Changes in Local S4 Environment Provide a Voltage-sensing Mechanism for Mammalian Hyperpolarization-activated HCN Channels

Journal of General Physiology

Volumn 123, Issue 1, 2004, Pages 5-19

  Bell, Damian C ^a   Yao, Huan ^a   Saenger, Renee C ^a   Riley, John H ^a   Siegelbaum, Steven A ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Cysteine; HCN1 channel; Ion channel gating; Sulfhydryl reagents; Voltage gated K+ channels

Indexed keywords

CYSTEINE; ION CHANNEL; THIOL DERIVATIVE; WATER;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; ELECTRIC FIELD; FEMALE; HYPERPOLARIZATION; HYPERPOLARIZATION ACTIVATED CYLIC NUCLEOTIDE GATED ION CHANNEL; LIPID BILAYER; MEMBRANE CURRENT; MEMBRANE DEPOLARIZATION; MEMBRANE S4 SEGMENT; NONHUMAN; PROTEIN FAMILY; ROTATION; SENSOR;

ANIMALS; CELL MEMBRANE; CYSTEINE; ELECTROPHYSIOLOGY; ION CHANNEL GATING; ION CHANNELS; MAMMALS; MEMBRANE POTENTIALS; MESYLATES; OOCYTES; POTASSIUM CHANNELS, VOLTAGE-GATED; SULFHYDRYL REAGENTS; XENOPUS;

EID: 0347302947     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200308918     Document Type: Article

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