Human HIF-3α4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma

FASEB Journal

Volumn 19, Issue 11, 2005, Pages 1396-1406

  Maynard, Mindy A ^a   Evans, Andrew J ^a,b   Hosomi, Tomoko ^c   Hara, Shuntaro ^c   Jewett, Michael A S ^d   Ohh, Michael ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c KITASATO UNIVERSITY   (Japan)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

HIF 3 4; Hypoxia; RCC; VHL

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 3ALPHA; HYPOXIA INDUCIBLE FACTOR 3ALPHA4; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ARNT PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; HIF3A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; BINDING AFFINITY; CARCINOGENESIS; DNA BINDING; ENHANCER REGION; FEEDBACK SYSTEM; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MOLECULAR CLONING; MUTATION; NUCLEOTIDE SEQUENCE; OXYGEN TENSION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; DNA RESPONSIVE ELEMENT; DOWN REGULATION; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; KIDNEY TUMOR; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BASE SEQUENCE; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CLONING, MOLECULAR; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY NEOPLASMS; MOLECULAR SEQUENCE DATA; RESPONSE ELEMENTS; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 24644484730     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-3788com     Document Type: Article

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