Sodium channel inactivation: Molecular determinants and modulation

Physiological Reviews

Volumn 85, Issue 4, 2005, Pages 1271-1301

  Ulbricht, Werner ^a,b  

^a UNIVERSITY OF KIEL   (Germany)

^b Kiel and Lungen Clinic Grosshansdorf   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACONITINE; BATRACHOTOXIN; BREVETOXIN; CIGUATOXIN; GLUTARALDEHYDE; GRAYANOTOXIN; OMEGA CONOTOXIN; SCORPION VENOM; SODIUM CHANNEL; SPIDER VENOM; TOSYLCHLORAMIDE SODIUM; VERATRIDINE; VOLTAGE GATED SODIUM CHANNEL;

BETA CHAIN; BINDING SITE; CENTRAL NERVOUS SYSTEM; CHANNEL GATING; CONFORMATIONAL TRANSITION; HEART MUSCLE; MEMBRANE DEPOLARIZATION; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NERVE EXCITABILITY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVIEW; SKELETAL MUSCLE; XENOPUS;

ANESTHETICS, LOCAL; ANIMALS; ELECTROPHYSIOLOGY; HUMANS; KINETICS; MEMBRANE POTENTIALS; MUSCLE, SKELETAL; POINT MUTATION; PROTEIN ISOFORMS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 25444498065     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.00024.2004     Document Type: Review

References (525)

1. Adelman WJ and Palti Y. The effects of external potassium and long duration voltage conditioning on the amplitude of sodium currents in the giant axon of the squid. J Gen Physiol 54: 589-606, 1969.
2. Afshari FS, Ptak K, Khaliq ZM, Grieco TM, Slater NT, McCrimmon DR, and Raman IM. Resurgent Na currents in four classes of neurons of the cerebellum. J Neurophysiol 92: 2831-2843, 2004.
3. Agnew WS, Cooper EC, Shenkel S, Correa AM, James WM, Ukomadu C, and Tomiko SA. Voltage-sensitive sodium channels: agents that perturb inactivation gating. Ann NY Acad Sci 625: 200-223, 1991.
4. Ahern CA and Horn R. Specificity of charge-carrying residues in the voltage sensor of potassium channels. J Gen Physiol 123: 205-216, 2004.
5. Aidley WJ and Stanfield PR. Ion Channels: Molecules in Action. Cambridge, UK: Cambridge Univ. Press, 1996.
6. Aldrich RW, Corey DP, and Stevens CF. A reinterpretation of mammalian sodium channel gating based on single channel recording. Nature 306: 436-441, 1983.
7. Aldrich RW and Stevens CF. Voltage-dependent gating of single sodium channels from mammalian neuroblastoma cells. J Neurosci 7: 418-431, 1987.
8. + channel disrupt fast and enhance slow inactivation. Neurosci Lett 306: 173-176, 2001.
9. Alekov AK, Rahman MM, Mitrovic N, Lehmann-Horn F, and Lerche H. A sodium channel mutation causing epilepsy in man exhibits subtle defects in fast inactivation and activation in vitro. J Physiol 529: 533-539, 2000.
10. Alekov AK, Rahman MM, Mitrovic N, Lehmann-Horn F, and Lerche H. Enhanced inactivation and acceleration of activation of the sodium channel associated with epilepsy in man. Eur J Neurosci 13: 2171-2176, 2001.
11. Almers W. Gating currents and charge movement in excitable membranes. Rev Physiol Biochem Pharmacol 82: 96-190, 1978.
12. Almers W, Stanfield PR, and Stuhmer W. Slow changes in currents through sodium channels in frog muscle membrane. J Physiol 339: 253-271, 1983.
13. + current in pyramidal neurons from rat and cat sensomotor cortex. J Neurosci 13: 660-673, 1993.
14. Århem P and Frankenhaeuser B. DDT and related substances: effects on permeability properties of myelinated Xenopus nerve fibre. Potential clamp analysis. Acta Physiol Scand 91: 502-511, 1974.
15. Armstrong CM. Sodium channels and gating currents. Physiol Rev 61: 644-683, 1981.
16. Armstrong CM and Bezanilla F. Charge movement associated with the opening and closing of the activation gate of the Na channel. J Gen Physiol 63: 533-552, 1974.
17. Armstrong CM and Bezanilla F. Inactivation of the sodium channel. II. Gating current experiments. J Gen Physiol 70: 567-590, 1977.
18. Armstrong CM, Bezanilla F, and Rojas E. Destruction of sodium conductance inactivation in squid axons perfused with pronase. J Gen Physiol 62: 375-391, 1973.
19. Attwell D, Cohen I, Eisner D, Ohba M, and Ojeda C. The steady state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres. Pflügers Arch 379: 137-142, 1979.
20. Baden DG. Brevetoxins: unique polyether dinoflagellate toxins. FASEB J 3: 1807-1817, 1989.
21. Bai CX, Glaaser IW, Sawanobori T, and Sunami A. Involvement of local anesthetic binding sites on IVS6 of sodium channels in fast and slow inactivation. Neurosci Lett 337: 41-45, 2003.
22. Balser JR, Nuss HB, Chiamvimonvat N, Pérez-García MT, Marban E, and Tomaselli GF. External pore residue mediates slow inactivation in μ1 rat skeletal muscle sodium channels. J Physiol 494: 431-442, 1996.
23. Balser JR, Nuss HB, Orias DW, Johns DC, Marban E, and Tomaselli GF. Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deflcient rat skeletal muscle Na channels. J Clin Invest 98: 2874-2886, 1996.
24. + channels but not in skeletal and cardiac muscles. J Biol Chem 279: 4680-4685, 2004.
25. Barchi RL. Ion channel mutations and diseases of skeletal muscle. Neurobiol Dis 4: 254-264, 1997.
26. + channel in muscle, with a selectivity for channels in the surface membrane. Pflügers Arch 400: 22-27, 1984.
27. Barnes S and Hille B. Veratridine modifies open sodium channels. J Gen Physiol 91: 421-443, 1988.
28. + channels to a site-directed antiserum against the cytosolic linker between domains III and IV and their sensitivity to other modifying agents. J Membr Biol 134: 213-239, 1993.
29. Bell DC, Yao H, Saenger RC, Riley JH, and Siegelbaum SA. Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels. J Gen Physiol 123: 5-20, 2004.
30. + channel by protein kinase C. Proc Natl Acad Sci USA 92: 12003-12007, 1995.
31. Bendahhou S, Cummins TR, Tawil R, Waxman SG, and Ptacek LJ. Activation and inactivation of the voltage-gated sodium channel: role of segment S5 revealed by a novel hyperkalaemic periodic paralysis mutation. J Neurosci 19: 4762-4771, 1999.
32. + channels. FEBS Lett 326: 21-24, 1993.
33. + channels. Modification of block by alterations in the α-subunit III-IV interdomain. Circ Res. 77: 584-592, 1995.
34. Bennett PB, Yazawa K, Makita N, and George AL. Molecular mechanism for an inherited cardiac arrhythmia. Nature 376: 683-685, 1995.
35. Benoit E, Corbier A, and Dubois JM. Evidence for two transient sodium currents in the frog node of Ranvier. J Physiol 361: 339-360, 1985.
36. Benoit E and Dubois JM. Properties of maintained sodium current induced by a toxin from Androctonus scorpion in frog node of Ranvier. J Physiol 383: 93-114, 1987.
37. Benoit E and Gordon D. The scorpion α-like toxin LqhIII specifically alters sodium channel inactivation in frog myelinated axons. Neuroscience 104: 551-559, 2001.
38. Benoit E, Legrand AM, and Dubois JM. Effects of ciguatoxin on current and voltage clamped frog myelinated nerve fibre. Toxicon 24: 357-364, 1986.
39. + inactivation. Eur Biophys J 25: 189-200, 1997.
40. + channels and their sensitivity to antiarrhythmics: is there a hidden drug receptor? J Membr Biol 139: 191-201, 1994.
41. Benzinger GR, Drum CL, Chen LQ, Kallen RG, and Hanck DA. Differences in the binding sites of two site-3 sodium channel toxins. Pflügers Arch 434: 742-749, 1997.
42. Benzinger GR, Tonkovich GS, and Hanck DA. Augmentation of recovery from inactivation by site-3 Na channel toxins. A single-channel and whole-cell study of persistent currents. J Gen Physiol 113: 333-346, 1999.
43. Bezanilla F. The voltage sensor in voltage-dependent ion channels. Physiol Rev 80: 555-592, 2000.
44. Bezanilla F. Voltage sensor movements. J Gen Physiol 120: 465-473, 2002.
45. Bezanilla F and Armstrong CM. Inactivation of the sodium channel. I. Sodium current experiments. J Gen Physiol 70: 549-566, 1977.
46. + channel mutation causing both long-QT and Brugada syndromes. Circ Res 85: 1206-1213, 1999.
47. Blumenthal KM and Seibert AL. Voltage-gated sodium channel toxins. Poisons, probes, and future promise. Cell Biochem Biophys 38: 215-238, 2003.
48. + channels in myocardiac mouse cells. Biophys J 68: 121-130, 1995.
49. + channels in three different gating modes. Biophys J 75: 1740-1748, 1998.
50. Bouhours M, Sternberg D, Davoine CS, Ferrer X, Willer JC, Fontaine B, and Tabti N. Functional characterization and cold sensitivity of T1313A, a new mutation of the skeletal muscle sodium channel causing paramyotonia congenita in humans. J Physiol 554: 635-647, 2003.
51. + currents by stereoisomers of piperidine local anesthetics. Anesth Analg 91: 1499-1505, 2000.
52. Brismar T. Slow mechanism for sodium permeability inactivation in myelinated nerve fibre of Xenopus laevis. J Physiol 270: 283-297, 1977.
53. Broomand A, Männikkö R, Larsson HP, and Elinder F. Molecular movements of the voltage sensor in a K channel. J Gen Physiol 122: 741-748, 2003.
54. Bruhn T, Schaller R, Schulze C, Sanchez-Rodriguez J, Dannmeier C, Ravens U, Heubach JF, Eckhardt K, Schmidtmayer J, Schmidt H, Aneiros A, Wachter E, and Béress L. Isolation and characterization of five neurotoxic and cardiotoxic polypeptides from the sea anemone Anthopleura elegantissima. Toxicon 39: 693-702, 2001.
55. Bulaj G, De la Cruz R, Azimi-Zonooz A, West P, Watkins M, Yoshikami D, and Olivera BM. δ-Conotoxin structure/function through cladistic analysis. Biochemistry 40: 13201-13208, 2001.
56. Butterworth JF and Strichartz GR. Molecular mechanisms of local anesthesia: a review. Anesthesiology 72: 711-734, 1990.
57. Cahalan MD. Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons. Biophys J 23: 285-311, 1978.
58. Campos FV, Coronas FIV, and Beirão PSL. Voltage-dependent displacement of the scorpion toxin Ts3 from sodium channels and its implication on the control of inactivation. Br J Pharmacol 142: 1115-1122, 2004.
59. Cannon SC. Sodium channel defects in myotonia and periodic paralysis. Annu Rev Neurosci 19: 141-164, 1996.
60. Cannon SC. Ion channel defects in the hereditary myotonias and periodic paralyses. In: Scientific American Molecular Neurology, edited by Martin JB. New York: Sci Am, 1998, p. 257-277.
