Genetic instability and the tumor microenvironment: Towards the concept of microenvironment-induced mutagenesis

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 569, Issue 1-2, 2005, Pages 75-85

  Bindra, Ranjit S ^a   Glazer, Peter M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA repair; Genetic instability; Hypoxia; Microenvironment

Indexed keywords

ATM PROTEIN; REACTIVE OXYGEN METABOLITE;

CELL CYCLE; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DNA SYNTHESIS; GENE AMPLIFICATION; GENE MUTATION; GENE TRANSLOCATION; GENETIC STABILITY; HUMAN; HYPOXIA; IONIZING RADIATION; MICROENVIRONMENT; MICROSATELLITE INSTABILITY; MITOSIS INHIBITION; MOLECULAR MECHANICS; MUTAGENESIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPORTER GENE; REVIEW; SIGNAL TRANSDUCTION; TUMOR; TUMOR GROWTH;

ANIMALS; CELL HYPOXIA; DNA DAMAGE; DNA REPAIR; GENOMIC INSTABILITY; MUTAGENESIS; NEOPLASMS; OXIDATIVE STRESS;

EID: 10444287596     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2004.03.013     Document Type: Review

References (79)

1. K.J. Williams, R.L. Cowen, and I.J. Stratford Hypoxia and oxidative stress tumour hypoxia - therapeutic considerations Breast Cancer Res. 3 5 2001 328 331
2. P. Vaupel, F. Kallinowski, and P. Okunieff Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review Cancer Res. 49 23 1989 6449 6465
3. R.K. Jain Determinants of tumor blood flow: a review Cancer Res. 48 10 1988 2641 2658
4. R.H. Thomlinson, and L.H. Gray The histological structure of some human lung cancers and the possible implications for radiotherapy Br. J. Cancer 9 4 1955 539 549
5. E. Holm Substrate balances across colonic carcinomas in humans Cancer Res. 55 6 1995 1373 1378
6. F. Kallinowski Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts Cancer Res. 49 14 1989 3759 3764
7. P. Subarsky, and R.P. Hill The hypoxic tumour microenvironment and metastatic progression Clin. Exp. Metastas. 20 3 2003 237 250
8. M. Nordsmark, M. Overgaard, and J. Overgaard Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck Radiother. Oncol. 41 1 1996 31 39
9. D.M. Brizel Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas Cancer Res. 56 23 1996 5347 5350
10. P.C. Nowell The clonal evolution of tumor cell populations Science 194 4260 1976 23 28
11. L.A. Loeb Mutator phenotype may be required for multistage carcinogenesis Cancer Res. 51 12 1991 3075 3079
12. T.Y. Reynolds, S. Rockwell, and P.M. Glazer Genetic instability induced by the tumor microenvironment Cancer Res. 56 24 1996 5754 5757
13. G. Slupphaug, B. Kavli, and H.E. Krokan The interacting pathways for prevention and repair of oxidative DNA damage Mutat. Res. 531 1-2 2003 231 251
14. R.D. Wood Human DNA repair genes Science 291 5507 2001 1284 1289
15. C.Y. Li Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures Cancer Res. 61 2 2001 428 432
16. B. Paquette, and J.B. Little In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays Cancer Res. 54 12 1994 3173 3178
17. D. Wilkinson Hprt mutants in a transplantable murine tumour arise more frequently in vivo than in vitro Br. J. Cancer 72 5 1995 1234 1240
18. N.R. Prabhakar Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms J. Appl. Physiol. 90 5 2001 1986 1994
19. C.R. Welbourn Pathophysiology of ischaemia reperfusion injury: central role of the neutrophil Br. J. Surg. 78 6 1991 651 655
20. T. Lindahl Instability and decay of the primary structure of DNA Nature 362 6422 1993 709 715
21. L. Wiesmuller, J.M. Ford, and R.H. Schiestl DNA damage repair diseases J. Biomed. Biotechnol. 2 2 2002 45
22. E.M. Hammond Hypoxia links ATR and p53 through replication arrest Mol. Cell. Biol. 22 6 2002 1834 1843
