메뉴 건너뛰기




Volumn 23, Issue 9, 2003, Pages 3265-3273

Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells

Author keywords

[No Author keywords available]

Indexed keywords

CHELATING AGENT; DEFEROXAMINE; DIMER; DINUCLEOTIDE; DNA; HISTONE; HISTONE DEACETYLASE INHIBITOR; IRON; MESSENGER RNA; MISMATCH REPAIR PROTEIN PMS2; OXYGEN; PROTEIN; PROTEIN MLH1; PROTEIN MSH6; TRICHOSTATIN A; UNCLASSIFIED DRUG;

EID: 0037404420     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.9.3265-3273.2003     Document Type: Article
Times cited : (232)

References (63)
  • 1
    • 0031915443 scopus 로고    scopus 로고
    • Regulation by hypoxia of methionine adenosyltransferase activity and gene expression in rat hepatocytes
    • Avila, M. A., M. V. Carretero, E. N. Rodriguez, and J. M. Mato. 1998. Regulation by hypoxia of methionine adenosyltransferase activity and gene expression in rat hepatocytes. Gastroenterology 114:364-371.
    • (1998) Gastroenterology , vol.114 , pp. 364-371
    • Avila, M.A.1    Carretero, M.V.2    Rodriguez, E.N.3    Mato, J.M.4
  • 4
    • 0032887713 scopus 로고    scopus 로고
    • Hypoxia downregulates tropoelastin gene expression in rat lung fibroblasts by pretranslational mechanisms
    • Berk, J. L., N. Massoomi, C. Hatch, and R. H. Goldstein. 1999. Hypoxia downregulates tropoelastin gene expression in rat lung fibroblasts by pretranslational mechanisms. Am. J. Physiol. 277:L566-572.
    • (1999) Am. J. Physiol. , vol.277
    • Berk, J.L.1    Massoomi, N.2    Hatch, C.3    Goldstein, R.H.4
  • 6
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick, R. K., and S. L. McKnight. 2001. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294:1337-1340.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 7
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • Bunn, H. F., and R. O. Poyton. 1996. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76:839-885.
    • (1996) Physiol. Rev. , vol.76 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 10
    • 0035923684 scopus 로고    scopus 로고
    • High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
    • Chen, S., S. H. Bigner, and P. Modrich. 2001. High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6. Proc. Natl. Acad. Sci. USA 98:13802-13807.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13802-13807
    • Chen, S.1    Bigner, S.H.2    Modrich, P.3
  • 11
    • 0032132806 scopus 로고    scopus 로고
    • A new role for hypoxia in tumor progression: Induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs
    • Coquelle, A., F. Toledo, S. Stern, A. Bieth, and M. Debatisse. 1998. A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Mol. Cell 2:259-265.
    • (1998) Mol. Cell , vol.2 , pp. 259-265
    • Coquelle, A.1    Toledo, F.2    Stern, S.3    Bieth, A.4    Debatisse, M.5
  • 12
    • 0026651649 scopus 로고
    • Mechanisms of directed mutation
    • Foster, P. L., and J. Cairns. 1992. Mechanisms of directed mutation. Genetics 131:783-789.
    • (1992) Genetics , vol.131 , pp. 783-789
    • Foster, P.L.1    Cairns, J.2
  • 14
    • 0024273450 scopus 로고
    • Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
    • Goldberg, M. A., S. P. Dunning, and H. F. Bunn. 1988. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242:1412-1415.
    • (1988) Science , vol.242 , pp. 1412-1415
    • Goldberg, M.A.1    Dunning, S.P.2    Bunn, H.F.3
  • 15
    • 0027236017 scopus 로고
    • High efficiency, restriction-deficient in vitro packaging extracts for bacteriophage lambda DNA using a new E. coli lysogen
    • Gunther, E. J., N. E. Murray, and P. M. Glazer. 1993. High efficiency, restriction-deficient in vitro packaging extracts for bacteriophage lambda DNA using a new E. coli lysogen. Nucleic Acids Res. 21:3903-3904.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 3903-3904
    • Gunther, E.J.1    Murray, N.E.2    Glazer, P.M.3
  • 17
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel, M., K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel. 1996. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56:4509-4515.
    • (1996) Cancer Res. , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 22
