Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons

Journal of Neurophysiology

Volumn 86, Issue 3, 2001, Pages 1351-1364

  Herzog, R I ^b   Cummins, T R ^b   Waxman, S G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CELL MEMBRANE DEPOLARIZATION; COMPUTER SIMULATION; EXCITATION; HODGKIN HUXLEY EQUATION; MEMBRANE STEADY POTENTIAL; MODEL; MOUSE; NERVE CELL EXCITABILITY; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CURRENT; SPINAL GANGLION; SPINAL NERVE;

EID: 0034843601     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.2001.86.3.1351     Document Type: Article

References (54)

1. Three dimensional analysis of unmyelinated fibers in normal and pathologic nerves
2. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
3. Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons
4. Spinal sensory neurons express multiple sodium channel α-subunit mRNAs
5. Activity-dependent excitability changes in normal and demyelinated rat spinal root axons
6. Three types of sodium channels in adult rat dorsal root ganglion neurons
7. Variation in serotonergic inhibition of calcium channel currents in four types of rat sensory neurons differentiated by membrane properties
8. A quantitative description of membrane currents in rabbit myelinated nerve
9. Immunolocalization of SNS/PN3 and NaN/SNSN 2 sodium channels in human pain states
10. Persistent sodium current in mammalian central neurons
11. Glial-derived neurotrophic factor upregulates expression of functional SNS and NaN sodium channels and their currents in axotomized dorsal root ganglion neurons
12. A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons
13. Impaired slow inactivation in mutant sodium channels
14. Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury
15. Down-regulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy
16. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy
17. Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons
18. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia
19. Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons
20. Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors
21. + concentration during electrical stimulation of rat isolated sympathetic ganglia, vagus and optic nerves
22. + currents in adult rat sensory neurons
23. +/K(+)-ATPase) activity in rat optic nerve
24. The NEURON simulation environment
25. A quantitative description of membrane current and its application to conduction and excitation in nerve
26. Slow sodium-dependent potential oscillations contribute to ectopic firing in mammalian demyelinated axons
27. Sodium channel kinetics in normal and denervated rabbit muscle membrane
28. Ionic currents in the somatic membrane of rat dorsal root ganglion neurons. I. Sodium currents
29. + channels amplify EPSPs in hippocampal CA 1 pyramidal cells
30. Spinal nerve injury enhances subthreshold membrane potential oscillations in DRG neurons: Relation to neuropathic pain
31. Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices
32. The unmyelinated nerve fiber
33. + channels in neurons of rat dorsal root ganglia
34. + channels in rat dorsal root ganglia
35. Sodium current in rat and cat thalamocortical neurons: Role of a non-inactivating component in tonic and burst firing
36. The hyperpolarization which follows activity in mammalian non-modulated fibers
37. Slow sodium conductances of dorsal root ganglion neurons: Intraneuronal homogeneity and interneuronal heterogeneity
38. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons
39. Slow inactivation of the sodium conductance in squid giant axons Pronase resistance
40. Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia
41. + channels and their functions in small dorsal root ganglion neurones of rat
42. A- and C-type rat nodose sensory neurons: Model interpretations of dynamic discharge characteristics
43. + current heterogeneity in rat nodose neurons and its impact on neuronal discharge
44. Amplification of synaptic current by persistent sodium conductance in apical dendrite of neocortical neurons
45. Variation in IH, IIR and ILEAK between acutely isolated adult rat dorsal root ganglion neurons of different size
46. Activity-dependent slowing of conduction differentiates functional subtypes of C fibres innervating human skin
47. Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy
48. + current types
49. Properties of subthreshold response and action potential recorded in layer V neurons from cat sensorimotor cortex in vitro
50. Amplification of EPSPs by axosomatic sodium channels in neocortical pyramidal neurons
51. + conductance in rat optic nerve axons
52. Electrophysiological properties of neurons in intact rat dorsal root ganglia classified by conduction velocity and action potential duration
53. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons and is reexpressed following axotomy
54. Electrophysiological studies on rat dorsal root ganglion neurons after peripheral axotomy: Changes in responses to neuropeptides