Microenvironmental influences on mutagenesis in mammary epithelial cells

International Journal of Cancer

Volumn 116, Issue 5, 2005, Pages 679-685

  Papp Szabó, Erzsébet ^a   Josephy, P David ^a   Coomber, Brenda L ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

cII assay; Mammary epithelial cells; Microenvironment; Mutagenesis; Tumor

Indexed keywords

GENOMIC DNA; GLUCOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER CELL CULTURE; CANCER GROWTH; CELL ASSAY; CELL HYPOXIA; CELL SURVIVAL; CELL TYPE; CLONOGENIC ASSAY; CONTROLLED STUDY; CULTURE MEDIUM; DEPLETION; GENE CONSTRUCT; GENE LOCUS; GENE SEQUENCE; IN VITRO STUDY; MICROENVIRONMENT; MOUSE; MOUSE STRAIN; MUTAGENICITY; MUTATION RATE; MUTATIONAL ANALYSIS; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SEQUENCE ANALYSIS; TRANSGENE; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

ANIMALS; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; DNA REPAIR; EPITHELIAL CELLS; FEMALE; HYDROGEN-ION CONCENTRATION; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MUTAGENESIS; TRANSCRIPTION FACTORS; VIRAL PROTEINS;

EID: 23244464226     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.21088     Document Type: Article

References (59)

