Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

Radiotherapy and Oncology

Volumn 75, Issue 1, 2005, Pages 89-98

  Williams, Kaye J ^a   Telfer, Brian A ^a   Xenaki, Dia ^a,b   Sheridan, Mary R ^a   Desbaillets, Isabelle ^c   Peters, Hans J W ^d   Honess, Davina ^e   Harris, Adrian L ^f   Dachs, Gabi U ^e,g   Van Der Kogel, Albert ^d   Stratford, Ian J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^e MOUNT VERNON HOSPITAL   (United Kingdom)

^f JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^g UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

HIF 1; Hypoxia; Radiotherapy; Tumour microenvironment

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; MISONIDAZOLE; OXYGEN; RADIOSENSITIZING AGENT;

ANIMAL CELL; ARTICLE; CANCER RADIOTHERAPY; CELL POPULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTRODE; GENE EXPRESSION; GROWTH RETARDATION; HEPATOMA CELL; HYPOXIC CELL; MOUSE; NONHUMAN; NUDE MOUSE; OXYGENATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE; XENOGRAFT;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL HYPOXIA; DNA-BINDING PROTEINS; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; MICE; MICE, NUDE; NUCLEAR PROTEINS; RADIATION TOLERANCE; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROLOGOUS; TREATMENT OUTCOME;

EID: 20944449117     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2005.01.009     Document Type: Article

References (41)

