A common local anesthetic receptor for benzocaine and etidocaine in voltage gated μ1 Na+ channels

Pflugers Archiv European Journal of Physiology

Volumn 435, Issue 2, 1998, Pages 293-302

  Wang, G K ^a   Quan, C ^a   Wang, S Y ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Benzocaine; Local anesthetics; Mutant muscle Na+ channels; Single receptor hypothesis

Indexed keywords

ANESTHETIC AGENT; BENZOCAINE; DRUG RECEPTOR; ETIDOCAINE; SODIUM CHANNEL;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; HYPOTHESIS; MUTANT; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANESTHETICS, LOCAL; BENZOCAINE; CELL LINE; ELECTRIC CONDUCTIVITY; EMBRYO; ETIDOCAINE; HUMANS; KIDNEY; LIDOCAINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, DRUG; SODIUM CHANNELS;

EID: 0031912281     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050515     Document Type: Article

References (24)

1. Backx PH, Yue DT, Lawrence JH, Marban E, Tomaselli GF (1992) Molecular localization of an ion-binding site within the pore of mammalian sodium channels. Science 257:248-251
2. Barber MJ, Starmer CF, Grant AO (1991) Blockade of cardiac sodium channels by amitriptyline and diphenylhydantoin: evidence for two use-dependent binding sites. Circ Res 69: 677-696
3. Butterworth JF, Strichartz GR (1990) Molecular mechanisms of local anesthetics: a review. Anesthesiology 72:711-734
4. Cannon SC, Strittmatter SM (1993) Functional expression of sodium channel mutations identified in families with periodic paralysis. Neuron 10:317-326
5. Catterall WA, Mackie K (1996) Local anesthetics. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 331-347
6. Elliott JR, Haydon DA, Hendry BM (1987) Local anesthetic effects of benzene and structurally related molecules, including benzocaine, on the squid giant axon. Pflügers Arch 409: 589-595
7. + channels by a quaternary ammonium ion: catalysis by a transition-intermediate state? J Physiol (Lond) 471:319-341
8. Hamill OP, Marty E, Neher ME, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85-100
9. Hille B (1977) Local anesthetics: hydrophilic and hydrophobic pathways for the drug receptor reaction. J Gen Physiol 69: 497-515
10. Hille B (1992) Mechanisms of block. In: Ionic channels of excitable membranes. Sinauer, Sunderland, Mass., pp 390-422
11. Hondeghem LM, Katzung BG (1977) Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta 472:373-398
12. Huang LYM, Ehrenstein G (1981) Local anesthetics QX-572 and benzocaine act at separate sites on the batrachotoxin-activated sodium channel. J Gen Physiol 77:137-153
13. Meeder T, Ulbricht W (1987) Action of benzocaine on sodium channels of frog nodes of Ranvier treated with chloramine-T. Pflügers Arch 409:265-273
14. Moczydlowski E, Uchara A, Hall S (1986) Blocking pharmacology of batrachotoxin activated sodium channels. In: Miller C (ed) Ion channel reconstitution. Plenum, New York, pp 405-428
15. Mrose HE, Ritchie JM (1978) Local anesthetics: do benzocaine and lidocaine act at the same single site? J Gen Physiol 71:223-225
16. + channel. Proc Natl Acad Sci USA 92:11839-11843
17. + currents by benzocaine homologs. Biophys J 70: 194-201
18. + channels by local anesthetics. Science 265:1724-1729
19. Rimmel C, Walle A, Kessler H, Ulbricht W (1978) Rates of block by procaine and benzocaine and the procaine-benzocaine interaction at the node of Ranvier. Pflügers Arch 376: 105-118
20. Schmidtmayer J, Ulbricht W (1980) Interaction of lidocaine and benzocaine in blocking sodium channels. Pflügers Arch 387:47-54
21. Strichartz GR (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J Gen Physiol 62:37-57
22. Trimmer JS, Cooperman SS, Tomiko SA, Zhou J, Crean SM, Boyle MB, Kallen RG, Sheng Z, Barchi RL, Sigmworth FJ, Goodman RH, Agnew WS, Mandel G (1989) Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron 3:33-49
23. Wang S-Y, Wang GK (1997) A mutation in seqment segment I-S6 alters slow inactivation of sodium channels. Biophys J 72: 1663-1640
24. Zamponi GW, French RJ (1993) Dissecting lidocaine action: diethylamide and phenol mimic separate modes of lidocaine block of sodium channels from heart and skeletal muscle. Biophys J 65:2335-2347