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane, M. F., M. Loda, G. M. Gaida, J. Lipman, R. Mishra, H. Goldman, J. M. Jessup, and R. Kolodner. 1997. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res. 57:808-811.
    • (1997) Cancer Res. , vol.57 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3    Lipman, J.4    Mishra, R.5    Goldman, H.6    Jessup, J.M.7    Kolodner, R.8
  • 24
    • 0029784320 scopus 로고    scopus 로고
    • Biochemistry and genetics of eukaryotic mismatch repair
    • Kolodner, R. 1996. Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev. 10:1433-1442.
    • (1996) Genes Dev. , vol.10 , pp. 1433-1442
    • Kolodner, R.1
  • 26
    • 0025773554 scopus 로고
    • Mutator phenotype may be required for multistage carcinogenesis
    • Loeb, L. A. 1991. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51:3075-3079.
    • (1991) Cancer Res. , vol.51 , pp. 3075-3079
    • Loeb, L.A.1
  • 27
    • 0034596309 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
    • Marks, P. A., V. M. Richon, and R. A. Rifkind. 2000. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J. Natl. Cancer Inst. 92:1210-1216.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 1210-1216
    • Marks, P.A.1    Richon, V.M.2    Rifkind, R.A.3
  • 28
    • 0028105848 scopus 로고
    • Hypoxia regulatory elements of the human vascular endothelial growth factor gene
    • Minchenko, A., S. Salceda, T. Bauer, and J. Caro. 1994. Hypoxia regulatory elements of the human vascular endothelial growth factor gene. Cell. Mol. Biol. Res. 40:35-39.
    • (1994) Cell. Mol. Biol. Res. , vol.40 , pp. 35-39
    • Minchenko, A.1    Salceda, S.2    Bauer, T.3    Caro, J.4
  • 29
    • 0029943449 scopus 로고    scopus 로고
    • Mismatch repair in replication fidelity, genetic recombination, and cancer biology
    • Modrich, P., and R. Lahue. 1996. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem. 65:101-133.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 101-133
    • Modrich, P.1    Lahue, R.2
  • 30
    • 0035837658 scopus 로고    scopus 로고
    • Paradoxical effects of trichostatin A: Inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA
    • Nair, A. R., L. J. Boersma, L. Schiltz, M. A. Chaudhry, R. J. Muschel, and A. Chaudry. 2001. Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA. Cancer Lett. 166:55-64.
    • (2001) Cancer Lett. , vol.166 , pp. 55-64
    • Nair, A.R.1    Boersma, L.J.2    Schiltz, L.3    Chaudhry, M.A.4    Muschel, R.J.5    Chaudry, A.6
  • 31
    • 0030965212 scopus 로고    scopus 로고
    • Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2
    • Narayanan, L., J. A. Fritzell, S. M. Baker, R. M. Liskay, and P. M. Glazer. 1997. Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2. Proc. Natl. Acad. Sci. USA 94:3122-3127.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3122-3127
    • Narayanan, L.1    Fritzell, J.A.2    Baker, S.M.3    Liskay, R.M.4    Glazer, P.M.5
  • 32
    • 0028179096 scopus 로고
    • In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays
    • Paquette, B., and J. B. Little. 1994. In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays. Cancer Res. 54:3173-3178.
    • (1994) Cancer Res. , vol.54 , pp. 3173-3178
    • Paquette, B.1    Little, J.B.2
  • 34
    • 0035852706 scopus 로고    scopus 로고
    • ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
    • Peretz, S., R. Jensen, R. Baserga, and P. M. Glazer. 2001. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proc. Natl. Acad. Sci. USA 98:1676-1681.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1676-1681
    • Peretz, S.1    Jensen, R.2    Baserga, R.3    Glazer, P.M.4
  • 35
    • 0032575655 scopus 로고    scopus 로고
    • Hypoxia exerts cell-type-specific effects on expression of the class 3 aldehyde dehydrogenase gene
    • Reisdorph, R., and R. Lindahl. 1998. Hypoxia exerts cell-type-specific effects on expression of the class 3 aldehyde dehydrogenase gene. Biochem. Biophys. Res. Commun. 249:709-712.
    • (1998) Biochem. Biophys. Res. Commun. , vol.249 , pp. 709-712
    • Reisdorph, R.1    Lindahl, R.2
  • 36
