-
1
-
-
0037169354
-
Cancer susceptibility and the functions of BRCA1 and BRCA2
-
Venkitaraman AR. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 2002;108:171-82.
-
(2002)
Cell
, vol.108
, pp. 171-182
-
-
Venkitaraman, A.R.1
-
2
-
-
0028073794
-
BRCA1 mutations in primary breast and ovarian carcinomas
-
Futreal PA, Liu Q, Shattuck-Eidens D, et al. BRCA1 mutations in primary breast and ovarian carcinomas. Science 1994;266:120-2.
-
(1994)
Science
, vol.266
, pp. 120-122
-
-
Futreal, P.A.1
Liu, Q.2
Shattuck-Eidens, D.3
-
3
-
-
0028960025
-
Somatic mutations in the BRCA1 gene in sporadic ovarian tumours
-
Merajver SD, Pham TM, Caduff RF, et al. Somatic mutations in the BRCA1 gene in sporadic ovarian tumours. Nat Genet 1995;9:439-43.
-
(1995)
Nat Genet
, vol.9
, pp. 439-443
-
-
Merajver, S.D.1
Pham, T.M.2
Caduff, R.F.3
-
4
-
-
2942536701
-
Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade
-
Ding SL, Sheu LF, Yu JC, et al. Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade. Br J Cancer 2004;90:1995-2001.
-
(2004)
Br J Cancer
, vol.90
, pp. 1995-2001
-
-
Ding, S.L.1
Sheu, L.F.2
Yu, J.C.3
-
5
-
-
2542590280
-
Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma
-
Beger C, Ramadani M, Meyer S, et al. Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma. Clin Cancer Res 2004;10:3780-7.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3780-3787
-
-
Beger, C.1
Ramadani, M.2
Meyer, S.3
-
6
-
-
0032953384
-
Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas
-
Wilson CA, Ramos L, Villasenor MR, et al. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 1999;21:236-40.
-
(1999)
Nat Genet
, vol.21
, pp. 236-240
-
-
Wilson, C.A.1
Ramos, L.2
Villasenor, M.R.3
-
7
-
-
10444287596
-
Genetic instability and the tumor microenvironment: Towards the concept of microenvironment-induced mutagenesis
-
Bindra RS, Glazer PM. Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis. Mutat Res 2005;569:75-85.
-
(2005)
Mutat Res
, vol.569
, pp. 75-85
-
-
Bindra, R.S.1
Glazer, P.M.2
-
8
-
-
0029753768
-
Genetic instability induced by the tumor microenvironment
-
Reynolds TY, Rockwell S, Glazer PM. Genetic instability induced by the tumor microenvironment. Cancer Res 1996;56:5754-7.
-
(1996)
Cancer Res
, vol.56
, pp. 5754-5757
-
-
Reynolds, T.Y.1
Rockwell, S.2
Glazer, P.M.3
-
9
-
-
0034662615
-
Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH
-
Yuan J, Narayanan L, Rockwell S. Glazer PM. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res 2000;60:4372-6.
-
(2000)
Cancer Res
, vol.60
, pp. 4372-4376
-
-
Yuan, J.1
Narayanan, L.2
Rockwell, S.3
Glazer, P.M.4
-
10
-
-
15244344206
-
HIF-1α induces genetic instability by transcriptionally downregulating MutSα expression
-
Koshiji M, To KK, Hammer S, et al. HIF-1α induces genetic instability by transcriptionally downregulating MutSα expression. Mol Cell 2005;17:793-803.
-
(2005)
Mol Cell
, vol.17
, pp. 793-803
-
-
Koshiji, M.1
To, K.K.2
Hammer, S.3
-
11
-
-
4544324453
-
Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells
-
Bindra RS, Schaffer PJ, Meng A, et al. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Mol Cell Biol 2004;24: 8504-18.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8504-8518
-
-
Bindra, R.S.1
Schaffer, P.J.2
Meng, A.3
-
12
-
-
9244234509
-
Defective DNA strand break repair after DNA damage in prostate cancer cells: Implications for genetic instability and prostate cancer progression
-
Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG. Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. Cancer Res 2004;64:8526-33.
