Molecular and cellular mechanisms of cardiac arrhythmias

Cell

Volumn 104, Issue 4, 2001, Pages 569-580

  Keating, Mark T ^a   Sanguinetti, Michael C ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; RYANODINE RECEPTOR; SODIUM CHANNEL;

GENE MUTATION; HEART ARRHYTHMIA; HEART MUSCLE POTENTIAL; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; LONG QT SYNDROME; NONHUMAN; PRIORITY JOURNAL; REENTRY ARRHYTHMIA; REVIEW; SUDDEN DEATH;

EID: 0035936798     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00243-4     Document Type: Review

References (71)

1. Kr potassium channels with HERG and is associated with cardiac arrhythmia
2. The sympathetic imbalance hypothesis of QT interval prolongation
3. KVLQT1 and IsK (minK) proteins associate to form the IKs cardiac potassium current
4. Molecular mechanism for an inherited cardiac arrhythmia
5. Right bundle branch block, ST segment elevation in leads V1-V3: A marker for sudden death in patients without demonstrable structural heart disease
6. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family
7. Long QT syndrome-associated mutations in the Per-Arnt Sim (PAS) domain of HERG potassium channels accelerate channel deactivation
8. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
9. Gene derived therapy in inherited long QT syndrome: Correction of abnormal repolarization by potassium
10. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
11. + channel and its structural implications
12. Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome
13. Multiple mechanisms of sodium channel-linked long QT syndrome
14. Molecular determinants of dofetilide block of HERG K+ channels
15. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel
16. Homozygous premature truncation of the HERG protein: The human HERG knockout
17. Congenital deaf-mutism, functional heart disease with prolongation of the QT interval, and sudden death
18. Two long QT syndrome loci map to chromosome 3 and 7 with evidence for further heterogeneity
19. Sudden death risk in overt coronary heart diseases: The Framingham study
20. Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene
21. Sodium channel block produces opposite electrophysiological effects in canine ventricular epicardium and endocardium
22. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
23. Twisting of the points
24. Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements
25. Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: Involvement of S6 sites
26. The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression
27. A new form of long QT syndrome associated with syndactyly
28. Ventricular fibrillation without apparent heart disease: Description of six cases
29. A minK-HERG complex regulates the cardiac potassium current I-Kr
30. A structural basis for drug-induced long QT syndrome
31. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate
32. Crystal structure and functional analysis of the HERG potassium channel N terminus: A eukaryotic PAS domain
33. ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome
34. Update on MADIT: The Multicenter Automatic Defibrillator Implantation Trial. The long QT interval syndrome
35. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome
36. Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholamine polymorphic ventricular tachycardia
37. Mechanisms and management of proarrhythmia
38. Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions
39. Artimie cardiach rare dell'eta pediatrica. II. Accessi sincopali per fibrillazione ventricolare parossitica
40. + current: Differential sensitivity to block by class-III antiarrhythmic agents
41. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
42. + channel dysfunction in an inherited cardiac arrhythmia
43. Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKs potassium channel
44. Mapping of a gene for long QT syndrome to chromosome 4q25-27
45. KCNE1 mutations cause Jervell and Lange-Nielsen syndrome
46. Diagnostic criteria for the long QT syndrome
47. A common polymorphism associated with antibiotic-induced cardiac arrhythmia
48. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns
49. The inward rectification mechanism of the HERG cardiac potassium channel
50. Fast inactivation causes rectification of the IKr channel
51. Molecular basis of the long-QT syndrome associated with deafness
52. Mutations in the hminK gene cause long QT syndrome and suppress IKs function
53. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2
54. MinK potassium channels are heteromultimeric complexes
55. Cloning of a membrane protein that induces a slow voltage-gated potassium current
56. HERG, a human inward rectifier in the voltage-gated potassium channel family
57. Inner ear defects induced by null mutation of the isk gene
58. The spectrum of symptoms and QT intervals in carriers of the gene for the long QT syndrome
59. Subunit composition of MinK potassium channels
60. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
61. Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia
62. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
63. Functional effects of mutations in KvLQT1 that cause long QT syndrome
64. A new familial cardiac syndrome in children
65. A family of potassium channel genes related to eag in Drosophila and mammals
66. Circadian variation in the incidence of sudden cardiac death in the Framingham heart study population
67. + channel mutations found in inherited cardiac arrhythmias
68. KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias
69. Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy
70. HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects