A sodium channel mutation causing epilepsy in man exhibits subtle defects in fast inactivation and activation in vitro

Journal of Physiology

Volumn 529, Issue 3, 2000, Pages 533-540

  Alekov, Alexi K ^a   Rahman, Md Masmudur ^a   Mitrovic, Nenad ^a   Lehmannhorn, Frank ^a   Lerche, Holger ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; COMPLEMENTARY DNA; HISTIDINE; SODIUM; SODIUM CHANNEL; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.4;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTICONVULSANT THERAPY; ARTICLE; BETA CHAIN; CELL LINE; CENTRAL NERVOUS SYSTEM; CHROMOSOME 19Q; CHROMOSOME 2Q; CONTROLLED STUDY; ELECTRIC POTENTIAL; EXCITABILITY; FEBRILE CONVULSION; GENE MUTATION; GENERALIZED EPILEPSY; GENETIC LINKAGE; IN VITRO STUDY; MAMMAL CELL; MUSCLE TISSUE; MYOPATHY; MYOTONIA; NERVE CELL; NONHUMAN; PATCH CLAMP; PERIODIC PARALYSIS; PRIORITY JOURNAL; SKELETAL MUSCLE; SODIUM CURRENT; TIME; ACTIVATION TIME CONSTANT; EPILEPSY; GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS; INACTIVATION TIME CONSTANT; MUTANT; SCN1A GENE; SCN4A GENE; WILD TYPE;

EID: 0034671216     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2000.00533.x     Document Type: Article

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