메뉴 건너뛰기




Volumn 8, Issue 4 SUPPL., 2002, Pages

HIF-1 and tumor progression: Pathophysiology and therapeutics

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1; PROTEIN INHIBITOR; PROTEIN SUBUNIT;

EID: 0036216692     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02317-1     Document Type: Review
Times cited : (960)

References (37)
  • 1
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 4
    • 0035027828 scopus 로고    scopus 로고
    • Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3436-3444
    • Seagroves, T.N.1
  • 5
    • 0033954247 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1 α
    • (2000) Genes Dev. , vol.14 , pp. 34-44
    • Ravi, R.1
  • 6
    • 0034529914 scopus 로고    scopus 로고
    • Suppression of tumor growth through disruption of hypoxia-inducible transcription
    • (2000) Nat. Med. , vol.6 , pp. 1335-1340
    • Kung, A.L.1
  • 7
    • 17944375360 scopus 로고    scopus 로고
    • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • (2001) Cell , vol.107 , pp. 43-54
    • Epstein, A.C.1
  • 11
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
    • (2001) Genes Dev. , vol.15 , pp. 2675-2686
    • Mahon, P.C.1
  • 12
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1
  • 13
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3995-4004
    • Laughner, E.1
  • 14
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of HIF-1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • (2000) Cancer Res. , vol.60 , pp. 1541-1545
    • Zhong, H.1
  • 15
    • 0034050050 scopus 로고    scopus 로고
    • Loss of PTEN facilitates HIF-1-mediated gene expression
    • (2000) Genes Dev. , vol.14 , pp. 391-396
    • Zundel, W.1
  • 16
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible transcription factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
    • (2000) Am. J. Pathol. , vol.157 , pp. 411-421
    • Talks, K.L.1
  • 17
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
    • (1999) Cancer Res. , vol.59 , pp. 5830-5835
    • Zhong, H.1
  • 18
    • 15444342958 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor 1α
    • (1998) Genes Dev. , vol.12 , pp. 149-162
    • Iyer, N.V.1
  • 19
    • 0037155247 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 (HIF-1) mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKBF3) gene: Its possible role in the Warburg effect
    • (2002) J. Biol. Chem. , vol.277 , pp. 6183-6187
    • Minchenko, A.1
  • 20
    • 0034213146 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1α in brain tumors: Association with angiogenesis, invasion, and progression
    • (2000) Cancer , vol.88 , pp. 2606-2618
    • Zagzag, D.1
  • 21
    • 0035395098 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor- 1α in oligodendrogliomas: Its impact on prognosis and on neoangiogenesis
    • (2001) Cancer , vol.92 , pp. 165-171
    • Birner, P.1
  • 22
    • 0034896068 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1α in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1661-1668
    • Birner, P.1
  • 24
    • 0034282518 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
    • (2000) Cancer Res. , vol.60 , pp. 4693-4596
    • Birner, P.1
  • 25
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor- 1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    • (2001) Cancer Res. , vol.61 , pp. 2911-2916
    • Aebersold, D.M.1
  • 26
    • 0035266307 scopus 로고    scopus 로고
    • Hypoxia inducible factor (HIF-1 a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy
    • (2001) Cancer Res. , vol.61 , pp. 1830-1832
    • Koukourakis, M.I.1
  • 27
    • 0342433777 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF- 1) and its relationship to apoptosis and proliferation in lung cancer
    • (2000) Anticancer Res. , vol.20 , pp. 1527-1533
    • Volm, M.1    Koomagi, R.2
  • 28
    • 0035860147 scopus 로고    scopus 로고
    • Relation of hypoxia inducible factor 1αand 2αin operable non-small cell lung cancer to angiogenic/ molecular profile of tumours and survival
    • (2001) Br. J. Cancer , vol.85 , pp. 881-890
    • Giatromanolaki, A.1
  • 29
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation, and tumour angiogenesis
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1
  • 31
    • 0035418621 scopus 로고    scopus 로고
    • Constitutive expression of hypoxia-inducible factor-1α renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation
    • (2001) Cancer Res. , vol.61 , pp. 6548-6554
    • Akakura, N.1
  • 32
    • 0035958932 scopus 로고    scopus 로고
    • ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor- 1α (HIF-1α) and inhibits HIF-1-mediated transcription
    • (2001) J. Biol. Chem. , vol.276 , pp. 28421-28429
    • Fatyol, K.1    Szatay, A.A.2
  • 33
    • 0034176782 scopus 로고    scopus 로고
    • Exploiting the hypoxic cancer cell: Mechanisms and therapeutic strategies
    • (2000) Mol. Med. Today , vol.6 , pp. 157-162
    • Brown, J.M.1
  • 34
    • 0035477438 scopus 로고    scopus 로고
    • Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway
    • (2001) Cancer Res. , vol.61 , pp. 7349-7355
    • Blancher, C.1
  • 35
    • 0033104847 scopus 로고    scopus 로고
    • Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
    • (1999) J. Clin. Invest. , vol.103 , pp. 691-696
    • Yu, A.Y.1
  • 37
    • 0035910729 scopus 로고    scopus 로고
    • Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension
    • (2001) Circ. Res. , vol.88
    • Yeager, M.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.