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Volumn 2, Issue 2, 2006, Pages 118-125

Do cholinergic therapies have disease-modifying effects in Alzheimer's disease?

Author keywords

Alzheimer's disease; Cholinesterase inhibitors; Muscarinic; Prevention; Therapy

Indexed keywords

AF 150; AF 267B; ALVAMELINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETHANECHOL; CARBACHOL; CEVIMELINE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DICHLORVOS; DONEPEZIL; GALANTAMINE; GALLAMINE; METRIFONATE; MUSCARINIC AGENT; NICOTINIC RECEPTOR; PHENSERINE; PHYSOSTIGMINE; PLACEBO; RIVASTIGMINE; TACRINE; TALSACLIDINE; TAU PROTEIN; UNCLASSIFIED DRUG;

EID: 33645756861     PISSN: 15525260     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jalz.2006.02.001     Document Type: Review
Times cited : (51)

References (98)
  • 1
    • 0026562382 scopus 로고
    • Convergent cholinergic activities in aging and Alzheimer's disease
    • Perry E.K., Johnson M., Kerwin J.M., et al. Convergent cholinergic activities in aging and Alzheimer's disease. Neurobiol Aging 13 (1992) 393-400
    • (1992) Neurobiol Aging , vol.13 , pp. 393-400
    • Perry, E.K.1    Johnson, M.2    Kerwin, J.M.3
  • 2
    • 0023905906 scopus 로고
    • Clinical, pathological, and neurochemical changes in dementia. a subgroup with preserved mental status and numerous neocortical plaques
    • Katzman R., Terry R., DeTeresa R., et al. Clinical, pathological, and neurochemical changes in dementia. a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 23 (1988) 138-144
    • (1988) Ann Neurol , vol.23 , pp. 138-144
    • Katzman, R.1    Terry, R.2    DeTeresa, R.3
  • 3
    • 0031020840 scopus 로고    scopus 로고
    • Cholinergic fibre loss associated with diffuse plaques in the non- demented elderly. the preclinical stage of Alzheimer's disease?
    • Beach T.G., Honer W.G., and Hughes L.H. Cholinergic fibre loss associated with diffuse plaques in the non- demented elderly. the preclinical stage of Alzheimer's disease?. Acta Neuropathol (Berl) 93 (1997) 146-153
    • (1997) Acta Neuropathol (Berl) , vol.93 , pp. 146-153
    • Beach, T.G.1    Honer, W.G.2    Hughes, L.H.3
  • 4
    • 0034737688 scopus 로고    scopus 로고
    • Cholinergic deafferentation of the rabbit cortex. a new animal model of Abeta deposition
    • Beach T.G., Potter P.E., Kuo Y.M., et al. Cholinergic deafferentation of the rabbit cortex. a new animal model of Abeta deposition. Neurosci Lett 283 (2000) 9-12
    • (2000) Neurosci Lett , vol.283 , pp. 9-12
    • Beach, T.G.1    Potter, P.E.2    Kuo, Y.M.3
  • 5
    • 33645780550 scopus 로고    scopus 로고
    • Cortical cholinergic deficit is associated with plaque development at preclinical stages of Alzheimer's disease
    • Potter P., Pandya Y., et al. Cortical cholinergic deficit is associated with plaque development at preclinical stages of Alzheimer's disease. Neurobiol Aging 25 S2 (2004) 79
    • (2004) Neurobiol Aging , vol.25 , Issue.SUPPL.2 , pp. 79
    • Potter, P.1    Pandya, Y.2
  • 6
    • 0031781795 scopus 로고    scopus 로고
    • Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease
    • Funato H., Yoshimura M., Kusui K., et al. Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease. Am. J. Pathol 152 (1998) 1633-1640
    • (1998) Am. J. Pathol , vol.152 , pp. 1633-1640
    • Funato, H.1    Yoshimura, M.2    Kusui, K.3
  • 7
    • 0023737806 scopus 로고
    • A4 amyloid protein deposition and the diagnosis of Alzheimer's disease. prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques
    • Davies L., Wolska B., Hilbich C., et al. A4 amyloid protein deposition and the diagnosis of Alzheimer's disease. prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques. Neurology 38 (1988) 1688-1693
    • (1988) Neurology , vol.38 , pp. 1688-1693
    • Davies, L.1    Wolska, B.2    Hilbich, C.3
  • 8
    • 0029863697 scopus 로고    scopus 로고
    • Acetycholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils. possible role of the peripheral site of the enzyme
    • Inestrosa N.C., Alvarez A., Perez C.A., et al. Acetycholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils. possible role of the peripheral site of the enzyme. Neuron 16 4 (1996) 881-891
    • (1996) Neuron , vol.16 , Issue.4 , pp. 881-891
    • Inestrosa, N.C.1    Alvarez, A.2    Perez, C.A.3
  • 9
    • 0033591017 scopus 로고    scopus 로고
    • Cholinergic markers in elderly patients with early signs of Alzheimer disease
    • Davis K.L., Mohs R.C., Marin D., et al. Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA 281 (1999) 1401-1406
    • (1999) JAMA , vol.281 , pp. 1401-1406
    • Davis, K.L.1    Mohs, R.C.2    Marin, D.3
  • 10
    • 0036156958 scopus 로고    scopus 로고
    • Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    • DeKosky S.T., Ikonomovic M.D., Styren S.D., et al. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol 51 (2002) 145-155