-
(2004)
Cancer Res
, vol.64
, pp. 8526-8533
-
-
Fan, R.1
Kumaravel, T.S.2
Jalali, F.3
Marrano, P.4
Squire, J.A.5
Bristow, R.G.6
-
13
-
-
0038146962
-
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
-
Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem 2003;278:12207-13.
-
(2003)
J Biol Chem
, vol.278
, pp. 12207-12213
-
-
Hammond, E.M.1
Dorie, M.J.2
Giaccia, A.J.3
-
14
-
-
0010170555
-
Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
-
Young SD, Marshall RS. Hill RP. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci U S A 1988;85: 9533-7.
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, pp. 9533-9537
-
-
Young, S.D.1
Marshall, R.S.2
Hill, R.P.3
-
15
-
-
0032132806
-
A new role for hypoxia in tumor progression: Induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs
-
Coquelle A, Toledo F, Stern S, Bieth A, Debatisse M. A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Mol Cell 1998;2: 259-65.
-
(1998)
Mol Cell
, vol.2
, pp. 259-265
-
-
Coquelle, A.1
Toledo, F.2
Stern, S.3
Bieth, A.4
Debatisse, M.5
-
16
-
-
0037404420
-
Decreased expression of the DNA mismatch repair gene Mlhl under hypoxic stress in mammalian cells
-
Mihaylova VT, Bindra RS, Yuan J, et al. Decreased expression of the DNA mismatch repair gene Mlhl under hypoxic stress in mammalian cells. Mol Cell Biol 2003;23:3265-73.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 3265-3273
-
-
Mihaylova, V.T.1
Bindra, R.S.2
Yuan, J.3
-
17
-
-
0038142184
-
Differential regulation of E2F1 apoptotic target genes in response to DNA damage
-
Pediconi N, Ianari A, Costanzo A, et al. Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat Cell Biol 2003;5:552-8.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 552-558
-
-
Pediconi, N.1
Ianari, A.2
Costanzo, A.3
-
18
-
-
0035878122
-
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
-
Lin WC, Lin FT, Nevins JR. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev 2001;15: 1833-44.
-
(2001)
Genes Dev
, vol.15
, pp. 1833-1844
-
-
Lin, W.C.1
Lin, F.T.2
Nevins, J.R.3
-
19
-
-
3242880237
-
The emerging role of E2F-1 in the DNA damage response and checkpoint control
-
Stevens C, La Thangue NB. The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair (Amst) 2004;3:1071-9.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 1071-1079
-
-
Stevens, C.1
La Thangue, N.B.2
-
20
-
-
0141707813
-
1/S transition and DNA replication
-
1/S transition and DNA replication. Cancer Cell 2003;3:311-6.
-
(2003)
Cancer Cell
, vol.3
, pp. 311-316
-
-
Cam, H.1
Dynlacht, B.D.2
-
21
-
-
16244406228
-
Adaptive myogenesis under hypoxia
-
Yun Z, Lin Q, Giaccia AJ. Adaptive myogenesis under hypoxia. Mol Cell Biol 2005;25:3040-55.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3040-3055
-
-
Yun, Z.1
Lin, Q.2
Giaccia, A.J.3
-
22
-
-
0142180081
-
E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9
-
Oberley MJ, Inman DR, Farnham PJ. E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9. J Biol Chem 2003;278: 42466-76.
-
(2003)
J Biol Chem
, vol.278
, pp. 42466-42476
-
-
Oberley, M.J.1
Inman, D.R.2
Farnham, P.J.3
-
23
-
-
0033569684
-
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
-
Pierce AJ, Johnson RD, Thompson LH, Jasin M. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev 1999;13:2633-8.
-
(1999)
Genes Dev
, vol.13
, pp. 2633-2638
-
-
Pierce, A.J.1
Johnson, R.D.2
Thompson, L.H.3
Jasin, M.4
-
25
-
-
0035834945
-
Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes
-
Dimitrov S, Brennerova M, Forejt J. Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes. Gene 2001;262:89-98.