1. Loeb LA. Cancer cells exhibit a mutator phenotype. Adv Cancer Res 1998;72:25-56.
2. Albertson DG, Collins C, McCormick F, Gray JW. Chromosome aberrations in solid tumors. Nat Genet 2003;34:369-76.
3. Cahill DP, Kinzler KW, Vogelstein B, Lengauer C. Genetic instability and Darwinian selection in tumours. Trends Cell Biol 1999;9: M57-60.
4. Heinen CD, Schmutte C, Fishel R. DNA repair and tumorigenesis: lessons from hereditary cancer syndromes. Cancer Biol Ther 2002;1:477-85.
5. Sarasin A. An overview of the mechanisms of mutagenesis and carcinogenesis. Mutat Res 2003;544:99-106.
6. Coomber BL, Yu JL, Fathers KE, Plumb C, Rak JW. Angiogenesis and the role of epigenetics in metastasis. Clin Exp Metastasis 2003;20:215-27.
7. Bernal JA, Luna R, Espina A, Lazaro I, Ramos-Morales F, Romero F, Arias C, Silva A, Tortolero M, Pintor-Toro JA. Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. Nat Genet 2002;32:306-11.
8. Zou H, McGarry TJ, Bernal T, Kirschner MW. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 1999;285:418-22.
9. Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, Kartalou M, Hussain SP, Roth RB, Zhou X, Mechanic LE, Zurer I, Rotter V, et al. The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J Clin Invest 2003;112:1887-94.
10. Kerbel RS. Growth dominance of the metastatic cancer cell: cellular and molecular aspects. Adv Cancer Res 1990;55:87-132.
11. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.
12. Boudreau N, Myers C. Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment. Breast Cancer Res 2003;5:140-6.
13. Yu JL, Rak JW. Host microenvironment in breast cancer development: inflammatory and immune cells in tumour angiogenesis and arteriogenesis. Breast Cancer Res 2003;5:83-8.
14. Reynolds TY, Rockwell S, Glazer PM. Genetic instability induced by the tumor microenvironment. Cancer Res 1996;56:5754-7.
15. van Kempen LC, Ruiter DJ, van Muijen GN, Coussens LM. The tumor microenvironment: a critical determinant of neoplastic evolution. Eur J Cell Biol 2003;82:539-48.
16. Jang A, Hill RP. An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells. Clin Exp Metastasis 1997;15:469-83.
17. Vaupel P, Hockel M. Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance. Int J Oncol 2000;17:869-79.
18. Subarsky P, Hill RP. The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 2003;20:237-50.
19. Henning T, Kraus M, Brischwein M, Otto AM, Wolf B. Relevance of tumor microenvironment for progression, therapy and drug development. Anticancer Drugs 2004;15:7-14.
20. Paquette B, Little JB. In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays. Cancer Res 1994;54:3173-8.
21. Yuan J, Narayanan L, Rockwell S, Glazer PM. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res 2000;60:4372-6.
22. Li CY, Little JB, Hu K, Zhang W, Zhang L, Dewhirst MW, Huang Q. Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. Cancer Res 2001;61:428-32.
23. Oliveira AM, Nascimento AG, Soft tissues. In: Alison MR, editor. The cancer handbook. London: Nature Publishing Group, 2004. 733-65.
24. Almholt K, Johnsen M. Stromal cell involvement in cancer. Recent Results Cancer Res 2003;162:31-42.
25. Mirsalis JC. Transgenic models for detection of mutations in tumors and normal tissues of rodents. Toxicol Lett 1995;82-83:131-4.
26. Baross-Francis A, Andrew SE, Penney JE, Jirik FR. Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability. Proc Natl Acad Sci USA 1998;95:8739-43.
27. Zhang S, Lloyd R, Bowden G, Glickman BW, de Boer JG. Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum. Mutat Res 2002;500:67-74.
28. Baross-Francis A, Milhausen MK, Andrew SE, Jevon G, Jirik FR. Tumors arising in DNA mismatch repair-deficient mice show a wide variation in mutation frequency as assessed by a transgenic reporter gene. Carcinogenesis 2000;21:1259-62.
29. McDiarmid HM, Douglas GR, Coomber BL, Josephy PD. Epithelial and fibroblast cell lines cultured from the transgenic BigBlue rat: an in vitro mutagenesis assay. Mutat Res 2001;497:39-47.
30. Vaupel P, Schlenger K, Knoop C, Hockel M. Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res 1991;51:3316-22.
31. Parker C, Milosevic M, Toi A, Sweet J, Panzarella T, Bristow R, Catton C, Catton P, Crook J, Gospodarowicz M, McLean M, Warde P, et al. Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 2004;58: 750-7.
32. Kallinowski F, Vaupel P, Runkel S, Berg G, Fortmeyer HP, Baessler KH, Wagner K, Mueller-Klieser W, Walenta S. Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats. Cancer Res 1988;48:7264-72.
33. Hlatky L, Sachs RK, Alpen EL. Joint oxygen-glucose deprivation as the cause of necrosis in a tumor analog. J Cell Physiol 1988;134:167-78.