    • (2002) Ann Neurol , vol.51 , pp. 145-155
    • DeKosky, S.T.1    Ikonomovic, M.D.2    Styren, S.D.3
  • 11
    • 0026070557 scopus 로고
    • Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert
    • Wallace W.C., Bragin V., Robakis N.K., et al. Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Brain Res Mol Brain Res 10 (1991) 173-178
    • (1991) Brain Res Mol Brain Res , vol.10 , pp. 173-178
    • Wallace, W.C.1    Bragin, V.2    Robakis, N.K.3
  • 12
    • 0027182224 scopus 로고
    • Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation
    • Wallace W., Ahlers S.T., Gotlib J., et al. Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation. Proc Natl Acad Sci U S A 90 (1993) 8712-8716
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 8712-8716
    • Wallace, W.1    Ahlers, S.T.2    Gotlib, J.3
  • 13
    • 0029076076 scopus 로고
    • 192IGG-saporin-induced selective lesion of cholinergic basal forebrain system. neurochemical effects on cholinergic neurotransmission in rat cerebral cortex and hippocampus
    • Rossner S., Schliebs R., Hartig W., and Bigl V. 192IGG-saporin-induced selective lesion of cholinergic basal forebrain system. neurochemical effects on cholinergic neurotransmission in rat cerebral cortex and hippocampus. Brain Res Bull 39 (1995) 371-381
    • (1995) Brain Res Bull , vol.39 , pp. 371-381
    • Rossner, S.1    Schliebs, R.2    Hartig, W.3    Bigl, V.4
  • 14
    • 0032536355 scopus 로고    scopus 로고
    • Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system
    • Lin L., LeBlanc C.J., Deacon T.W., and Isacson O. Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system. Neuroreport 9 (1998) 547-552
    • (1998) Neuroreport , vol.9 , pp. 547-552
    • Lin, L.1    LeBlanc, C.J.2    Deacon, T.W.3    Isacson, O.4
  • 15
    • 33645775652 scopus 로고    scopus 로고
    • Immunotoxin lesion of the cholinergic nucleus basalis causes Ab deposition. towards a physiologic animal model of Alzheimer's disease
    • Beach T.G., Walker D., Sue L., et al. Immunotoxin lesion of the cholinergic nucleus basalis causes Ab deposition. towards a physiologic animal model of Alzheimer's disease. Curr Med Chem 3 (2003) 57-75
    • (2003) Curr Med Chem , vol.3 , pp. 57-75
    • Beach, T.G.1    Walker, D.2    Sue, L.3
  • 16
    • 0034101474 scopus 로고    scopus 로고
    • Cortical cholinergic denervation elicits vascular A beta deposition
    • Roher A.E., Kuo Y.M., Potter P.E., et al. Cortical cholinergic denervation elicits vascular A beta deposition. Ann NY Acad Sci 903 (2000) 366-373
    • (2000) Ann NY Acad Sci , vol.903 , pp. 366-373
    • Roher, A.E.1    Kuo, Y.M.2    Potter, P.E.3
  • 18
    • 0036881416 scopus 로고    scopus 로고
    • Muscarinic agonists as preventative therapy for Alzheimer's disease
    • Beach T.G. Muscarinic agonists as preventative therapy for Alzheimer's disease. Curr Opin Investig Drugs 3 (2002) 1633-1636
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 1633-1636
    • Beach, T.G.1
  • 19
    • 5144234244 scopus 로고    scopus 로고
    • M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. a role for Wnt signaling pathway
    • Farias G.G., Godoy J.A., Hernandez F., Avila J., Fisher A., and Inestrosa N.C. M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. a role for Wnt signaling pathway. Neurobiol Dis 17 (2004) 337-348
    • (2004) Neurobiol Dis , vol.17 , pp. 337-348
    • Farias, G.G.1    Godoy, J.A.2    Hernandez, F.3    Avila, J.4    Fisher, A.5    Inestrosa, N.C.6
  • 20
    • 33645786227 scopus 로고    scopus 로고
    • Decreased cortical blood flow after intraventricular administration of the 192 IgG-saporin immunotoxin
    • Holschneider D.P., Waite J.J., Li M.G., and Scremin O.U. Decreased cortical blood flow after intraventricular administration of the 192 IgG-saporin immunotoxin. Soc Neurosci Abs 23 (1997) 1575
    • (1997) Soc Neurosci Abs , vol.23 , pp. 1575
    • Holschneider, D.P.1    Waite, J.J.2    Li, M.G.3    Scremin, O.U.4
  • 21
    • 0026448114 scopus 로고
    • Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor
    • Buxbaum J.D., Oishi M., Chen H.I., et al. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc Natl Acad Sci U S A 89 (1992) 10075-10078
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10075-10078
    • Buxbaum, J.D.1    Oishi, M.2    Chen, H.I.3
  • 22
    • 0026476297 scopus 로고
    • Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors
    • NitschRM, SlackBE, WurtmanRJ, and GrowdonJH. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 28 (1992) 304-307
    • (1992) Science , vol.28 , pp. 304-307
    • NitschRM1    SlackBE2    WurtmanRJ3    GrowdonJH4
  • 23
    • 0027453490 scopus 로고
    • Activation of protein kinase C inhibits cellular production of the amyloid beta-protein
    • Hung A.Y., Haass C., Nitsch R.M., et al. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J Biol Chem 268 (1993) 22959-22962