-
(2001)
Gene
, vol.262
, pp. 89-98
-
-
Dimitrov, S.1
Brennerova, M.2
Forejt, J.3
-
26
-
-
0034635478
-
Regulation of BRCA1 expression by the Rb-E2F pathway
-
Wang A, Schneider-Broussard R, Kumar AP, MacLeod MC, Johnson DG. Regulation of BRCA1 expression by the Rb-E2F pathway. J Biol Chem 2000;275:4532-6.
-
(2000)
J Biol Chem
, vol.275
, pp. 4532-4536
-
-
Wang, A.1
Schneider-Broussard, R.2
Kumar, A.P.3
MacLeod, M.C.4
Johnson, D.G.5
-
27
-
-
11244276992
-
The E2F family: Specific functions and overlapping interests
-
Attwooll C, Denchi EL, Helin K. The E2F family: specific functions and overlapping interests. EMBO J 2004;23:4709-16.
-
(2004)
EMBO J
, vol.23
, pp. 4709-4716
-
-
Attwooll, C.1
Denchi, E.L.2
Helin, K.3
-
28
-
-
22344449138
-
Opposing roles of E2Fs in cell proliferation and death
-
Crosby ME, Almasan A. Opposing roles of E2Fs in cell proliferation and death. Cancer Biol Ther 2004;3: 1208-11.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 1208-1211
-
-
Crosby, M.E.1
Almasan, A.2
-
30
-
-
0037080483
-
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints
-
Ren B, Cam H, Takahashi Y, et al. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev 2002;16:245-56.
-
(2002)
Genes Dev
, vol.16
, pp. 245-256
-
-
Ren, B.1
Cam, H.2
Takahashi, Y.3
-
31
-
-
8644281106
-
A common set of gene regulatory networks links metabolism and growth inhibition
-
Cam H, Balciunaite E, Biais A, et al. A common set of gene regulatory networks links metabolism and growth inhibition. Mol Cell 2004;16:399-411.
-
(2004)
Mol Cell
, vol.16
, pp. 399-411
-
-
Cam, H.1
Balciunaite, E.2
Biais, A.3
-
32
-
-
11244315697
-
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
-
Manalo DJ, Rowan A, Lavoie T, et al. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 2005;105:659-69.
-
(2005)
Blood
, vol.105
, pp. 659-669
-
-
Manalo, D.J.1
Rowan, A.2
Lavoie, T.3
-
33
-
-
3142631736
-
HIF-1α induces cell cycle arrest by functionally counteracting Myc
-
Koshiji M, Kageyama Y. Pete EA, Horikawa I, Barrett JC, Huang LE. HIF-1α induces cell cycle arrest by functionally counteracting Myc. EMBO J 2004;23:1949-56.
-
(2004)
EMBO J
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
34
-
-
0034901463
-
Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
-
Semenza GL. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 2001;7:345-50.
-
(2001)
Trends Mol Med
, vol.7
, pp. 345-350
-
-
Semenza, G.L.1
-
35
-
-
0031907152
-
Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2
-
Lonergan KM, Iliopoulos O, Ohh M, et al. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Mol Cell Biol 1998;18: 732-41.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 732-741
-
-
Lonergan, K.M.1
Iliopoulos, O.2
Ohh, M.3
-
36
-
-
16544365033
-
Quantitative sequential chromatin immunoprecipitation, a method for analyzing co-occupancy of proteins at genomic regions in vivo
-
Geisberg JV, Struhl K. Quantitative sequential chromatin immunoprecipitation, a method for analyzing co-occupancy of proteins at genomic regions in vivo. Nucleic Acids Res 2004;32:e151.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Geisberg, J.V.1
Struhl, K.2
-
38
-
-
0037330709
-
Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins
-
Helt AM, Galloway DA. Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins. Carcinogenesis 2003;24:159-69.
-
(2003)
Carcinogenesis
, vol.24
, pp. 159-169
-
-
Helt, A.M.1
Galloway, D.A.2
-
39
-
-
0037047387
-
BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks
-
Zhong Q, Chen CF, Chen PL, Lee WH. BRCA1 facilitates microhomology- mediated end joining of DNA double strand breaks. J Biol Chem 2002;277: 28641-7.