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • Reynolds, T. Y., S. Rockwell, and P. M. Glazer. 1996. Genetic instability induced by the tumor microenvironment. Cancer Res. 56:5754-5757.
    • (1996) Cancer Res. , vol.56 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 37
    • 0004580887 scopus 로고
    • Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells
    • Rice, G. C., C. Hoy, and R. T. Schimke. 1986. Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proc. Natl. Acad. Sci. USA 83:5978-5982.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5978-5982
    • Rice, G.C.1    Hoy, C.2    Schimke, R.T.3
  • 38
    • 0017603563 scopus 로고
    • In vivo-in vitro tumor systems: New models for studying the response of tumours to therapy
    • Rockwell, S. 1977. In vivo-in vitro tumor systems: new models for studying the response of tumours to therapy. Lab. Anim. Sci. 27:831-851.
    • (1977) Lab. Anim. Sci. , vol.27 , pp. 831-851
    • Rockwell, S.1
  • 39
    • 0031307796 scopus 로고    scopus 로고
    • Oxygen delivery: Implications for the biology and therapy of solid tumors
    • Rockwell, S. 1997. Oxygen delivery: implications for the biology and therapy of solid tumors. Oncol. Res. 9:383-390.
    • (1997) Oncol. Res. , vol.9 , pp. 383-390
    • Rockwell, S.1
  • 40
    • 0035404535 scopus 로고    scopus 로고
    • Evolving responsively: Adaptive mutation
    • Rosenberg, S. M. 2001. Evolving responsively: adaptive mutation. Nat. Rev. Genet. 2:504-515.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 504-515
    • Rosenberg, S.M.1
  • 41
    • 0035962632 scopus 로고    scopus 로고
    • DNA methylation, chromatin inheritance, and cancer
    • Rountree, M. R., K. E. Bachman, J. G. Herman, and S. B. Baylin. 2001. DNA methylation, chromatin inheritance, and cancer. Oncogene 20:3156-3165.
    • (2001) Oncogene , vol.20 , pp. 3156-3165
    • Rountree, M.R.1    Bachman, K.E.2    Herman, J.G.3    Baylin, S.B.4
  • 43
    • 0033991530 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1: Mechanisms and consequences
    • Semenza, G. L. 2000. Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem. Pharmacol. 59:47-53.
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 47-53
    • Semenza, G.L.1
  • 44
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
    • Semenza, G. L. 2000. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol. 88:1474-1480.
    • (2000) J. Appl. Physiol. , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 45
    • 0035812772 scopus 로고    scopus 로고
    • HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
    • Semenza, G. L. 2001. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107:1-3.
    • (2001) Cell , vol.107 , pp. 1-3
    • Semenza, G.L.1
  • 46
    • 0034021690 scopus 로고    scopus 로고
    • Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    • Semenza, G. L. 2000. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit. Rev. Biochem. Mol. Biol. 35:71-103.
    • (2000) Crit. Rev. Biochem. Mol. Biol. , vol.35 , pp. 71-103
    • Semenza, G.L.1
  • 47
    • 0034816279 scopus 로고    scopus 로고
    • Human rad21 gene, hHR21(SP), is downregulated by hypoxia in human tumor cells
    • Sook Kim, M., J. Hyen Baek, M. K. Bae, and K. W. Kim. 2001. Human rad21 gene, hHR21(SP), is downregulated by hypoxia in human tumor cells. Biochem. Biophys. Res. Commun. 281:1106-1112.
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 1106-1112
    • Sook Kim, M.1    Hyen Baek, J.2    Bae, M.K.3    Kim, K.W.4
  • 48
    • 0027306173 scopus 로고
    • Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
    • Erratum, 368:569, 1994
    • Strand, M., T. A. Prolla, R. M. Liskay, and T. D. Petes. 1993. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365:274-276. (Erratum, 368:569, 1994.)
    • (1993) Nature , vol.365 , pp. 274-276
    • Strand, M.1    Prolla, T.A.2    Liskay, R.M.3    Petes, T.D.4
  • 49
    • 0031735450 scopus 로고    scopus 로고
    • Tumor hypoxia and gene expression - Implications for malignant progression and therapy
    • Sutherland, R. M. 1998. Tumor hypoxia and gene expression - implications for malignant progression and therapy. Acta Oncol. 37:567-574.
    • (1998) Acta Oncol. , vol.37 , pp. 567-574
    • Sutherland, R.M.1
