Molecular determinants of β1 subunit-induced gating modulation in voltage-dependent Na+ channels

Journal of Neuroscience

Volumn 16, Issue 22, 1996, Pages 7117-7127

  Makita, Naomasa ^a,c   Bennett, Paul B ^a   George Jr , Alfred L ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

electrophysiology; heart; hH1; hSkM1; human ion channels; ion channel gating; Na+ channel; SCN4A; SCNSA; skeletal muscle; subunit interaction

Indexed keywords

SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CHANNEL GATING; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM TRANSPORT; TISSUE DISTRIBUTION; XENOPUS;

EID: 0029826499     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-22-07117.1996     Document Type: Article

References (48)

1. + channel α subunit with novel gating properties. Neuron 1:449-461.
2. Backx PH, Yue DT, Lawrence JH, Marban E, Tomaselli GF (1992) Molecular localization of an ion-binding site within the pore of mammalian sodium channels. Science 257:248-251.
3. Beneski DA, Catterall WA (1980) Covalent labeling of protein components of the sodium channel with a photactivable derivative of scorpion toxin. Proc Natl Acad Sci USA 77:639-643.
4. Bennett PB, Makita N, George Jr AL (1993) A molecular basis for gating mode transitions in human skeletal muscle sodium channels. FEBS Lett 326:21-24.
5. + current conducted by the rat skeletal muscle α subunit by coexpression with a human brain β subunit. Pflügers Arch 423:155-157.
6. Catterall WA (1988) Structure and function of voltage-sensitive ion channels. Science 242:50-61.
7. Catterall WA (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol Rev 72:S15-S48.
8. 1 subunit: a deletion analysis. Pflügers Arch 431:186-195.
9. Cohen SA, Levitt LK (1993) Partial characterization of the rH1 sodium channel protein from rat heart using subtype-specific antibodies. Circ Res 73:735-742.
10. + channel isoform. FEBS Lett 275:195-200.
11. + channel mutant: possible localization of a binding site at the outer vestibule. Biophys J 69:1657-1665.
12. Gellens ME, George AL, Chen L, Chahine M, Horn R, Barchi RL, Kallen RG (1992) Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc Natl Acad Sci USA 89:554-558.
13. George AL, Komisarof J, Kallen RG, Barchi RL (1992) Primary structure of the adult human skeletal muscle voltage-dependent sodium channel. Ann Neurol 31:131-137.
14. Goldin AL, Snutch T, Lubbert H, Dowsett A, Marshall J, Auld V, Downey W, Fritz LC, Lester HA, Dunn R, Catterall WA, Davidson N (1986) Messenger RNA coding for only the a subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes. Proc Natl Acad Sci USA 83:7503-7507.
15. Gordon D, Merrick D, Wollner DA, Catterall WA (1988) Biochemical properties of sodium channels in a wide range of excitable tissues studied with site-directed antibodies. Biochemistry 27:7032-7038.
16. Guy HR, Conti F (1990) Pursuing the structure and function of voltage-gated channels. Trends Neurosci 13:201-206.
17. Heinemann SH, Terlau H, Stühmer W, Imoto K, Numa S (1992) Calcium channel characteristics conferred on the sodium channel by single mutations. Nature 356:441-443.
18. Higuchi R (1989) Using PCR to engineer DNA. In: PCR technology (Erlich HA, ed), pp 61-70. New York: Stockton.
19. 1 subunit of the rat brain sodium channel. Science 256:839-842.
20. 2 subunit of brain sodium channels, a transmembrane glycoprolein with a CAM motif. Cell 83:433-442.
21. 1 and type IIA α subunits of sodium channels in a mammalian cell line. J Biol Chem 270:3306-3312.
22. Klugbauer N, Lacinova L, Flockerzi V, Hofmann F (1995) Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. EMBO J 14:1084-1090.
23. Krieg PA, Melton DA (1987) In vitro RNA synthesis with SP6 RNA polymerase. Methods Enzymol 155:397-415.
24. 1 Na channel subunit interactions with rat brain IIa, skeletal muscle (μ1), and rat heart (RH1) α-subunits. Biophys J 64:A88.
25. + channel using Tityus toxin gamma. Eur J Biochem 141:651-660.
26. 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene. J Biol Chem 269:7571-7578.
27. + channels. Circ Res 78:244-252.
28. McPhee JC, Ragsdale DS, Scheuer T, Catterall WA (1994) A mutation in segment IVS6 disrupts fast inactivation of sodium channels. Proc Natl Acad Sci USA 91:12346-12350.
29. Messner DJ, Catterall WA (1985) The sodium channel from rat brain. Separation and characterization of subunits. J Biol Chem 260:10597-10604.
30. 2 subunit. J Biol Chem 261:14882-14890.
31. Noda M, Suzuki H, Numa S, Stühmer W (1989) A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II. FEBS Lett 259:213-216.
32. 1 subunit with human cardiac (hH1) and rat skeletal muscle (μI) sodium channel α subunits expressed in Xenopus oocytes. J Gen Physiol 106:1171-1191.
33. 1 subunit modifies activation and inactivation gating of multiple sodium channel α subunits. J Biol Chem 269:17649-17655.
34. 1-subunit. Nature 368:67-70.
35. Pusch M, Noda M, Stühmer W, Numa S, Conti F (1991) Single point mutations of the sodium channel drastically reduce the pore permeability without preventing its gating. Eur Biophys J 20:127-133.
36. 1 subunits. J Biol Chem 270:25696-25701.
37. + channels altered by presence of β-subunit. Nature 369:289-294.
38. Roberts RH, Barchi RL (1987) The voltage-sensitive sodium channel from rabbit skeletal muscle. Chemical characterization of subunits. J Biol Chem 262:2298-2303.
39. Satin J, Kyle JW, Chen M, Bell P, Cribbs LL, Fozzard HA, Rogart RB (1992) A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties. Science 256:1202-1205.
40. Stühmer W, Conti F, Suzuki H, Wang X, Noda M, Yahagi N, Kubo H, Numa S (1989) Structural parts involved in activation and inactivation of the sodium channel. Nature 339:597-603.
41. Sun W, Barchi RL, Cohen SA (1995) Probing sodium channel cytoplasmic domain structure. Evidence for the interaction of the rSkM1 amino and carboxyl termini. J Biol Chem 270:22271-22276.
42. Tejedor FJ, Catterall WA (1988) Site of covalent attachment of α-scorpion toxin derivatives in domain I of the sodium channel α subunit. J Biol Chem 85:8742-8746.
43. Terlau H, Heinemann SH, Stühmer W, Pusch M, Conti F, Imoto K, Numa S (1991) Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. FEBS Lett 293:93-96.
44. Thomsen WJ, Catterall WA (1989) Localization of the receptor site for α-scorpion toxins by antibody mapping: implications for sodium channel topology. Proc Natl Acad Sci USA 86:10161-10165.
45. Trainer VL, Baden DG, Catterall WA (1994) Identification of peptide components of the brevetoxin receptor site of rat brain sodium channels. J Biol Chem 269:19904-19909.
46. Trimmer JS, Cooperman SS, Tomiko SA, Zhou J, Crean SM, Boyle MB, Kallen RG, Sheng Z, Barchi RL, Sigworth FJ, Goodman RH, Agnew WS, Mandel G (1989) Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron 3:33-49.
47. +-channel inactivation. Proc Natl Acad Sci USA 89:10910-10914.
48. Zhang JF, Ellinor PT, Tsien RW, Aldrich RW (1995) Molecular determinants of sodium channel inactivation include residues near segment IS6. Biophys J 68:A361.