-chemical changes. J Cereb Blood Flow Metab 2005; 25(6): 663-72.
    • (2005) J Cereb Blood Flow Metab , vol.25 , Issue.6 , pp. 663-672
    • de la Torre, J.C.1    Aliev, G.2
  • 186
    • 39549115445 scopus 로고    scopus 로고
    • Progression ofamyloid pathology to Alzheimer's disease pathology in an amyloidprecursor protein transgenic mouse model by removal of nitric ox-ide synthase 2
    • Wilcock DM, Lewis MR, Van Nostrand WE, et al. Progression ofamyloid pathology to Alzheimer's disease pathology in an amyloidprecursor protein transgenic mouse model by removal of nitric ox-ide synthase 2. J Neurosci 2008; 28(7): 1537-45.
    • (2008) J Neurosci , vol.28 , Issue.7 , pp. 1537-1545
    • Wilcock, D.M.1    Lewis, M.R.2    van Nostrand, W.E.3
  • 187
    • 33748072442 scopus 로고    scopus 로고
    • NO synthase 2 (NOS2)deletion promotes multiple pathologies in a mouse model of Alz-heimer's disease
    • Colton CA, Vitek MP, Wink DA, et al. NO synthase 2 (NOS2)deletion promotes multiple pathologies in a mouse model of Alz-heimer's disease. Proc Natl Acad Sci USA 2006; 103(34): 12867-72.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.34 , pp. 12867-12872
    • Colton, C.A.1    Vitek, M.P.2    Wink, D.A.3
  • 188
    • 0036242431 scopus 로고    scopus 로고
    • Progress inthe development of selective nitric oxide synthase (NOS) inhibi-tors
    • Salerno L, Sorrenti V, Di GC, Romeo G, Siracusa MA. Progress inthe development of selective nitric oxide synthase (NOS) inhibi-tors. Curr Pharm Des 2002; 8(3): 177-200
    • (2002) Curr Pharm Des , vol.8 , Issue.3 , pp. 177-200
    • Salerno, L.1    Sorrenti, V.2    Di, G.C.3    Romeo, G.4    Siracusa, M.A.5
  • 189
    • 0025194144 scopus 로고
    • L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible in-hibitor of endothelium-dependent vasodilatation in vitro
    • Moore PK, al-Swayeh OA, Chong NW, Evans RA, Gibson A. L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible in-hibitor of endothelium-dependent vasodilatation in vitro. Br JPharmacol 1990; 99(2): 408-12.
    • (1990) Br JPharmacol , vol.99 , Issue.2 , pp. 408-412
    • Moore, P.K.1    Al-Swayeh, O.A.2    Chong, N.W.3    Evans, R.A.4    Gibson, A.5
  • 190
    • 0032502351 scopus 로고    scopus 로고
    • N5-(1-Imino-3-butenyl)-L-ornithine. Aneuronal isoform selective mechanism-based inactivator of nitricoxide synthase
    • Babu BR, Griffith OW. N5-(1-Imino-3-butenyl)-L-ornithine. Aneuronal isoform selective mechanism-based inactivator of nitricoxide synthase. J Biol Chem 1998; 273(15): 8882-9.
    • (1998) J Biol Chem , vol.273 , Issue.15 , pp. 8882-8889
    • Babu, B.R.1    Griffith, O.W.2
  • 191
    • 0027184034 scopus 로고
    • Selective inhibitionof constitutive nitric oxide synthase by L-NG-nitroarginine
    • Furfine ES, Harmon MF, Paith JE, Garvey EP. Selective inhibitionof constitutive nitric oxide synthase by L-NG-nitroarginine. Bio-chemistry 1993; 32(33): 8512-7.
    • (1993) Bio-chemistry , vol.32 , Issue.33 , pp. 8512-8517
    • Furfine, E.S.1    Harmon, M.F.2    Paith, J.E.3    Garvey, E.P.4
  • 192
    • 0028314083 scopus 로고
    • Synthesis of L-thiocitrulline, L-homothiocitrulline, and S-methyl-L-thiocitrulline: A new class ofpotent nitric oxide synthase inhibitors
    • Narayanan K, Griffith OW. Synthesis of L-thiocitrulline, L-homothiocitrulline, and S-methyl-L-thiocitrulline: a new class ofpotent nitric oxide synthase inhibitors. J Med Chem 1994; 37(7):885-7.