61. Cannon SC. Spectrum of sodium channel disturbances in the nondystrophic myotonias and periodic paralyses. Kidney Int 57: 772-779, 2000.
62. + current conducted by the rat skeletal muscle alpha subunit by coexpression with a human brain β subunit. Pflügers Arch 423: 155-157, 1993.
63. Catterall WA. Binding of scorpion toxin to receptor sites associated with sodium channels in frog muscle. Correlation of voltage-dependent binding with activation. J Gen Physiol 74: 375-391, 1979.
64. Catterall WA. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu Rev Pharmacol Toxicol 20: 15-43, 1980.
65. Catterall WA. The molecular basis of neuronal excitability. Science 223: 653-661, 1984.
66. Catterall WA. Voltage-dependent gating of sodium channels: correlating structure and function. Trends Neurosci 9: 7-10, 1986.
67. Catterall WA. Cellular and molecular biology of voltage-gated sodium channels. Physiol Rev 72 Suppl: S15-S48, 1992.
68. Catterall WA. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26: 13-25, 2000.
69. Catterall WA. A 3D view of sodium channels. Nature 409: 988-991, 2001.
70. Catterall WA, Chandy KG, and Gutman GA (Editors). The IUPHAR Compendium of Voltage-Gated Ion Channels. Leeds, UK: IUPHAR Media, 2002.
71. + ionophore. Proc Natl Acad Sci USA 73: 2682-2686, 1976.
72. Cestèle S, Stankiewicz M, Mansuelle P, De Waard M, Dargent B, Gilles N, Pelhate M, Rochat H, Martin-Eauclaire MF, and Gordon D. Scorpion α-like toxins toxic to both mammals and insects differentially interact with receptor site 3 on voltage-gated sodium channels in mammals and insects. Eur J Neurosci 11: 975-985, 1999.
73. + channel fast inactivation. Neuron 22: 73-87, 1999.
74. Chahine M, Plante E, and Kallen RG. Sea anemone toxin (ATX II) modulation of heart and skeletal muscle sodium channel α-subunits expressed in tsA201 cells. J Membr Biol 152: 39-48, 1996.
75. Chandler WK and Meves H. Evidence for two types of sodium conductance in axons perfused with sodium fluoride. J Physiol 211: 653-678, 1970.
76. Chandler WK and Meves H. Slow changes in membrane permeability and long-lasting action potentials in axons perfused with fluoride solutions. J Physiol 211: 707-728, 1970.
77. + channels expressed in mammalian cells. Am JPhysiol Heart Circ Physiol 274: H1643-H1654, 1998.
78. + channel model versus the five-state Markovian model. Biopolymers 31: 1483-1502, 1991.
79. 1 subunit: a deletion analysis. Pflügers Arch 431: 186-195, 1995.
80. Chen H, Gordon D, and Heinemann SH. Modulation of cloned skeletal muscle sodium channels by scorpion toxins LqhII, LqhIII, and LqhaIT. Pflügers Arch 439: 423-432, 2000.
81. Chen H and Heinemann SH. Interaction of scorpion α-toxin with cardiac sodium channels: binding properties and enhancement of slow inactivation. J Gen Physiol 117: 505-518, 2001.
82. Chen LQ, Santarelli V, Horn R, and Kallen RG. A unique role for the S4 segment in domain 4 in the inactivation of sodium channels. J Gen Physiol 118: 549-556, 1996.
83. Chen YH, Dale TJ, Romanos MA, Whittaker WRJ, Xie XM, and Clare JJ. Cloning, distribution and functional analysis of the type III sodium channel from human brain. Eur J Neurosci 12: 4281-4289, 2000.
84. Chiu SY. Inactivation of sodium channels: second order kinetics in myelinated nerve. J Physiol 273: 573-596, 1977.
85. Chiu SY, Ritchie JM, Rogart RB, and Stagg D. A quantitative description of membrane currents in rabbit myelinated nerve. J Physiol 292: 149-166, 1979.
86. Clarkson CW. Stereoselective block of cardiac sodium channels by RAC109 in single guinea pig ventricular myocytes. Circ Res 65: 1306-1323, 1989.
87. Clarkson CW. Modification of Na channel inactivation by α-chymotrypsin in single cardiac myocytes. Pflügers Arch 417: 48-57, 1990.
88. Clay JR. On the persistent sodium current in squid giant axons. J Neurophysiol 89: 640-644, 2003.
89. + conductance inactivation following modification of fast inactivation gating in frog muscle fibres. Biomed Res 4: 363-373, 1983.
90. Conti F, Hille B, Neumcke B, Nonner W, and Stämpfli R. Conductance of the sodium channel in myelinated nerve fibres with modified sodium inactivation. J Physiol 262: 729-742, 1976.
91. + channel C terminus. Evidence for a role of helical structures in modulation of channel inactivation. J Biol Chem 277: 9233-9241, 2002.
92. Correa AM and Bezanilla F. Gating of the squid sodium channel at positive potentials. I. Macroscopic ionic and gating currents. Biophys J 66: 1853-1863, 1994.
93. Correa AM and Bezanilla F. Gating of the squid sodium channel at positive potentials. II. Single channels reveal two open states. Biophys J 66: 1864-1878, 1994.
94. Corzo G and Escoubas P. Pharmacologically active spider peptide toxins. Cell Mol Life Sci 60: 2409-2426, 2003.
95. Corzo G, Escoubas P, Stankiewicz M, Pelhate M, Kristensen CP, and Nakajima T. Isolation, synthesis and pharmacological characterization of δ-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae). Eur J Biochem 267: 5783-5795, 2000.
96. Courtney KR. Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA 968. J Pharmacol Exp Ther 195: 225-236, 1975.
97. Crill WE. Persistent sodium current in mammalian central neurons. Annu Rev Physiol 58: 349-362, 1996.
98. + channels in planar lipid bilayers. Pflügers Arch 419: 514-521, 1991.
99. Cukierman S. Regulation of voltage-dependent sodium channels. J Membr Biol 151: 203-214, 1996.
100. Cummins TR, Dib-Hajj SD, Black JA, Akopian AN, Wood JN, and Waxman SG. A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild type small primary sensory neurons. J Neurosci 19: 1-6, 1999.
101. Cummins TR and Sigworth FJ. Impaired slow inctivation in mutant sodium channels. Biophys J 71: 227-236, 1996.
102. Dechraoui MY, Naar J, Pauillac S, and Legrand AM. Ciguatoxins and brevetoxins, neurotoxic polyether compounds active on sodium channels. Toxicon 37: 125-143, 1999.
103. De Leon L and Ragsdale DS. State-dependent access to the batrachotoxin receptor on the sodium channel. Neuroreport 14: 1353-1356, 2003.
104. Del Negro CA, Koshiya N, Butera RJ, and Smith JC. Persistent sodium current, membrane properties and bursting behavior of pre-Bötzinger complex inspiratory neurons in vitro. J Neurophysiol 88: 2242-2250, 2002.
105. De Luca A, Natuzzi F, Desaphy JF, Loni G, Lentini G, Franchini C, Tortorella V, and Conte Camerino D. Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels. Mol Pharmacol 57: 268-277, 2002.
106. Denac H, Meuysssen M, and Scholtysik G. Structure, function and pharmacology of voltage-gated sodium channels. Naunyn-Schmiedbergs Arch Pharmacol 362: 453-479, 2000.
107. De Olivera Belebonl R, Pizzo R, Fontana ACK, De Carolino R OG, Coutinho-Netto J, and Dos Santos WF. Spider and wasp neurotoxins: pharmacological and biochemical aspects. Eur J Pharmacol 493: 1-17, 2004.
108. Deschênes I, Chen LQ, Kallen RC, and Chahine M. Electrophysiological study of chimeric sodium channels from heart and skeletal muscle. J Membr Biol 164: 25-34, 1998.
109. Deschênes I, Trottier E, and Chahine M. Implication of the C-terminal region of the α-subunit of voltage-gated sodium channels in fast inactivation. J Membr Biol 183: 103-114, 2001.
110. Dice MS, Abbruzzese JL, Wheeler JT, Groome JK, Fujimoto E, and Ruben PC. Temperature-sensitive defects in paramyotonia congenita mutants R1448C and T1313M. Muscle Nerve 30: 277-288, 2004.
111. Drews G. Effects of chloramine-T on charge movement and fraction of open channels in frog nodes of Ranvier. Pflügers Arch 409: 251-257, 1987.
112. Dubois JM and Bergman C. Asymmetrical currents and sodium currents in Ranvier nodes exposed to DDT. Nature 266: 741-742, 1977.
113. Dubois JM and Schneider MF. Kinetics of intramembrane charge movement and sodium current in frog node of Ranvier. J Gen Physiol 79: 571-602, 1982.
114. Dubois JM, Schneider MF, and Khodorov BI. Voltage dependence of intramembrane charge movement and conductance activation of batrachotoxin- modified sodium channels of frog node of Ranvier. J Gen Physiol 81: 829-844, 1983.
115. Duch DS, Hernandez A, Levinson SR, and Urban B. Grayanotoxin-I-modifled eel electroplax sodium channels. Correlation with batrachotoxin and veratridine modifications. J Gen Physiol 100: 623-645, 1992.
116. Eaholtz G, Colvin A, Leonard D, Taylor C, and Catterall WA. Block of brain sodium channels by peptide mimetics of the isoleucine, phenylalanine, and methionine (IFM) motif from the inactivation gate. J Gen Physiol 113: 279-203, 1999.
117. Eaholtz G, Scheuer T, and Catterall WA. Restoration of inactivation and block of open sodium channels by an inactivation gate peptide. Neuron 12: 1041-1048, 1994.
118. Eaholtz G, Zagotta WN, and Catterall WA. Kinetic analysis of block of open sodium channels by a peptide containing the isoleucine, phenylalanine, methionine (IFM) motif from the inactivation gate. J Gen Physiol 111: 75-82, 1998.
119. Elinder F and Århem P. Tail currents in the myelinated axon of Xenopus laevis suggest a two-open-state Na channel. Biophys J 73: 179-185, 1997.
120. + channel inactivation and bursting discharge in a simple model axon: implications for neuropathic pain. Brain Res 754: 221-226, 1997.
121. El-Sherif N, Fozzard HA, and Hanck DA. Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATX II. Circ Res 70: 285-301, 1992.
122. Fainzilber M, Kofman O, Zlotkin E, and Gordon D. A new neurotoxin receptor site on sodium channels is identified by a conotoxin that affects sodium channel inactivation in molluscs and acts as an antagonist in rat brain. J Biol Chem 269: 2574-2580, 1994.
123. Fainzilber M, Lodder JC, Kits KS, Kofman O, Vinnitsky I, Van Rietschoten J, Zlotkin E, and Gordon D. A new conotoxin affecting sodium current inactivation interacts with the δ-conotoxin receptor site. J Biol Chem 270: 1123-1129, 1995.
124. + channels expressed in a mammalian cell line. J Physiol 296: 275-286, 1996.
