Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: Implications for the role of nitration in the progression of Alzheimer's disease

Brain Research

Volumn 1148, Issue 1, 2007, Pages 243-248

  Butterfield, D Allan ^a,b   Reed, Tanea T ^a   Perluigi, Marzia ^a,c   De Marco, Carlo ^c   Coccia, Raffaella ^c   Keller, Jeffrey N ^b   Markesbery, William R ^a,b   Sultana, Rukhsana ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Alzheimer's disease; Hippocampus; Inferior parietal lobule; Mild cognitive impairment; Nitrosative stress; Protein nitration

Indexed keywords

3 NITROTYROSINE;

AGED; ALZHEIMER DISEASE; AMNESIA; ARTICLE; BRAIN LEVEL; BRAIN REGION; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NITRATION; NITROSATIVE STRESS; PARIETAL LOBE; PRIORITY JOURNAL;

AGED, 80 AND OVER; ALZHEIMER DISEASE; AMNESIA; BIOLOGICAL MARKERS; BRAIN; COGNITION DISORDERS; DISEASE PROGRESSION; EARLY DIAGNOSIS; FEMALE; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NERVE TISSUE PROTEINS; NITRATES; OXIDATIVE STRESS; PARIETAL LOBE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TYROSINE; UP-REGULATION;

EID: 34247142905     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.02.084     Document Type: Article

References (32)

