Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain

NeuroMolecular Medicine

Volumn 2, Issue 1, 2002, Pages 29-45

  Lee, Jaewon ^a   Chan, Sic L ^a   Mattson, Mark P ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid; Astrocytes; Calcium; Hippocampus; Inflammation; Interleukin 1; Tumor necrosis factor; Vaccine

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM; CYTOKINE; GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE; PRESENILIN 1; TUMOR NECROSIS FACTOR ALPHA; AMYLOID PRECURSOR PROTEIN; IL1RN PROTEIN, HUMAN; IL1RN PROTEIN, MOUSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; MEMBRANE PROTEIN; NERVE PROTEIN; NOS2 PROTEIN, MOUSE; NOS2A PROTEIN, HUMAN; PSEN1 PROTEIN, HUMAN; SIALOGLYCOPROTEIN; VACCINE;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN FUNCTION; CELL ACTIVATION; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME INDUCTION; EXCITOTOXICITY; GENE MUTATION; GENE REPLACEMENT THERAPY; GLIA CELL; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOMODULATION; IMMUNOPATHOLOGY; INFLAMMATION; MALE; MICROGLIA; MOUSE; NERVE DEGENERATION; NERVE EXCITABILITY; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; STATISTICAL SIGNIFICANCE; SYNAPTIC DYSFUNCTION; SYNAPTIC TRANSMISSION; VACCINE PRODUCTION; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; BRAIN; CODON; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENE DOSAGE; GENE EXPRESSION PROFILING; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; SECRETION; SIGNAL TRANSDUCTION; SPLEEN;

ANIMALIA; BACTERIA (MICROORGANISMS);

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELLS, CULTURED; CODON; CYTOKINES; ENZYME INDUCTION; GENE DOSAGE; GENE EXPRESSION PROFILING; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICROGLIA; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; ORGAN SPECIFICITY; PRESENILIN-1; RNA, MESSENGER; SIALOGLYCOPROTEINS; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA; VACCINES;

EID: 0036362861     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/NMM:2:1:29     Document Type: Article

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