34. Brown JM, Giaccia AJ. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 1998;58:1408-16.
35. Mihaylova VT, Bindra RS, Yuan J, Campisi D, Narayanan L, Jensen R, Giordano F, Johnson RS, Rockwell S, Glazer PM. Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mol Cell Biol 2003;23:3265-73.
36. Papp-Szabo E, Douglas GR, Coomber BL, Josephy PD. Mutagenicity of the oral carcinogen 4-nitroquinoline-1-oxide in cultured BigBlue rat tongue epithelial cells and fibroblasts. Mutat Res 2003;522: 107-17.
37. McDiarmid HM, Douglas GR, Coomber BL, Josephy PD. 2-Amino-1-methyl-6- phenylimidazo[4, 5-b]pyridine (PhIP)-induced mutagenesis in cultured BigBlue™ rat mammary epithelial and fibroblast cells. Environ Mol Mutagen 2002;39:245-53.
38. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992;68:869-77.
39. McDiarmid HM. An in vitro assay of chemical mutagenicity in rat mammary epithelial and fibroblast cells. PhD thesis. University of Guelph, Guelph, Ontario, Canada. 2003. 222p.
40. Rofstad EK, Halsor EF. Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8. Br J Cancer 2002;86:301-8.
41. Peretz S, Kim C, Rockwell S, Baserga R, Glazer PM. IGF1 receptor expression protects against microenvironmental stress found in the solid tumor. Radiat Res 2002;158:174-80.
42. Postovit LM, Adams MA, Lash GE, Heaton JP, Graham CH. Oxygen-mediated regulation of tumor cell invasiveness. Involvement of a nitric oxide signaling pathway. J Biol Chem 2002;277:35730-7.
43. Rofstad EK, Rasmussen H, Galappathi K, Mathiesen B, Nilsen K, Graff BA. Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor. Cancer Res 2002;62:1847-53.
44. Kondo A, Safaei R, Mishima M, Niedner H, Lin X, Howell SB. Hypoxia-induced enrichment and mutagenesis of cells that have lost DNA mismatch repair. Cancer Res 2001;61:7603-7.
45. Heddle JA, Martus HJ, Douglas GR. Treatment and sampling protocols for transgenic mutation assays. Environ Mol Mutagen 2003;41:1-6.
46. Stuart GR, Oda Y, de Boer JG, Glickman BW. Mutation frequency and specificity with age in liver, bladder and brain of lac1 transgenic mice. Genetics 2000;154:1291-300.
47. Wilkinson D, Sandhu JK, Breneman JW, Tucker JD, Birnboim HC. Hprt mutants in a transplantable murine tumour arise more frequently in vivo than in vitro. Br J Cancer 1995;72:1234-40.
48. Kobayashi H, Man S, MacDougall JR, Graham CH, Lu C, Kerbel RS. Variant sublines of early-stage human melanomas selected for tumorigenicity in nude mice express a multicytokine-resistant phenotype. Am J Pathol 1994;144:776-86.
49. Lev DC, Kiriakova G, Price JE. Selection of more aggressive variants of the gllOIA human breast cancer cell line: a model for analyzing the metastatic phenotype of breast cancer. Clin Exp Metastasis 2003;20:515-23.
50. Rumpler G, Becker B, Hafner C, McClelland M, Stolz W, Landthaler M, Schmitt R, Bosserhoff A, Vogt T. Identification of differentially expressed genes in models of melanoma progression by cDNA array analysis: SPARC, MIF and a novel cathepsin protease characterize aggressive phenotypes. Exp Dermatol 2003;12:761-71.
51. Korczak B, Robson IB, Lamarche C, Bernstein A, Kerbel RS. Genetic tagging of tumor cells with retrovirus vectors: clonal analysis of tumor growth and metastasis in vivo. Mol Cell Biol 1988;8: 3143-9.
52. Rosenberg MS, Subramanian S, Kumar S. Patterns of transitional mutation biases within and among mammalian genomes. Mol Biol Evol 2003;20:988-93.
53. Watson DE, Cunningham ML, Tindall KR. Spontaneous and ENU-induced mutation spectra at the ell locus in Big Blue™ Rat2 embryonic fibroblasts. Mutagenesis 1998;13:487-97.
54. Jorge SA, Menck CF, Sies H, Osborne MR, Phillips DH, Sarasin A, Stary A. Mutagenic fingerprint of ozone in human cells. DNA Repair (Amst) 2002;1:369-78.
55. Will O, Gocke E, Eckert I, Schulz I, Pflaum M, Mahler HC, Epe B. Oxidative DNA damage and mutations induced by a polar photosensitizer, Ro19-8022. Mutat Res 1999;435:89-101.
56. Jakubczak JL, Merlino G, French JE, Muller WJ, Paul B, Adhya S, Garges S. Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target. Proc Natl Acad Sci USA 1996;93:9073-8.
57. Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 2002;21:5400-13.
58. Chen T, Gamboa dC, Marques MM, Shelton SD, Beland FA, Manjanatha MG. Mutations induced by alpha-hydroxytamoxifen in the lad and ell genes of Big Blue transgenic rats. Carcinogenesis 2002;23: 1751-7.
59. Boyiri T, Guttenplan J, Khmelnitsky M, Kosinska W, Lin JM, Desai D, Amin S, Pittman B, El Bayoumy K. Mammary Carcinogenesis and molecular analysis of in vivo ell gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene. Carcinogenesis 2004;25:637-43.