23. E.M. Hammond, M.J. Dorie, and A.J. Giaccia ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation J. Biol. Chem. 278 14 2003 12207 12213
24. C.A. Russo An anoxia inducible endonuclease and enhanced DNA breakage as contributors to genomic instability in cancer Cancer Res. 55 5 1995 1122 1128
25. A. Varshavsky On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages Proc. Natl. Acad. Sci. U.S.A. 78 6 1981 3673 3677
26. G.C. Rice, I.J. Spiro, and C.C. Ling Detection of S-phase overreplication following chronic hypoxia using a monoclonal anti-BrdUrd Int. J. Radiat. Oncol., Biol., Phys. 11 10 1985 1817 1822
27. G.C. Rice, C. Hoy, and R.T. Schimke Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells Proc. Natl. Acad. Sci. U.S.A. 83 16 1986 5978 5982
28. G.C. Rice, V. Ling, and R.T. Schimke Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance. Proc. Natl. Acad. Sci. U.S.A. 84 24 1987 9261 9264
29. S.D. Young, R.S. Marshall, and R.P. Hill Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells Proc. Natl. Acad. Sci. U.S.A. 85 24 1988 9533 9537
30. S.D. Young, and R.P. Hill Effects of reoxygenation on cells from hypoxic regions of solid tumors: anticancer drug sensitivity and metastatic potential J. Natl. Cancer Inst. 82 5 1990 371 380
31. C. Cuvier, A. Jang, and R.P. Hill Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion Clin. Exp. Metastas. 15 1 1997 19 25
32. N. Goda, S.J. Dozier, and R.S. Johnson HIF-1 in cell cycle regulation, apoptosis, and tumor progression Antioxid. Redox. Signal. 5 4 2003 467 473
33. V. Gekeler Selective and synchronous activation of early-S-phase replicons of Ehrlich ascites cells Mol. Cell. Biol. 13 8 1993 5020 5033
34. E.M. Hammond, S.L. Green, and A.J. Giaccia Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest Mutat. Res. 532 1-2 2003 205 213
35. J. Seim Hypoxia-induced irreversible S-phase arrest involves down-regulation of cyclin A Cell Prolif. 36 6 2003 321 332
36. T.G. Graeber Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status Mol. Cell. Biol. 14 9 1994 6264 6277
37. S.L. Green, R.A. Freiberg, and A.J. Giaccia p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest Mol. Cell. Biol. 21 4 2001 1196 1206
38. L.B. Gardner Hypoxia inhibits G1/S transition through regulation of p27 expression J. Biol. Chem. 276 11 2001 7919 7926
39. T. Helleday Pathways for mitotic homologous recombination in mammalian cells Mutat. Res. 532 1-2 2003 103 115
40. Q. Yu UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases Chk2 and Chk1 Cancer Res. 62 20 2002 5743 5748
41. O. Brison Gene amplification and tumor progression Biochim. Biophys. Acta 1155 1 1993 25 41
42. C.K. Luk Effect of transient hypoxia on sensitivity to doxorubicin in human and murine cell lines J. Natl. Cancer Inst. 82 8 1990 684 692
43. D.I. Smith, H. Huang, and L. Wang Common fragile sites and cancer (review) Int. J. Oncol. 12 1 1998 187 196
44. A. Hellman A role for common fragile site induction in amplification of human oncogenes Cancer Cell 1 1 2002 89 97
45. A. Coquelle Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons Cell 89 2 1997 215 225
46. A. Coquelle A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs Mol. Cell 2 2 1998 259 265
47. A. Coquelle Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements Oncogene 21 50 2002 7671 7679
48. S. Rockwell Oxygen delivery: implications for the biology and therapy of solid tumors Oncol. Res. 9 6-7 1997 383 390
49. K.A. Eckert, and T.A. Kunkel Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pH Nucl. Acids Res. 21 22 1993 5212 5220
