Hypoxia and defective apoptosis drive genomic instability and tumorigenesis

Genes and Development

Volumn 18, Issue 17, 2004, Pages 2095-2107

  Nelson, Deirdre A ^a,d   Tan, Ting Ting ^b,d   Rabson, Arnold B ^b,c,e,f   Anderson, Diana ^b,d   Degenhardt, Kurt ^c,d   White, Eileen ^a,b,c,d,f  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c Dept of Molec Biol and Biochem ^*  (United States)

^d RUTGERS UNIVERSITY   (United States)

^e ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^f RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Apoptosis; BCL 2; E1B 19K; Genomic instability; Hypoxia; Tumorigenesis

Indexed keywords

APOPTOSIS INDUCING FACTOR; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; PUMA PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL SURVIVAL; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; GENE INDUCTION; GENETIC STABILITY; GIANT CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; KIDNEY EPITHELIUM; MOUSE; NONHUMAN; NUDE MOUSE; PLOIDY; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; ANOXIA; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL LINE; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; GENES, BCL-2; GENOMIC INSTABILITY; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 4444287238     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1204904     Document Type: Article

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