    • (1994) J Med Chem , vol.37 , Issue.7 , pp. 885-887
    • Narayanan, K.1    Griffith, O.W.2
  • 193
    • 0029078058 scopus 로고
    • S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide syn-thase with strong pressor activity in vivo
    • Narayanan K, Spack L, McMillan K, et al. S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide syn-thase with strong pressor activity in vivo. J Biol Chem 1995;270(19): 11103-10.
    • (1995) J Biol Chem , vol.270 , Issue.19 , pp. 11103-11110
    • Narayanan, K.1    Spack, L.2    McMillan, K.3
  • 194
    • 0027967765 scopus 로고
    • Potent and selectiveinhibition of human nitric oxide synthases. Selective inhibition ofneuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline
    • Furfine ES, Harmon MF, Paith JE, et al. Potent and selectiveinhibition of human nitric oxide synthases. Selective inhibition ofneuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline. J Biol Chem 1994; 269(43): 26677-83.
    • (1994) J Biol Chem , vol.269 , Issue.43 , pp. 26677-26683
    • Furfine, E.S.1    Harmon, M.F.2    Paith, J.E.3
  • 195
    • 0032874388 scopus 로고    scopus 로고
    • ThreadgillMD. Heterocyclic analogues of L-citrulline as inhibitors of the iso-forms of nitric oxide synthase (NOS) and identification of N(delta)-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor
    • Ulhaq S, Chinje EC, Naylor MA, Jaffar M, Stratford IJ, ThreadgillMD. Heterocyclic analogues of L-citrulline as inhibitors of the iso-forms of nitric oxide synthase (NOS) and identification of N(delta)-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor. BioorgMed Chem 1999; 7(9): 1787-96.
    • (1999) BioorgMed Chem , vol.7 , Issue.9 , pp. 1787-1796
    • Ulhaq, S.1    Chinje, E.C.2    Naylor, M.A.3    Jaffar, M.4    Stratford, I.J.5
  • 196
    • 0032212754 scopus 로고    scopus 로고
    • Conformationallyconstrained NO synthase inhibitors: Rigid analogs of L-N-iminoethylornithine
    • Eustache J, Grob A, Lam C, Sellier O, Schulz G. Conformationallyconstrained NO synthase inhibitors: rigid analogs of L-N-iminoethylornithine. Bioorg Med Chem Lett 1998; 8(21): 2961-6.
    • (1998) Bioorg Med Chem Lett , vol.8 , Issue.21 , pp. 2961-2966
    • Eustache, J.1    Grob, A.2    Lam, C.3    Sellier, O.4    Schulz, G.5
  • 197
    • 0033549862 scopus 로고    scopus 로고
    • N(omega)-Nitroarginine-containing dipeptide amides. Potent andhighly selective inhibitors of neuronal nitric oxide synthase
    • Huang H, Martasek P, Roman LJ, Masters BS, Silverman RB.N(omega)-Nitroarginine-containing dipeptide amides. Potent andhighly selective inhibitors of neuronal nitric oxide synthase. J MedChem 1999; 42(16): 3147-53.
    • (1999) J MedChem , vol.42 , Issue.16 , pp. 3147-3153
    • Huang, H.1    Martasek, P.2    Roman, L.J.3    Masters, B.S.4    Silverman, R.B.5
  • 198
    • 0032820128 scopus 로고    scopus 로고
    • NaganoT. Dipeptides containing L-arginine analogs: New isozyme-selective inhibitors of nitric oxide synthase
    • Kobayashi N, Higuchi T, Urano Y, Kikuchi K, Hirobe M, NaganoT. Dipeptides containing L-arginine analogs: new isozyme-selective inhibitors of nitric oxide synthase. Biol Pharm Bull 1999;22(9): 936-40.
