메뉴 건너뛰기




Volumn 1028, Issue , 2004, Pages 14-27

Common fragile sites and cancer: Targeted cloning by insertional mutagenesis

Author keywords

Breakage fusion bridge cycle; Cancer; Cloned fragile sites; Common fragile sites; FHIT; FRA3B; Gene amplification; Insertional mutagenesis; List of human fragile sites; Preferential integration; Recombination; Targeted cloning

Indexed keywords

CANCER; CARCINOGENESIS; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILE SITE; CONFERENCE PAPER; DNA SEQUENCE; GENE AMPLIFICATION; GENETIC HETEROGENEITY; GENETIC STABILITY; GENETIC VARIABILITY; HUMAN; MARKER GENE; MOLECULAR CLONING;

EID: 14944367013     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper
Times cited : (31)

References (80)
  • 1
    • 0013805802 scopus 로고
    • Persisting clone of cells with an abnormal chromosome in a woman previously irradiated
    • DEKABAN, A. 1965. Persisting clone of cells with an abnormal chromosome in a woman previously irradiated. J. Nucl. Med. 6: 740-746.
    • (1965) J. Nucl. Med. , vol.6 , pp. 740-746
    • Dekaban, A.1
  • 2
    • 0017381277 scopus 로고
    • Fragile sites on human chromosomes: Demonstration of their dependence on the type of tissue culture medium
    • SUTHERLAND, G.R. 1977. Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium. Science 197: 265-266.
    • (1977) Science , vol.197 , pp. 265-266
    • Sutherland, G.R.1
  • 3
    • 0024469656 scopus 로고
    • Spontaneous chromosome fragility in band 3q21, 11p11, or 11q13 of cultured bone marrow cells from two patients with hematologic disorders
    • ABE, S. et al. 1989. Spontaneous chromosome fragility in band 3q21, 11p11, or 11q13 of cultured bone marrow cells from two patients with hematologic disorders. Cancer Genet. Cytogenet. 40: 47-53.
    • (1989) Cancer Genet. Cytogenet. , vol.40 , pp. 47-53
    • Abe, S.1
  • 4
    • 0028934193 scopus 로고
    • New heritable fragile site with spontaneous expression at 1q41
    • DAR, H. et al. 1995. New heritable fragile site with spontaneous expression at 1q41. Am. J. Med. Genet. 55: 145-146.
    • (1995) Am. J. Med. Genet. , vol.55 , pp. 145-146
    • Dar, H.1
  • 5
    • 0022591794 scopus 로고
    • Spontaneous expression of fra(11)(q23) in a patient with Ewing's sarcoma and t(11;22)(q23;q11)
    • GOLLIN, S.M. et al. 1986. Spontaneous expression of fra(11)(q23) in a patient with Ewing's sarcoma and t(11;22)(q23;q11). Cancer Genet. Cytogenet. 20: 331-339.
    • (1986) Cancer Genet. Cytogenet. , vol.20 , pp. 331-339
    • Gollin, S.M.1
  • 6
    • 0025995253 scopus 로고
    • "Spontaneous" FRA16B is a hot spot for sister chromatid exchanges
    • LUKUSA, T. et al. 1991. "Spontaneous" FRA16B is a hot spot for sister chromatid exchanges. Hum. Genet. 87: 583-586.
    • (1991) Hum. Genet. , vol.87 , pp. 583-586
    • Lukusa, T.1
  • 7
    • 0037469080 scopus 로고    scopus 로고
    • Preferential integration of a transfected marker gene into spontaneously expressed fragile sites of a breast cancer cell line
    • MATZNER, I., L. SAVELYEVA & M. SCHWAB. 2003. Preferential integration of a transfected marker gene into spontaneously expressed fragile sites of a breast cancer cell line. Cancer Lett. 189: 207-219.
    • (2003) Cancer Lett. , vol.189 , pp. 207-219
    • Matzner, I.1    Savelyeva, L.2    Schwab, M.3
  • 8
    • 0025996714 scopus 로고
    • Spontaneous chromosome fragility in chorionic villus cells
    • MIGUEZ, L. et al. 1991. Spontaneous chromosome fragility in chorionic villus cells. Early Hum. Dev. 26: 93-99.
