Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 17, 1996, Pages 9270-9275

  Ragsdale, David S ^a   Mcphee, Jancy C ^a   Scheuer, Todd ^a   Catterall, William A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTICONVULSIVE AGENT; FLECAINIDE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MESSENGER RNA; PHENYTOIN; QUINIDINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ISOLATION; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; NONHUMAN; OOCYTE; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SODIUM CURRENT; VOLTAGE CLAMP; XENOPUS;

ANESTHETICS, LOCAL; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTICONVULSANTS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLECAINIDE; ION CHANNEL GATING; LIDOCAINE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENYTOIN; QUINIDINE; RATS; RECOMBINANT PROTEINS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0029787945     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.17.9270     Document Type: Article

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