Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties

ChemMedChem

Volumn 4, Issue 5, 2009, Pages 828-841

  Fernández Bachiller, María Isabel ^a   Pérez, Concepción ^a   Campillo, Nuria Eugenia ^a   Páez, Juan Antonio ^a   González Muñoz, Gema Cristina ^a   Usán, Paola ^b   García Palomero, Esther ^b   López, Manuela G ^c   Villarroya, Mercedes ^c   García, Antonio G ^c,d   Martínez, Ana ^a,b   Rodríguez Franco, María Isabel ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b Noscira   (Spain)

^c INSTITUTO TEÓFILO HERNANDO   (Spain)

^d HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

Alzheimer's disease; Cholinergic; Drug design; Molecular modeling; Neuroprotection

Indexed keywords

6 (6,8 DICHLORO 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)N [2 (5 METHOXY 1H INDOL 3 YL)ETHYL]HEXANAMIDE; ALDOSTERONE; ASTEMIZOLE; ATENOLOL; CHLORPROMAZINE; CLONIDINE; CORTICOSTERONE; DESIPRAMINE; ENOXACIN; HYDROCORTISONE; IMIPRAMINE; ISOXICAM; LOMEFLOXACIN; MELATONIN; N [2 (1H INDOL 3 YL)ETHYL] 5 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTANAMIDE; N [2 (1H INDOL 3 YL)ETHYL] 6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXANETHIOAMIDE; N [2 (1H INDOL 3 YL)ETHYL] 6 (7 FLUORO 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXANAMIDE; N [2 (1H INDOL 3 YL)ETHYL] 8 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTANAMIDE; N [2 (1H INDOL 3 YL)ETHYL] 8 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTANETHIOAMIDE; N [2 (1H INDOL 3 YL)ETHYL] 8 (6,8 DICHLORO 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTANAMIDE; N [2 (5 HYDROXY 1H INDOL 3 YL)ETHYL] 8 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTANAMIDE; N [2 (5 METHOXY 1H INDOL 3 YL)ETHYL] 5 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTANAMIDE; N [2 (5 METHOXY 1H INDOL 3 YL)ETHYL] 8 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTANAMIDE; OFLOXACIN; PIROXICAM; PROMAZINE; TACRINE; TESTOSTERONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; ANTIOXIDANT; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR; NEUROPROTECTIVE AGENT;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CATALYSIS; CENTRAL NERVOUS SYSTEM; CHOLINERGIC ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MOLECULAR MODEL; NEUROBLASTOMA; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN AGGREGATION; AMINO ACID SEQUENCE; CELL LINE; CHEMICAL MODEL; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVE SITE; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; SYNTHESIS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANTIOXIDANTS; BLOOD-BRAIN BARRIER; CATALYTIC DOMAIN; CELL LINE; CHOLINERGIC AGENTS; CHOLINESTERASE INHIBITORS; HUMANS; MELATONIN; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; NEUROPROTECTIVE AGENTS; SEQUENCE ALIGNMENT; TACRINE;

EID: 67651114110     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800414     Document Type: Article

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