    • (1991) Early Hum. Dev. , vol.26 , pp. 93-99
    • Miguez, L.1
  • 9
    • 0020662470 scopus 로고
    • Spontaneous expression of the chromosome fragile site fra(10)(q25)
    • TAYLOR, A.M. & S. BUNDEY. 1983. Spontaneous expression of the chromosome fragile site fra(10)(q25). Am. J. Hum. Genet. 35: 123-125.
    • (1983) Am. J. Hum. Genet. , vol.35 , pp. 123-125
    • Taylor, A.M.1    Bundey, S.2
  • 10
    • 0023753486 scopus 로고
    • New common fragile sites
    • HECHT, F. et al. 1988. New common fragile sites. Cancer Genet. Cytogenet. 33: 1-9.
    • (1988) Cancer Genet. Cytogenet. , vol.33 , pp. 1-9
    • Hecht, F.1
  • 11
    • 0031005091 scopus 로고    scopus 로고
    • Aphidicolin-sensitive specific common fragile sites: A biomarker of exposure to pesticides
    • MUSIO, A. & I. SBRANA. 1997. Aphidicolin-sensitive specific common fragile sites: a biomarker of exposure to pesticides. Environ. Mol. Mutagen. 29: 250-255.
    • (1997) Environ. Mol. Mutagen. , vol.29 , pp. 250-255
    • Musio, A.1    Sbrana, I.2
  • 13
    • 0029878014 scopus 로고    scopus 로고
    • The enigma of common fragile sites
    • SIMONIC, I. & G.S. GERICKE. 1996. The enigma of common fragile sites. Hum. Genet. 97: 524-531.
    • (1996) Hum. Genet. , vol.97 , pp. 524-531
    • Simonic, I.1    Gericke, G.S.2
  • 14
    • 0035081264 scopus 로고    scopus 로고
    • Regional localization of 10 mariner transposon-like ESTs by means of FISH-evidence for a correlation with fragile sites
    • LIEHR, T. et al. 2001. Regional localization of 10 mariner transposon-like ESTs by means of FISH-evidence for a correlation with fragile sites. Mamm. Genome 12: 326-328.
    • (2001) Mamm. Genome , vol.12 , pp. 326-328
    • Liehr, T.1
  • 15
    • 0031899979 scopus 로고    scopus 로고
    • Common fragile sites on human chromosomes represent transcriptionally active regions: Evidence from camptothecin
    • SBRANA, I. et al. 1998. Common fragile sites on human chromosomes represent transcriptionally active regions: evidence from camptothecin. Hum. Genet. 102: 409-414.
    • (1998) Hum. Genet. , vol.102 , pp. 409-414
    • Sbrana, I.1
  • 16
    • 0024333576 scopus 로고
    • Fibroblast-specific common fragile sites induced by aphidicolin
    • MURANO, I., A. KUWANO & T. KAJII. 1989. Fibroblast-specific common fragile sites induced by aphidicolin. Hum. Genet. 83: 45-48.
    • (1989) Hum. Genet. , vol.83 , pp. 45-48
    • Murano, I.1    Kuwano, A.2    Kajii, T.3
  • 18
    • 0022371326 scopus 로고
    • Report of the Committee on Chromosome Rearrangements in Neoplasia and on Fragile Sites
    • BERGER, R., C.D. BLOOMFIELD & G.R. SUTHERLAND. 1985. Report of the Committee on Chromosome Rearrangements in Neoplasia and on Fragile Sites. Cytogenet. Cell Genet. 40: 490-535.
    • (1985) Cytogenet. Cell Genet. , vol.40 , pp. 490-535
    • Berger, R.1    Bloomfield, C.D.2    Sutherland, G.R.3
  • 19
    • 0032242325 scopus 로고    scopus 로고
    • Instability at chromosomal fragile sites
    • GLOVER, T.W. 1998. Instability at chromosomal fragile sites. Recent Results Cancer Res. 154: 185-199.
    • (1998) Recent Results Cancer Res. , vol.154 , pp. 185-199
    • Glover, T.W.1
  • 20
    • 0029061046 scopus 로고
    • The molecular basis of fragile sites in human chromosomes
    • SUTHERLAND, G.R. & R.I. RICHARDS. 1995. The molecular basis of fragile sites in human chromosomes. Curr. Opin. Genet. Dev. 5: 323-327.
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 323-327
    • Sutherland, G.R.1    Richards, R.I.2
  • 21
    • 0021278143 scopus 로고
    • DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes
    • GLOVER, T.W. et al. 1984. DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum. Genet. 67: 136-142.