  • 50
    • 0028859271 scopus 로고
    • Targeted mutagenesis in mammalian cells mediated by intracellular triple helix formation
    • Wang, G., D. D. Levy, M. M. Seidman, and P. M. Glazer. 1995. Targeted mutagenesis in mammalian cells mediated by intracellular triple helix formation. Mol. Cell. Biol. 15:1759-1768.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1759-1768
    • Wang, G.1    Levy, D.D.2    Seidman, M.M.3    Glazer, P.M.4
  • 51
    • 0027427588 scopus 로고
    • Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
    • Wang, G. L., and G. L. Semenza. 1993. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 268:21513-21518.
    • (1993) J. Biol. Chem. , vol.268 , pp. 21513-21518
    • Wang, G.L.1    Semenza, G.L.2
  • 52
    • 0027136260 scopus 로고
    • Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
    • Wang, G. L., and G. L. Semenza. 1993. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82:3610-3615.
    • (1993) Blood , vol.82 , pp. 3610-3615
    • Wang, G.L.1    Semenza, G.L.2
  • 54
    • 0028792556 scopus 로고
    • Hprt mutants in a transplantable murine tumour arise more frequently in vivo than in vitro
    • Wilkinson, D., J. K. Sandhu, J. W. Breneman, J. D. Tucker, and H. C. Birnboim. 1995. Hprt mutants in a transplantable murine tumour arise more frequently in vivo than in vitro. Br. J. Cancer 72:1234-1240.
    • (1995) Br. J. Cancer , vol.72 , pp. 1234-1240
    • Wilkinson, D.1    Sandhu, J.K.2    Breneman, J.W.3    Tucker, J.D.4    Birnboim, H.C.5
  • 55
    • 0034842881 scopus 로고    scopus 로고
    • Hypoxia and oxidative stress. Tumour hypoxia - Therapeutic considerations
    • Williams, K. J., R. L. Cowen, and I. J. Stratford. 2001. Hypoxia and oxidative stress. Tumour hypoxia - therapeutic considerations. Breast Cancer Res. 3:328-331.
    • (2001) Breast Cancer Res. , vol.3 , pp. 328-331
    • Williams, K.J.1    Cowen, R.L.2    Stratford, I.J.3
  • 56
    • 0029892791 scopus 로고    scopus 로고
    • DNA repair in eukaryotes
    • Wood, R. D. 1996. DNA repair in eukaryotes. Annu. Rev. Biochem. 65:135-167.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 135-167
    • Wood, R.D.1
  • 57
    • 0030825309 scopus 로고    scopus 로고
    • COBRA: A sensitive and quantitative DNA methylation assay
    • Xiong, Z., and P. W. Laird. 1997. COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res. 25:2532-2534.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2532-2534
    • Xiong, Z.1    Laird, P.W.2
  • 59
    • 0024996768 scopus 로고
    • Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
    • Yoshida, M., M. Kijima, M. Akita, and T. Beppu. 1990. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 265:17174-17179.
    • (1990) J. Biol. Chem. , vol.265 , pp. 17174-17179
    • Yoshida, M.1    Kijima, M.2    Akita, M.3    Beppu, T.4
  • 60
    • 0010170555 scopus 로고
    • Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
    • Young, S. D., R. S. Marshall, and R. P. Hill. 1988. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc. Natl. Acad. Sci. USA 85:9533-9537.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9533-9537
    • Young, S.D.1    Marshall, R.S.2    Hill, R.P.3
  • 61
    • 0032565578 scopus 로고    scopus 로고
    • Mutagenesis induced by the tumor microenvironment
    • Yuan, J., and P. M. Glazer. 1998. Mutagenesis induced by the tumor microenvironment. Mutat. Res. 400:439-446.
    • (1998) Mutat. Res. , vol.400 , pp. 439-446
    • Yuan, J.1    Glazer, P.M.2
  • 62
    • 0034662615 scopus 로고    scopus 로고
    • Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH
    • Yuan, J., L. Narayanan, S. Rockwell, and P. M. Glazer. 2000. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res. 60:4372-4376.
    • (2000) Cancer Res. , vol.60 , pp. 4372-4376
    • Yuan, J.1    Narayanan, L.2    Rockwell, S.3    Glazer, P.M.4
  • 63
    • 0035918327 scopus 로고    scopus 로고
    • Signal transduction. How do cells sense oxygen?
    • Zhu, H., and H. F. Bunn. 2001. Signal transduction. How do cells sense oxygen? Science 292:449-451.
    • (2001) Science , vol.292 , pp. 449-451
    • Zhu, H.1    Bunn, H.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.