    • (1993) J Biol Chem , vol.268 , pp. 22959-22962
    • Hung, A.Y.1    Haass, C.2    Nitsch, R.M.3
  • 24
    • 0028181720 scopus 로고
    • Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232)
    • Bymaster F.P., Wong D.T., Mitch C.H., et al. Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232). J Pharmacol Exp Ther 269 (1994) 282-289
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 282-289
    • Bymaster, F.P.1    Wong, D.T.2    Mitch, C.H.3
  • 25
    • 0028201847 scopus 로고
    • Role of neurotransmission in the regulation of amyloid beta-protein precursor processing
    • Nitsch R.M., and Growdon J.H. Role of neurotransmission in the regulation of amyloid beta-protein precursor processing. Biochem Pharmacol 47 (1994) 1275-1284
    • (1994) Biochem Pharmacol , vol.47 , pp. 1275-1284
    • Nitsch, R.M.1    Growdon, J.H.2
  • 26
    • 0028098787 scopus 로고
    • Amyloid precursor protein secretion via muscarinic receptors. reduced desensitization using the M1-selective agonist AF102B
    • Haring R., Gurwitz D., Barg J., et al. Amyloid precursor protein secretion via muscarinic receptors. reduced desensitization using the M1-selective agonist AF102B. Biochem Biophys Res Commun 203 (1994) 652-658
    • (1994) Biochem Biophys Res Commun , vol.203 , pp. 652-658
    • Haring, R.1    Gurwitz, D.2    Barg, J.3
  • 27
    • 0029117462 scopus 로고
    • NGF promotes amyloid precursor protein secretion via muscarinic receptor activation
    • Haring R., Gurwitz D., Barg J., et al. NGF promotes amyloid precursor protein secretion via muscarinic receptor activation. Biochem Biophys Res Commun 213 (1995) 15-23
    • (1995) Biochem Biophys Res Commun , vol.213 , pp. 15-23
    • Haring, R.1    Gurwitz, D.2    Barg, J.3
  • 28
    • 0029166330 scopus 로고
    • The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from Chinese hamster ovary-m1 cells
    • Eckols K., Bymaster F.P., Mitch C.H., Shannon H.E., Ward J.S., and DeLapp N.W. The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from Chinese hamster ovary-m1 cells. Life Sci 57 (1995) 1183-1190
    • (1995) Life Sci , vol.57 , pp. 1183-1190
    • Eckols, K.1    Bymaster, F.P.2    Mitch, C.H.3    Shannon, H.E.4    Ward, J.S.5    DeLapp, N.W.6
  • 29
    • 0028926941 scopus 로고
    • Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells
    • Wolf B.A., Wertkin A.M., Jolly Y.C., et al. Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells. J Biol Chem 270 (1995) 4916-4922
    • (1995) J Biol Chem , vol.270 , pp. 4916-4922
    • Wolf, B.A.1    Wertkin, A.M.2    Jolly, Y.C.3
  • 30
    • 0343811715 scopus 로고    scopus 로고
    • Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain
    • Muller D.M., Mendla K., Farber S.A., and Nitsch R.M. Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain. Life Sci 60 (1997) 985-991
    • (1997) Life Sci , vol.60 , pp. 985-991
    • Muller, D.M.1    Mendla, K.2    Farber, S.A.3    Nitsch, R.M.4
  • 31
    • 0032496752 scopus 로고    scopus 로고
    • Compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects
    • Bymaster F.P., Carter P.A., Peters S.C., et al. Compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects. Brain Res 795 (1998) 179-190
    • (1998) Brain Res , vol.795 , pp. 179-190
    • Bymaster, F.P.1    Carter, P.A.2    Peters, S.C.3
  • 32
    • 0032489322 scopus 로고    scopus 로고
    • Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells
    • DeLapp N., Wu S., Belagaje R., et al. Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells. Biochem Biophys Res Commun 244 (1998) 156-160
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 156-160
    • DeLapp, N.1    Wu, S.2    Belagaje, R.3
  • 33
    • 0033758338 scopus 로고    scopus 로고
    • Therapeutic strategies in Alzheimer's disease. M1 muscarinic agonists
    • Fisher A. Therapeutic strategies in Alzheimer's disease. M1 muscarinic agonists. Jpn J Pharmacol 84 (2000) 101-112
    • (2000) Jpn J Pharmacol , vol.84 , pp. 101-112
    • Fisher, A.1
  • 34
    • 0031891929 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity
    • Hock C., Golombowski S., Muller-Spahn F., et al. Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity. Eur Neurol 39 (1998) 111-118
    • (1998) Eur Neurol , vol.39 , pp. 111-118
    • Hock, C.1    Golombowski, S.2    Muller-Spahn, F.3
  • 35
    • 0031768806 scopus 로고    scopus 로고
    • Lu 25-109, a combined m1 agonist and m2 antagonist, modulates regulated processing of the amyloid precursor protein of Alzheimer's disease
    • Muller D., Wiegmann H., Langer U., Moltzen-Lenz S., and Nitsch R.M. Lu 25-109, a combined m1 agonist and m2 antagonist, modulates regulated processing of the amyloid precursor protein of Alzheimer's disease. J Neural Transm 105 (1998) 1029-1043
    • (1998) J Neural Transm , vol.105 , pp. 1029-1043
