Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins

Cellular Signalling

Volumn 15, Issue 2, 2003, Pages 151-159

  Wang, Sho Ya ^a   Wang, Ging Kuo ^b  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Batrachotoxin; Lipid soluble toxins; Local anaesthetics; Pyrethroids; Receptor mapping; S6 segment; Voltage gated sodium channel

Indexed keywords

4 [3 (4 BENZHYDRYL 1 PIPERAZINYL) 2 HYDROXYPROPOXY] 1H INDOLE 2 CARBONITRILE; 4 [3 [4 (4 CYANOMETHOXYBENZHYDRYL) 1 PIPERAZINYL] 2 HYDROXYPROPOXY] 1H INDOLE 2 CARBONITRILE; ACONITINE; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BATRACHOTOXIN; BREVETOXIN; CARDIOTONIC AGENT; CHLORPHENOTANE; CIGUATOXIN; DELTAMETHRIN; GRAYANOTOXIN; INSECTICIDE; LOCAL ANESTHETIC AGENT; LY 368052; MEMBRANE RECEPTOR; NEUROTOXIN; PYRETHROID; RU 39568; SODIUM CHANNEL; SODIUM ION; UNCLASSIFIED DRUG; VERATRIDINE;

ACTION POTENTIAL; ALPHA CHAIN; BINDING SITE; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; CHEMICAL STRUCTURE; CONVULSION; DEATH; DEPOLARIZATION; DRUG RECEPTOR BINDING; HEART MUSCLE EXCITABILITY; INTOXICATION; LIPID BILAYER; LIPID SOLUBILITY; MEMBRANE STEADY POTENTIAL; MUSCLE EXCITATION; NERVE EXCITABILITY; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; RADIOACTIVITY; RECEPTOR BINDING; REVIEW; SITE DIRECTED MUTAGENESIS; VOLTAGE CLAMP; ANIMAL; CHEMISTRY; DRUG EFFECT; HUMAN; LIPID METABOLISM; METABOLISM; PHYSIOLOGY; SOLUBILITY;

ANIMALIA;

ACTION POTENTIALS; ANIMALS; HUMANS; ION CHANNEL GATING; LIPID METABOLISM; NEUROTOXINS; SODIUM CHANNELS; SOLUBILITY;

EID: 0037290637     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0898-6568(02)00085-2     Document Type: Review

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