50. K.A. Eckert, and T.A. Kunkel Effect of reaction pH on the fidelity and processivity of exonuclease-deficient Klenow polymerase J. Biol. Chem. 268 18 1993 13462 13471
51. O.K. Schlappack, A. Zimmermann, and R.P. Hill Glucose starvation and acidosis: effect on experimental metastatic potential DNA content and MTX resistance of murine tumour cells Br. J. Cancer 64 4 1991 663 670
52. N.C. Denko Investigating hypoxic tumor physiology through gene expression patterns Oncogene 22 37 2003 5907 5914
53. S. Pennacchietti Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene Cancer Cell 3 4 2003 347 361
54. E.I. Goncharova, A. Nadas, and T.G. Rossman Serum deprivation, but not inhibition of growth per se, induces a hypermutable state in Chinese hamster G12 cells Cancer Res. 56 4 1996 752 756
55. R. Kolodner Biochemistry and genetics of eukaryotic mismatch repair Genes Dev. 10 12 1996 1433 1442
56. P. Modrich, and R. Lahue Mismatch repair in replication fidelity, genetic recombination, and cancer biology Annu. Rev. Biochem. 65 1996 101 133
57. I. Mellon Transcription-coupled repair deficiency and mutations in human mismatch repair genes Science 272 5261 1996 557 560
58. L. Worth Jr. Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs Proc. Natl. Acad. Sci. U.S.A. 91 8 1994 3238 3241
59. M.T. Hawn Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint Cancer Res. 55 17 1995 3721 3725
60. T. Yan Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation Cancer Res. 61 22 2001 8290 8297
61. M. Esteller A gene hypermethylation profile of human cancer Cancer Res. 61 8 2001 3225 3229
62. M.F. Kane Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines Cancer Res. 57 5 1997 808 811
63. J. Koike Undetectable expression of hMLH1 protein in sporadic colorectal cancer with replication error phenotype Dis. Colon. Rectum. 40 Suppl. 10 1997 S23 S28
64. M. Arita Multiple sites required for expression in 5′-flanking region of the hMLH1 gene Gene 306 2003 57 65
65. D.K. Chang Steady-state regulation of the human DNA mismatch repair system J. Biol. Chem. 275 24 2000 18424 18431
66. V.T. Mihaylova Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells Mol. Cell. Biol. 23 9 2003 3265 3273
67. B. Quaresima Transcriptional regulation of the mismatch repair gene hMLH1 Gene 275 2 2001 261 265
68. J. Yuan Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH Cancer Res. 60 16 2000 4372 4376
69. C.L. Chang Oxidative stress inactivates the human DNA mismatch repair system Am. J. Physiol. Cell Physiol. 283 1 2002 C148 154
70. R.A. Hardman, C.A. Afshari, and J.C. Barrett Involvement of mammalian MLH1 in the apoptotic response to peroxide-induced oxidative stress Cancer Res. 61 4 2001 1392 1397
71. L.A. Loeb, K.R. Loeb, and J.P. Anderson Multiple mutations and cancer Proc. Natl. Acad. Sci. U.S.A. 100 3 2003 776 781
72. H.H. Guo, and L.A. Loeb Tumbling down a different pathway to genetic instability J. Clin. Invest. 112 12 2003 1793 1795
73. M.V. Blagosklonny Antiangiogenic therapy and tumor progression Cancer Cell 5 1 2004 13 17
74. W.P. Chang, and J.B. Little Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype Mutat. Res. 270 2 1992 191 199
75. M.A. Kadhim Transmission of chromosomal instability after plutonium alpha-particle irradiation Nature 355 6362 1992 738 740
76. R.S. Harris Mismatch repair is diminished during stationary-phase mutation Mutat. Res. 437 1 1999 51 60
77. S.M. Rosenberg Adaptive mutation by deletions in small mononucleotide repeats Science 265 5170 1994 405 407
78. S.M. Rosenberg Evolving responsively: adaptive mutation Nat. Rev. Genet. 2 7 2001 504 515
79. J.E. Moulder, and S. Rockwell Tumor hypoxia: its impact on cancer therapy Cancer Metastas. Rev. 5 4 1987 313 341