Does Nitric Oxide Synthase Contribute to the Pathogenesis of Alzheimer's Disease? Effects of β-Amyloid Deposition on NOS in Transgenic Mouse Brain with AD Pathology

Annals of the New York Academy of Sciences

Volumn 1010, Issue , 2003, Pages 639-642

  Lahiri, D K ^a   Chen, D ^a   Ge, Y W ^a   Farlow, M ^a   Kotwal, G ^b   Kanthasamy, A ^c   Ingram, D K ^d   Greig, N H ^d  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c IOWA STATE UNIVERSITY   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Aging; Beta protein; Dementia; Free radicals; Neurodegeneration; Nitric oxide; Oxidative stress; ROS

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BRAIN EXTRACT; NITRIC OXIDE SYNTHASE; PRESENILIN 1; SUPEROXIDE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; BRAIN; BRAIN CORTEX; CEREBELLUM; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HIPPOCAMPUS; MALE; MOUSE; MOUSE STRAIN; MUTATION; NONHUMAN; OXIDATIVE STRESS; RISK FACTOR; STATISTICAL SIGNIFICANCE; STRAIN DIFFERENCE; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS; MUS;

EID: 1342326751     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1299.117     Document Type: Conference Paper

References (7)

1. LAHIRI, D.K. et al. 2002. Current drug targets for Alzheimer's disease treatment. Drug Dev. Res. 56: 267-281.
2. LUTH, H.J. et al. 2001. Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology. Brain Res. 913: 57-67.
3. LEE, J. et al. 2002. Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain. Neuromol. Med. 2: 29-45
4. BONDY, S.C. et al. 2002. Dietary modulation of age-related changes in cerebral prooxidant status. Neurochem. Int. 40: 123-130.
5. LAHIRI, D.K. et al. 1998. The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells. Mol. Brain Res. 62: 131-140.
6. BORCHELT, D.R. et al. 1997. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19: 939-945.
7. LAHIRI, D.K. et al. 2003. A critical analysis of new prolecular targets and strategies for drug developments in Alzheimer's disease. Curr. Drug Targets 4: 97-112.