100 Years and counting: Prospects for defeating Alzheimer's disease

Science

Volumn 314, Issue 5800, 2006, Pages 781-784

  Roberson, Erik D ^a   Mucke, Lennart ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG THERAPY; NEUROLOGY; PATHOLOGY; PATIENT TREATMENT; PROTEINS;

ALZHEIMER'S DISEASE; BLOCK PATHOGENIC AMYLOID; MICROTUBULE-ASSOCIATED PROTEIN;

DISEASES;

4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMYLOID BETA PROTEIN; ANTIOXIDANT; APOLIPOPROTEIN E; CALCIUM CHANNEL BLOCKING AGENT; CHOLINESTERASE INHIBITOR; DONEPEZIL; ENZYME INHIBITOR; GALANTAMINE; GAMMA SECRETASE INHIBITOR; GLYCOGEN SYNTHASE KINASE; GLYCOGEN SYNTHASE KINASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN; MEMANTINE; MUSCARINIC AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NERVE GROWTH FACTOR RECEPTOR AFFECTING AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR AFFECTING AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PHOSPHODIESTERASE INHIBITOR; RIVASTIGMINE; SEROTONIN ANTAGONIST; TACRINE; TAU PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

DISEASE INCIDENCE; DRUG; PATHOGENICITY;

AGING; ALZHEIMER DISEASE; CLINICAL TRIAL; DEGENERATIVE DISEASE; DRUG RESEARCH; HISTORY; HUMAN; MEMORY DISORDER; PRIORITY JOURNAL; REVIEW;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CLINICAL TRIALS; ENZYME INHIBITORS; HUMANS; IMMUNIZATION, PASSIVE; NOOTROPIC AGENTS; VACCINATION;

EID: 33750731675     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1132813     Document Type: Review

References (91)