    • (1999) Biol Pharm Bull , vol.22 , Issue.9 , pp. 936-940
    • Kobayashi, N.1    Higuchi, T.2    Urano, Y.3    Kikuchi, K.4    Hirobe, M.5
  • 199
    • 38649131473 scopus 로고    scopus 로고
    • Cyclo(dehydrohistidyl-l-tryptophyl) inhibits nitric oxide production by preventing the di-merization of inducible nitric oxide synthase
    • Sohn MJ, Hur GM, Byun HS, Kim WG. Cyclo(dehydrohistidyl-l-tryptophyl) inhibits nitric oxide production by preventing the di-merization of inducible nitric oxide synthase. Biochem Pharmacol 2008; 75(4): 923-30.
    • (2008) Biochem Pharmacol , vol.75 , Issue.4 , pp. 923-930
    • Sohn, M.J.1    Hur, G.M.2    Byun, H.S.3    Kim, W.G.4
  • 200
    • 0028360840 scopus 로고
    • Aminoguanidine, an inhibitor of inducible nitric oxide synthase,ameliorates experimental autoimmune encephalomyelitis in SJLmice
    • Cross AH, Misko TP, Lin RF, Hickey WF, Trotter JL, Tilton RG.Aminoguanidine, an inhibitor of inducible nitric oxide synthase,ameliorates experimental autoimmune encephalomyelitis in SJLmice. J Clin Invest 1994; 93(6): 2684-90.
    • (1994) J Clin Invest , vol.93 , Issue.6 , pp. 2684-2690
    • Cross, A.H.1    Misko, T.P.2    Lin, R.F.3    Hickey, W.F.4    Trotter, J.L.5    Tilton, R.G.6
  • 201
    • 0028089793 scopus 로고
    • Potent and selectiveinhibition of human nitric oxide synthases. Inhibition by non-aminoacid isothioureas
    • Garvey EP, Oplinger JA, Tanoury GJ, et al. Potent and selectiveinhibition of human nitric oxide synthases. Inhibition by non-aminoacid isothioureas. J Biol Chem 1994; 269(43): 26669-76.
    • (1994) J Biol Chem , vol.269 , Issue.43 , pp. 26669-26676
    • Garvey, E.P.1    Oplinger, J.A.2    Tanoury, G.J.3
  • 202
    • 13344277274 scopus 로고    scopus 로고
    • Fok KF, et al. 2-Iminopiperidine andother 2-iminoazaheterocycles as potent inhibitors of human nitricoxide synthase isoforms
    • Moore WM, Webber RK, Fok KF, et al. 2-Iminopiperidine andother 2-iminoazaheterocycles as potent inhibitors of human nitricoxide synthase isoforms. J Med Chem 1996; 39(3): 669-72.
    • (1996) J Med Chem , vol.39 , Issue.3 , pp. 669-672
    • Moore, W.M.1    Webber, R.K.2
  • 203
    • 0034643290 scopus 로고    scopus 로고
    • A potent inhibitor of induc-ible nitric oxide synthase, ONO-1714, a cyclic amidine derivative
    • Naka M, Nanbu T, Kobayashi K, et al. A potent inhibitor of induc-ible nitric oxide synthase, ONO-1714, a cyclic amidine derivative.Biochem Biophys Res Commun 2000; 270(2): 663-7.
    • (2000) Biochem Biophys Res Commun , vol.270 , Issue.2 , pp. 663-667
    • Naka, M.1    Nanbu, T.2    Kobayashi, K.3
  • 204
    • 0027323351 scopus 로고
    • Inhibition ofrat cerebellar nitric oxide synthase by 7-nitro indazole and relatedsubstituted indazoles
    • Babbedge RC, Bland-Ward PA, Hart SL, Moore PK. Inhibition ofrat cerebellar nitric oxide synthase by 7-nitro indazole and relatedsubstituted indazoles. Br J Pharmacol 1993; 110(1): 225-8.
