HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia

EMBO Journal

Volumn 22, Issue 16, 2003, Pages 4082-4090

  Berra, Edurne ^a   Benizri, Emmanuel ^a   Ginouvès, Amandine ^a   Volmat, Véronique ^a   Roux, Danièle ^a   Pouysségur, Jacques ^a  

^a CENTRE ANTOINE LACASSAGNE   (France)

Author keywords

Angiogenesis; HIF prolyl hydroxylases; Hypoxia signalling; Oxygen sensor; Small interfering RNA

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE 1; PROLYL HYDROXYLASE 2; PROLYL HYDROXYLASE 3; RNA; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ANGIOGENESIS; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOXIA; IN VIVO STUDY; MAMMAL; NUCLEOTIDE SEQUENCE; OXYGEN SATURATION; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VERTEBRATE;

ANOXIA; BIOLOGICAL TRANSPORT; CELL HYPOXIA; CELL LINE; CELL NUCLEUS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE SILENCING; HELA CELLS; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMEDIATE-EARLY PROTEINS; ISOENZYMES; NUCLEAR PROTEINS; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; RECOMBINANT PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; UP-REGULATION;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; MAMMALIA; VERTEBRATA;

EID: 0041465022     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg392     Document Type: Article

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