    • Muller, D.1    Wiegmann, H.2    Langer, U.3    Moltzen-Lenz, S.4    Nitsch, R.M.5
  • 36
    • 0032032493 scopus 로고    scopus 로고
    • Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester
    • Savage M.J., Trusko S.P., Howland D.S., et al. Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester. J Neurosci 18 (1998) 1743-1752
    • (1998) J Neurosci , vol.18 , pp. 1743-1752
    • Savage, M.J.1    Trusko, S.P.2    Howland, D.S.3
  • 37
    • 0027435535 scopus 로고
    • Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide
    • Buxbaum J.D., Koo E.H., and Greengard P. Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proc Natl Acad Sci U S A 90 (1993) 9195-9198
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 9195-9198
    • Buxbaum, J.D.1    Koo, E.H.2    Greengard, P.3
  • 38
    • 0027487188 scopus 로고
    • Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha
    • Slack B., Nitsch R., Livneh E., et al. Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha. J Bio Chem 268 (1993) 21097-21101
    • (1993) J Bio Chem , vol.268 , pp. 21097-21101
    • Slack, B.1    Nitsch, R.2    Livneh, E.3
  • 39
    • 22144494112 scopus 로고    scopus 로고
    • An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
    • Greig N.H., Sambamurti K., Yu Q.S., Brossi A., Bruinsma G.B., and Lahiri D.K. An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res 2 (2005) 281-290
    • (2005) Curr Alzheimer Res , vol.2 , pp. 281-290
    • Greig, N.H.1    Sambamurti, K.2    Yu, Q.S.3    Brossi, A.4    Bruinsma, G.B.5    Lahiri, D.K.6
  • 40
    • 0035912825 scopus 로고    scopus 로고
    • Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development
    • Shaw K.T., Utsuki T., Rogers J., Yu Q.S., Sambamurti K., Brossi A., et al. Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci U S A 98 13 (2001) 7605-7610
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.13 , pp. 7605-7610
    • Shaw, K.T.1    Utsuki, T.2    Rogers, J.3    Yu, Q.S.4    Sambamurti, K.5    Brossi, A.6
  • 41
    • 0030092766 scopus 로고    scopus 로고
    • Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines
    • Lahiri D.K., and Farlow M.R. Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines. Mol Neurosci 7 1 (1996) 41-49
    • (1996) Mol Neurosci , vol.7 , Issue.1 , pp. 41-49
    • Lahiri, D.K.1    Farlow, M.R.2
  • 42
    • 0028971033 scopus 로고
    • Regulated secretion of beta-amyloid precursor protein in rat brain
    • Farber S.A., Nitsch R.M., Schulz J.G., and Wurtman R.J. Regulated secretion of beta-amyloid precursor protein in rat brain. J Neurosci 15 (1995) 7442-7451
    • (1995) J Neurosci , vol.15 , pp. 7442-7451
    • Farber, S.A.1    Nitsch, R.M.2    Schulz, J.G.3    Wurtman, R.J.4
  • 43
    • 0028918426 scopus 로고
    • Cholinesterase inhibitors increase secretion of APPs in rat brain cortex
    • Mori F., Lai C.C., Fusi F., and Giacobini E. Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. Neuroreport 6 (1995) 633-636
    • (1995) Neuroreport , vol.6 , pp. 633-636
    • Mori, F.1    Lai, C.C.2    Fusi, F.3    Giacobini, E.4
  • 44
    • 0030581107 scopus 로고    scopus 로고
    • Amyloidogenic processing of Alzheimer's amyloid precursor protein in vitro and its modulation by metal ions and tacrine
    • Chong Y.H., and Suh Y.H. Amyloidogenic processing of Alzheimer's amyloid precursor protein in vitro and its modulation by metal ions and tacrine. Life Sci 59 7 (1996) 545-547
    • (1996) Life Sci , vol.59 , Issue.7 , pp. 545-547
    • Chong, Y.H.1    Suh, Y.H.2
  • 45
    • 0034885166 scopus 로고    scopus 로고
    • Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein
    • Racchi M., Sironi M., Caprera A., Konig G., and Govoni S. Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein. Mol Psychiatry 6 5 (2001) 520-528
    • (2001) Mol Psychiatry , vol.6 , Issue.5 , pp. 520-528
    • Racchi, M.1    Sironi, M.2    Caprera, A.3    Konig, G.4    Govoni, S.5
  • 46
    • 0030566744 scopus 로고    scopus 로고
    • Muscarinic control of amyloid precursor protein secretion in rat cerebral cortex and cerebellum
    • Pittel Z., Heldman E., Barg J., Haring R., and Fisher A. Muscarinic control of amyloid precursor protein secretion in rat cerebral cortex and cerebellum. Brain Res 742 (1996) 299-304
    • (1996) Brain Res , vol.742 , pp. 299-304
    • Pittel, Z.1    Heldman, E.2    Barg, J.3    Haring, R.4    Fisher, A.5
  • 47
    • 0030986003 scopus 로고    scopus 로고
    • Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions
    • Haroutunian V., Greig N., Pei X.F., et al. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain Res Mol Brain Res 46 (1997) 161-168
    • (1997) Brain Res Mol Brain Res , vol.46 , pp. 161-168
    • Haroutunian, V.1    Greig, N.2    Pei, X.F.3
  • 48
    • 0035823426 scopus 로고    scopus 로고
    • Reduction of cortical amyloid beta levels in guinea pig brain after systemic administration of physostigmine
    • ??