1. W.G. An, M. Kanekal, M.C. Simon, E. Maltepe, M.V. Blagosklonny, and L.M. Neckers Stabilization of wild-type p53 by hypoxia-inducible factor 1α Nature 392 1998 405 408
2. J. Bussink, J.H.A.M. Kaanders, P.F.J.W. Rijken, C.A. Martindale, and A.J. van der Kogel Multiparameter analysis of vasculature, perfusion and proliferation in human tumour xenografts Br J Cancer 77 1998 57 64
3. P. Carmeliet, Y. Dor, and J.-M. Herbert Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis Nature 394 1998 485 490
4. J. Chen, S. Zhao, and K. Nakada Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism Am J Pathol 4 2003 1283 1291
5. M. Garcia-Barros, F. Paris, and C. Cordon-Cardo Tumor response to radiotherapy regulated by endothelial cell apoptosis Science 5622 2003 1155 1159
6. 2-regulated prolyl hydroxylation Science 292 2001 468 472
7. R.A. Gatenby, H.B. Kessler, and J.S. Rosenblum Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy Int J Radiat Oncol Biol Phys 14 1988 831 838
8. J.R. Griffiths, P.M.H.J. Mcsheehy, and S.P. Robinson Metabolic changes detected by in vivo magnetic resonance studies of Hepa-1 wild-type tumours and tumours deficient in hypoxia-inducible-factor-1β (HIF-1β): evidence of an anabolic role for the HIF-1 pathway Cancer Res 62 2002 688 695
9. 2 predicts survival in advanced cancer of the uterine cervix Radiother Oncol 26 1993 45 50
10. R.J. Hodgkiss, G. Jones, and A. Long Flow cytometric evaluation of hypoxic cells in solid experimental tumours using fluorescence immunodetection Br J Cancer 63 1991 119 125
11. G. Hopfl, R.H. Wenger, and U. Ziegler Rescue of hypoxia-inducible factor-1α-deficient tumor growth by wild-type cells is independent of the vascular endothelial growth factor Cancer Res 62 2002 2962 2970
12. 2-dependent degradation domain via the ubiquitin-proteasome pathway Proc Natl Acad Sci USA 95 1998 7987 7992
13. 2 sensing Science 292 2001 464 468
14. B-H. Jiang, F. Agani, A. Passaniti, and G.L. Semenza V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumour progression Cancer Res 57 1997 5328 5335
15. 2-histography Int J Radiat Oncol Biol Phys 19 1990 953 961
16. P.J. Kallio, W.J. Wilson, S. O'Brien, Y. Makino, and L. Poellinger Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway J Biol Chem 274 1999 6519 6525
17. S.J. Kuerbitz, B.S. Plunkett, W.V. Walsh, and M.B. Kastan Wild-type p53 is a cell cycle checkpoint determinant following irradiation Proc Natl Acad Sci USA 89 1992 7491 7495
18. A.L. Kung, S. Wang, J.M. Klco, W.G. Kaelin Jr, and D.M. Livingston Suppression of tumor growth through disruption of hypoxia-inducible transcription Nat Med 12 2000 1335 1340
19. Y. Makino, R. Cao, and K. Svensson Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression Nature 414 2002 550 554
20. P.H. Maxwell, C.W. Pugh, and P.J. Ratcliffe Inducible expression of the erythropoietin 3′ enhancer in multiple cell lines: evidence for a widespread oxygen sensing mechanism Proc Natl Acad Sci USA 90 1993 2423 2427
21. P.H. Maxwell, G.U. Dachs, and J.M. Gleadle Hypoxia-inducible factor-1 modulates gene expression in solid tumours and influences both angiogenesis and tumour growth Proc Natl Acad Sci USA 94 1997 8104 8109
22. B.J. Moeller, Y. Cao, C.Y. Li, and M.W. Dewhirst Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules Cancer Cell 5 2004 405 406
23. M. Nordsmark, S.M. Bentzen, and J. Overgaard Measurement of human tumour oxygenation status by a polarographic needle electrode Acta Oncol 33 1994 383 389
24. P. Okunieff, M. Höckel, M.D. Dunphy, K. Schlenger, C. Knoop, and P. Vaupel Oxygen tension distributions are sufficient to explain the local response of human breast tumours treated with radiation alone Int J Radiat Oncol Biol Phys 26 1993 631 636
25. H.E. Ryan, J. Lo, and R.S. Johnson HIF-1α is required for solid tumour formation and embryonic vascularisation Eur Mol Biol Org J 17 1998 3005 3015
26. H.E. Ryan, M. Poloni, and W. Mcnulty Hypoxia-inducible factor-1α is a positive factor in tumour growth Cancer Res 60 2000 4010 4015
27. G.L. Semenza Targeting HIF-1 for cancer therapy Nat Rev Cancer 10 2003 721 732
28. P.W. Sheldon, and S.A. Hill Further investigations of the effects of the hypoxic cell radiosensitizer Ro 07-0582 on local control of a mouse tumour Br J Cancer 36 1977 198 205
29. I.J. Stratford, A.V. Patterson, G.U. Dachs, B. Telfer, and K.J. Williams P. Vaupel D.K. Kelleher Tumour hypoxia: pathophysiology, clinical significance and therapeutic perspectives 1999 Wissenschaftliche verlagsgesellschaft mbh Stuttgart 107 113
30. I.L. Stratford, G.E. Adams, J Godden, and N. Howells Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU1069 in vivo Int J Radiat Oncol Biol Phys 55 1989 411 422
31. B.A. Teicher Hypoxia and drug resistance Cancer Metas Rev 13 1994 139 168
32. A. Unruh, A. Ressel, and H.G. Mohamed The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy Oncogene 21 2003 3213 3220
33. 2 tension measurements Cancer Res 51 1991 3316 3322
34. G.L. Wang, and G.L. Semenza General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia Proc Natl Acad Sci USA 90 1993 4304 4308
35. 2 tension Proc Natl Acad Sci USA 92 1995 5510 5514
36. R.H. Wenger, and M. Gassmann Oxygen(es) and the hypoxia-inducible factor 1 Biol Chem 378 1997 609 616
37. 1/S cell cycle arrest in irradiated Li-Fraumeni lymphoblastoid cell lines Br J Cancer 74 1996 698 703
38. K.J. Williams, B.A. Telfer, and R. Airley A protective role for HIF-1 in response to redox manipulation and glucose deprivation: implications for tumourigenesis Oncogene 21 2002 282 290
39. S.M. Wood, J.M. Gleadle, C.W. Pugh, O. Hankinson, and P.J. Ratcliffe The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression J Biol Chem 271 1996 15117 15123
40. Y. Xiong, G.J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach p21 is a universal inhibitor of cyclin kinases Nature 366 1993 701 704
41. E.J. Yeo, Y.S. Chun, and Y.S. Cho YC-1: a potential anticancer drug targeting hypoxia inducible factor 1 J Natl Cancer Inst 7 2003 516 525