X-ray structure of a voltage-dependent K+ channel

Nature

Volumn 423, Issue 6935, 2003, Pages 33-41

  Jiang, Youxing ^a,b   Lee, Alice ^a   Chen, Jiayun ^a   Ruta, Vanessa ^a   Cadene, Martine ^a   Chait, Brian T ^a   MacKinnon, Roderick ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; ELECTRIC CONDUCTIVITY; ELECTRIC POTENTIAL; MUSCLE; POTASSIUM; SENSORS; X RAY ANALYSIS;

CELL MEMBRANE VOLTAGE;

POSITIVE IONS;

CALCIUM CHANNEL; CATION CHANNEL; IMMUNOGLOBULIN F(AB) FRAGMENT; POTASSIUM CHANNEL; SODIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

BIOCHEMISTRY;

ARTICLE; CHANNEL GATING; CRYSTAL STRUCTURE; ION CONDUCTANCE; MUSCLE ACTION POTENTIAL; PRIORITY JOURNAL; SENSOR;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ARCHAEAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; DESULFUROCOCCACEAE; ELECTROSTATICS; HYDROPHOBICITY; IMMUNOGLOBULIN FAB FRAGMENTS; ION CHANNEL GATING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, TERTIARY;

AEROPYRUM PERNIX;

EID: 0038076054     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01580     Document Type: Article

References (43)

1. Hille, B. Ion Channels of Excitable Membranes (Sinauer, Sunderland, Massachusetts, 2001).
2. Hodgkin, A. L. & Huxley, A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond.) 117, 500-544 (1952).
3. + channels. J. Gen. Physiol. 63, 533-552 (1974).
4. Sigworth, F. J. Voltage gating of ion channels. Q. Rev. Biophys. 27, 1-40 (1994).
5. Bezanilla, F. The voltage sensor in voltage-dependent ion channels. Physiol. Rev. 80, 555-592 (2000).
6. Schoppa, N. E., McCormack, K., Tanouye, M. A. & Sigworth, F. J. The size of gating charge in wildtype and mutant Shaker potassium channels. Science 255, 1712-1715 (1992).
7. + channel. Neuron 16, 1159-1167 (1996).
8. + channel. Neuron 16, 1169-1177 (1996).
9. Noda, M et al. Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. Nature 312, 121-127 (1984).
10. Tanabe, T. et al. Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature 328, 313-318 (1987).
11. Tempel, B. L., Papazian, D. M., Schwarz, T. L., Jan, L. Y. & Jan, Y. N. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. Science 237, 770-775 (1987).
12. Yang, N. & Horn, R. Evidence for voltage-dependent S4 movement in sodium channels. Neuron 15, 213-218 (1995).
13. + channel S4. Neuron 16, 387-397 (1996).
14. Yusaf, S. P., Wray, D. & Sivaprasadarao, A. Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel. Pflugers Arch. 433, 91-97 (1996).
15. + channel gating. Neuron 20, 1283-1294 (1998).
16. Mannuzzu, L. M., Moronne, M. M. & Isacoff, E. Y. Direct physical measure of conformational rearrangement underlying potassium channel gating. Science 271, 213-216 (1996).
17. + channel with fluorescence. Neuron 19, 1127-1140 (1997).
18. Horn, R. Coupled movements in voltage-gated ion channels. J. Gen. Physiol. 120, 449-453 (2002).
19. Gandhi, C. S. & Isacoff, E. Y. Molecular models of voltage sensing. J. Gen. Physiol. 120, 455-463 (2002).
20. Bezanilla, F. Voltage sensor movements. J. Gen. Physiol. 120, 465-473 (2002).
21. + channel. Nature 422, 180-185; advance online publication, 2 March 2003 (doi:10.1038/ nature01473).
22. + channel. Nature 423, 42-48 (2003).
23. + conduction and selectivity. Science 280, 69-77 (1998).
24. + channel-Fab complex at 2.0 Å resolution. Nature 414, 43-48 (2001).
25. Jiang, Y. et al. Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417, 515-522 (2002).
26. Jiang, Y. et al. The open pore conformation of potassium channels. Nature 417, 523-526 (2002).
27. + channels. Neuron 18, 675-682 (1997).
28. + channel through multiple binding sites. Neuron 18, 665-673 (1997).
29. Lu, Z., Klem, A. M. & Ramu, Y. Ion conduction pore is conserved among potassium channels. Nature 413, 809-813 (2001).
30. Santacruz-Toloza, L., Huang, Y., John, S. A. & Papazian, D. M. Glycosylation of Shaker potassium channel protein in insect cell culture and in Xenopus oocytes. Biochemistry 33, 5607-5613 (1994).
31. + channel. Nature Struct. Biol. 7, 309-311 (2000).
32. Slatin, S. L., Qiu, X. Q., Jakes, K. S. & Finkelstein, A. Identification of a translocated protein segment in a voltage-dependent channel. Nature 371, 158-161 (1994).
33. Qiu, X. Q., Jakes, K. S., Kienker, P. K., Finkelstein, A. & Slatin, S. L. Major transmembrane movement associated with colicin Ia channel gating. J. Gen. Physiol. 107, 313-328 (1996).
34. Harlow, E. & Lane, D. Antibodies: A Laboratory Manual (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1989).
35. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).
36. Collaborative Computational Project, N.4 The CCP4 suite: programs for X-ray crystallography. Acta Crystallogr. D 50, 760-763 (1994).
37. Navaza, J. AMoRe: an automated package for molecular replacement. Acta Crystallogr A 50, 157-163 (1994).
38. Brunger, A. T., Leahy, D. J., Hynes, T. R. & Fox, R. O. 2.9 Å resolution structure of an antidinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten. J. Mol. Biol. 221, 239-256 (1991).
39. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119 (1991).
40. Brunger, A. T. et al. Crystallography & NMR System: a new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905-921 (1998).
41. + channels. Functional asymmetries and sidedness of proton activation. J. Gen. Physiol. 114, 551-560 (1999).
42. Carson, M. Ribbons. Methods Enzymol. 277, 493-505 (1997).
43. Thompson, J. D., Higgins, D. G. & Gibson, T. J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680 (1994).