125. Favreau P, Le Gall F, Benoit E, and Molgó J. A review on conotoxins targeting ion channels and acetylcholine receptors in vertebrate neuromuscular junction. Acta Physiol Pharmacol Ther Latinoam 49: 257-267, 1999.
126. Featherstone DE, Fujimoto E, and Ruben PC. A defect in skeletal muscle sodium channel deactivation exacerbates hyperexcitability in human paramyotonia congenita. J Physiol 506: 627-638, 1998.
127. Featherstone DE, Richmond JE, and Ruben PC. Interaction between fast and slow inactivation in Skml sodium channels. Biophys J 71: 3098-3109, 1996.
128. Fletcher JI, Chapman BE, Mackay JP, Howden MEH, and King GF. The structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel. Structure 5: 1525-1535, 1997.
129. Fox JM. Ultra-slow inactivation of the ionic currents through the membrane of myelinated nerve. Biochim Biophys Acta 426: 232-244, 1976.
130. Fozzard HA and Hanck DA. Structure and function of voltage-dependent sodium channels: comparison of brain and cardiac isoforms. Physiol Rev 76: 887-926, 1996.
131. Frankenhaeuser B. Quantitative description of sodium current in myelinated nerve fibres of Xenopus laevis. J Physiol 151: 491-501, 1960.
132. Furue T, Yakehiro M, Yamaoka K, Sumii K, and Seyama I. Characteristics of two slow inactivation mechanisms and their influence on the sodium channel activity of frog ventricular myocytes. Pflügers Arch 436: 631-638, 1998.
133. + channel voltage-sensing domain. Neuron 40: 515-525, 2003.
134. Gandhi CS and Isacoff EY. Molecular models of voltage sensing. J Gen Physiol 120: 455-463, 2002.
135. + channels activated by veratridine and batrochotoxin. J Gen Physiol 89: 459-480, 1987.
136. Gawley RE, Rein KS, Jeglitsch G, Adams DJ, Theodorakis EA, Tiebes J, Nicolaou KC, and Baden DG. The relationship of brevetoxin "length" and A-ring functionality to binding and activity in neuronal sodium channels. Chem Biol 2: 533-541, 1995.
137. Gilles N, Blanchet C, Shichor I, Zaninetti M, Lotan I, Bertrand D, and Gordon D. A scorpion α-like toxin that is active on insects and mammals reveals an unexpected specificity and distribution of sodium channel subtypes in rat brain neurons. J Neurosci 19: 8730-8739, 1999.
138. Gilles N, Chen H, Wilson H, Le Gall F, Montoya G, Molgó J, Schönherr R, Nicholson G, Heinemann SH, and Gordon D. Scorpion α and α-like toxins differentially interact with sodium channels in mammalian CNS and periphery. Eur J Neurosci 12: 2823-2832, 2000.
139. Gilles N, Leipold E, Chen H, Heinemann SH, and Gordon D. Effect of depolarization on binding kinetics of scorpion α-toxin highlights conformational changes of rat brain sodium channels. Biochemistry 40: 14576-14584, 2001.
140. Gillespie JI and Meves H. The time course of sodium inactivation in squid giant axons. J Physiol 299: 289-307, 1980.
141. Ginsburg KS and Narahashi T. Differential sensitivity of tetrodotoxin-sensitive sodium channels to the insecticide allethrin in rat dorsal root ganglion neurons. Brain Res 627: 239-248, 1993.
142. Ginsburg KS and Narahashi T. Time course and temperature dependence of allethrin modulation of sodium channels in rat dorsal root ganglion cells. Brain Res 847: 38-49, 1999.
143. Goldin AL. Accessory subunits and sodium channel inactivation. Curr Opin Neurobiol 3: 272-277, 1993.
144. Goldin AL. Resurgence of sodium channel research. Annu Rev Physiol 63: 871-894, 2001.
145. + channels. J Exp Biol 205: 575-584, 2002.
146. Goldin AL. Mechanisms of sodium channel inactivation. Curr Opin Neurobiol 13: 284-290, 2003.
147. Goldin AL, Barchi RL, Caldwell JH, Hofmann F, Howe JR, Hunter JC, Kallen RG, Mandel G, Meisler MH, Berwald-Netter Y, Noda M, Tamkun MM, Waxman SG, Wood JN, and Catterall WA. Nomenclature of voltage-gated sodium channels. Neuron 28: 365-368, 2000.
148. Goldman L. Kinetics of channel gating in excitable membranes. Q Rev Biophys 9: 491-526, 1976.
149. Goldman L. Sodium channel opening as a precursor to inactivation. A route to the inactivated state. Eur Biophys J 16: 321-325, 1989.
150. Goldman L and Kenyon JL. Delays in inactivation development and activation kinetics in Myxicola giant axons. J Gen Physiol 80: 83-102, 1982.
151. Goldman L and Schauf CL. Inactivation of the sodium current in Myxicola giant axons. Evidence for coupling to the activation process. J Gen Physiol 59: 659-675, 1972.
152. Gonoi T, Ashida K, Feller D, Schmidt J, Fujiwara M, and Catterall WA. Mechanism of action of a polypeptide neurotoxin from the coral Goniopora on sodium channels in mouse neuroblastoma cells. Mol Pharmacol 29: 347-354, 1986.
153. Gonoi T and Hille B. Gating of Na channels. Inactivation modifiers discriminate among models. J Gen Physiol 89: 253-274, 1987.
154. Gonoi T, Ohizumi Y, Kobayashi J, Nakamura H, and Catterall WA. Actions of a polypeptide toxin from the marine snail Conus striatus on voltage-sensitive sodium channels. Mol Pharmacol 32: 691-698, 1987.
155. Gordon D. A new approach to insect-pest control: combination of neurotoxins with voltage sensitive sodium channels to increase selectivity and specificity. Invert Neurosci 3: 103-116, 1997.
156. Gordon D, Savarin P, Gurevitz M, and Zinn-Justin S. Functional anatomy of scorpion toxins affecting sodium channels. J Toxicol Toxin Rev 17: 131-159, 1998.
157. Goudet C, Ferrer T, Galán L, Artiles A, Batista CF, Possani LD, Alvarez J, Aneiros A, and Tytgat J. Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels. Br J Pharmacol 134: 1195-1206, 2001.
158. Grant AO. Models of drug interaction with the sodium channel. Clin Invest Med 14: 447-457, 1991.
159. Grant AO, Chandra R, Keller C, Carboni M, and Starmer CF. Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells. Biophys J 79: 3019-3035, 2000.
160. Grant AO, Wendt DJ, Zilberter Y, and Starmer CF. Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potential. J Membr Biol 136: 199-214, 1993.
161. Grishchenko II, Naumov AP, and Zubov AN. Gating and selectivity of aconitine-modified sodium channels in neuroblastoma cells. Neuroscience 9: 549-554, 1983.
162. Grishin E. Polypeptide neurotoxins from spider venoms. Eur J Biochem 264: 276-280, 1999.
163. + channels. J Exp Biol 204: 711-721, 2001.
164. Groome JR, Fujimoto E, George AL, and Ruben PC. Differential effects of homologous S4 mutations in human skeletal muscle sodium channels on deactivation gating from open and inactivated states. J Physiol 516: 687-698, 1999.
165. + channels regulate deactivation gating. J Physiol 548: 85-96, 2003.
166. Guy HR and Seetharamulu P. Molecular model of the action potential sodium channel. Proc Natl Acad Sci USA 83: 508-512, 1986.
167. Haeseler G, Leuwer M, Kavan J, Würz A, Dengler R, and Piepenbrock S. Voltage-dependent block of normal and mutant muscle sodium channels by 4-Chloro-m-Cresol. Br J Pharmacol 128: 1259-1267, 1999.
168. Haeseler G, Mamarvar M, Bufler J, Dengler R, Hecker H, Aronson JK, Piepenbrock S, and Leuwer M. Voltage-dependent blockade of normal and mutant sodium channels by benzylalcohol. Br J Pharmacol 130: 1321-1330, 2000.
169. Hahin R. Removal of inactivation causes time-invariant sodium current delays. J Gen Physiol 92: 331-350, 1988.
170. Hahin R, Wang GK, Shapiro BI, and Strichartz G. Alterations in sodium channel gating produced by the venom of the marine mollusc Conus striatus. Toxicon 29: 245-259, 1991.
171. + channel inactivation gating. Circ Res 75: 114-122, 1994.
172. Hasson A, Fainzilber M, Gordon D, Zlotkin E, and Spira ME. Alteration of sodium currents by new peptide toxins from the venom of a molluscivorous Conus snail. Eur J Neurosci 5: 56-64, 1993.
173. Hasson A, Shon KJ, Olivera BM, and Spira ME. Alterations of voltage-activated sodium current by a novel conotoxin from the venom of Conus gloriamaris. J Neurophysiol 73: 1295-1301, 1995.
174. Hayward LJ, Brown RH, and Cannon SC. Slow inactivation differs among mutant Na channels associated with myotonia and periodic paralysis. Biophys J 72: 1204-1219, 1997.
175. + current affects resting potential and response to depolarization in simulated spinal sensory neurons. J Neurophysiol 86: 1351-1364, 2001.
176. v16 and differentially modulates their functional properties. J Neurosci 23: 8261-8270, 2003.
177. Hilber K, Sandtner W, Kudlacek O, Glaaser IW, Kyle JW, French RJ, Fozzard HA, Dudley SC, and Todt H. The selectivity filter of the voltage-gated sodium channel is involved in channel activation. J Biol Chem 276: 27831-27839, 2001.
178. Hille B. Pharmacological modifications of the sodium channels of frog nerve. J Gen Physiol 51: 199-219, 1968.
179. Hille B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol 69: 497-515, 1977.
180. Hille B. Ionic channels in excitable membranes. Current problems and biophysical approaches. Biophys J 22: 283-294, 1978.
181. Hille B. Ion Channel's of Excitable Membranes (3rd ed.). Sunderland, MA: Sinauer, 2001.
182. Hille B, Courtney K, and Dum R. Rate and site of action of local anesthetics in myelinated nerve fibers. In: Molecular Mechanisms of Anesthesia. Progress in Anesthesiology, edited by B. R. Fink. New York: Raven, 1975, vol. 1, p. 13-20.
183. Hille B, Leibowitz MD, Sutro JB, Schwarz JR, and Holan G. State-dependent modification of sodium channels by lipid-soluble agonists. In: Proteins of Excitable Membranes, edited by B. Hille and D. M. Fambrough. New York: Wiley, 1987, p. 109-123.
184. Hodgkin AL and Huxley AF. The dual effect of membrane potential on sodium
185. Hodgkin AL and Huxley AF. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117: 500-544, 1952.
186. Hoey A, Amos GJ, and Ravens U. Comparison of the action potential prolonging and positive inotropic activity of DPI 201-106 and BDF 9148 in human ventricular myocardium. J Mol Cell Cardiol 26: 985-994, 1994.
187. Hoffman EP, Lehmann-Horn F, and Rüdel R. Overexcited or inactive: ion channels in muscle disease. Cell 80: 681-686, 1995.
188. Hondeghem LM and Katzung BG. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta 472: 373-398, 1977.
189. Horn R. Coupled movements in voltage-gated ion channels. J Gen Physiol 120: 449-453, 2002.
190. Horn R. How S4 segments move charge. Let me count the ways. J Gen Physiol 123: 1-4, 2004.
191. Horn R, Brodwick MS, and Eaton DC. Effect of protein cross-linking reagents on membrane currents of squid axon. Am J Physiol Cell Physiol 238: C127-C132, 1980.
