Molecular models of voltage sensing

Journal of General Physiology

Volumn 120, Issue 4, 2002, Pages 455-463

  Gandhi, Chris S ^a   Isacoff, Ehud Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSS LINKING; CRYSTAL STRUCTURE; ELECTRIC FIELD; MEMBRANE CURRENT; MOLECULAR MODEL; PROTEIN DOMAIN; REVIEW; SENSOR; VOLTAGE CLAMP;

ANIMALS; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, THEORETICAL; PERMEABILITY; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEINS;

EID: 0036792837     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.20028678     Document Type: Review

References (44)

1. Aggarwal, S.K., and R. MacKinnon. 1996. Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron. 16:1169-1177.
2. Baker, O.S., H.P. Larsson, L.M. Mannuzzu, and E.Y. Isacoff. 1998. Three transmembrane conformations and sequence-dependent displacement of the S4 domain in shaker K+ channel gating. Neuron. 20:1283-1294.
3. Bezanilla, F., E. Perozo, and E. Stefani. 1994. Gating of Shaker K+ channels: II. The components of gating currents and a model of channel activation. Biophys. J. 66:1011-1021.
4. Catterall, W.A. 1986. Molecular properties of voltage-sensitive sodium channels. Annu. Rev. Biochem. 55:953-985.
5. Cha, A., and F. Bezanilla. 1997. Characterizing voltage-dependent conformational changes in the Shaker K+ channel with fluorescence. Neuron. 19:1127-1140.
6. Cha, A., G.E. Snyder, P.R. Selvin, and F. Bezanilla. 1999. Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy. Nature. 402:809-813.
7. Doyle, D.A., J. Morais Cabral, R.A. Pfuetzner, A. Kuo, J.M. Gulbis, S.L. Cohen, B.T. Chait, and R. MacKinnon. 1998. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science. 280:69-77.
8. Elinder, F., R. Mannikko, and H.P. Larsson. 2001. S4 charges move close to residues in the pore domain during activation in a K channel. J. Gen. Physiol. 118:1-10.
9. Gandhi, C.S., E. Loots, and E.Y. Isacoff. 2000. Reconstructing voltage sensor-pore interaction from a fluorescence scan of a voltage-gated K+ channel. Neuron. 27:585-595.
10. Gandhi, C.S., and E.Y. Isacoff. 2002. Optical measurements from a voltage-gated channel reveal interactions between voltage-sensing and opening. Biophys. J. 82:232a.
11. Glauner, K.S., L.M. Mannuzzu, C.S. Gandhi, and E.Y. Isacoff. 1999. Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel. Nature. 402:813-817.
12. Gonzalez, C., E. Rosenman, F. Bezanilla, O. Alvarez, and R. Latorre. 2000. Modulation of the Shaker K(+) channel gating kinetics by the S3-S4 linker. J. Gen. Physiol. 115:193-208.
13. Gonzalez, C., E. Rosenman, E Bezanilla, O. Alvarez, and R, Latorre. 2001. Periodic perturbations in Shaker K+ channel gating kinetics by deletions in the S3-S4 linker. Proc. Natl. Acad. Sci. USA. 98:9617-9623.
14. Guerrero, G., M.S. Siegel, B. Roska, E. Loots, and E.Y. Isacoff. 2002, Tuning FlaSh: redesign of the dynamics, voltage range and color of the genetically-encoded optical sensor of membrane potential. Biophys. J. In press.
15. Guy, H.R., and P. Seetharamulu. 1986. Molecular model of the action potential sodium channel. Proc. Natl. Acad. Sci. USA. 83:508-512.
16. Horn, R. 2002. Coupled movements in voltage-gated ion channels. J. Gen. Physiol. 120:449-453.
17. Jiang, Y., A. Lee, J. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002. The open pore conformation of potassium channels. Nature. 417:523-526.
18. Laine, M., J.P.A. Bannister, W.R. Silverman, M.C. Lin, A.F. Mock, and D.M. Papazian. 2002. Structural interaction between voltage sensor and pore in Shaker K+ channels. Biophys. J. 82:231a.
19. Larsson, H.P., O.S. Baker, D.S. Dhillon, and E.Y. Isacoff. 1996. Transmembrane movement of the shaker K+ channel S4. Neuron. 16:387-397.
20. Lecar, H., and H.P. Larsson. 1997. Theory of S4 motion in voltage-gated channels. Biophys. J. 72:341a.
