Lysine point mutations in Na+ channel D4-S6 reduce inactivated channel block by local anesthetics

Molecular Pharmacology

Volumn 54, Issue 4, 1998, Pages 733-739

  Wright, Sterling N ^a,c   Wang, Sho Ya ^b   Wang, Ging Kuo ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c MURRAY STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BENZOCAINE; COCAINE; ION CHANNEL; LOCAL ANESTHETIC AGENT; LYSINE; SODIUM CHANNEL;

AMINO ACID SUBSTITUTION; ANESTHESIA MECHANISM; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG RECEPTOR BINDING; EMBRYO; HUMAN; HUMAN CELL; KIDNEY CELL; LOCAL ANESTHESIA; POINT MUTATION; PRIORITY JOURNAL;

ANESTHETICS, LOCAL; ANIMALS; BENZOCAINE; BINDING SITES; CELLS, CULTURED; COCAINE; HUMANS; KINETICS; LYSINE; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 0031725974     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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