192. Horn R, Ding S, and Gruber HJ. Immobilizing the moving parts of voltage-gated ion channels. J Gen Physiol 116: 461-475, 2000.
193. Horn R and Vandenberg CA. Statistical properties of single sodium channels. J Gen Physiol 84: 505-534, 1984.
194. Horn R, Vandenberg CA, and Lange K. Statistical analysis of single sodium channels. Effects of N-bromoacetamide. Biophys J 45: 323-335, 1984.
195. Hoshi T and Heinmann SH. Regulation of cell function by methionine oxidation and reduction. J Physiol 531: 1-11, 2001.
196. Howe JR and Ritchie JM. Multiple kinetic components of sodium channel inactivation in rabbit Schwann cells. J Physiol 455: 529-566, 1992.
197. Hoyt RC. Sodium inactivation in nerve fibers. Biophys J 8: 1074-1097, 1968.
198. Huang JMC, Tanguy J, and Yeh JZ. Removal of sodium inactivation and block of sodium channels by chloramine-T in crayfish and squid giant axons. Biophys J 52: 155-163, 1987.
199. Hudson AJ, Ebers GC, and Bulman DE. The skeletal muscle sodium and chloride channel diseases. Brain 118: 547-563, 1995.
200. Irvine LA, Jafri S, and Winslow RC. Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation. Biophys J 76: 1868-1885, 1999.
201. + channel isoforms. Jpn J Physiol 49: 457-461, 1999.
202. 1 subunit of the rat brain sodium channel. Science 256: 839-842, 1992.
203. 1 and type IIAα subunits of sodium channels in a mammalian cell line. J Biol Chem 270: 3306-3312, 1995.
204. Jeglitsch G, Rein K, Baden DG, and Adams DJ. Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons. J Pharmacol Exp Ther 284: 516-525, 1998.
205. + channel. Nature 423: 33-41, 2003.
206. + channel. Nature 423: 42-48, 2003.
207. Jonas P. Temperature dependence of gating current in myelinated nerve fibers. J Membr Biol 112: 277-289, 1989.
208. Jonas P, Vogel W, Arantes EC, and Giglio JK. Toxin γ of the scorpion Tityus serrulatus modifies both activation and inactivation of sodium permeability of nerve membrane. Pflügers Arch 407: 92-99, 1986.
209. Jurkat-Rott K, Lerche H, and Lehmann-Horn F. Skeletal muscle channelopathies. J Neurol 249: 1493-1502, 2002.
210. Jurkat-Rott K, Mitrovic N, Hang C, Kouzmekine A, Iaizzo P, Herzog J, Lerche H, Nicole S, Vale-Santos J, Chauveau D, Fontaine B, and Lehmann-Horn F. Voltage-sensor sodium channel mutations cause hypokalemic periodic paralysis type 2 by enhanced inactivation and reduced current. Proc Natl Acad Sci USA 97: 9549-9554, 2000.
211. Kambouris NG, Hastings LA, Stepanovic S, Marban E, Tomaselli GF, and Balser JR. Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat μ1 skeletal muscle sodium channel. J Physiol 512: 693-705, 1998.
212. Kambouris NG, Nuss HB, Johns DC, Tomaselli GF, Marban E, and Balser JR. Phenotypic characterization of a novel long-QT syndrome mutation (R1623) in the cardiac sodium channel. Circulation 97: 640-644, 1998.
213. Karlin A and Akabas MH. Substituted-cysteine accessibility method. In: Methods in Enzymology. Ion Channels, edited by P. M. Conn. San Diego, CA: Academic, 1998, vol. 293, pt. B, p. 123-145.
214. Kay AR, Sugimori M, and Llinás R. Kinetic and stochastic properties of a persistent sodium current in mature guinea pig cerebellar Purkinje cells. J Neurophysiol 80: 1167-1179, 1998.
215. Keating MT and Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell 104: 569-580, 2001.
216. + channel inactivation gate during inactivation. J Biol Chem 271: 30971-30979, 1996.
217. + channels. J Gen Physiol 109: 589-605, 1997.
218. Kem WR. Sea anemone toxins: structure and action. In: The Biology of Nematocysts, edited by D. A. Hessenger and H. N. Lehoff. San Diego, CA: Academic, 1988, p. 375-405.
219. Keynes RD. The kinetics of voltage-gated ion channels. Q Rev Biophys 27: 339-434, 1994.
220. Keynes RD and Elinder F. The screw-helical voltage gating of ion channels. Proc R Soc Lond B Biol Sci 266: 843-852, 1999.
221. Keynes RD and Rojas E. Kinetics and steady-state properties of the charged system controlling sodium conductance in the squid giant axon. J Physiol 239: 393-434, 1974.
222. Khodakhah K, Melishchu A, and Armstrong CM. Charge immobilization caused by modification of internal cysteines in squid Na channels. Biophys J 75: 2821-2829, 1998.
223. Khodorov BI. Sodium inactivation and drug-induced immobilization of the gating charge in nerve membrane. Prog Biophys Mol Biol 37: 49-89, 1981.
224. Khodorov BI. Batrachotoxin as a tool to study voltage-sensitive sodium channels of excitable membranes. Prog Biophys Mol Biol 45: 57-148, 1985.
225. Kimura T, Kinoshita E, Yamaoka K, Yuki T, Takehira M, and Seyama I. On site of action of grayanotoxin in domain 4 segment 6 of rat skeletal muscle sodium channel. FEBS Lett 465: 18-22, 2000.
226. Kinoshita E, Maejima H, Yamaoka K, Konno K, Kawai N, Shimuzu E, Yokote S, Nakayama H, and Seyama S. Novel wasp toxin discriminates between neuronal and cardiac sodium channels. Mol Pharmacol 59: 1457-1463, 2001.
227. Kirsch GE. Ion channel defects in cardiac arrhythmias. J Membr Biol 170: 181-190, 1999.
228. Kirsch GE, Skattebøl A, Possani LD, and Brown AM. Modification of Na channel gating by an α scorpion toxin from Tityus serrulatus. J Gen Physiol 93: 67-83, 1989.
229. Kleopa KA and Barchi RL. Genetic disorders of neuromuscular ion channels. Muscle Nerve 26: 299-325, 2002.
230. Kniffki KD, Siemen D, and Vogel W. Development of sodium permeability inactivation in nodal membranes. J Physiol 313: 37-48, 1981.
231. + channels. Eur Biophys J 15: 289-292, 1988.
232. + channels. J Membr Biol 112: 67-78, 1989.
233. + channels by DPI 201-106. J Membr Biol 89: 163-172, 1986.
234. + channels. Proc R Soc Lond B Biol Sci 232: 71-93, 1987.
235. + channels. Mol Pharmacol 64: 741-752, 2003.
236. Kontis KJ and Goldin AL. Sodium channel inactivation is altered by substitution of voltage sensor positive charges. J Gen Physiol 110: 403-413, 1997.
237. Kontis KJ, Rounaghi A, and Goldin AL. Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains. J Gen Physiol 110: 391-401, 1997.
238. Koppenhöfer E and Vogel W. Wirkung von Tetrodotoxin und Tetraäthylammoniumchlorid an der Innenseite der Schnürringsmembran von Xenopus laevis. Pflügers Arch 313: 361-380, 1969.
239. Kühn FJP and Greeff NG. Movement of voltage sensor S4 in domain 4 is tightly coupled to sodium channel fast inactivation and gating charge immobilization. J Gen Physiol 114: 167-183, 1999.
240. Kühn FJP and Greeff NC. Gating properties of a sodium channel with three arginines substituted by histidines in the central part of voltage sensor S4D4. J Membr Biol 193: 23-34, 2003.
241. + channels must deactivate to recover from inactivation. Neuron 12: 819-829, 1994.
242. + flow dependence. J Gen Physiol 124: 27-42, 2004.
243. Larsson HP. The search is on for the voltage sensor-to-gate coupling. J Gen Physiol 120: 475-481, 2002.
244. Lawrence JH, Orias DW, Balser JE, Nuss HB, Tomaselli GF, O'Rourke B, and Marban E. Single-channel analysis of inactivation-defective rat skeletal muscle sodium channels containing the F1304Q mutation. Biophys J 71: 1285-1294, 1996.
245. Lazdunski M, Balerna M, Chicheportiche R, Fosset M, Jacques Y, Lombet A, Romey G, Schweitz H, and Vincent JP. Marine neurotoxins to study the voltage-dependent sodium channel in excitable membranes. In: Neurotoxins: Fundamental and Clinical Advances, edited by I. W. Chubb and L. G. Geffen. Adelaide, Australia: Flinders Univ. of South Australia, 1979, p. 111-119.
246. + channels. Ann NY Acad Sci 479: 204-220, 1986.
247. Lee HC, Wang JM, and Swartz KJ. Interaction between extracellular hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels. Neuron 40: 527-536, 2003.
248. Lehmann-Horn F and Jurkat-Rott K. Voltage-gated ion channels and hereditary disease. Physiol Rev 79: 1217-1372, 1999.
249. Lehmann-Horn F and Jurkat-Rott K. Channelopathies: voltage-gated sodium channels. Pharmaceut News 8: 29-36, 2001.
250. Lehmann-Horn F and Rüdel R. Molecular pathophysiology of voltage-gated ion channels. Rev Physiol Biochem Pharmacol 128: 195-268, 1996.
251. Leibowitz MD, Schwarz JR, Holan G, and Hille B. Electrophysiological comparison of insecticide and alkaloid agonists of Na channel. J Gen Physiol 90: 75-93, 1987.
252. Leibowitz MD, Sutro SB, and Hille B. Voltage-dependent gating of veratridine-modified Na channels. J Gen Physiol 87: 25-46, 1986.
253. Leifert WK, McMurphie EJ, and Saint DA. Inhibition of cardiac sodium currents in adult rat myocytes by n-3 polyunsaturated fatty acids. J Physiol 520: 671-679, 1999.
254. Leipold E, Lu S, Gordon D, Hansel A, and Heinemann SH. Combinatorial interaction of scorpion toxins Lqh-2, Lqh-3, and LqαIT with sodium channel receptor sites-3. Mol Pharmacol 65: 685-691, 2004.
255. Lerche H, Jurkat-Rott K, and Lehmann-Horn F. Ion channels and epilepsy. Am J Med Genet 106: 146-159, 2001.
256. Li HL, Hadid D, and Ragsdale DS. The batrachotoxin receptor on the voltage-gated sodium channel is guarded by the channel activation gate. Mol Pharmacol 61: 905-912, 2002.
257. Linford NJ, Cantrell AC, Qu Y, Scheuer T, and Catterall WA. Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel. Proc Natl Acad Sci USA 95: 13947-13952, 1998.
258. Little MJ, Wilson H, Zappia C, Cestèle S, Tyler MI, Martin-Eauclaire MF, Gordon D, and Nicholson GM. δ-Atracotoxins from Australian funnel web spiders compete with scorpion α-toxins on both rat brain and insect sodium channels. FEBS Lett 439: 246-252, 1998.