    • (1993) Br J Pharmacol , vol.110 , Issue.1 , pp. 225-228
    • Babbedge, R.C.1    Bland-Ward, P.A.2    Hart, S.L.3    Moore, P.K.4
  • 205
    • 0027942138 scopus 로고
    • The NOSinhibitor, 7-nitroindazole, decreases focal infarct volume but notthe response to topical acetylcholine in pial vessels
    • Yoshida T, Limmroth V, Irikura K, Moskowitz MA. The NOSinhibitor, 7-nitroindazole, decreases focal infarct volume but notthe response to topical acetylcholine in pial vessels. J Cereb BloodFlow Metab 1994; 14(6): 924-9.
    • (1994) J Cereb BloodFlow Metab , vol.14 , Issue.6 , pp. 924-929
    • Yoshida, T.1    Limmroth, V.2    Irikura, K.3    Moskowitz, M.A.4
  • 206
    • 0029549375 scopus 로고
    • Neuroprotective effects of free radical scav-engers and energy repletion in animal models of neurodegenerativedisease
    • Schulz JB, Beal MF. Neuroprotective effects of free radical scav-engers and energy repletion in animal models of neurodegenerativedisease. Ann N Y Acad Sci 1995; 765: 100-10.
    • (1995) Ann N Y Acad Sci , vol.765 , pp. 100-110
    • Schulz, J.B.1    Beal, M.F.2
  • 207
    • 0026735580 scopus 로고
    • Nitric oxide synthase is a cytochrome P-450 type hemoprotein
    • White KA, Marletta MA. Nitric oxide synthase is a cytochrome P-450 type hemoprotein. Biochemistry 1992; 31(29): 6627-31.
    • (1992) Biochemistry , vol.31 , Issue.29 , pp. 6627-6631
    • White, K.A.1    Marletta, M.A.2
  • 208
    • 0027194920 scopus 로고
    • Calmodulin-dependent nitric-oxide synthase. Mechanism of inhibition by imi-dazole and phenylimidazoles
    • Wolff DJ, Datto GA, Samatovicz RA, Tempsick RA. Calmodulin-dependent nitric-oxide synthase. Mechanism of inhibition by imi-dazole and phenylimidazoles. J Biol Chem 1993; 268(13): 9425-9.
    • (1993) J Biol Chem , vol.268 , Issue.13 , pp. 9425-9429
    • Wolff, D.J.1    Datto, G.A.2    Samatovicz, R.A.3    Tempsick, R.A.4
  • 209
    • 0017687255 scopus 로고
    • Steric factors in theinhibitory interaction of imidazoles with microsomal enzymes
    • Rogerson TD, Wilkinson CF, Hetarski K. Steric factors in theinhibitory interaction of imidazoles with microsomal enzymes. Biochem Pharmacol 1977; 26(11): 1039-42.
    • (1977) Biochem Pharmacol , vol.26 , Issue.11 , pp. 1039-1042
    • Rogerson, T.D.1    Wilkinson, C.F.2    Hetarski, K.3
  • 210
    • 0029043644 scopus 로고
    • In search of a function for tetrahydrobiop-terin in the biosynthesis of nitric oxide
    • Mayer B, Werner ER. In search of a function for tetrahydrobiop-terin in the biosynthesis of nitric oxide. Naunyn SchmiedebergsArch Pharmacol 1995; 351(5): 453-63.
    • (1995) Naunyn SchmiedebergsArch Pharmacol , vol.351 , Issue.5 , pp. 453-463
    • Mayer, B.1    Werner, E.R.2
  • 211
    • 0032509360 scopus 로고    scopus 로고
    • Anti-pterins as tools tocharacterize the function of tetrahydrobiopterin in NO synthase
    • Bommel HM, Reif A, Frohlich LG, et al. Anti-pterins as tools tocharacterize the function of tetrahydrobiopterin in NO synthase. JBiol Chem 1998; 273(50): 33142-9.
