Genetic instability: The dark side of the hypoxic response

Cell Cycle

Volumn 4, Issue 7, 2005, Pages 881-882

  To, Kenneth K W ^a   Koshiji, Minori ^b   Hammer, Stefanie ^c   Huang, L Eric ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

Cell proliferation; HIF 1 ; Hypoxia; Mismatch repair; Myc; Oxygen homeostasis; p21cip1

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; MYC PROTEIN; ONCOPROTEIN; TRANSCRIPTION FACTOR SP1;

CANCER SURVIVAL; CELL DEATH; DOWN REGULATION; GENE EXPRESSION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; HYPOXIA; MISMATCH REPAIR; PROTEIN PROTEIN INTERACTION; SHORT SURVEY; TUMOR GROWTH; UPREGULATION;

EID: 25444432052     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.7.1839     Document Type: Short Survey

References (23)

1. Bunn HF, Poyton RO. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 1996; 76:839-85.
2. Semenza GL. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 1999; 15:551-78.
3. Wenger RH. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. Faseb J 2002; 16:1151-62.
4. Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2:38-47.
5. Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3(10):721-32.
6. Giaccia A, Siim BG, Johnson RS. HIF-1 as a target for drug development. Nat Rev Drug Discov 2003; 2:803-11.
7. Huang LE, Bunn HF. Hypoxia-inducible factor and its biomedical relevance. J Biol Chem 2003; 278:19575-8.
8. Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: Role of the HIF system. Nat Med 2003; 9:677-84.
9. Poellinger L, Johnson RS. HIF-1 and hypoxic response: The plot thickens. Curr Opin Genet Dev 2004; 14:81-5.
10. Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995; 270:1230-7.
11. Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA, Bunn HF, Livingston DM. An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 1996; 93:12969-73.
12. Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev 1999; 13:64-75.
13. Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, Poellinger L. Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. Embo J 1998; 17:6573-86.
14. Wang GL, Semenza GL. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 1993; 268:21513-8.
15. Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. Embo J 2004; 23:1949-56.
16. Koshiji M, Huang LE. Dynamic balancing of the dual nature of HIF-1 alpha for cell survival. Cell Cycle 2004; 3:853-4.
17. Koshiji M, To KK, Hammer S, Kumamoto K, Harris AL, Modrich P, Huang LE. HIF-1 alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Mol Cell 2005; 17:793-803.
18. Modrich P, Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem 1996; 65:101-33.
19. Kolodner RD, Marsischky GT. Eukaryotic DNA mismatch repair. Curr Opin Genet Dev 1999; 9:89-96.
20. Buermeyer AB, Deschenes SM, Baker SM, Liskay RM. Mammalian DNA mismatch repair. Annu Rev Genet 1999; 33:533-64.
21. Menssen A, Hermeking H. Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes. Proc Natl Acad Sci USA 2002; 99:6274-9.
22. Sanchez-Puig N, Veprintsev DB, Fersht AR. Binding of natively unfolded HIF-1 alpha ODD domain to p53. Mol Cell 2005; 17:11-21.
23. Kolodner R. Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev 1996; 10:1433-42.