1. Aksenova M.V., Aksenov M.Y., Payne R.M., Trojanowski J.Q., Schmidt M.L., Carney J.M., Butterfield D.A., and Markesbery W.R. Oxidation of cytosolic proteins and expression of creatine kinase BB in frontal lobe in different neurodegenerative disorders. Dement. Geriatr. Cogn. Disord. 10 (1999) 158-165
2. Beckman J.S. Oxidative damage and tyrosine nitration from peroxynitrite. Chem. Res. Toxicol. 9 (1996) 836-844
3. Butterfield D.A. Proteomics: a new approach to investigate oxidative stress in Alzheimer's disease brain. Brain Res. 1000 (2004) 1-7
4. Butterfield D.A., and Kanski J. Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins. Mech. Ageing Dev. 122 (2001) 945-962
5. Butterfield D.A., and Stadtman E.R. Protein oxidation processes in aging brain. Adv. Cell Aging Gerontol. 2 (1997) 161-191
6. Butterfield D.A., Poon H.F., St Clair D., Keller J.N., Pierce W.M., Klein J.B., and Markesbery W.R. Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease. Neurobiol. Dis. 22 (2006) 223-232
7. Butterfield D.A., Reed T., Perluigi M., De Marco C., Coccia R., Cini C., and Sultana R. Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment. Neurosci. Lett. 397 (2006) 170-173
8. Castegna A., Aksenov M., Aksenova M., Thongboonkerd V., Klein J.B., Pierce W.M., Booze R., Markesbery W.R., and Butterfield D.A. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free Radic. Biol. Med. 33 (2002) 562-571
9. Castegna A., Aksenov M., Thongboonkerd V., Klein J.B., Pierce W.M., Booze R., Markesbery W.R., and Butterfield D.A. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71. J. Neurochem. 82 (2002) 1524-1532
10. Castegna A., Thongboonkerd V., Klein J.B., Lynn B., Markesbery W.R., and Butterfield D.A. Proteomic identification of nitrated proteins in Alzheimer's disease brain. J. Neurochem. 85 (2003) 1394-1401
11. Choi J., Levey A.I., Weintraub S.T., Rees H.D., Gearing M., Chin L.S., and Li L. Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J. Biol. Chem. 279 (2004) 13256-13264
12. Gow A.J., Duran D., Malcolm S., and Ischiropoulos H. Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation. FEBS Lett. 385 (1996) 63-66
13. Halliwell B. What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?. FEBS Lett. 411 (1997) 157-160
14. Hensley K., Hall N., Subramaniam R., Cole P., Harris M., Aksenov M., Aksenova M., Gabbita S.P., Wu J.F., Carney J.M., Lovell M., Markesbery W.R., and Butterfield D.A. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J. Neurochem. 65 (1995) 2146-2156
15. Hensley K., Maidt M.L., Yu Z., Sang H., Markesbery W.R., and Floyd R.A. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. J. Neurosci. 18 (1998) 8126-8132
16. Horiguchi T., Uryu K., Giasson B.I., Ischiropoulos H., LightFoot R., Bellmann C., Richter-Landsberg C., Lee V.M., and Trojanowski J.Q. Nitration of tau protein is linked to neurodegeneration in tauopathies. Am. J. Pathol. 163 (2003) 1021-1031
17. Keller J.N., Schmitt F.A., Scheff S.W., Ding Q., Chen Q., Butterfield D.A., and Markesbery W.R. Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology 64 (2005) 1152-1156
18. Koppal T., Drake J., Yatin S., Jordan B., Varadarajan S., Bettenhausen L., and Butterfield D.A. Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease. J. Neurochem. 72 (1999) 310-317
19. Morris J.C. Mild cognitive impairment and preclinical Alzheimer's disease. Geriatrics (2005) 9-14 (Suppl)
20. Morris J.C., and Cummings J. Mild cognitive impairment (MCI) represents early-stage Alzheimer's disease. J. Alzheimer's Dis. 7 (2005) 235-239 (discussion 255-62)
21. Perry J.M., Zhao Y., and Marletta M.A. Cu2+ and Zn2+ inhibit nitric-oxide synthase through an interaction with the reductase domain. J. Biol. Chem. 275 (2000) 14070-14076
22. Petersen R.C., Smith G.E., Waring S.C., Ivnik R.J., Tangalos E.G., and Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch. Neurol. 56 (1999) 303-308
23. Radi R., Rodriguez M., Castro L., and Telleri R. Inhibition of mitochondrial electron transport by peroxynitrite. Arch. Biochem. Biophys. 308 (1994) 89-95
24. Smith M.A., Richey Harris P.L., Sayre L.M., Beckman J.S., and Perry G. Widespread peroxynitrite-mediated damage in Alzheimer's disease. J. Neurosci. 17 (1997) 2653-2657
25. Souza J.M., Giasson B.I., Chen Q., Lee V.M., and Ischiropoulos H. Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J. Biol. Chem. 275 (2000) 18344-18349
26. Sultana R., and Butterfield D.A. Oxidatively modified GST and MRP1 in Alzheimer's disease brain: implications for accumulation of reactive lipid peroxidation products. Neurochem. Res. 29 (2004) 2215-2220
27. Sultana R., Newman S., Mohmmad-Abdul H., Keller J.N., and Butterfield D.A. Protective effect of the xanthate, D609, on Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress in primary neuronal cells. Free Radic. Res. 38 (2004) 449-458
28. Sultana R., Ravagna A., Mohmmad-Abdul H., Calabrese V., and Butterfield D.A. Ferulic acid ethyl ester protects neurons against amyloid beta-peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J. Neurochem. 92 (2005) 749-758
29. Sultana R., Boyd-Kimball D., Poon H.F., Cai J., Pierce W.M., Klein J.B., Merchant M., Markesbery W.R., and Butterfield D.A. Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD. Neurobiol. Aging 27 (2006) 1564-1576
30. Sultana R., Poon H.F., Cai J., Pierce W.M., Merchant M., Klein J.B., Markesbery W.R., and Butterfield D.A. Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach. Neurobiol. Dis. 22 (2006) 76-87
31. Varadarajan S., Yatin S., Aksenova M., and Butterfield D.A. Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J. Struct. Biol. 130 (2000) 184-208
32. Yamakura F., Taka H., Fujimura T., and Murayama K. Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine. J. Biol. Chem. 273 (1998) 14085-14089