    • (1984) Hum. Genet. , vol.67 , pp. 136-142
    • Glover, T.W.1
  • 22
    • 0028907045 scopus 로고
    • Effect of radiation and cigarette smoking on expression of FUdR- Inducible common fragile sites in human peripheral lymphocytes
    • BAN, S., J.B. COLOGNE & K. NERIISHI. 1995. Effect of radiation and cigarette smoking on expression of FUdR- inducible common fragile sites in human peripheral lymphocytes. Mutat... Res. 334: 197-203.
    • (1995) Mutat. Res. , vol.334 , pp. 197-203
    • Ban, S.1    Cologne, J.B.2    Neriishi, K.3
  • 23
    • 0032413191 scopus 로고    scopus 로고
    • The role of the FHIT/FRA3B locus in cancer
    • HUEBNER, K. et al. 1998. The role of the FHIT/FRA3B locus in cancer. Annu. Rev. Genet. 32: 7-31.
    • (1998) Annu. Rev. Genet. , vol.32 , pp. 7-31
    • Huebner, K.1
  • 24
    • 0035753424 scopus 로고    scopus 로고
    • FRA3B and other common fragile sites: The weakest links
    • HUEBNER, K. & C.M. CROCE. 2001. FRA3B and other common fragile sites: the weakest links. Nat. Rev. Cancer 1: 214-221.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 214-221
    • Huebner, K.1    Croce, C.M.2
  • 25
    • 0037473048 scopus 로고    scopus 로고
    • Characterization of the common fragile site FRA9E and its potential role in ovarian cancer
    • CALLAHAN, G. et al. 2003. Characterization of the common fragile site FRA9E and its potential role in ovarian cancer. Oncogene 22: 590-601.
    • (2003) Oncogene , vol.22 , pp. 590-601
    • Callahan, G.1
  • 26
    • 0141864371 scopus 로고    scopus 로고
    • Molecular basis for expression of common and rare fragile sites
    • ZLOTORYNSKI, E. et al. 2003. Molecular basis for expression of common and rare fragile sites. Mol. Cell Biol. 23: 7143-7151.
    • (2003) Mol. Cell Biol. , vol.23 , pp. 7143-7151
    • Zlotorynski, E.1
  • 27
    • 0023204641 scopus 로고
    • Fragile sites are targets of diverse mutagens and carcinogens
    • YUNIS, J.J., A.L. SORENG & A.E. BOWE. 1987. Fragile sites are targets of diverse mutagens and carcinogens. Oncogene 1: 59-69.
    • (1987) Oncogene , vol.1 , pp. 59-69
    • Yunis, J.J.1    Soreng, A.L.2    Bowe, A.E.3
  • 28
    • 0036159474 scopus 로고    scopus 로고
    • Fragile sites in human and Macaca fascicularis chromosomes are breakpoints in chromosome evolution
    • RUIZ-HERRERA, A. et al. 2002. Fragile sites in human and Macaca fascicularis chromosomes are breakpoints in chromosome evolution. Chromosome Res. 10: 33-44.
    • (2002) Chromosome Res. , vol.10 , pp. 33-44
    • Ruiz-Herrera, A.1
  • 29
    • 0023269925 scopus 로고
    • A comparative mapping study of fragile sites in the human and murine genomes
    • DJALALI, M. et al. 1987. A comparative mapping study of fragile sites in the human and murine genomes. Hum. Genet. 77: 157-162.
    • (1987) Hum. Genet. , vol.77 , pp. 157-162
    • Djalali, M.1
  • 30
    • 0036266065 scopus 로고    scopus 로고
    • The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1
    • KRUMMEL, K.A. et al. 2002. The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1. Genes Chromosomes Cancer 34: 154-167.
    • (2002) Genes Chromosomes Cancer , vol.34 , pp. 154-167
    • Krummel, K.A.1
  • 31
    • 0023090923 scopus 로고
    • Fragile sites, chromosome evolution, and human neoplasia
    • MIRO, R. et al. 1987. Fragile sites, chromosome evolution, and human neoplasia. Hum. Genet. 75: 345-349.
    • (1987) Hum. Genet. , vol.75 , pp. 345-349
    • Miro, R.1
  • 32
    • 0021690129 scopus 로고
    • Constitutive fragile sites and cancer
    • YUNIS, J.J. & A.L. SORENG. 1984. Constitutive fragile sites and cancer. Science 226: 1199-1204.
    • (1984) Science , vol.226 , pp. 1199-1204
    • Yunis, J.J.1    Soreng, A.L.2
  • 33
    • 0022373122 scopus 로고
    • Evolutionary conservation of fragile sites induced by 5-azacytidine and 5-azadeoxycytidine in man, gorilla, and chimpanzee
    • SCHMID, M. et al. 1985. Evolutionary conservation of fragile sites induced by 5-azacytidine and 5-azadeoxycytidine in man, gorilla, and chimpanzee. Hum Genet. 71: 342-350.
    • (1985) Hum Genet. , vol.71 , pp. 342-350
    • Schmid, M.1
  • 34
    • 0035826908 scopus 로고    scopus 로고
    • Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit
    • SHIRAISHI, T. et al. 2001. Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit. Proc. Natl. Acad. Sci. USA 98: 5722-5727.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5722-5727
    • Shiraishi, T.1
  • 35
    • 0022580241 scopus 로고
    • Fragile sites: Overview, occurrence in acute nonlymphocytic leukemia and effects of caffeine on expression
    • GLOVER, T.W., J. COYLE-MORRIS & R. MORGAN. 1986. Fragile sites: overview, occurrence in acute nonlymphocytic leukemia and effects of caffeine on expression. Cancer Genet. Cytogenet. 19: 141-150.
    • (1986) Cancer Genet. Cytogenet. , vol.19 , pp. 141-150
    • Glover, T.W.1    Coyle-Morris, J.2    Morgan, R.3
  • 36
    • 0031924605 scopus 로고    scopus 로고
    • Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: Implications for the mechanism of fragile site induction
    • LE BEAU, M.M. et al. 1998. Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction. Hum Mol Genet. 7: 755-761.
    • (1998) Hum Mol Genet. , vol.7 , pp. 755-761
    • Le Beau, M.M.1
  • 37
    • 0033051760 scopus 로고    scopus 로고
    • Allele-specific late replication and fragility of the most active common fragile site, FRA3B
    • WANG, L. et al. 1999. Allele-specific late replication and fragility of the most active common fragile site, FRA3B. Hum. Mol. Genet. 8: 431-437.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 431-437
    • Wang, L.1
  • 38
    • 0034117095 scopus 로고    scopus 로고
    • Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability
    • HELLMAN, A. et al. 2000. Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability. Mol. Cell Biol. 20: 4420-4427.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 4420-4427
    • Hellman, A.1
  • 39
    • 13144283613 scopus 로고    scopus 로고
    • Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site
    • MISHMAR, D. et al. 1998. Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site. Proc. Natl. Acad. Sci. USA 95: 8141-8146.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8141-8146
    • Mishmar, D.1
  • 40
    • 0033595004 scopus 로고    scopus 로고
    • Cancer-specific chromosome alterations in the constitutive fragile region FRA3B
    • MIMORI, K. et al. 1999. Cancer-specific chromosome alterations in the constitutive fragile region FRA3B. Proc. Natl. Acad. Sci. USA 96: 7456-7461.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7456-7461
    • Mimori, K.1
  • 41
    • 0037126393 scopus 로고    scopus 로고
    • Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors
    • MORELLI, C. et al. 2002. Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors. Oncogene 21: 7266-7276.
    • (2002) Oncogene , vol.21 , pp. 7266-7276
    • Morelli, C.1
  • 42
    • 17444440946 scopus 로고    scopus 로고
    • Common chromosomal fragile site FRA16D sequence: Identification of the for gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells
    • RIED, K. et al. 2000. Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells. Hum. Mol. Genet. 9: 1651-1663.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 1651-1663
    • Ried, K.1
  • 43
    • 0037074013 scopus 로고    scopus 로고
    • ATR regulates fragile site stability
    • CASPER, A.M. et al. 2002. ATR regulates fragile site stability. Cell 111: 779-789.
    • (2002) Cell , vol.111 , pp. 779-789
    • Casper, A.M.1
  • 44
    • 0034312277 scopus 로고    scopus 로고
    • Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
    • Guo, Z. et al. 2000. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev. 14: 2745-2756.
    • (2000) Genes Dev. , vol.14 , pp. 2745-2756
    • Guo, Z.1
  • 45
    • 0032472330 scopus 로고    scopus 로고
    • Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
    • CLIBY, W.A. et al. 1998. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17: 159-169.
