Scorpion α-like toxins, toxic to both mammals and insects, differentially interact with receptor site 3 on voltage-gated sodium channels in mammals and insects

European Journal of Neuroscience

Volumn 11, Issue 3, 1999, Pages 975-985

  Sandrine, Auclaire ^a  

^a CNRS   (France)

Author keywords

Neurotoxin receptor; Periplaneta americana axon; Receptor binding; Scorpion toxin; Voltage clamp

Indexed keywords

IODINE 125; MEMBRANE RECEPTOR; NEUROTOXIN; SCORPION VENOM; SODIUM CHANNEL; SODIUM ION; VOLTAGE GATED CHANNEL FORMING PROTEIN;

ANIMAL TISSUE; ARTICLE; BRAIN; COCKROACH; INSECT; MAMMAL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RADIOASSAY; RAT; RECEPTOR BINDING; SODIUM CURRENT; TOXIN STRUCTURE;

ANIMALS; AXONS; BINDING SITES; BRAIN CHEMISTRY; ELECTRIC STIMULATION; IODINE RADIOISOTOPES; ION CHANNEL GATING; MALE; MAMMALS; MASS SPECTROMETRY; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NEURONS; PATCH-CLAMP TECHNIQUES; PERIPLANETA; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, WISTAR; SCORPION VENOMS; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNELS; SPINAL CORD; TETRODOTOXIN;

EID: 0033045213     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00505.x     Document Type: Article

References (3)

1. Catterall, W.A. (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol. Rev., 72, 15-48.
2. Cestèle, S., Ben Khalifa, R., Pelhate, M. & Rochat, H. & Gordon, D. (1995) α-Scorpion toxins binding on rat brain and insect sodium channels reveal divergent allosteric modulations by brevetoxin and veratridine. J. Biol. Cliem., 270, 15 153-15 161.
3. Cestèle, S. & Gordon, D. (1998) Depolarization differently affects allosteric modulation by neurotoxins of scorpion-toxin binding on voltage-gated sodium channels. J. Neiirochem., 70, 1217-1226.