-
(2002)
J Biol Chem
, vol.277
, pp. 28641-28647
-
-
Zhong, Q.1
Chen, C.F.2
Chen, P.L.3
Lee, W.H.4
-
40
-
-
0030932869
-
Cancer-susceptibility genes. Gatekeepers and caretakers
-
Kinzler KW, Vogelstein B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 1997;386: 761, 763.
-
(1997)
Nature
, vol.386
, pp. 761
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
41
-
-
0346095320
-
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair
-
Zhang J, Willers H, Feng Z, et al. Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol 2004;24:708-18.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 708-718
-
-
Zhang, J.1
Willers, H.2
Feng, Z.3
-
42
-
-
18344393150
-
The E2F transcriptional network: Old acquaintances with new faces
-
Dimova DK, Dyson NJ. The E2F transcriptional network: old acquaintances with new faces. Oncogene 2005;24:2810-26.
-
(2005)
Oncogene
, vol.24
, pp. 2810-2826
-
-
Dimova, D.K.1
Dyson, N.J.2
-
43
-
-
0343484254
-
Regulation of E2F1 activity by acetylation
-
Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A. Kouzarides T. Regulation of E2F1 activity by acetylation. EMBO J 2000;19:662-71.
-
(2000)
EMBO J
, vol.19
, pp. 662-671
-
-
Martinez-Balbas, M.A.1
Bauer, U.M.2
Nielsen, S.J.3
Brehm, A.4
Kouzarides, T.5
-
44
-
-
0001445037
-
E2F4 loss suppresses tumorigenesis in Rb mutant mice
-
Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA, Dynlacht BD. E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell 2002;2:463-72.
-
(2002)
Cancer Cell
, vol.2
, pp. 463-472
-
-
Lee, E.Y.1
Cam, H.2
Ziebold, U.3
Rayman, J.B.4
Lees, J.A.5
Dynlacht, B.D.6
-
45
-
-
3242657301
-
Expression of E2F-4 in invasive breast carcinomas is associated with poor prognosis
-
Rakha EA, Finder SE, Paish EC, Robertson JF, Ellis IO. Expression of E2F-4 in invasive breast carcinomas is associated with poor prognosis. J Pathol 2004;203:754-61.
-
(2004)
J Pathol
, vol.203
, pp. 754-761
-
-
Rakha, E.A.1
Finder, S.E.2
Paish, E.C.3
Robertson, J.F.4
Ellis, I.O.5
-
46
-
-
3042743989
-
Genotoxic stress induces expression of E2F4 leading to its association with pl30 in prostate carcinoma cells
-
DuPree EL, Mazumder S, Almasan A. Genotoxic stress induces expression of E2F4. leading to its association with pl30 in prostate carcinoma cells. Cancer Res 2004;64:4390-3.
-
(2004)
Cancer Res
, vol.64
, pp. 4390-4393
-
-
DuPree, E.L.1
Mazumder, S.2
Almasan, A.3
-
47
-
-
22344455442
-
E2F4 deficiency promotes drug-induced apoptosis
-
Ma Y, Freeman SN, Cress WD. E2F4 deficiency promotes drug-induced apoptosis. Cancer Biol Ther 2004;3:1262-69.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 1262-1269
-
-
Ma, Y.1
Freeman, S.N.2
Cress, W.D.3
-
48
-
-
3142622910
-
The hypoxic tumor microenvironment and gene expression
-
Leo C, Giaccia AJ, Denko NC. The hypoxic tumor microenvironment and gene expression. Semin Radiat Oncol 2004;14:207-14.
-
(2004)
Semin Radiat Oncol
, vol.14
, pp. 207-214
-
-
Leo, C.1
Giaccia, A.J.2
Denko, N.C.3
-
49
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-21.
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
-
50
-
-
7744238149
-
The use of transient chromatin immunoprecipitation assays to test models for E2F1-specific transcriptional activation
-
Lavrrar JL, Farnham PJ. The use of transient chromatin immunoprecipitation assays to test models for E2F1-specific transcriptional activation. J Biol Chem 2004;379:46343-9.
-
(2004)
J Biol Chem
, vol.379
, pp. 46343-46349
-
-
Lavrrar, J.L.1
Farnham, P.J.2
|