259. Little MJ, Zappia C, Gilles N, Connor M, Tyler MI, Martin-Eauclaire MF, Gordon D, and Nicholson GM. δ-Atracotoxins from the Australian funnel-web spiders compete with scorpion α-toxin binding but differentially modulate alkaloid toxin activation of voltage-gated sodium channels. J Biol Chem 273: 27076-27083, 1998.
260. Lossin C, Rhodes TH, Desai RR, Vanoye CG, Wang D, Carniciu S, Devinsky O, and George AL. Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A. J Neurosci 23: 11289-11295, 2003.
261. Lossin C, Wang DW, Rhodes TH, Vanoye CG, and George AL. Molecular basis of an inherited epilepsy. Neuron 34: 877-884, 2002.
262. Lund AE and Narahashi T. Interaction of DDT with sodium channels in squid giant axon membrane. Neuroscience 6: 2253-2258, 1981.
263. Lund AE and Narahashi T. Kinetics of sodium channel modification by the insecticide tetramethrin in squid giant axons. J Pharmacol Exp Ther 219: 464-473, 1981.
264. Ma JY, Catterall WA, and Scheuer T. Perisistent sodium current through brain sodium channels by G protein βγ subunits. Neuron 19: 443-452, 1997.
265. MacKinnon R. Potassium channels. FEBS Lett 555: 62-65, 2003.
266. v1.4 sodium channels as revealed by improved estimation of toxin sensitivity. J Biol Chem 278: 9464-9471, 2003.
267. Magistretti J and Alonso A. Fine gating properties of channels responsible for persistent sodium current generation in entorhinal cortex neurons. J Gen Physiol 120: 855-973, 2002.
268. + channels. J Neurosci 16: 7117-7127, 1996.
269. Mandel G. Tissue-specific expression of the voltage-sensitive sodium channel. J Membr Biol 125: 193-205, 1992.
270. Mantegazza M, Yu FH, Catterall WA, and Scheuer T. Role of the C-terminal domain in inactivation of brain and cardiac sodium channels. Proc Natl Acad Sci USA 98: 15348-15353, 2001.
271. Marbán E. Cardiac channelopathies. Nature 415: 213-218, 2002.
272. Marban E, Yamagishi T, and Tomaselli GF. Structure and function of voltage-gated sodium channels. J Physiol 508: 647-657, 1998.
273. Matavel A, Cruz JS, Penaforte CL, Araújo DAM, Kalapothakis E, Prado VF, Diniz CR, Cordeiro MN, and Beirão PSL. Electrophysiological characterization and molecular identification of the Phoneutria nigriventer peptide toxin PnTx2-6. FEBS Lett 523: 219-223, 2002.
274. Mattei C, Molgó J, Legrand AM, and Benoit E. Ciguatoxines et brévétoxines: dissection de leur actions neurobiologiques. J Soc Biol 193: 329-344, 1999.
275. v1.4 differentially affect slow inactivation. FEBS Lett 552: 163-169, 2003.
276. + channel function in the extracellular domain of the β1 subunit. J Biol Chem 273: 3954-3962, 1998.
277. McCormick KA, Srinivasan J, White K, Scheuer T, and Catterall WA. The extracellular domain of the β1 subunit is both necessary and sufficient for β1-like modulation of sodium channel gating. J Biol Chem 274: 32638-32646, 1999.
278. McPhee JC, Ragsdale DS, Scheuer T, and Catterall WA. A mutation in segment IVS6 disrupts fast inactivation of sodium channels. Proc Natl Acad Sci USA 91: 12346-12350, 1994.
279. McPhee JC, Ragsdale DS, Scheuer T, and Catterall WA. A critical role for transmembrane segment IVS6 of the sodium channel a subunit in fast inactivation. J Biol Chem 270: 12025-12034, 1995.
280. McPhee JC, Ragsdale DS, Scheuer T, and Catterall WA. A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel α-subunit in fast inactivation. J Biol Chem 273: 1121-1129, 1998.
281. Meeder T and Ulbricht W. Action of benzocaine on sodium channels of frog node of Ranvier treated with chloramine-T. Pflügers Arch 409: 265-273, 1987.
282. Meves H. Inactivation of the sodium permeabiltity in squid giant nerve fibres. Prog Biophys Mol Biol 33: 207-230, 1978.
283. Meves H. Effect of scorpion toxin on sodium channels. In: Structure and Function in Excitable Cells, edited by D. C. Chang, I. Tasaki, W. J. Adelman, and H. R. Leuchtag. New York: Plenum, 1983, p. 273-280.
284. Meves H. The gating current of the node of Ranvier. In: Ion Channels, edited by T. Narahashi. New York: Plenum, 1990, vol. 2, p. 65-121.
285. Meves H, Rubly N, and Watt DD. Voltage-dependent effects of a scorpion toxin on sodium current inactivation. Pflügers Arch 402: 24-33, 1984.
286. Meves H and Vogel W. Inactivation of the asymmetrical displacement current in giant axons of Loligo forbesi. J Physiol 267: 377-393, 1977.
287. Meves H and Vogel W. Slow recovery of sodium current and gating current from inactivation. J Physiol 267: 395-410, 1977.
288. Mickus T, Jung HY, and Spruston N. Properties of slow, cumulative sodium channel inactivation in rat hippocampal CA1 pyramidal neurons. Biophys J 76: 846-860, 1999.
289. Miller JR, Patel MK, John JE, Mounsey JP, and Moorman JR. Contributions of charged residues in a cytoplasmic linking region to Na channel gating. Biophys Biochim Acta 1509: 275-291, 2000.
290. Millonas MM and Hanck DA. Nonequilbrium response spectroscopy of voltage-sensitive ion channel gating. Biophys J 74: 210-229, 1998.
291. Mitrovic N, George AL, and Horn R. Role of domain 4 in sodium channel slow inactivation. J Gen Physiol 115: 707-717, 2000.
292. + current activation in N-bromoacetamide-treated cardiac myocytes of guinea-pig. J Physiol 465: 245-263, 1993.
293. Miyamoto K, Nakagawa T, and Kuroda Y. Solution structure of the cytoplasmic linker between domain III-S6 and domain IV-S1 (III-IV linker) of the rat brain sodium channel in SDS micelles. Biopolymers 59: 380-393, 2001.
294. Moczydlowski E and Schild L. Unitary properties of the batrachotoxin-trapped state of voltage-sensitive sodium channels. In: Handbook of Membrane Channels, Molecular and Cellular Physiology, edited by C. Peracchia. San Diego, CA: Academic, 1994, p. 137-160.
295. Mohammadi B, Mitrovic N, Lehmann-Horn F, Dengler R, and Bufler J. Mechanisms of cold sensitivity of paramyotonia congenita mutation R1448H and overlap syndrome mutation M1360V. J Physiol 547: 691-698, 2003.
296. 1-subunit does not modify the inactivation kinetics. Neurosci Res Commun 26: 17-26, 2000.
297. Moran O, Conti F, and Tammaro P. Sodium channel heterologous expression in mammalian cells and the role of the endogenous β1-subunits. Neurosci Lett 336: 175-179, 2003.
298. Moran O, Nizzari M, and Conti F. Myopathic mutations affect differently the inactivation of the two gating modes of sodium channels. J Bioerg Biomembr 31: 591-608, 1999.
299. Moran O, Nizzari M, and Conti F. Endogenous expression of the β1A sodium channel subunit in HEK-293 cells. FEBS Lett 473: 132-134, 2000.
300. Morgan K, Stevens EB, Shah B, Cox PJ, Dixon AK, Lee K, Pinnock RD, Hughes J, Richardson PJ, Mizuguchi K, and Jackson AP. β3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Proc Natl Acad Sci USA 97: 2308-2313, 2000.
301. + channel inactivation gate is a molecular complex: a novel role of the COOH-terminal domain. J Gen Physiol 123: 155-165, 2004.
302. Motomura H and Narahashi T. Temperature dependence of pyrethroid modification of single sodium channels in rat hippocampal neurons. J Membr Biol 177: 23-39, 2000.
303. Mozhayeva GN, Naumov AP, Kuryshev YA, and Nosyreva ED. Some properties of sodium channels in neuroblastoma cells modified with scorpion toxin and chloramine-T. Single channel measurements. Gen Physiol Biophys 9: 3-18, 1990.
304. Mozhayeva GN, Naumov AP, Negulyaev YA, and Nosyreva ED. The permeability of aconitine-modified sodium channels to univalent cations in myelinated nerve. Biochim Biophys Acta 466: 461-473, 1977.
305. Mozhayeva GN, Naumov AP, Nosyreva ED, and Grishin EV. Potential-dependent interaction of toxin from venom of the scorpion Buthus eupeus with sodium channels in myelinated fibre. Voltage clamp experiments. Biochim Biophys Acta 597: 587-602, 1980.
306. + channel modulating effect of the inotropic compound (S-)BDF 9196 in human myocardium. Naunyn-Schmiedebergs Arch Pharmacol 359: 60-64, 1999.
307. Muramatsu I, Fujiwara M, Miura A, and Narahashi T. Effects of goniopora toxin on crayfish giant axon. J Pharmacol Exp Ther 234: 307-315, 1985.
308. Nagy K. Mechanism of inactivation of single channels after modification by chloramine-T, sea anemone toxin and scorpion toxin. J Membr Biol 106 :29-40, 1988.
309. Nagy K, Kiss T, and Hof D. Single Na channels in mouse neuroblastoma cell membrane. Indications for two open states. Pflügers Arch 399: 302-308, 1983.
310. Narahashi T. Neuroreceptors and ion channels as the basis for drug action: past, present, and future. J Pharmacol Exp Ther 294: 1-26, 2000.
311. Narahashi T, Ginsburg KS, Nagata K, Song JH, and Tabebayashi H. Ion channels as targets for insecticides. Neurotoxicology 19: 581-590, 1998.
312. Narahashi T and Haas HG. Interaction of DDT with the components of lobster nerve membrane conductance. J Gen Physiol 51: 177-198, 1968.
313. Nau C, Seaver M, Wang SY, and Wang GK. Block of human heart hH1 sodium channels by amitryptiline. J Pharmacol Exp Ther 292: 1015-1023, 2000.
314. + channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers. Mol Pharmacol 56: 404-413, 1999.
315. Nau C, Wang SY, Strichartz GR, and Wang GK. Block of human heart hH1 sodium channnels by the enantiomers of bupivacine. Anesthesiology 93: 1022-1033, 2000.
316. v1.4 channel D3-S6 modulate binding affinity and stereoselectivity of bupivacaine enantiomers. Mol Pharmacol 63: 1398-1406, 2003.
317. Neumcke B. Diversity of sodium channels in adult and cultured cells, in oocytes and in lipid bilayers. Rev Physiol Biochem Pharmacol 115: 1-49, 1990.
318. Neumcke B, Fox JM, Drouin H, and Schwarz W. Kinetics of the slow variation of peak sodium current in the membrane of myelinated nerve following changes of holding potential or extracellular pH. Biochim Biophys Acta 426: 245-257, 1976.
319. Neumcke B, Schwarz JR, and Stämpfli R. A comparison of sodium currents in rat and frog myelinated nerve: normal and modified sodium inactivation. J Physiol 382: 175-191, 1987.
