Genetic instability induced by the tumor microenvironment

Cancer Research

Volumn 56, Issue 24, 1996, Pages 5754-5757

  Reynolds, Toni Y ^a   Rockwell, Sara ^a   Glazer, Peter M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CANCER; CANCER GROWTH; CELL PH; GENE MUTATION; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH;

ANIMALS; BACTERIOPHAGE LAMBDA; CELL DIVISION; CELL HYPOXIA; GENE DELETION; GENES, REPORTER; GENETIC VECTORS; MICE; MICE, NUDE; MUTAGENESIS; NEOPLASMS; POINT MUTATION; TUMOR CELLS, CULTURED;

EID: 0029753768     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Nowell, P C. The clonal evolution of tumor cell populations Science (Washington DC), 194: 23-28, 1976
2. Loeb, L. A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res , 51: 3075-3079, 1991.
3. Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L G., Lescoe, M. K., Karte, M., Earabino, C , Lipford, J., Lindblom, A , Tannergard, P., Bollag, R. J., Godwin, A. R., Ward, D C., Nordenskjold, M., Fishel, R., Kolodner, R , and Liskay, R. M Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposts colon cancer. Nature (Lond.). 368: 258-261, 1994.
4. Harris, C C , and Hollstein, M. Clinical implications of the p53 tumor-suppressor gene. N. Engl J. Med., 329: 1318-1327, 1993.
5. Havre, P A , Yuan, J., Hedrick, L., Cho, K. R., and Glazer, P M. p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells Cancer Res., 55 4420-4424, 1995
6. Moulder, J. E., and Rockwell, S. Tumor hypoxia: its impact on cancer therapy Cancer Metastasis Rev., 5: 313-341, 1987.
7. Rockwell, S. Use of hypoxia-directed drugs in the therapy of solid tumors. Semin Oncol. 19: 29-40, 1992.
8. Rockwell, S., and Moulder, J. E. Hypoxic fractions of human tumors xenografted into mice a review. Int. J Radiat. Oncol. Biol. Phys , 19: 197-202, 1990.
9. Vaupel, P., Kallinowski, F., and Okunieff, P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors a review. Cancer Res., 49: 6449-6465, 1989.
10. Wike-Hooley, J. L., Haveman, J., and Reinhold, H S. The relevance of tumour pH to the treatment of malignant disease. Radiother. Oncol., 2: 343-366, 1984.
11. Glazer, P. M , Sarkar, S. N., and Summers, W. C. Detection and analysis of UV-induced mutations in mammalian cell DNA using a lambda phage shuttle vector. Proc. Natl. Acad. Sci. USA, 83: 1041-1044, 1986.
12. Gunther, E. J , Yeasky, T. M., Gasparro, F. P., and Glazer, P. M. Mutagenesis by 8-methoxypsoralen and 5-methylangelicin photoadducts in mouse fibroblasts mutations at cross-linkable sites induced by monoadducts as well as cross-links. Cancer Res , 55: 1283-1288, 1995.
13. Rockwell, S. In vivo-in vitro tumor systems: new models for studying the response of tumors to therapy Lab. Animal Sci , 27: 831-851, 1977.
14. Nordsmark, M., Bentzen, S. M., and Overgaard, J Measurement of human tumor oxygenation status by a polarographic needle electrode Acta Oncol, 33: 383-389, 1994.
15. Rockwell, S Effect of some proliferative and environmental factors on the toxicity of mitomycin C to tumor cells in vitro. Int J. Cancer, 38: 229-235, 1986.
16. Gunther, E J., Murray, N. E., and Glazer, P M. High efficiency, restriction-deficient in vitro packaging extracts for bactertophage lambda DNA using a new E. coli lysogen. Nucleic Acids Res, 21: 3903-3904, 1993.
17. Leach, E. G., Gunther, E. J., Yeasky, T. M , Gibson, L. H., Yang-Feng, T. L., and Glazer, P. M. Frequent spontaneous deletions at a shuttle vector locus in transgenic mice. Mutagenesis, 11: 49-56, 1996
18. Yuan, J., Yeasky, T. M , Rhee, M C., and Glazer, P. M. Frequent T. A→G:C transversions in X-irradiated mouse cells. Carcinogenesis, 16: 83-88, 1995.
19. Yuan, J , Yeasky, T M., Havre, P A , and Glazer, P. M. Induction of p53 in mouse cells decreases mutagenesis by UV radiation. Carcinogenesis, 16 2295-2300, 1995
20. Cheng, K. C , Cahill, D. S., Kasai, H , Nishimura, S , and Loeb, L A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G→T and A→C substitutions. J. Biol Chem , 267: 166-172, 1992.
21. 1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol., 14 6264-6277, 1994.
22. Graeber, T. G , Osmanian, C , Jacks, T , Housman, D E , Koch, C. J., Lowe, S W., and Giaccia, A. J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours Nature (Lond), 379: 88-91, 1996.
23. Wang, X. W., Yeh, H , Schaeffer, L. Roy, R , Moncollin, V., Egly, J., Wang, Z., Friedberg, E. C , Evans, M. K., Taffe, B. G , Bohr, V. A , Weeda, G., Hoeijmakers, J. H. J., Forrester, K , and Harris, C. C p53 modulation of TFIIH-associated nucleotide excision repair activity Nat. Genet., 10: 188-195, 1995.
24. Fan, S , Smith, M L , Rivet, D. J. n , Duba, D , Zhan, Q , Kohn, K. W., Fornace, A J., Jr., and O'Connor, P. M. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer Res , 55: 1649-1654, 1995.
25. Smith, M L., Chen, I. T., Zhan, Q , Bae, I , Chen, C. Y , Gilmer, T. M., Kastan, M. B., O'Connor, P M , and Fornace, A. J , Jr Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen Science (Washington DC), 266: 1376-1380, 1994
26. Smith, M L , Chen, I., Zhan, Q., O'Connor, P M , and Fornace, A J Involvement of p53 tumor suppressor in repair of u v.-type DNA damage. Oncogene, 10: 1053-1059, 1995.
27. Kuerbitz, S. J , Plunkett, B. S , Walsh, W. V , and Kastan, M. B Wild-type p53 is a cell cycle checkpoint determinant following irradiation Proc Natl Acad Sci USA, 89: 7491-7495, 1992