A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence

Journal of General Physiology

Volumn 116, Issue 5, 2000, Pages 653-661

  Ong, B H ^a   Tomaselli, G F ^a   Balser, J R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cysteine mutagenesis; Electrophysiology; Gating; Lidocaine; Local anesthetic

Indexed keywords

AMMONIUM DERIVATIVE; CYSTEINE; LIDOCAINE; SODIUM CHANNEL; SODIUM ION; SULFONIC ACID DERIVATIVE; THIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN; CHANNEL GATING; CONFORMATIONAL TRANSITION; ELECTROPHYSIOLOGY; EMBRYO; HUMAN; HUMAN CELL; MEMBRANE ELECTROPHYSIOLOGY; MOLECULAR RECOGNITION; MUSCLE CELL; NERVE CELL EXCITABILITY; NONHUMAN; TRANSPORT KINETICS;

ANESTHETICS, LOCAL; ANIMALS; CYSTEINE; ELECTROPHYSIOLOGY; ETHYL METHANESULFONATE; INDICATORS AND REAGENTS; KINETICS; LIDOCAINE; MEMBRANE POTENTIALS; MUSCLE, SKELETAL; MUTAGENESIS, SITE-DIRECTED; RATS; SODIUM CHANNELS;

EID: 0033761775     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.116.5.653     Document Type: Article

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