320. Neumcke B, Schwarz W, and Stämpfli R. Modification of sodium inactivation in myelinated nerve by Anemonia toxin II and iodate. Analysis of current fluctuations and current relaxations. Biochim Biophys Acta 600: 456-466, 1980.
321. Nicholson GM, Walsh R, Little MJ, and Tyler MI. Characterisation of the effects of robustoxin, a lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, on sodium channel activation and inactivation. Pflügers Arch 436: 117-126, 1998.
322. Nicholson GM, Willow M, Howden MEH, and Narahashi T. Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spider Hadronyche versuta. Pflügers Arch 428: 400-409, 1994.
323. Niemann P, Schmidtmayer J, and Ulbricht W. Chloramine-T effect on sodium conductance of neuroblastoma cells as studied by whole-cell and single-channel analysis. Pflügers Arch 418: 129-136, 1991.
324. Nilius B, Benndorf K, Markwardt F, and Franke T. Modulation of single cardiac sodium channels by DPI 201-106. Gen Physiol Biophys 6: 409-424, 1987.
325. Nonner W, Spalding BC, and Hille B. Low intracellular pH and chemical agents slow inactivation gating in sodium channels of muscle. Nature 284: 360-363, 1980.
326. Norton RS. Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel. Toxicon 29: 1051-1084, 1991.
327. Nosyreva ED, Grishchenko II, and Negulyaev YA. Effects of chloramine-T on activation and inactivation of sodium channels in neuroblastoma cells. Neurophysiology 19: 574-579, 1987.
328. Nuss HB, Balser JR, Orias DW, Lawrence JH, Tomaselli GF, and Marban E. Coupling between fast and slow inactivation revealed by analysis of a point mutation (F1403Q) in μ1 rat skeletal muscle sodium channels. J Physiol 494: 411-429, 1996.
329. 1 subunit with human cardiac (hH1) and rat skeletal muscle (μ1) sodium channel α subunits expressed in Xenopus oocytes. J Gen Physiol 106: 1171-1191, 1995.
330. Ochs G, Bromm B, and Schwarz JR. A three-state model for inactivation of sodium permeability. Biochim Biophys Acta 645: 243-252, 1981.
331. + channels. Jpn J Pharmacol 88: 365-377, 2002.
332. + channels in neurons of rat dorsal root ganglia. J Membr Biol 129: 71-80, 1992.
333. O'Leary ME. Characterization of the isoform-specific differences in the gating of neuronal and muscle sodium channels. Can J Physiol Pharmacol 76: 1041-1050, 1998.
334. Ong BH, Tomaselli GF, and Baiser JP. A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence. J Gen Physiol 116: 653-661, 2000.
335. + channel chimaeras. J Physiol 515: 61-73, 1999.
336. v1.4 sodium channels. Biophys J 81: 2100-2111, 2001.
337. Oxford GS. Some kinetic and steady-state properties of sodium channels after removal of inactivation. J Gen Physiol 77: 1-22, 1981.
338. 3 pituitary cells and its modification by chemical reagents. J Physiol 410: 587-612, 1989.
339. Oxford GS, Wu CH, and Narahashi T. Removal of sodium channel inactivation in squid giant axons by N-bromoacetamide. J Gen Physiol 71: 227-247, 1978.
340. Parri HR and Crunelli V. Sodium current in rat and cat thalamocortical neurons: role of a non-inactivating component in tonic and burst firing. J Neurosci 18: 854-867, 1998.
341. Patlak JB. Sodium channel subconductance levels measured with a new variance-mean analysis. J Gen Physiol 92: 413-430, 1988.
342. + channels. Physiol Rev 71: 1047-1080, 1991.
343. 1 subunit modifies activation and inactivation gating of multiple sodium channel α subunits. J Biol Chem 269: 17649-17655, 1994.
344. Patton DE, West JW, Catterall WA, and Goldin AL. Amino acid residues required for fast sodium channel inactivation. Charge neutralizations and deletions in the III-IV linker. Proc Natl Acad Sci USA 89: 10905-10909, 1992.
345. + channel: alteration of its properties in pyrethroid-resistant flies. Biochemistry 28: 1673-1677, 1989.
346. Pichon Y, Guillet JC, Heilig U, and Pelhate M. Recent studies of the effects of DDT and pyrethroid insecticides on nervous activity in cockroaches. Pestic Sci 16: 627-640, 1985.
347. + channels. Eur J Biochem 264: 287-300, 1999.
348. Pound EM, Kang JX, and Leaf A. Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes. J Lipid Res 42: 346-351, 2001.
349. Purkerson SL, Baden DG, and Fieber LA. Brevetoxin modulates neuronal sodium channels in two cell lines derived from rat brain. Neurotoxicology 20: 909-920, 1999.
350. Purkerson-Parker SL, Fieber LA, Rein KS, Podona T, and Baden DG. Brevetoxin derivatives that inhibit toxin activity. Chem Biol 1: 385-393, 2000.
351. Qu Y, Rogers JC, Chen SF, McCormick KA, Scheuer T, and Catterall WA. Functional roles of the extracellular segments of the sodium channel α subunit in voltage-dependent gating and modulation by β1 subunits. J Biol Chem 274: 32647-32654, 1999.
352. + channel inactivation gate is required for modulation by protein kinase C. J Gen Physiol 108: 375-379, 1996.
353. Quandt FN. Modification of slow inactivation of single sodium channels by phenytoin in neuroblastoma cells. Mol Pharmacol 34: 557-565, 1988.
354. + channels by batrachotoxin. Proc Natl Acad Sci USA 79: 6732-6736, 1982.
355. Quiñonez M, DiFranco M, and González F. Involvement of methionine residues in the fast inactivation mechanism of sodium current from toad skeletal muscle fibers. J Membr Biol 169: 83-90, 1999.
356. Rack M, Rubly N, and Waschow C. Effects of some chemical reagents on sodium current inactivation in myelinated nerve fibers of the frog. Biophys J 50: 557-564, 1986.
357. + channels by local anesthetics. Science 265: 1724-1728, 1994.
358. + channels. Proc Natl Acd Sci USA 93: 9270-9275, 1996.
359. Rakowski RF, Gadsby DC, and De Weer P. Single ion occupancy and steady-state gating of Na channels in squid giant axon. J Gen Physiol 119: 235-249, 2002.
360. Raman IM and Bean BP. Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms. Biophys J 80: 729-737, 2001.
361. Ramos E and O'Leary ME. State-dependent trapping of flecainide in the cardiac sodium channel. J Physiol 560: 37-49, 2004.
362. Rao S and Sikdar SK. Modification of a α subunit of RIIA sodium channels by aconitine. Pflügers Arch 439: 349-355, 2000.
363. Ravens U, Wettwer E, Pfeifer T, Himmel H, and Armah B. Characterization of the effects of the new inotropic agent BDF 9148 in isolated papillary muscles and myocytes of the guinea-pig heart. Br Pharmacol 104: 1019-1023, 1991.
364. Recio-Pinto E, Duch SD, Levinson SR, and Urban B. Purified and unpurified sodium channels from eel electroplax in planar lipid bilayers. J Gen Physiol 90: 375-395, 1987.
365. Ren D, Navarro B, Xu H, Yue L, Shi Q, and Clapham DE. A prokaryotic voltage-gated sodium channel. Science 294: 2372-2375, 2001.
366. Rhodes TH, Lossin C, Vanoye CG, Wang DW, and George AL. Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy. Proc Natl Acad Sci USA 101: 11147-11152, 2004.
367. Richmond JE, Featherstone DE, Hartman HA, and Ruben PC. Slow inactivation in human cardiac sodium channels. Biophys J 74: 2945-2952, 1998.
368. Richmond JE, VanDeCarr D, Featherstone DE, George AL, and Ruben PC. Defective fast inactivation recovery and deactivation account for sodium channel myotonia in I1169V mutant. Biophys J 73: 1896-1903, 1997.
369. Rivolta I, Abriel H, Tateyama M, Liu H, Memmi M, Vardas P, Napolitano C, Priori SG, and Kass RS. Inherited Brugada and long QT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes. J Biol Chem 276: 30623-30630, 2001.
370. Rochat H, Bernard P, and Couraud F. Scorpion toxins: chemistry and mode of action. Adv Cytopharmacol 3: 325-334, 1979.
371. Roden DM, Balser JR, George AL, and Anderson ME. Cardiac ion channels. Annu Rev Physiol 64: 431-475, 2002.
372. + channel α subunit. J Biol Chem 271: 15950-15962, 1996.
373. Rohl CA, Boeckman FA, Baker C, Scheuer T, Catterall WA, and Klevit RE. Solution structure of the sodium channel inactivation gate. Biochemistry 38: 855-861, 1999.
374. Rojas E and Armstrong CM. Sodium conductance activation without inactivation in pronase-perfused axons. Nature New Biol 229: 177-178, 1971.
375. Rojas E and Rudy B. Destruction of sodium conductance inactivation by a specific protease in perfused nerve fibres from Loligo. J Physiol 262: 501-531, 1976.
376. + channels as sites of action of the cardiactive agent DPI 201-106 with agonist and antagonist enantiomers. Proc Natl Acad Sci USA 84: 896-900, 1987.
377. Rouzaire-Dubois B and Dubois JM. Modification of electrophysiological and pharmacological properties of K channels in neuroblastoma cells induced by chloramine-T. Pflügers Arch 416: 393-397, 1990.
378. Ruben PC, Starkus JG, and Rayner MD. Steady-state availability of sodium channels. Interactions between activation and slow inactivation. Biophys J 61: 941-955, 1992.
379. Rudy B. Slow inactivation of the sodium conductance in squid giant axons. Pronase resistance. J Physiol 283: 1-21, 1978.
380. + channels in rat skeletal muscle. Am J Physiol Cell Physiol 271: C971-C981, 1996.
381. + channels. Am J Physiol Cell Physiol 277: C937-C947, 1999.
382. Ruff RL, Simoncini L, and Stühmer W. Comparison between slow sodium channel inactivation in rat slow- and fast-twitch muscle. J Physiol 383: 339-348, 1987.
383. Ruff RL, Simoncini L, and Stühmer W. Slow sodium channel inactivation in mammalian muscle: a possible role in regulating excitability. Muscle Nerve 11: 502-510, 1988.
384. v1.9 subunit in myenteric sensory neurons. J Neurosci 23: 2715-2725, 2003.
385. v1.8 sodium channel resistance to the venom from scorpion Leiurus quinquestriatus hebraeus. Neurosci Lett 331: 79-82, 2002.
386. + channels containing equine hyperkalemic periodic paralysis mutation. Am J Physiol Cell Physiol 275: C389-C400, 1998.
387. Sahara Y, Gotoh M, Konno K, Miwa A, Tsubokawa H, Robinson HPC, and Kawai N. A new class of neurotoxin from wasp venom slows inactivation of sodium current. Eur J Neurosci 12: 1961-1970, 2000.
388. Saint DA, Ju YK, and Gage PW. A persistent sodium current in rat ventricular myocytes. J Physiol 453: 219-231, 1992.
389. Salceda E, Garateix A, and Soto E. The sea anemone toxins BgII and BgIII prolong the inactivation time course of the tetrodotoxin-sensitive sodium current in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 303: 1067-1074, 2002.
