Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1α gene

Cancer Chemotherapy and Pharmacology

Volumn 58, Issue 6, 2006, Pages 776-784

  Song, Xianrang ^a,b,d   Liu, Xianxi ^a   Chi, Weiling ^a,c   Liu, Yonglei ^b   Wei, Ling ^b   Wang, Xingwu ^b   Yu, Jinming ^b  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Tumour Hospital   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^d SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Drug resistance; Hypoxia inducible factor 1 alpha; Non small cell lung cancer; RNA interference

Indexed keywords

BLASTICIDIN S; CISPLATIN; DOXORUBICIN; GLYCOPROTEIN P; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LENTIVIRUS VECTOR; MESSENGER RNA;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RESISTANCE; CELL HYPOXIA; CHEMOSENSITIVITY; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; OXYGEN; P-GLYCOPROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER;

EID: 33748458071     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-006-0224-7     Document Type: Article

References (34)

1. Belani CP (2002) Chemotherapy regimens in advanced non-small-cell lung cancer: recent randomized trials. Clin Lung Cancer 3(Suppl 1):S5-S9
2. Arriagada R, Bergman B, Dunant A et al (2004) International adjuvant lung cancer trial collaborative group. N Engl J Med 350:351-360
3. Kunz M, Ibrahim SM (2003) Molecular responses to hypoxia in tumor cells. Mol Cancer 2(1):23
4. Harris AL (2002) Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2:38-47
5. Fedele AO, Whitelaw ML, Peet DJ (2002) Regulation of gene expression by the hypoxia-inducible factors. Mol Interv 2(4):229-243
6. Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. PNAS 92:5510-5514
7. Manfred Kunz, Saleh M Ibahim (2003) Molecular responses to hypoxia in tumor cells. Mol Cancer 2:23
8. Claudio J Conti (2002) Vascular endothelial growth factor: regulation I the mouse skin carcinogenesis model and use in antiangiogenesis cancer therapy. Oncologist 7(suppl 3):4-11
9. Semenza G (2000) HIF-1 and human disease: one highly involved factor. Genes Dev 14(16):1983-1991
10. Goda N, Ryan HE, Khadivi B et al (2003) Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol 23(1):359-369
11. Postovit LM, Adams MA, Lash GE et al (2002) Oxygen-mediated regulation of tumor cell invasiveness. Involvement of a nitric oxide signaling pathway. J Biol Chem 277:35730
12. Balaji K, Shannon B-D, Brain K et al (2003) Regulation of colon carcinoma cell invasion by hypoxia-inducible factor. Cancer Res 63:1138-1143
13. Frederiksen LJ, Siemens DR, Heaton JP et al (2003) Hypoxia induced resistance to doxorubicin in prostate cancer cells is inhibited by low concentrations of glyceryl trinitrate. J Urol 170(3):1003-1007
14. Teicher BA (1994) Hypoxia and drug resistance. Cancer Metastasis Rev 13:139
15. Wartenberg M, Ling FC, Muschen M et al (2003) Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J 17(3):503-505
16. Comerford KM, Wallace TJ, Karhausen J et al (2002) Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res 62(12):3387-3394
17. Kizaka-Kondoh S, Inoue M, Harada H, Hiraoka M (2003) Tumor hypoxia: a target for selective cancer therapy. Cancer Sci 94(12):1021-1028
18. Chen J, Zhao SJ, Nakada K et al (2003) Dominant-negative hypoxia-inducible factor-1α reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 162(4):1283-1291
19. Kung AL, Wang S, Klco JM et al (2000) Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med 6:1335-1340
20. Stoeltzing O, McCarty MF, Wey JS et al (2004) Role of hypoxia-inducible factor-1in gastric cancer cell growth, angiogenesis and vessel maturation. JNCI 96:946-956
21. Unruh A, Ressel A, Mohamed HG et al (2003) The hypoxia-inducible factor-1↑ is a negative factor for tumor therapy. Oncogene 22:3213-3220
22. Erler JT, Cawthorne CJ, Williams KJ et al (2004) Hypoxia-mediated down-regulation of Bid and Bax in tumours occurs via HIF-1-dependent and-independent mechanisms and contributes to drug resistance. Mol Cell Biol 24:2875-2889
23. Yeo EJ, Chun YS, Cho YS et al (2003) YC-1 a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 95:516-525
24. Michaela S, Michael AM, Matthial E (2003) Gene silencing mediated by small interfering RNAs in mammalian cells. Curr Med Chem 10:245-256
25. Tuschl T, Borkhardt A (2002) Small interfering RNAs. Mol Interv 2:158-167
26. Zhang M, Zhang Xin, Bai CX et al (2005) Silencing the epidermal growth factor receptor gene with RNAi may be developed as a potential therapy for non small cell lung cancer. Genet Vaccines Ther 3:5-16
27. Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW (2004) Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. Exp Mol Med 36(1):1-12
28. Bruick RK (2000) Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. PNAS 97(16):9082-9087
29. Mazure NM, Brahimi-Horn MC, Berta MA, Benizri E, Bilton RL, Dayan F, Ginouves A, Berra E, Pouyssegur J (2004) HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs. Biochem Pharmacol 68(6):971-980
30. Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1_, HIF-2-Expression in Lung Epithelial Cells (2004) J Biol Chem 279(15):14871-14878
31. Maxwell P, Wiesener M, Chang G-W et al (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275
32. Kamura T, Sato S, Iwai K et al (2000) Activation of HIF1 alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. PNAS 97(19):10430-10435
33. Ivan M, Kondo K, Yang H et al (2001) HIF alpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292(5516):464-468
34. Jaideep VT, Gerard P Zambetti, Kazuhiko Arimori, Erin G Schuetz, John D (1997) Schuetz: p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. PNAS 94:11037-11042