1. C. P. Ferri et al., Lancet 366, 2112 (2005).
2. P. M. Doraiswamy, G. L. Xiong, Expert Opin. Pharmacother. 7, 1 (2006).
3. A. Lleó, S. M. Greenberg, J. H. Growdon, Annu. Rev. Med. 57, 513 (2006).
4. M. P. Mattson, Nature 430, 631 (2004).
5. C. W. Ritchie, D. Ames, T. Clayton, R. Lai, Am. J. Geriatr. Psychiatry 12, 358 (2004).
6. A. Whitehead et al., Int. J. Geriatr. Psychiatry 19, 624 (2004).
7. J. Birks, Cochrane Database Syst. Rev. 10.1002/14651858.CD005593 (2006).
8. R. Bullock, Alzheimer Dis. Assoc. Disord. 20, 23 (2006).
9. R. McShane, A. Areosa Sastre, N. Minakaran, Cochrane Database Syst. Rev. 10.1002/14651858.CD003154 (2006).
10. M. Maggini, N. Vanacore, R. Raschetti, PloS Med. 3, e140 (2006).
11. M. R. Farlow, Expert Rev. Neurotherapeutics 4, 799 (2004).
12. L. A. Boothby, P. L. Doering, Ann. Pharmacother. 39, 2073 (2005).
13. E. R. Miller III et al., Ann. Intern. Med. 142, 37 (2005).
14. A. Nunomura et al., J. Neuropathol. Exp. Neurol. 65, 631 (2006).
15. J. S. Jacobsen, P. Reinhart, M. N. Pangalos, NeuroRx 2, 612 (2005).
16. M. Citron, Nat. Rev. Neurosci. 5, 677 (2004).
17. E. R. Siemers et al., Neurology 66, 602 (2006).
18. A. Geling, H. Steiner, M. Willem, L. Bally-Cuif, C. Haass, EMBO Rep. 3, 688 (2002).
19. G. T. Wong et al., J. Biol. Chem. 279, 12876 (2004).
20. M. S. Wolfe, Biochemistry 45, 7931 (2006).
21. P. C. Fraering et al., J. Biol. Chem. 280, 41987 (2005).
22. W. J. Netzer et al., Proc. Natl. Acad. Sci. U.S.A. 100, 12444 (2003).
23. F. Chen et al., Nature 440, 1208 (2006).
24. J. L. Eriksen et al., J. Clin. Invest. 112, 440 (2003).
25. A. Lied et al., Nat. Med. 10, 1065 (2004).
26. M. Citron, Trends Pharmacol. Sci. 25, 92 (2004).
27. M. Ohno et al., Eur. J. Neurosci. 23, 251 (2006).
28. R. Etcheberrigaray et al., Proc. Natl. Acad. Sci. U.S.A. 101, 11141 (2004).
29. A. Caccamo et al., Neuron 49, 671 (2006).
30. W. Qin et al., Biol. Chem. 281, 21745 (2006).
31. V. Galvan et al., Proc. Natl. Acad. Sci. U.S.A. 103, 7130 (2006).
32. H. L. Weiner, D. Frenkel, Nat. Rev. Immunol. 6, 404 (2006).
33. F. Bard et al., Nat. Med. 6, 916 (2000).
34. M. Pfeifer et al., Science 298, 1379 (2002).
35. D. M. Wilcock et al., J. Neurosci. 26, 5340 (2006).
36. M. Maier et al., J. Neurosci. 26, 4717 (2006).
37. H. L. Weiner et al., Ann. Neurol. 48, 567 (2000).
38. D. Frenkel, R. Maron, D. S. Burt, H. L. Weiner, J. Clin. Invest. 115, 2423 (2005).
39. F. Gervais et al., Neurobiol. Aging 10.1016/j.neurobiolaging. 2006.02.015 (2006).
40. J. McLaurin et al., Nat. Med. 12, 801 (2006).
41. M. H. Tuszynski, Lancet Neurol. 1, 51 (2002).
42. M. H. Tuszynski et al., Nat. Med. 11, 551 (2005).
43. K. P. Townsend, D. Praticò, FASEB J. 19, 1592 (2005).
44. B. Wolozin, Proc. Natl. Acad. Sci. U.S.A. 98, 5371 (2001).
45. T. Kukar et al., Nat. Med. 11, 545 (2005).
46. L. A. Farrer et al., JAMA 27B, 1349 (1997).
47. J. Raber, Y. Huang, J. W. Ashford, Neurobiol. Aging 25, 641 (2004).
48. D. M. Hatters, C. A. Peters-Libeu, K. H. Weisgraber, Trends Biochem. Sci. 31, 445 (2006).
49. R. W. Mahley, K. H. Weisgraber, Y. Huang, Proc. Natl. Acad. Sci. U.S.A. 103, 5644 (2006).
50. M. Koistinaho et al., Nat. Med. 10, 719 (2004).
51. M. Sadowski et al., Am. J. Pathol. 165, 937 (2004).
52. J. C. Dodart et al., Proc. Natl. Acad. Sci. U.S.A. 102, 1211 (2005).
53. C. X. Gong, F. Liu, I. Grundke-Iqbal, K. Iqbal, J. Neurol Transm. 112, 813 (2005).
54. W. H. Stoothoff, G. V. Johnson, Biochim. Biophys. Acta 1739, 280 (2005).
55. I. Khlistunova et al., J. Biol. Chem. 281, 1205 (2006).
56. C. W. Cotman, W. W. Poon, R. A. Rissman, M. Blurton-Jones, J. Neuropathol. Exp. Neurol. 64, 104 (2005).
57. B. Zhang et al., Proc. Natl. Acad. Sci. U.S.A. 102, 227 (2005).
58. A. J. Myers et al., Hum. Mol. Genet. 14, 2399 (2005).
59. N. Brouwers et al., Brain 10.1093/brain/awl212 (2006).
60. S. H. Zhang, R. L. Reddick, J. A. Piedrahita, N. Maeda, Science 258, 468 (1992).
61. A. Harada et al., Nature 369, 488 (1994).
62. H. Zheng et al., Cell 81, 525 (1995).
63. S. Tucker et al., Curr. Alzheimer Res. 3, 221 (2006).
64. C. A. Dickey et al., FASEB J. 20, 753 (2006).
65. M. D. Greicius, G. Srivastava, A. L. Reiss, V. Menon, Proc. Natl. Acad. Sci U.S.A. 101, 4637 (2004).
66. R. L. Buckner et al., J. Neurosci. 25, 7709 (2005).
67. F. Kamenetz et al., Neuron 37, 925 (2003).
68. J. R. Cirrito et al., Neuron 48, 913 (2005).
69. L. Fratiglioni, S. Paillard-Borg, B. Winblad, Lancet Neurol. 3, 343 (2004).
70. O. Lazarov et al., Cell 120, 701 (2005).
71. J. J. Palop, J. Chin, L. Mucke, Nature 443, 768 (2006).
72. N. Iwata et al., Nat. Med. 6, 143 (2000).
73. D. J. Selkoe, Neuron 32, 177 (2001).
74. S. Mueller-Steiner et al., Neuron 51, 703 (2006).
75. N. Iwata, Y. Takaki, S. Fukami, S. Tsubuki, T. C. Saido, J. Neurosci. Res. 70, 493 (2002).
76. A. Caccamo, S. Oddo, M. C. Sugarman, Y. Akbari, F. M. Laferla, Neurobiol. Aging 26, 645 (2005).
77. M. A. Leissring et al., Neuron 40, 1087 (2003).
78. R. A. Marr et al., J. Neurosci. 23, 1992 (2003).
79. D.-S. Choi et al., Proc. Natl. Acad. Sci. U.S.A. 103, 8215 (2006).
80. T. Saito et al., Nat. Med. 11, 434 (2005).
81. R. S. Sohal, R. Weindruch, Science 273, 59 (1996).
82. J. A. Luchsinger, M. X. Tang, S. Shea, R. Mayeux, Arch. Neurol. 59, 1258 (2002).
83. G. M. Bernal, O. A. Peterson, Aging Cell 3, 345 (2004).
84. G. Martino, S. Pluchino, Nat. Rev. Neurosci. 7, 395 (2006).
85. O. Lindvall, Z. Kokaia, Nature 441, 1094 (2006).
86. S. G. Deeks, Br. Med. J. 332, 1489 (2006).
87. A. H. V. Schapira, J. Obeso, Ann. Neurol. 59, 559 (2006).
88. D. Edbauer et al., Nat. Cell Biol. 5, 486 (2003).
89. National Library of Medicine, National Institutes of Health, www.clinicaltrials.gov.
90. Alzheimer Research Forum, www.alzforum.org/dis/tre/drc/.
91. We thank L. Gan and Y. Huang for helpful discussions, J. Carroll for graphics, G. Howard and S. Ordway for editorial review, and D. McPherson and L. Manuntag for administrative assistance. Supported by a Stephen O. Bechtel Jr. Young Investigator Award (E.D.R.) and NIH grants NS054811 (E.D.R), AG011385, and AG022074 (L.M.). L.M. has received consulting fees from Merck and honoraria or speaking fees from Amgen, Elan, and Pfizer. E.R. has received consulting fees from Rinat Neuroscience.