390. Salgado VL, Yeh JZ, and Narahashi T. Voltage-dependent removal of sodium inactivation by N-bromoacetamide and pronase. Biophys J 47: 567-571, 1985.
391. Sato C, Ueno Y, Asal K, Takahashi K, Sato M, Engel A, and Fujiyoshi Y. The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities. Nature 409: 1047-1051, 2001.
392. Schauf CL. Zonisamide enhances slow sodium inactivation in Myxicola. Brain Res 413: 185-188, 1987.
393. Schmidtmayer J. Behaviour of chemically modified sodium channels in frog nerve support a three-state model of inactivation. Pflügers Arch 404: 21-28, 1985.
394. Schmidtmayer J. Voltage and temperature dependence of normal and chemically modified inactivation of sodium channels. Quantitative description by a cyclic three-state model. Pflügers Arch 414: 273-281, 1989.
395. Schmidtmayer J, Stoye-Herzog M, and Ulbricht W. Rate of action of Anemonia sulcata toxin II on sodium channels in myelinated nerve fibres. Pflügers Arch 394: 313-319, 1982.
396. Schmidtmayer J, Stoye-Herzog M, and Ulbricht W. Combined action of intraaxonal iodate and external sea anemone toxin ATX II on sodium channel inactivation of frog nerve fibres. Pflügers Arch 398: 204-209, 1983.
397. Schmidtmayer J and Ulbricht W. Interaction of lidocaine and benzocaine in blocking sodium channels. Pflügers Arch 387: 47-54, 1980.
398. Schneider MF and Dubois JM. Effects of benzocaine on the kinetics of normal and batrachotoxin-modifled Na channels in frog node of Ranvier. Biophys J 50: 523-530, 1986.
399. Scholtysik G, Quast U, and Schaad A. Evidence for different receptor sites for the novel cardiotonic S-DPI 201-106, ATX II and veratridine on the cardiac sodium channel. Eur J Pharmacol 125: 111-118, 1986.
400. Scholz A. Mechanisms of (local) anaesthetics on voltage-gated sodium and other ion channels. Br J Anaesth 89: 52-61, 2002.
401. Schreibmayer W. Isoform diversity and modulation of sodium channels by protein kinases. Cell Physiol Biochem 9: 187-200, 1999.
402. Schreibmayer W, Kazerani H, and Tritthart HA. A mechanistic interpretation of the action of toxin II from Anemonia sulcata on the cardiac sodium channel. Biochim Biophys Acta 901: 273-282, 1987.
403. Schreibmayer W, Tritthart HA, and Schindler H. The cardiac sodium channel shows a regular substate pattern indicating synchronized activity of several pathways instead of one. Biochim Biophys Acta 986: 172-186, 1989.
404. Schwarz JR. The effect of temperature on Na currents in rat myelinated nerve fibres. Pflügers Arch 406: 397-404, 1986.
405. Schwarz W. Temperature experiments on nerve and muscle membranes of frogs. Pflügers Arch 382: 27-34, 1979.
406. Shah BS, Stevens EB, Pinnock RD, Dixon Ali, and Lee K. Developmental expression of the novel voltage-gated sodium channel auxiliary subunit β3, in rat CNS. J Physiol 534: 763-776, 2001.
407. Sheets MF and Hanck DA. Gating of skeletal and cardiac muscle sodium channels in mammalian cells. J Physiol 514: 425-436, 1999.
408. Sheets MF, Kyle JW, and Hanck DA. The role of the putative inactivation lid in sodium channel gating current immobilization. J Gen Physiol 115: 609-619, 2000.
409. Sheets MF, Kyle JW, Kallen RG, and Hanck DA. The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4. Biophys J 77: 747-757, 1999.
410. Shichor I, Fainzilber M, Pelhate M, Malecot CO, Zlotkin E, and Gordon D. Interactions of δ-conotoxins with alkaloid neurotoxins reveal differences between silent and effective binding sites on voltage-sensitive sodium channels. J Neurochem 67: 2451-2460, 1996.
411. Shon KJ, Hasson A, Spira ME, Cruz LJ, Gray WR, and Olivera BM. δ-Conotoxin GmVIA, a novel peptide from the venom of Conus gloriamaris. Biochemistry 33: 11420-11425, 1994.
412. Shoukimas JJ and French RF. Incomplete inactivation of sodium currents in nonperfused squid axon. Biophys J 32: 857-862, 1980.
413. Sigel E. Effects of veratridine on single neuronal sodium channels expressed in Xenopus oocytes. Pflügers Arch 410: 112-120, 1987.
414. Simard JM, Meves H, and Watt DD. Neurotoxins in venom from the North American scorpion, Centruroides sculpturatus Ewing. In: Natural Toxins: Toxicology, Chemistry and Safety, edited by Keeler R. F., N. B. Mandava, and A. T. Tu. Fort Collins, CO: Alaken, 1992, p. 236-263.
415. Simoncini L and Stühmer W. Slow sodium channel inactivation in rat fast-twitch muscle. J Physiol 383: 327-337, 1987.
416. Sirota FL, Pascutti PG, and Anteneodo C. Molecular modeling and dynamics of the sodium channel inactivation gate. Biophys J 82: 1207-1215, 2002.
417. Smith MR and Goldin AL. Interaction between the sodium channel inactivation linker and domain III S4-S5. Biophys J 73: 1885-1895, 1997.
418. Soderlund DM, Smith TJ, and Lee SH. Differential sensitivity of sodium channel isoforms and sequence variants to pyrethroid insecticides. Neurotoxicology 21: 127-138, 2000.
419. Song JH and Narahashi T. Modulation of sodium channels of rat cerebellar Purkinje neurons by the pyrethroid tetramethrin. J Pharmacol Exp Ther 277: 445-453, 1996.
420. Spampanato J, Escayg A, Meisler MH, and Goldin AL. Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2. J Neurosci 21: 7481-7490, 2001.
421. Stämpfli R. Intra-axonal iodate inhibits sodium inactivation. Experientia 30: 505-508, 1974.
422. Starkus JG, Heggeness ST, and Rayner MD. Kinetic analysis of sodium channel block by internal methylene blue in pronased crayfish giant axons. Biophys J 46: 205-218, 1984.
423. Starmer CF, Grant AO, and Strauss AC. Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics. Biophys J 46: 15-27, 1984.
424. Stephens GJ and Robertson B. Inactivation of the cloned potassium channel mouse Kv1.1 by the human Kv34 "ball" peptide and its chemical modification. J Physiol 484: 1-13, 1995.
425. Sternberg D, Maisonobe T, Jurkat-Rott K, Nicole S, Launay E, Chauveau D, Tabti N, Lehmann-Horn F, Hainque B, and Fontaine B. Hypokalemic periodic paralsysis type 2 caused by mutations at codon 672 in the muscle sodium channel gene SCN4A. Brain 124: 1091-1099, 2001.
426. Stevens EB, Cox PJ, Shah BS, Dixon AK, Richardson PJ, Pinnock RD, and Lee K. Tissue distribution and functional expression of the human voltage-gated sodium channel β3 subunit. Pflügers Arch 441: 481-488, 2001.
427. Stimers JR, Bezanilla F, and Taylor RE. Sodium channel activation in the squid giant axon. Steady state properties. J Gen Physiol 85: 65-82, 1985.
428. Strachan C, Lewis RJ, and Nicholson GM. Differential actions of pacific ciguatoxin-1 on sodium channel subtypes in mammalian sensory neurons. J Pharmacol Exp Ther 288: 379-388, 1999.
429. Strichartz GR and Wang GK. Rapid voltage-dependent dissociation of scorpion α-toxins coupled to Na channel inactivation in amphibian myelinated nerve. J Gen Physiol 88: 413-435, 1986.
430. Struyk AF and Cannon SC. Slow inactivation does not block the aqueous accessibility to the outer pore of voltage-gated Na channels. J Gen Physiol 120: 509-516, 2002.
431. Struyk AF, Scoggan KA, Bulman DE, and Cannon CS. The human skeletal muscle Na channel mutation R669H associated with hypokalemic periodic paralysis enhances slow inactivation. J Neurosci 20: 8610-8617, 2000.
432. Stühmer W, Conti F, Suzuki H, Wang X, Noda M, Yahagi N, Kubo H, and Numa S. Structural parts involved in activation and inactivation of the sodium channel. Nature 339: 597-603, 1989.
433. Sudarslal S, Majumdar S, Ramasamy P, Dhawan R, Pal PP, Ramaswami M, Lala AK, Sikdar SK, Sarma SP, Krishnan KS, and Balaram P. Sodium channel modulating activity in a δ-conotoxin from an Indian marine snail. FEBS Lett 553: 209-212, 2003.
434. Szeto TH, Birinyi-Strachan LC, Smith R, Connor M, Christie MJ, King GF, and Nicholson GM. Isolation and pharmacological characterization of δ-atracotoxin-Hv1b, a vertebrate-selective sodium channel toxin. FEBS Lett 470: 293-299, 2000.
435. Tabarean IV and Narahashi T. Potent modulation of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels by the type II pyrethroid deltamethrin. J Pharmacol Exp Ther 284: 958-965, 1998.
436. Taddese A and Bean BP. Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron 33: 587-600, 2002.
437. Takahashi MP and Cannon SC. Enhanced slow inactivation by V445M: a sodium channel mutation associated with myotonia. Biophys J 76: 861-868, 1999.
438. + channel. J Physiol 537: 701-714, 2001.
439. Tanguy J and Yeh JZ. Batrachotoxin uncouples gating charge immobilization from fast Na inactivation in squid giant axons. Biophys J 54: 719-730, 1988.
440. Tanguy J and Yeh JZ. BTX modification of Na channels in squid axons. I. State dependence of BTX action. J Gen Physiol 97: 499-519, 1991.
441. Tatebayashi H and Narahashi T. Differential mechanism of action of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J Pharmacol Exp Ther 270: 595-603, 1994.
442. + channel gating. Biophys J 86: 1843-1851, 2004.
443. + currents that fail to inactivate. Trends Neurosci 16: 455-460, 1993.
444. Tejedor FJ and Catterall WA. Site of covalent attachment of α-scorpion toxin derivatives in domain I of the sodium channel α subunit. Proc Natl Acad Sci USA 85: 8742-8746, 1988.
445. Terlau H and Olivera B. Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol Rev 84: 41-68, 2004.
446. Tlomsen WJ and Catterall WA. Localization of the receptor site for α-scorpion toxins by antibody mapping: implications for sodium channel topology. Proc Natl Acad Sci USA 86: 10161-10165, 1989.
447. + channels is produced by a structural rearrangement of the outer vestibule. Biophys J 76: 1335-1345, 1999.
448. + channels. J Neurosci 18: 1893-1903, 1998.
449. Tomaselli GF, Chiamvimonvat N, Nuss HB, Balser JR, Perez-García MT, Xu RH, Orias DW, Backx PH, and Marban E. A mutation in the pore of the sodium channel alters gating. Biophys J 68: 1814-1827, 1995.
450. + channels. J Gen Physiol 110: 23-33, 1997.
