β-Amyloid-related mitochondrial fission and neuronal injury

Science

Volumn 324, Issue 5923, 2009, Pages 102-105

  Cho, Dong Hyung ^a,b   Nakamura, Tomohiro ^a   Fang, Jianguo ^a   Cieplak, Piotr ^a   Godzik, Adam ^a   Gu, Zezong ^a,b   Lipton, Stuart A ^a  

^a BURNHAM INSTITUTE   (United States)

^b University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN PROTEIN; CYSTEINE; DYNAMIN RELATED PROTEIN 1; GUANOSINE TRIPHOSPHATASE; NITRIC OXIDE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (25 35); AMYLOID BETA-PROTEIN (25-35); DNM1L PROTEIN, HUMAN; DRUG DERIVATIVE; MICROTUBULE ASSOCIATED PROTEIN; MITOCHONDRIAL PROTEIN; PEPTIDE FRAGMENT; S NITROSOCYSTEINE; S NITROSOTHIOL; S-NITROSOCYSTEINE;

INJURY; MITOCHONDRION; MUTATION; NERVOUS SYSTEM DISORDER; NITRIC OXIDE; PATHOGENICITY; PATHOLOGY; PROTEIN;

ALZHEIMER DISEASE; ARTICLE; BRAIN MITOCHONDRION; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN CELL; NERVE CELL LESION; NERVE DEGENERATION; NITROSYLATION; PRIORITY JOURNAL; SYNAPSE; ANIMAL; BRAIN CORTEX; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; FEMALE; GENETICS; MALE; METABOLISM; MITOCHONDRION; MOUSE; MUTATION; NERVE CELL; PATHOLOGY; PHYSIOLOGY; PROTEIN MOTIF; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; TRANSGENIC MOUSE; TUMOR CELL LINE; ULTRASTRUCTURE;

ALZHEIMER DISEASE; AMINO ACID MOTIFS; AMYLOID BETA-PROTEIN; ANIMALS; CELL LINE; CELL LINE, TUMOR; CEREBRAL CORTEX; CYSTEINE; FEMALE; GTP PHOSPHOHYDROLASES; HUMANS; MALE; MICE; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MUTATION; NEURONS; NITRIC OXIDE; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; S-NITROSOTHIOLS;

EID: 64249133725     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1171091     Document Type: Article

References (25)

1. R. J. Youle, M. Karbowski, Nat. Rev. Mol. Cell Biol. 6, 657 (2005).
2. M. J. Barsoum et al., EMBO J. 25, 3900 (2006).
3. A. B. Knott, G. Perkins, R. Schwarzenbacher, E. Bossy-Wetzel, Nat. Rev. Neurosci. 9, 505 (2008).
4. H. Li et al., Proc. Natl. Acad. Sci. U.S.A. 105, 2169 (2008).
5. Z. Li, K. Okamoto, Y. Hayashi, M. Sheng, Cell 119, 873 (2004).
6. X. Wang et al., Proc. Natl. Acad. Sci. U.S.A. 105, 19318 (2008).
7. S. J. Baloyannis, J. Alzheimers Dis. 9, 119 (2006).
8. N. Kang-Decker et al., J. Cell Sci. 120, 492 (2007).
9. G. Wang, N. H. Moniri, K. Ozawa, J. S. Stamler, Y. Daaka, Proc. Natl. Acad. Sci. U.S.A. 103, 1295 (2006).
10. H. Yuan et al., Cell Death Differ. 14, 462 (2007).
11. See supporting material on Science Online.
12. S. R. Jaffrey, H. Erdjument-Bromage, C. D. Ferris, P. Tempst, S. H. Snyder, Nat. Cell Biol. 3, 193 (2001).
13. T. Uehara et al., Nature 441, 513 (2006).
14. P. P. Zhu et al., J. Biol. Chem. 279, 35967 (2004).
15. H. H. Low, J. Lowe, Nature 444, 766 (2006).
16. J. S. Stamler, E. J. Toone, S. A. Lipton, N. J. Sucher, Neuron 18, 691 (1997).
17. R. Ramachandran et al., EMBO J. 26, 559 (2007).
18. K. R. Pitts, M. A. McNiven, Y. Yoon, J. Biol. Chem. 279, 50286 (2004).
19. Y. J. Chen, P. Zhang, E. H. Egelman, J. E. Hinshaw, Nat. Struct. Mol. Biol. 11, 574 (2004).
20. J. Estaquier, D. Arnoult, Cell Death Differ. 14, 1086 (2007).
21. H. Yuan et al., Cell Death Differ. 14, 462 (2007).
22. G. M. Shankar et al., J. Neurosci. 27, 2866 (2007).
23. A. I. Bush, C. L. Masters, R. E. Tanzi, Proc. Natl. Acad. Sci. U.S.A. 100, 11193 (2003).
24. D. T. Hess, A. Matsumoto, S. O. Kim, H. E. Marshall, J. S. Stamler, Nat. Rev. Mol. Cell Biol. 6, 150 (2005).
25. We thank T. Newmeyer, J. Zaremba, J. Russo, E. Masliah, H. Xu, and Y. Zhang for help or reagents. Supported by the Japan Society for the Promotion of Science (T.N.) and NIH grants P01 HD29587, R01 EY05477, P01 ES016738, and P30 NS057096 (S.A.L.).