    • Beach T.G., KuoY, Schwab C., Walker D.G., and Roher A.E. Reduction of cortical amyloid beta levels in guinea pig brain after systemic administration of physostigmine. ??. Neurosci Lett 310 (2001) 21-24
    • (2001) Neurosci Lett , vol.310 , pp. 21-24
    • Beach, T.G.1    KuoY2    Schwab, C.3    Walker, D.G.4    Roher, A.E.5
  • 49
    • 0035968057 scopus 로고    scopus 로고
    • Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists
    • Beach T.G., Walker D.G., Potter P.E., Sue L.I., and Fisher A. Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists. Brain Res 905 (2001) 220-223
    • (2001) Brain Res , vol.905 , pp. 220-223
    • Beach, T.G.1    Walker, D.G.2    Potter, P.E.3    Sue, L.I.4    Fisher, A.5
  • 50
    • 0033663907 scopus 로고    scopus 로고
    • The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease
    • Nitsch R.M., Deng M., Tennis M., Schoenfeld D., and Growdon J.H. The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol 48 (2000) 913-918
    • (2000) Ann Neurol , vol.48 , pp. 913-918
    • Nitsch, R.M.1    Deng, M.2    Tennis, M.3    Schoenfeld, D.4    Growdon, J.H.5
  • 51
    • 12444313989 scopus 로고    scopus 로고
    • Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease
    • Hock C., Maddalena A., Raschig A., et al. Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease. Amyloid 10 (2003) 1-6
    • (2003) Amyloid , vol.10 , pp. 1-6
    • Hock, C.1    Maddalena, A.2    Raschig, A.3
  • 52
    • 0036355751 scopus 로고    scopus 로고
    • Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrine
    • Basun H., Nilsberth C., Eckman C., Lannfelt L., and Younkin S. Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrine. Dement Geriatr Cogn Disord 14 (2002) 156-160
    • (2002) Dement Geriatr Cogn Disord , vol.14 , pp. 156-160
    • Basun, H.1    Nilsberth, C.2    Eckman, C.3    Lannfelt, L.4    Younkin, S.5
  • 53
    • 0032569990 scopus 로고    scopus 로고
    • The secretion of amyloid beta-peptide is inhibited the tacrine-treated human neuroblastoma cells
    • Lahiri D.K., Farlow M.R., and Sambamurti K. The secretion of amyloid beta-peptide is inhibited the tacrine-treated human neuroblastoma cells. Brain Res Mol Brain Res 2 2 (1998) 131-140
    • (1998) Brain Res Mol Brain Res , vol.2 , Issue.2 , pp. 131-140
    • Lahiri, D.K.1    Farlow, M.R.2    Sambamurti, K.3
  • 54
    • 4544239545 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines
    • Zimmerman M., Gardoni G., Marcello E., Colciaghi E., et al. Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines. J Neurochem 90 6 (2004) 1489-1499
    • (2004) J Neurochem , vol.90 , Issue.6 , pp. 1489-1499
    • Zimmerman, M.1    Gardoni, G.2    Marcello, E.3    Colciaghi, E.4
  • 55
    • 0035107233 scopus 로고    scopus 로고
    • Amyloid precursor protein in platelets of patients with Alzheimer's disease. effect of acetycholinesterase inhibitor treatment
    • Boronni B., Colchiaghi F., Pastorino L., Pettenati C., et al. Amyloid precursor protein in platelets of patients with Alzheimer's disease. effect of acetycholinesterase inhibitor treatment. Arch Neurol 58 3 (2001) 442-446
    • (2001) Arch Neurol , vol.58 , Issue.3 , pp. 442-446
    • Boronni, B.1    Colchiaghi, F.2    Pastorino, L.3    Pettenati, C.4
  • 56
    • 0036253645 scopus 로고    scopus 로고
    • ApoE genotype influences the biological effect at donepezil on APP metabolism in Alzheimer disease. evidence from a peripheral model
    • Borroni B., Colchiaghi F., Pastorino L., Archetti S., et al. ApoE genotype influences the biological effect at donepezil on APP metabolism in Alzheimer disease. evidence from a peripheral model. Eur Neuropsychopharmacol 12 3 (2002) 195-200
    • (2002) Eur Neuropsychopharmacol , vol.12 , Issue.3 , pp. 195-200
    • Borroni, B.1    Colchiaghi, F.2    Pastorino, L.3    Archetti, S.4
  • 57
    • 18644369811 scopus 로고    scopus 로고
    • Cholinesterase inhibitor affects the amyloid precursor protein isoforms in patients with Alzheimer's disease
    • Liu H.C., Chi C.W., Ko S.Y., Want H.C., et al. Cholinesterase inhibitor affects the amyloid precursor protein isoforms in patients with Alzheimer's disease. Dementia Geriatr Cogn Disord 19 5-6 (2005) 345-348
    • (2005) Dementia Geriatr Cogn Disord , vol.19 , Issue.5-6 , pp. 345-348
    • Liu, H.C.1    Chi, C.W.2    Ko, S.Y.3    Want, H.C.4
  • 58
    • 2942598335 scopus 로고    scopus 로고
    • Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice
    • Hellstrom-Lindahl E., Court J., Keverne J., et al. Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice. Eur J Neurosci 19 (2004) 2703-2710
    • (2004) Eur J Neurosci , vol.19 , pp. 2703-2710
    • Hellstrom-Lindahl, E.1    Court, J.2    Keverne, J.3
  • 59
    • 0036316642 scopus 로고    scopus 로고
    • Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw)
    • Nordberg A., Hellstrom-Lindahl E., Lee M., et al. Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw). J Neurochem 81 (2002) 655-658
    • (2002) J Neurochem , vol.81 , pp. 655-658
    • Nordberg, A.1    Hellstrom-Lindahl, E.2    Lee, M.3
  • 60
    • 27744436607 scopus 로고    scopus 로고
    • Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells. roll of nicotinic receptors
    • Arias E., Gallego-Sandin S., Villaroya M., Garcia A.G., and Lopez M.G. Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells. roll of nicotinic receptors. J Pharmacol Exp Ther 315 3 (2005) 1346-1353
    • (2005) J Pharmacol Exp Ther , vol.315 , Issue.3 , pp. 1346-1353
    • Arias, E.1    Gallego-Sandin, S.2    Villaroya, M.3    Garcia, A.G.4    Lopez, M.G.5
  • 61
    • 0344688198 scopus 로고    scopus 로고
    • Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin. involvement of nicotinic acetylcholine receptors
    • Arias E., Ales E., Gabilan N.H., Cano-Abad M.D., Villaroya M., Garcia A.G., et al. Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin. involvement of nicotinic acetylcholine receptors. Neuropharmacology 46 1 (2004) 103-114
    • (2004) Neuropharmacology , vol.46 , Issue.1 , pp. 103-114
    • Arias, E.1    Ales, E.2    Gabilan, N.H.3    Cano-Abad, M.D.4    Villaroya, M.5    Garcia, A.G.6
  • 63
    • 23744476468 scopus 로고    scopus 로고
    • Cognitive performance in patients with Alzheimer's disease receiving cholinesterase inhibitors for up to 5 years
    • Bullock R., and Dengiz A. Cognitive performance in patients with Alzheimer's disease receiving cholinesterase inhibitors for up to 5 years. Int J Clin Pract 59 7 (2005) 817-822
    • (2005) Int J Clin Pract , vol.59 , Issue.7 , pp. 817-822
    • Bullock, R.1    Dengiz, A.2
  • 64
    • 0028262405 scopus 로고
    • A longitudinal study of Alzheimer's disease. measurement, rate, and predictors of cognitive deterioration
    • Stern R.G., Mohs R.C., Davidson M., et al. A longitudinal study of Alzheimer's disease. measurement, rate, and predictors of cognitive deterioration. Am J Psychiatry 151 3 (1994) 390-396
    • (1994) Am J Psychiatry , vol.151 , Issue.3 , pp. 390-396
    • Stern, R.G.1    Mohs, R.C.2    Davidson, M.3
  • 65
    • 0035209309 scopus 로고    scopus 로고
    • The Alzheimer's Disease Assessment Scale. evaluation of psychometric properties and patterns of cognitive decline in multicenter clinical trials of mild to moderate Alzheimer's disease
    • Doraiswamy P.M., Kaiser L., Bieber F., and Garman R.L. The Alzheimer's Disease Assessment Scale. evaluation of psychometric properties and patterns of cognitive decline in multicenter clinical trials of mild to moderate Alzheimer's disease. Alzheimer Dis Assoc Disord 15 4 (2001) 174-183
    • (2001) Alzheimer Dis Assoc Disord , vol.15 , Issue.4 , pp. 174-183
    • Doraiswamy, P.M.1    Kaiser, L.2    Bieber, F.3    Garman, R.L.4
  • 66
    • 0035001864 scopus 로고    scopus 로고
    • Chronic donepezil treatment is associated with slowed cognitive decline in Alzheimer's disease
    • Doody R.S., Dunn J.K., Clark C.M., et al. Chronic donepezil treatment is associated with slowed cognitive decline in Alzheimer's disease. Dement Geriatr Cogn Disord 12 4 (2001) 295-300
    • (2001) Dement Geriatr Cogn Disord , vol.12 , Issue.4 , pp. 295-300
    • Doody, R.S.1    Dunn, J.K.2    Clark, C.M.3
  • 67
    • 0035859879 scopus 로고    scopus 로고
    • A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD
    • Winblad B., Engedal K., Soininen H., et al. A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD. Neurology 57 3 (2001) 489-495
    • (2001) Neurology , vol.57 , Issue.3 , pp. 489-495
    • Winblad, B.1    Engedal, K.2    Soininen, H.3
  • 68
    • 0033828064 scopus 로고    scopus 로고
    • Donepezil in Alzheimer's disease. eighteen months from Southampton Memory Clinic
    • Matthews H.P., Korbey J., Wilkinson D.G., and Rowden J. Donepezil in Alzheimer's disease. eighteen months from Southampton Memory Clinic. Int J Geriatric Psychiatry 15 (2000) 713-720
    • (2000) Int J Geriatric Psychiatry , vol.15 , pp. 713-720
    • Matthews, H.P.1    Korbey, J.2    Wilkinson, D.G.3    Rowden, J.4
  • 69
    • 0031983322 scopus 로고    scopus 로고
    • Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease. interim analysis of the results of a US multicentre open label extension study
    • Rogers S.L., and Friedhoff L.T. Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease. interim analysis of the results of a US multicentre open label extension study. Eur Neuropsychopharmacol 8 (1998) 67-75
    • (1998) Eur Neuropsychopharmacol , vol.8 , pp. 67-75
    • Rogers, S.L.1    Friedhoff, L.T.2
  • 70
    • 0035103036 scopus 로고    scopus 로고
    • Open-label, multicenter, phase 3 extension study of the safety and efficacy of donepezil in patients with Alzheimer disease
    • Doody R., Geldmacher D., Gordon B., et al. Open-label, multicenter, phase 3 extension study of the safety and efficacy of donepezil in patients with Alzheimer disease. Arch Neurol 58 (2001) 427-433
    • (2001) Arch Neurol , vol.58 , pp. 427-433
    • Doody, R.1    Geldmacher, D.2    Gordon, B.3
  • 71
    • 0033998977 scopus 로고    scopus 로고
    • Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease. final analysis of a US multicentre open label extension study
    • Rogers S.L., Doody R.S., Pratt R.D., and Ieni J.R. Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease. final analysis of a US multicentre open label extension study. Eur Neuropsychopharmacol 10 (2000) 195-203
