The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-l-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice

Journal of Neurotrauma

Volumn 26, Issue 11, 2009, Pages 1963-1975

  Terpolilli, Nicole A ^a   Zweckberger, Klaus ^a   Trabold, Raimund ^a   Schilling, Lothar ^b   Schinzel, Reinhard ^c   Tegtmeier, Frank ^c   Plesnila, Nikolaus ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Vasopharm GmbH   (Germany)

Author keywords

Brain edema; Nitric oxide; Nitric oxide synthase inhibitor; Tetrahydrobiopterine (BH4); Traumatic brain injury

Indexed keywords

3 NITROTYROSINE; 4 AMINO 5,6,7,8 TETRAHYDROBIOPTERINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; VAS 203;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN EDEMA; CONTINUOUS INFUSION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFECT; DRUG INFUSION; DRUG STRUCTURE; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; INTRACRANIAL HYPERTENSION; MALE; MIDDLE CEREBRAL ARTERY; MOUSE; NONHUMAN; RAT; TRAUMATIC BRAIN INJURY; VASOCONSTRICTION;

ANIMALS; BASILAR ARTERY; BIOPTERIN; BRAIN EDEMA; BRAIN INJURIES; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; INTRACRANIAL HYPERTENSION; MALE; MICE; MICE, INBRED C57BL; MIDDLE CEREBRAL ARTERY; NITRIC OXIDE SYNTHASE; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; VASOCONSTRICTION;

EID: 75449087712     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2008.0853     Document Type: Article

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