451. Trainer VL, McPhee JC, Boutelef-Bochan H, Baker C, Scheuer T, Babin D, Demoute JP, Guedin D, and Catterall WA. High affinity binding of pyrethroids to the α subunit of brain sodium channels. Mol Pharmacol 51: 651-657, 1997.
452. + current by RWJ 24517 and its enantiomers in guinea pig ventricular myocytes. J Pharmacol Exp Ther 291: 845-855, 1999.
453. Ulbricht W. The effect of veratridine on excitable membranes of nerve and muscle. Ergeb Physiol 61: 18-71, 1969.
454. Ulbricht W. The inactivation of sodium channels in the node of Ranvier and its chemical modification. In: Ion Channels, edited by Narahashi T. New York: Plenum, 1990, vol. 2, p 123-268.
455. Ulbricht W. Effects of veratridine on sodium currents and fluxes. Rev Physiol Biochem Pharmacol 133: 1-54, 1998.
456. Ulbricht W and Schmidtmayer J. Modification of sodium channels in myelinated nerve by Anemonia sulcata toxin II. J Physiol 77: 1103-1111, 1981.
457. Ulbricht W and Stoye-Herzog M. Distinctly different rates of benzocaine action on sodium channels of Ranvier nodes kept open by chloramine-T and veratridine. Pflügers Arch 402: 439-445, 1984.
458. Ulbricht W and Wagner HH. The influence of pH on equilibrium effects of tetrodotoxin on myelinated nerve fibres of Rana esculenta. J Physiol 252: 159-184, 1975.
459. Valenzuela C, Snyders DJ, Bennett PB, Tamargo J, and Hondeghem LM. Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes. Circulation 92: 3014-3024, 1995.
460. Vandenberg CA and Horn R. Inactivation viewed through single sodium channels. J Gen Physiol 84: 535-561, 1984.
461. Vassilev PM, Scheuer T, and Catterall WA. Identification of an intracellular peptide segment involved in sodium channel inactivation. Science 241: 1658-1661, 1988.
462. Vassilev PM, Scheuer T, and Catterall WA. Inhibition of inactivation of single sodium channels by a site-directed antibody. Proc Natl Acad Sci USA 86: 8147-8151, 1989.
463. + channels. J Gen Physiol 111: 83-93, 1998.
464. + channels. J Gen Physiol 113: 7-16, 1999.
465. + channel. Circ Res 86: e91-e97, 2000.
466. v18 peripheral nerve sodium channels. J Neurosci 21: 7909-7918, 2001.
467. Vijverberg HPM and De Weille JR. The interaction of pyrethroids with voltage-dependent Na channels. Neurotoxicology 6: 23-34, 1985.
468. Vijverberg HPM, Puaron D, and Lazdunski M. The effect of Tityus serrulatus scorpion toxin γ on Na channels in neuroblastoma cells. Pflügers Arch 401: 297-303, 1984.
469. Vijverberg HPM, Van der Salm JM, and Van den Bercken J. Similar mode of action of pyrthroids and DDT on sodium channel gating in myelinated nerves. Nature 295: 601-603, 1982.
470. + channel slow inactivation. Biophys J 80: 2221-2230, 2001.
471. Vilin YY, Makita M, George AL, and Ruben PC. Structural determinants of slow inactivation in human cardiac and skeletal muscle sodium channels. Biophys J 77: 1384-1393, 1999.
472. Vilin YY and Ruben PC. Slow inactivation in voltage-gated sodium channels. Molecular substrates and contributions to channelopathies. Cell Biochem Biophys 35: 171-190, 2001.
473. Vincent JP, Balerna M, Barhanin J, Fosset M, and Lazdunski M. Binding of sea anemone toxin to receptor sites associated with gating system of sodium channels in synaptic nerve endings in vitro. Proc Natl Acad Sci USA 77: 1646-1650, 1980.
474. +-channel β1 subunit gene SCN1B. Nat Genet 19: 366-370, 1998.
475. Wang DW, VanDeCarr D, Ruben PC, George AL, and Bennett PB. Functional consequences of a domain 1/S6 segment sodium channel mutation associated with painful congenital myotonia. FEBS Lett 448: 231-234, 1999.
476. + channel mutations in the congenital long QT syndrome. Proc Natl Acad Sci USA 93: 13200-13205, 1996.
477. Wang G, Dugas M, Armah BI, and Honerjäger P. Sodium channel comodiflcation with full activator reveals veratridine reaction dynamics. Mol Pharmacol 37: 144-148, 1990.
478. Wang GK. Modification of sodium channel inactivation in single myelinated nerve fibers by methionine-reactive chemicals. Biophys J 46: 121-124, 1984.
479. Wang GK. Irreversible modification of sodium channel inactivation in toad myelinated nerve fibres by the oxidant chloramine-T. J Physiol 346: 127-141, 1984.
480. Wang GK, Brodwick MS, and Eaton DC. Removal of sodium channel inactivation in squid axon by the oxidant chloramine-T. J Gen Physiol 86: 289-302, 1985.
481. Wang GK, Brodwick MS, Eaton DC, and Strichartz GR. Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation. J Gen Physiol 89: 645-667, 1987.
482. + channels by veratridine. Pflügers Arch 439: 705-713, 2000.
483. + channels. Pflügers Arch 435: 293-302, 1998.
484. + channels. Mol Pharmacol 54: 389-396, 1998.
485. Wang GK and Strichartz G. Kinetic analysis of the action of Leiurus scorpion α-toxin on ionic currents in myelinated nerve. J Gen Physiol 86: 739-762, 1985.
486. + channels by batrachotoxin. Pflügers Arch 427: 309-316, 1994.
487. Wang GK and Wang SY. Modification of human cardiac sodium channels gating by UVA light. J Membr Biol 189: 153-165, 2002.
488. Wang GK and Wang SY. Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule. J Physiol 548: 667-673, 2003.
489. + channel D2-S6 residues in batrachotoxin and local anesthetic action. Mol Pharmacol 59: 1100-1107, 2001.
490. + channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities. Biophys J 79: 1379-1387, 2000.
491. + channels in permanently transfected mammalian cells. Pflügers Arch 432: 692-699, 1996.
492. Wang SY and Wang GK. A mutation in segment I-S6 alters slow inactivation of sodium channels. Biophys J 72: 1633-1640, 1997.
493. + channels resistant to batrachotoxin. Proc Natl Acad Sci USA 95: 2653-2658, 1998.
494. + channels derived from point mutations in transmembrane segment D4-S6. Biophys J 76: 3141-3149, 1999.
495. Wang SY and Wang GK. Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins. Cell Signal 15: 151-159, 2003.
496. Warashina A and Fujita S. Effects of sea anemone toxins on the sodium inactivation process in crayfish axons. J Gen Physiol 81: 305-323, 1983.
497. Warashina A, Jiang ZY, and Ogura T. Potential-dependent action of Anemonia sulcata toxins III and IV on sodium channels in crayfish giant axons. Pflügers Arch 411: 88-93, 1988.
498. Watt DD and Simard JM. Neurotoxic proteins in scorpion venoms. J Toxicol Toxin Rev 3: 181-221, 1984.
499. + channel. Circulation 99: 3165-3171, 1999.
500. + channel required for modulation by protein kinase C. Science 254: 866-868, 1991.
501. + currents in transfected Chinese hamster ovary cells. Biophys J 62: 31-33, 1992.
502. + channel inactivation. Proc Natl Acad Sci USA 89: 10910-10914, 1992.
503. Wright SN. Irreversible block of human heart (hH1) sodium channels by the plant alkaloid lappaconitine. Mol Pharmacol 59: 183-192, 2001.
504. + channel D4-S6 reduce inactivated channel block by local anesthetics. Mol Pharmacol 54: 737-739, 1998.
505. Wu CH and Narahashi T. Mechanism of action of novel marine neurotoxins on ion channels. Annu Rev Pharmacol Toxicol 28: 141-161, 1988.
506. + channels. Proc Natl Acad Sci USA 98: 3606-3611, 2001.
507. Xiong W, Li EA, Tian Y, and Tomaselli GF. Molecular motions of the outer ring of charge of the sodium channel: do they couple to slow inactivation? J Gen Physiol 122: 323-332, 2003.
508. Yakehiro M, Yuki T, Yamaoka K, Furue T, Mori Y, Imoto K, and Seyama I. An analysis of the variations in potency of grayanotoxin analogs in modifying frog sodium channels of differing subtypes. Mol Pharmacol 58: 692-700, 2000.
509. Yamamoto D, Yeh JZ, and Narahashi T. Ion permeation and selectivity of squid axon sodium channels modified by tetramethrin. Brain Res 272: 193-197, 1986.
510. Yang N, George AL, and Horn R. Probing the outer vestibule of a sodium channel voltage sensor. Biophys J 73: 2260-2268, 1997.
511. Yang N, Ji S, Zhou M, Ptácek LJ, Barchi KL, Horn R, and George AL. Sodium channel mutations in paramyotonia congenita exhibit similar biophysical phenotypes in vitro. Proc Natl Acad Sci USA 91: 12785-12789, 1994.
512. + channels. J Neurosci 23: 4922-4930, 2003.
513. + channel α subunit. J Biol Chem 276: 20-27, 2001.
514. + channel α subunit in voltage-dependent gating and drug block. J Biol Chem 277: 35393-35401, 2002.
515. Yeh JZ. Blockage of sodium channels by stereo-isomers of local anesthetics. Prog Anesthesiol 2: 35-44, 1980.
516. Yu FH, Westenbroek RE, Silos-Santiago I, McCormick KA, Lawson D, Ge P, Ferriera H, Lilly J, DiStefano PS, Catterall WA, Scheuer T, and Curtis R. Sodium channel β4, a new disulfide-linked auxiliary subunit with similarity to β2. J Neurosci 23: 7577-7585, 2003.
517. Yuill KII, Convery MK, Dooley PC, Doggrell SA, and Hancox JC. Effects of BDF 9198 on action potentials and ionic currents from guinea-pig isolated ventricular myocytes. Br J Pharmacol 130: 1753-1766, 2000.
518. + channels in frog ventricular myocytes. J Physiol 534: 777-790, 2001.
519. Zaborovskaya LS and Khodorov BI. The role of inactivation in the cumulative blockage of voltage-dependent sodium channels by local anesthetics and antiarrhythmics. Gen Physiol Biophys 3: 517-520, 1984.
520. Zhang Z, Xu Y, Dong PII, Sharma D, and Chiamvimonvat N. A negatively charged residue in the outer mouth of rat sodium channel determines the gating kinetics of the channel. Am J Physiol Cell Physiol 284: C1247-C1254, 2003.
521. + channels: a molecular switch for electrical signaling. Neuron 41: 859-865, 2004.
522. + channels interact with different molecular regions. J Gen Physiol 120: 887-895, 2002.
523. + channel (hH1) already within the endoplasmic reticulum. J Membr Biol 186: 13-21, 2002.
524. Zlotkin E. The insect voltage-gated sodium channel as target of insecticides. Annu Rev Entomol 44: 429-455, 1999.
525. Zygmunt AC, Eddlestone GT, Thomas GP, Nesterenko VV, and Antzelevitch D. Larger late conductance in M cells contributes to electrical heterogeneity in canine ventricle. Am J Physiol Heart Circ Physiol 281: H689-H697, 2001.