    • (2000) Eur Neuropsychopharmacol , vol.10 , pp. 195-203
    • Rogers, S.L.1    Doody, R.S.2    Pratt, R.D.3    Ieni, J.R.4
  • 72
    • 0038796988 scopus 로고    scopus 로고
    • Analysis of outcome in retrieved dropout patients in a rivastigmine vs placebo, 26-week, Alzheimer disease trial
    • Farlow M., Potkin S., Koumaras B., Veach J., and Mirski D. Analysis of outcome in retrieved dropout patients in a rivastigmine vs placebo, 26-week, Alzheimer disease trial. Arch Neurol 60 6 (2003) 843-848
    • (2003) Arch Neurol , vol.60 , Issue.6 , pp. 843-848
    • Farlow, M.1    Potkin, S.2    Koumaras, B.3    Veach, J.4    Mirski, D.5
  • 73
    • 0029790469 scopus 로고    scopus 로고
    • Observations and suggestions on antidementia drug development
    • Leber P. Observations and suggestions on antidementia drug development. Alzheimer Dis Assoc Disord 10 suppl1 (1996) 31-35
    • (1996) Alzheimer Dis Assoc Disord , vol.10 , Issue.suppl1 , pp. 31-35
    • Leber, P.1
  • 74
    • 16344378591 scopus 로고    scopus 로고
    • Cognitive performance in Alzheimer's disease patients receiving rivastigmine for up to 5 years
    • Small G.W., Kaufer D., Mendiondo M.S., Quarg P., and Spiegel R. Cognitive performance in Alzheimer's disease patients receiving rivastigmine for up to 5 years. Int J Clin Pract 59 4 (2005) 473-477
    • (2005) Int J Clin Pract , vol.59 , Issue.4 , pp. 473-477
    • Small, G.W.1    Kaufer, D.2    Mendiondo, M.S.3    Quarg, P.4    Spiegel, R.5
  • 78
    • 10344246980 scopus 로고    scopus 로고
    • Galantamine demonstrates cognitive benefits in patients with AD for at least 18 months
    • Tariot P.N., and Kershaw P. Galantamine demonstrates cognitive benefits in patients with AD for at least 18 months. Neurology 58 (2002) A277-A278
    • (2002) Neurology , vol.58
    • Tariot, P.N.1    Kershaw, P.2
  • 79
    • 9344231915 scopus 로고    scopus 로고
    • Long-term efficacy and safety of galantamine in patients with mild-to-moderate Alzheimer's disease. multicenter trial
    • Pirttila T., Wilcock G., Truyen L., and Damaraju C.V. Long-term efficacy and safety of galantamine in patients with mild-to-moderate Alzheimer's disease. multicenter trial. Eur J Neurol 11 11 (2004) 734-741
    • (2004) Eur J Neurol , vol.11 , Issue.11 , pp. 734-741
    • Pirttila, T.1    Wilcock, G.2    Truyen, L.3    Damaraju, C.V.4
  • 80
    • 1042291157 scopus 로고    scopus 로고
    • The cognitive benefits of galantamine are sustained for at least 36 months
    • Raskind M.A., Peskind E.R., Truyen L., Kershaw P., and Damaraju C.V. The cognitive benefits of galantamine are sustained for at least 36 months. Arch Neurol 61 (2004) 252-256
    • (2004) Arch Neurol , vol.61 , pp. 252-256
    • Raskind, M.A.1    Peskind, E.R.2    Truyen, L.3    Kershaw, P.4    Damaraju, C.V.5
  • 81
    • 14644412958 scopus 로고    scopus 로고
    • Rivastigmine. an open-label, observational study of safety and effectiveness in treating patients with Alzheimer's disease for up to 5 years
    • ENA 713 B352 Study Group
    • Farlow M.R., Lilly M.L., and ENA 713 B352 Study Group. Rivastigmine. an open-label, observational study of safety and effectiveness in treating patients with Alzheimer's disease for up to 5 years. BMC Geriatrics 5 1 (2005) 3
    • (2005) BMC Geriatrics , vol.5 , Issue.1 , pp. 3
    • Farlow, M.R.1    Lilly, M.L.2
  • 82
    • 9544240348 scopus 로고    scopus 로고
    • A 1-year multicenter, placebo-controlled study of acetyl-l-carnitine in patients with Alzheimer's disease
    • Thal L.J., Carta A., Clarke W.R., Ferris S.H., et al. A 1-year multicenter, placebo-controlled study of acetyl-l-carnitine in patients with Alzheimer's disease. Neurology 47 3 (1996) 705-711
    • (1996) Neurology , vol.47 , Issue.3 , pp. 705-711
    • Thal, L.J.1    Carta, A.2    Clarke, W.R.3    Ferris, S.H.4
  • 83
    • 0034718466 scopus 로고    scopus 로고
    • A 1-year controlled trial of acetyl-l-carnitine in early-onset AD
    • Thal L.J., Calvani M., Amato A., and Carta A. A 1-year controlled trial of acetyl-l-carnitine in early-onset AD. Neurology 55 6 (2000) 805-810
    • (2000) Neurology , vol.55 , Issue.6 , pp. 805-810
    • Thal, L.J.1    Calvani, M.2    Amato, A.3    Carta, A.4
  • 84
    • 0034620538 scopus 로고    scopus 로고
    • A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study
    • Aisen P.S., Davis K.L., Berg J.D., Schafer K., et al. A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study. Neurology 54 3 (2000) 588-593
    • (2000) Neurology , vol.54 , Issue.3 , pp. 588-593
    • Aisen, P.S.1    Davis, K.L.2    Berg, J.D.3    Schafer, K.4
  • 85
    • 0037638809 scopus 로고    scopus 로고
    • Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression. a randomized controlled trial
    • Aisen P.S., Schafer K.A., Grundman M., Pfeiffer E., et al. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression. a randomized controlled trial. JAMA 289 21 (2003) 2819-2826
    • (2003) JAMA , vol.289 , Issue.21 , pp. 2819-2826
    • Aisen, P.S.1    Schafer, K.A.2    Grundman, M.3    Pfeiffer, E.4
  • 86
    • 0345830739 scopus 로고    scopus 로고