21. Ledwell, J.L., and R.W. Aldrich. 1999. Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J. Gen. Physiol. 113:389-414.
22. Li-Smerin, Y., D.H. Hackos, and K.J. Swartz. 2000a. alpha-helical structural elements within the voltage-sensing domains of a K(+) channel. J. Gen. Physiol. 115:33-50.
23. Li-Smerin, Y., D.H. Hackos, and K.J. Swartz. 2000b. A localized interaction surface for voltage-sensing domains on the pore domain of a K+ channel. Neuron. 25:411-423.
24. Loots, E., and E.Y. Isacoff. 2000. Molecular coupling of S4 to a K(+) channel's slow inactivation gate. J. Gen. Physiol. 116:623-636.
25. Mannuzzu, L.M., M.M. Moronne, and E.Y. Isacoff. 1996. Direct physical measure of conformational rearrangement underlying potassium channel gating. Science. 271:213-216.
26. Papazian, D.M., X.M. Shao, S.A. Seoh, A.E Mock, Y. Huang, and D.H. Wainstock. 1995. Electrostatic interactions of S4 voltage sensor in Shaker K+ channel. Neuron. 14:1293-1301.
27. Peled-Zehavi, H., I.T. Arkin, D.M. Engelman, and Y. Shai. 1996. Coassembly of synthetic segments of shaker K+ channel within phospholipid membranes. Biochemistry. 35:6828-6838.
28. Pomes, R., and B. Roux. 2002. Molecular mechanism of h(+) conduction in the single-file water chain of the gramicidin channel. Biophys. J. 82:2304-2316.
29. Schoppa, N.E., K. McCormack, M.A. Tanouye, and F.J. Sigworth. 1992. The size of gating charge in wild-type and mutant Shaker potassium channels. Science. 255:1712-1715.
30. + channel. Neuron. In press.
31. Schoppa, N.E., and F.J. Sigworth. 1998. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J. Gen. Physiol. 111:313-342.
32. Seoh, S.A., D. Sigg, D.M. Papazian, and E Bezanilla. 1996. Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel. Neuron. 16:1159-1167.
33. Siegel, M.S., and E.Y. Isacoff. 1997. A genetically encoded optical probe of membrane voltage. Neuron. 19:735-741.
34. Silverman, W.R., C.Y. Tang, A.F Mock, K.B. Huh, and D.M. Papazian. 2000. Mg(2+) modulates voltage-dependent activation in ether-a-go-go potassium channels by binding between transmembrane segments S2 and S3. J. Gen. Physiol. 116:663-678.
35. Starace, D.M., and F. Bezanilla. 2002. Resonance energy transfer measurements of transmembrane motion in the Shaker K+ channel voltage sensing region. Biophys. J. 82:174a.
36. Starace, D.M., and F. Bezanilla. 2001. Histidine scanning mutagenesis of basic residues of the S4 segment of the shaker k+ channel. J. Gen. Physiol. 117:469-490.
37. Starace, D.M., and E Bezanilla. 1999. Histidine at position 362 causes inwardly rectifying H+ conductance in the Shaker K+ channel. Biophys. J. 74:254a.
38. Starace, D.M., E. Stefani, and F. Bezanilla. 1997. Voltage-dependent proton transport by the voltage sensor of the Shaker K+ channel. Neuron. 19:1319-1327.
39. Tiwari-Woodruff, S.K., C.T. Schulteis, A.F. Mock, and D.M. Papazian. 1997. Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits. Biophys. J. 72:1489-1500.
40. Tiwari-Woodruff, S.K., M.A. Lin, C.T. Schulteis, and D.M. Papazian. 2000. Voltage-dependent structural interactions in the Shaker K(+) channel. J. Gen. Physiol. 115:123-138.
41. Wang, M.H., S.P. Yusaf, DJ. Elliott, D. Wray, and A. Sivaprasadarao. 1999. Effect of cysteine substitutions on the topology of the S4 segment of the Shaker potassium channel: implications for molecular models of gating. J. Physiol. 521:315-326.
42. Yang, N., A.L. George, and R. Horn. 1996. Molecular basis of charge movement in voltage-gated sodium channels. Neuron. 16:113-122.
43. Yusaf, S.P., D. Wray, and A. Sivaprasadarao. 1996. Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel. Pflugers Arch. 433:91-97.
44. Yellen, G. 1998. The moving parts of voltage-gated ion channels. Q. Rev. Biophys. 31:239-295.