Novel wasp toxin discriminates between neuronal and cardiac sodium channels

Molecular Pharmacology

Volumn 59, Issue 6, 2001, Pages 1457-1463

  Kinoshita, E ^a   Maejima, H ^a   Yamaoka, K ^a   Konno, K ^a   Kawai, N ^a   Shimizu, E ^a   Yokote, S ^a   Nakayama, H ^a   Seyama, I ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

POMPILIDOTOXIN; SODIUM CHANNEL; UNCLASSIFIED DRUG; WASP VENOM;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; EMBRYO; HUMAN; HUMAN CELL; KIDNEY CELL; MEMBRANE CURRENT; NERVE CELL; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT; STEADY STATE; SYNAPTIC TRANSMISSION;

EID: 0034992435     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.6.1457     Document Type: Article

References (34)

1. Charge movement associated with the opening and closing of the activation gates of the Na channels
2. Differences in the binding sites of two site-3 sodium channel toxins
3. A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B
4. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes
5. Structure and function of voltage-gated ion channels
6. From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels
7. Sea anemone toxin (ATX II) modulation of heart and skeletal muscle sodium channel α-subunits expressed in tsA201 cells
8. Regulation of sodium channel gene expression by transcriptional silencing
9. A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: Purification, primary structure, and mode of action
10. The putative bioactive surface of insect-selective scorpion excitatory neurotoxins
11. Importance of the unique cationic residues arginine 12 and lysine 49 in the activity of the cardiotonic polypeptide anthopleurin B
12. Gating of Na channels inactivation modifiers discriminate among models
13. Effects of α-pompilidotoxin on synchronized firing in networks of rat cortical neurons
14. + channel isoforms
15. Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination
16. On site of action of grayanotoxin in domain 4 segment 6 of rat skeletal muscle sodium channel
17. Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms
18. + channels proteins
19. α-pompilidotoxin (α-PMTX), a novel neurotoxin from the venom of a solitary wasp, facilitates transmission in the crustacean neuromuscular synapse
20. Positively charged amino acid residues located similarly in sea anemone and scorpion toxins
21. Anemone toxin (ATX II)-induced increase in persistent sodium current: Effects on the firing properties of rat neocortical pyramidal neurones
22. +-channels
23. Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons
24. + channel isoform
25. + channel α subunit
26. Sea anemone toxin: A tool to study molecular mechanisms of nerve conduction and excitation-secretion coupling
27. A new class of neurotoxin from wasp venom slows inactivation of sodium current
28. An integrated view of the molecular toxinology of sodium channel gating in excitable cells
29. Structural parts involved in activation and inactivation of the sodium channel
30. + channels
31. Site of covalent attachment of α-scorpion toxin derivatives in domain I of the sodium channel α subunit
32. Localization of the receptor site for α-scorpion toxins by antibody mapping: Implications for sodium channel topology
33. Molecular diversity of voltage-sensitive Na channels
34. Identification of structural elements of a scorpion α-neurotoxin important for receptor site recognition