    • Rofecoxib. no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study
    • Reines S.A., Block G.A., Morris J.C., et al. Rofecoxib. no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. Neurology 62 1 (2004) 66-71
    • (2004) Neurology , vol.62 , Issue.1 , pp. 66-71
    • Reines, S.A.1    Block, G.A.2    Morris, J.C.3
  • 88
    • 20344381835 scopus 로고    scopus 로고
    • Vitamin E and donepezil for the treatment of mild cognitive impairment
    • Alzheimer's Disease Cooperative Study Group Epub 2005 Apr 13
    • Petersen R.C., Thomas R.G., Grundman M., et al., Alzheimer's Disease Cooperative Study Group. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 352 23 (2005) 2379-2388 Epub 2005 Apr 13
    • (2005) N Engl J Med , vol.352 , Issue.23 , pp. 2379-2388
    • Petersen, R.C.1    Thomas, R.G.2    Grundman, M.3
  • 89
    • 3042567016 scopus 로고    scopus 로고
    • Long-term donepezil treatment in 565 patients with Alzheimer's disease AD 2000. randomised double-blind trial
    • Courtney C., Farrell D., Gray R., Hills R., et al. Long-term donepezil treatment in 565 patients with Alzheimer's disease AD 2000. randomised double-blind trial. Lancet 363 9427 (2004) 2105-2115
    • (2004) Lancet , vol.363 , Issue.9427 , pp. 2105-2115
    • Courtney, C.1    Farrell, D.2    Gray, R.3    Hills, R.4
  • 90
    • 1842830710 scopus 로고    scopus 로고
    • Randomized, placebo controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease
    • Krishnan K.R.R., Charles H.C., Doraiswamy P.M., et al. Randomized, placebo controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease. Am J Psychiatry 160 (2003) 2003-2011
    • (2003) Am J Psychiatry , vol.160 , pp. 2003-2011
    • Krishnan, K.R.R.1    Charles, H.C.2    Doraiswamy, P.M.3
  • 91
    • 16844372347 scopus 로고    scopus 로고
    • Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease?
    • Hashimoto M., Kazui H., Matsumoto K., Nakano Y., Yasuda M., and Mori E. Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease?. Am J Psychiatry 162 4 (2005) 676-682
    • (2005) Am J Psychiatry , vol.162 , Issue.4 , pp. 676-682
    • Hashimoto, M.1    Kazui, H.2    Matsumoto, K.3    Nakano, Y.4    Yasuda, M.5    Mori, E.6
  • 92
    • 4243762151 scopus 로고    scopus 로고
    • Donepezil HCL maintains global glucose activity in patients with Alzheimer's disease; results of a 24 weeks study
    • Tune L.E., Hoffman J.M., Tisco P.J., et al. Donepezil HCL maintains global glucose activity in patients with Alzheimer's disease; results of a 24 weeks study. J Cereb Blood Flow Metab 19 suppl 1 (1999) 5838
    • (1999) J Cereb Blood Flow Metab , vol.19 , Issue.SUPPL. 1 , pp. 5838
    • Tune, L.E.1    Hoffman, J.M.2    Tisco, P.J.3
  • 93
    • 0035699431 scopus 로고    scopus 로고
    • Brain metabolic and clinical effects of rivastigmine in Alzheimer's disease
    • Potkin S.G., Anand R., Fleming K., Alva G., et al. Brain metabolic and clinical effects of rivastigmine in Alzheimer's disease. Int J Neuropsychopharmacol 4 3 (2001) 223-230
    • (2001) Int J Neuropsychopharmacol , vol.4 , Issue.3 , pp. 223-230
    • Potkin, S.G.1    Anand, R.2    Fleming, K.3    Alva, G.4
  • 94
    • 33645767117 scopus 로고    scopus 로고
    • Longitudinal PET evaluation of cerebral glucose metabolism in rivastigmine treated patients with mild Alzheimer's disease
    • July 29[epub ahead of print].
    • Stefanova E., Wall A., Almkvist O., et al. Longitudinal PET evaluation of cerebral glucose metabolism in rivastigmine treated patients with mild Alzheimer's disease. J Neural Transmission (2005) July 29[epub ahead of print].
    • (2005) J Neural Transmission
    • Stefanova, E.1    Wall, A.2    Almkvist, O.3
  • 95
    • 20844452049 scopus 로고    scopus 로고
    • Metabolic patterns associated with the clinical response to galantamine therapy. a fluorodeoxyglucose f18 positron emission tomographic study
    • Mega M.S., Dinov I.D., Porter V., Chow G., et al. Metabolic patterns associated with the clinical response to galantamine therapy. a fluorodeoxyglucose f18 positron emission tomographic study. Arch Neurol 62 5 (2005) 721-728
    • (2005) Arch Neurol , vol.62 , Issue.5 , pp. 721-728
    • Mega, M.S.1    Dinov, I.D.2    Porter, V.3    Chow, G.4
  • 96
    • 0030035653 scopus 로고    scopus 로고
    • Long-term tacrine (Cognex) treatment. effects on nursing home placement and mortality, Tactrine Study Group
    • Knopman D., Schneider L., Davis K., et al. Long-term tacrine (Cognex) treatment. effects on nursing home placement and mortality, Tactrine Study Group. Neurology 47 1 (1996) 166-177
    • (1996) Neurology , vol.47 , Issue.1 , pp. 166-177
    • Knopman, D.1    Schneider, L.2    Davis, K.3
  • 97
    • 0037707465 scopus 로고    scopus 로고
    • Donepezil is associated with delayed nursing home placement in patients with Alzheimer's disease
    • Geldmacher D., Provenzanok G., McRae T., et al. Donepezil is associated with delayed nursing home placement in patients with Alzheimer's disease. J Am Ger Soc 51 (2003) 937-944
    • (2003) J Am Ger Soc , vol.51 , pp. 937-944
    • Geldmacher, D.1    Provenzanok, G.2    McRae, T.3


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