    • (1998) EMBO J. , vol.17 , pp. 159-169
    • Cliby, W.A.1
  • 46
    • 0034649590 scopus 로고    scopus 로고
    • Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint
    • HEKMAT-NEJAD, M. et al. 2000. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Curr. Biol. 10: 1565-1573.
    • (2000) Curr. Biol. , vol.10 , pp. 1565-1573
    • Hekmat-Nejad, M.1
  • 47
    • 0037452872 scopus 로고    scopus 로고
    • Fragile sites: Breaking up over a slowdown
    • CIMPRICH, K. A. 2003. Fragile sites: breaking up over a slowdown. Curr. Biol. 13: R231-233.
    • (2003) Curr. Biol. , vol.13
    • Cimprich, K.A.1
  • 48
    • 0023789150 scopus 로고
    • Chromosome breakage and recombination at fragile sites
    • GLOVER, T.W. & C.K. STEIN. 1988. Chromosome breakage and recombination at fragile sites. Am. J. Hum. Genet. 43: 265-273.
    • (1988) Am. J. Hum. Genet. , vol.43 , pp. 265-273
    • Glover, T.W.1    Stein, C.K.2
  • 49
    • 0343035597 scopus 로고    scopus 로고
    • Comparative study of chromosome aberrations induced with aphidicolin in women affected by breast cancer and cervix uterine cancer
    • PAZ-Y-MINO, C. et al. 1997. Comparative study of chromosome aberrations induced with aphidicolin in women affected by breast cancer and cervix uterine cancer. Cancer Genet. Cytogenet. 94: 120-124.
    • (1997) Cancer Genet. Cytogenet. , vol.94 , pp. 120-124
    • Paz-Y-Mino, C.1
  • 50
    • 0037288332 scopus 로고    scopus 로고
    • Expression of aphidicolin-induced fragile sites and their relationship between genetic susceptibility in breast cancer, ovarian cancer, and non-small-cell lung cancer patients
    • DHILLON, V.S., S.A. HUSAIN & G.N. RAY. 2003. Expression of aphidicolin-induced fragile sites and their relationship between genetic susceptibility in breast cancer, ovarian cancer, and non-small-cell lung cancer patients. Terat. Carcin. Mutagen. Suppl 1: 35-45.
    • (2003) Terat. Carcin. Mutagen. , Issue.SUPPL. 1 , pp. 35-45
    • Dhillon, V.S.1    Husain, S.A.2    Ray, G.N.3
  • 51
    • 0033836494 scopus 로고    scopus 로고
    • The relationship between genetic susceptibility to head and neck cancer with the expression of common fragile sites
    • EGELI, U. et al. 2000. The relationship between genetic susceptibility to head and neck cancer with the expression of common fragile sites. Head Neck 22: 591-598.
    • (2000) Head Neck , vol.22 , pp. 591-598
    • Egeli, U.1
  • 52
    • 0028871656 scopus 로고
    • Expression of common fragile sites in lymphocytes of Wilms tumor in patients, their parents, and siblings
    • SUNDARESHAN, T.S. & M. AUGUSTUS. 1995. Expression of common fragile sites in lymphocytes of Wilms tumor in patients, their parents, and siblings. Cancer Genet. Cytogenet. 84: 51-55.
    • (1995) Cancer Genet. Cytogenet. , vol.84 , pp. 51-55
    • Sundareshan, T.S.1    Augustus, M.2
  • 53
    • 0024268761 scopus 로고
    • Common fragile sites and human cancer: A study on lymphocytes from neuroblastoma patients
    • VERNOLE, P. et al. 1988. Common fragile sites and human cancer: a study on lymphocytes from neuroblastoma patients. Cancer Genet. Cytogenet. 36: 13-23.
    • (1988) Cancer Genet. Cytogenet. , vol.36 , pp. 13-23
    • Vernole, P.1
  • 55
    • 0035954234 scopus 로고    scopus 로고
    • Amplification of oncogenes revisited: From expression profiling to clinical application
    • SAVELYEVA, L. & M. SCHWAB. 2001. Amplification of oncogenes revisited: from expression profiling to clinical application. Cancer Lett. 167: 115-123.
    • (2001) Cancer Lett. , vol.167 , pp. 115-123
    • Savelyeva, L.1    Schwab, M.2
  • 56
    • 0026645532 scopus 로고
    • Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification
    • TOLEDO, F. et al. 1992. Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification. EMBO J. 11: 2665-2673.
