Interaction of scorpion α-toxins with cardiac sodium channels: Binding properties and enhancement of slow inactivation

Journal of General Physiology

Volumn 117, Issue 6, 2001, Pages 505-518

  Chen, H ^a   Heinemann, S H ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Cardiac muscle; Leiurus quinquestriatus hebraeus; Patch clamp; Receptor site 3; Skeletal muscle

Indexed keywords

ALPHA TOXIN; MEMBRANE PROTEIN; RECEPTOR; SCORPION VENOM; SODIUM CHANNEL;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DISSOCIATION; ELECTRIC POTENTIAL; EMBRYO; HEART DEPOLARIZATION; HEART MUSCLE; HUMAN; HUMAN CELL; PATCH CLAMP; PROTEIN BINDING; SKELETAL MUSCLE; STEADY STATE;

ANIMALS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; HEART; HUMANS; KIDNEY; MYOCARDIUM; SCORPION VENOMS; SODIUM CHANNELS;

EID: 0034970706     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.117.6.505     Document Type: Article

References (38)

1. External pore residue mediates slow inactivation in μl rat skeletal muscle sodium channels
2. Differences in the binding sites of two site-3 sodium channel toxins
3. A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B
4. + channel toxins
5. Cellular and molecular biology of voltage-gated sodium channels
6. Electrophysiological characteristics of cloned skeletal and cardiac muscle sodium channels
7. Sea anemone toxin (ATX II) modulation of heart and skeletal muscle sodium channel alpha-subunits expressed in tsA201 cells
8. Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and LqhαIT
9. Impaired slow inactivation in mutant sodium channels
10. A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: Purification, primary structure, and mode of action
11. Interaction between fast and slow inactivation in Skm1 sodium channels
12. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel
13. Sodium channels as targets for neurotoxins: Mode of action and interaction of neurotoxins with receptor sites on sodium channels
14. Functional anatomy of scorpion toxins affecting sodium channels
15. Slow inactivation differs among mutant sodium channels associated with myotonia and periodic paralysis
16. NMR structures and activity of a novel a-like toxin from the scorpion Leiurus quinquestriatus hebraeus
17. + channels
18. + channel
19. + channel
20. Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin ω-grammotoxin-SIA
21. Role of domain 4 in sodium channel slow inactivation
22. A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence
23. + channel chimaeras
24. + channel fast and slow inactivation in paramyotonia congen-ita mutants expressed in Xenopus laevis oocytes
25. Slow inactivation in human cardiac sodium channels
26. + channel alpha subunit
27. Slow inactivation of the sodium channel conductance in squid giant axons. Pronase resistance
28. New toxins acting on sodium channels from the scorpion Leiurus quinquestriatus hebraeus suggest a clue to mammalian vs insect selectivity
29. + channels
30. Localization of the receptor site for α-scorpion toxins by antibody mapping: Implications for sodium channel topology
31. + channels in excised membrane patches after modification by alpha-chymotrypsin
32. + channels
33. Structural determinants of slow inactivation in human cardiac and skeletal muscle sodium channels
34. A mutation in segment I-S6 alters slow inactivation of sodium channels
35. +-channel inactivation
36. A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels
37. Identification of structural elements of a scorpion a-neurotoxin important for receptor site recognition