    • (1998) JBiol Chem , vol.273 , Issue.50 , pp. 33142-33149
    • Bommel, H.M.1    Reif, A.2    Frohlich, L.G.3
  • 212
    • 75449087712 scopus 로고    scopus 로고
    • The novel nitricoxide synthase inhibitor 4-amino-tetrahydro-L-biopterine preventsbrain edema formation and intracranial hypertension followingtraumatic brain injury in mice
    • Terpolilli NA, Zweckberger K, Trabold R, et al. The novel nitricoxide synthase inhibitor 4-amino-tetrahydro-L-biopterine preventsbrain edema formation and intracranial hypertension followingtraumatic brain injury in mice. J Neurotrauma 2009; 26(11): 1963-75.
    • (2009) J Neurotrauma , vol.26 , Issue.11 , pp. 1963-1975
    • Terpolilli, N.A.1    Zweckberger, K.2    Trabold, R.3
  • 213
    • 0242268945 scopus 로고    scopus 로고
    • Immunotherapeutic approaches toAlzheimer's disease
    • Monsonego A, Weiner HL. Immunotherapeutic approaches toAlzheimer's disease. Science 2003; 302(5646): 834-8.
    • (2003) Science , vol.302 , Issue.5646 , pp. 834-838
    • Monsonego, A.1    Weiner, H.L.2
  • 215
    • 33646384419 scopus 로고    scopus 로고
    • Immunology and immunotherapy of Alz-heimer's disease
    • .Received: July 9, 2010 Accepted: July 21, 2010
    • Weiner HL, Frenkel D. Immunology and immunotherapy of Alz-heimer's disease. Nat Rev Immunol 2006; 6(5): 404-16.Received: July 9, 2010 Accepted: July 21, 2010
    • (2006) Nat Rev Immunol , vol.6 , Issue.5 , pp. 404-416
    • Weiner, H.L.1    Frenkel, D.2
  • 216
    • 60849128810 scopus 로고    scopus 로고
    • GlatzelM. Autoantibodies against beta-amyloid are common in Alz-heimer's disease and help control plaque burden
    • Kellner A, Matschke J, Bernreuther C, Moch H, Ferrer I, GlatzelM. Autoantibodies against beta-amyloid are common in Alz-heimer's disease and help control plaque burden. Ann Neurol 2009;65(1): 24-31.
    • (2009) Ann Neurol , vol.65 , Issue.1 , pp. 24-31
    • Kellner, A.1    Matschke, J.2    Bernreuther, C.3    Moch, H.4    Ferrer, I.5
  • 217
    • 21044453723 scopus 로고    scopus 로고
    • Amyloid beta proteinimmunotherapy neutralizes Abeta oligomers that disrupt synapticplasticity in vivo
    • Klyubin I, Walsh DM, Lemere CA, et al. Amyloid beta proteinimmunotherapy neutralizes Abeta oligomers that disrupt synapticplasticity in vivo. Nat Med 2005; 11(5): 556-61.
    • (2005) Nat Med , vol.11 , Issue.5 , pp. 556-561
    • Klyubin, I.1    Walsh, D.M.2    Lemere, C.A.3
  • 218
    • 0032521111 scopus 로고    scopus 로고
    • Fibrillar beta-amyloidinduces microglial phagocytosis, expression of inducible nitric ox-ide synthase, and loss of a select population of neurons in the ratCNS in vivo
    • Weldon DT, Rogers SD, Ghilardi JR, et al. Fibrillar beta-amyloidinduces microglial phagocytosis, expression of inducible nitric ox-ide synthase, and loss of a select population of neurons in the ratCNS in vivo. J Neurosci 1998; 18(6): 2161-73.
    • (1998) J Neurosci , vol.18 , Issue.6 , pp. 2161-2173
    • Weldon, D.T.1    Rogers, S.D.2    Ghilardi, J.R.3
  • 219
    • 64249133725 scopus 로고    scopus 로고
    • S-nitrosylation of Drp1 medi-ates beta-amyloid-related mitochondrial fission and neuronal in-jury
    • Cho DH, Nakamura T, Fang J, et al. S-nitrosylation of Drp1 medi-ates beta-amyloid-related mitochondrial fission and neuronal in-jury. Science 2009; 324(5923): 102-5.
    • (2009) Science , vol.324 , Issue.5923 , pp. 102-105
    • Cho, D.H.1    Nakamura, T.2    Fang, J.3


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