    • (1992) EMBO J. , vol.11 , pp. 2665-2673
    • Toledo, F.1
  • 57
    • 0030904279 scopus 로고    scopus 로고
    • Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons
    • COQUELLE, A. et al. 1997. Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons. Cell 89: 215-225.
    • (1997) Cell , vol.89 , pp. 215-225
    • Coquelle, A.1
  • 58
    • 0027982007 scopus 로고
    • Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells
    • KUO, M.T. et al. 1994. Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells. Mol Cell Biol. 14: 5202-11.
    • (1994) Mol Cell Biol. , vol.14 , pp. 5202-5211
    • Kuo, M.T.1
  • 59
    • 12944329959 scopus 로고    scopus 로고
    • Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
    • GISSELSSON, D. et al. 2000. Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity. Proc. Natl. Acad. Sci. USA 97: 5357-5362.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5357-5362
    • Gisselsson, D.1
  • 60
    • 0036463767 scopus 로고    scopus 로고
    • A role for common fragile site induction in amplification of human oncogenes
    • HELLMAN, A. et al. 2002. A role for common fragile site induction in amplification of human oncogenes. Cancer Cell. 1: 89-97.
    • (2002) Cancer Cell , vol.1 , pp. 89-97
    • Hellman, A.1
  • 61
    • 0036849512 scopus 로고    scopus 로고
    • Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: The model of PIP gene duplication from a break at FRA7I
    • CIULLO, M. et al. 2002. Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: the model of PIP gene duplication from a break at FRA7I. Hum. Mol. Genet. 11: 2887-2894.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2887-2894
    • Ciullo, M.1
  • 62
    • 0023805880 scopus 로고
    • Regional chromosome localization of human papillomavirus integration sites near fragile sites, oncogenes, and cancer chromosome breakpoints
    • CANNIZZARO, L.A. et al. 1988. Regional chromosome localization of human papillomavirus integration sites near fragile sites, oncogenes, and cancer chromosome breakpoints. Cancer Genet. Cytogenet. 33: 93-98.
    • (1988) Cancer Genet. Cytogenet. , vol.33 , pp. 93-98
    • Cannizzaro, L.A.1
  • 63
    • 0024453311 scopus 로고
    • Preferential sites for viral integration on mammalian genome
    • POPESCU, N.C. & J.A. DIPAOLO. 1989. Preferential sites for viral integration on mammalian genome. Cancer Genet. Cytogenet. 42: 157-171.
    • (1989) Cancer Genet. Cytogenet. , vol.42 , pp. 157-171
    • Popescu, N.C.1    Dipaolo, J.A.2
  • 64
    • 0025265727 scopus 로고
    • Viral integration, fragile sites, and proto-oncogenes in human neoplasia
    • POPESCU, N.C., D. ZIMONJIC & J.A. DIPAOLO. 1990. Viral integration, fragile sites, and proto-oncogenes in human neoplasia. Hum. Genet. 84: 383-386.
    • (1990) Hum. Genet. , vol.84 , pp. 383-386
    • Popescu, N.C.1    Zimonjic, D.2    Dipaolo, J.A.3
  • 65
    • 0037468256 scopus 로고    scopus 로고
    • Common fragile sites are preferential targets for HPV16 integrations in cervical tumors
    • THORLAND, E.C. et al. 2003. Common fragile sites are preferential targets for HPV16 integrations in cervical tumors. Oncogene 22: 1225-1237.
    • (2003) Oncogene , vol.22 , pp. 1225-1237
    • Thorland, E.C.1
  • 66
    • 0034326237 scopus 로고    scopus 로고
    • Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites
    • THORLAND, E.C. et al. 2000. Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites. Cancer Res. 60: 5916-5921.
    • (2000) Cancer Res. , vol.60 , pp. 5916-5921
    • Thorland, E.C.1
  • 67
    • 0242720711 scopus 로고    scopus 로고
    • Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma
    • FERBER, M.J. et al. 2003. Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma. Oncogene 22: 7233-42.
    • (2003) Oncogene , vol.22 , pp. 7233-7242
    • Ferber, M.J.1
  • 68
    • 0031916693 scopus 로고    scopus 로고
    • Sites of recombinant adeno-associated virus integration
    • RIVADENEIRA, E. D. et al. 1998. Sites of recombinant adeno-associated virus integration. Int. J. Oncol. 12: 805-810.
    • (1998) Int. J. Oncol. , vol.12 , pp. 805-810
    • Rivadeneira, E.D.1
  • 69
    • 0037294118 scopus 로고    scopus 로고
    • Characterization of the human common fragile site FRA2G
    • LIMONGI, M.Z., F. PELLICCIA & A. ROCCHI. 2003. Characterization of the human common fragile site FRA2G. Genomics 81: 93-97.
    • (2003) Genomics , vol.81 , pp. 93-97
    • Limongi, M.Z.1    Pelliccia, F.2    Rocchi, A.3
  • 70
    • 0030201095 scopus 로고    scopus 로고
    • Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2
    • RASSOOL, F.V. et al. 1996. Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2. Genomics 35: 109-117.
    • (1996) Genomics , vol.35 , pp. 109-117
    • Rassool, F.V.1
  • 71
    • 0026017993 scopus 로고
    • Preferential integration of marker DNA into the chromosomal fragile site at 3p14: An approach to cloning fragile sites
    • RASSOOL, F.V. et al. 1991. Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites. Proc. Natl. Acad. Sci. USA 88: 6657-6661.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6657-6661
    • Rassool, F.V.1
  • 72
    • 0028169985 scopus 로고
    • Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma
    • WILKE, C.M. et al. 1994. Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma. Genomics 22: 319-326.
    • (1994) Genomics , vol.22 , pp. 319-326
    • Wilke, C.M.1
  • 73
    • 0030890750 scopus 로고    scopus 로고
    • Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene
    • ZIMONJIC, D. B. et al. 1997. Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene. Cancer Res. 57: 1166-1170.
    • (1997) Cancer Res. , vol.57 , pp. 1166-1170
    • Zimonjic, D.B.1
  • 74
    • 0031447174 scopus 로고    scopus 로고
    • Sequence of the FRA3B common fragile region: Implications for the mechanism of FHIT deletion
    • INOUE, H. et al. 1997. Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion. Proc. Natl. Acad. Sci. USA 94: 14584-14589.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14584-14589
    • Inoue, H.1
  • 75
    • 0032493124 scopus 로고    scopus 로고
    • FRA7G extends over a broad region: Coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites
    • HUANG, H. et al. 1998. FRA7G extends over a broad region: coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites. Oncogene 16: 2311-2319.
    • (1998) Oncogene , vol.16 , pp. 2311-2319
    • Huang, H.1
  • 76
    • 0034704856 scopus 로고    scopus 로고
    • Definitive functional evidence for a tumor suppressor gene on human chromosome 7q31.1 neighboring the Fra7G site
    • ZENKLUSEN, J.C. et al. 2000. Definitive functional evidence for a tumor suppressor gene on human chromosome 7q31.1 neighboring the Fra7G site. Oncogene 19: 1729-1733.
    • (2000) Oncogene , vol.19 , pp. 1729-1733
    • Zenklusen, J.C.1
  • 77
    • 0034306548 scopus 로고    scopus 로고
    • The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations
    • KRUMMEL, K.A. et al. 2000. The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations. Genomics 69: 37-46.
    • (2000) Genomics , vol.69 , pp. 37-46
    • Krummel, K.A.1
  • 78
    • 0034654641 scopus 로고    scopus 로고
    • Chromosomal fragile site FRA16D and DNA instability in cancer
    • MANGELSDORF, M. et al. 2000. Chromosomal fragile site FRA16D and DNA instability in cancer. Cancer Res. 60: 1683-1689.
    • (2000) Cancer Res. , vol.60 , pp. 1683-1689
    • Mangelsdorf, M.1
  • 79
    • 0036131979 scopus 로고    scopus 로고
    • Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells
    • ARLT, M.F. et al. 2002. Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells. Genes Chromosomes Cancer 33: 82-92.
    • (2002) Genes Chromosomes Cancer , vol.33 , pp. 82-92
    • Arlt, M.F.1
  • 80
    • 0037293054 scopus 로고    scopus 로고
    • Candidate tumor suppressor genes at FRA7G are coamplified with MET and do not suppress malignancy in a gastric cancer
    • HAN, S.Y., T. DRUCK & K. HUEBNER. 2003. Candidate tumor suppressor genes at FRA7G are coamplified with MET and do not suppress malignancy in a gastric cancer. Genomics 81: 105-107.
    • (2003) Genomics , vol.81 , pp. 105-107
    • Han, S.Y.1    Druck, T.2    Huebner, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.