Point mutations at L1280 in Nav1.4 Channel D3-S6 modulate binding affinity and stereoselectivity of bupivacaine enantiomers

Molecular Pharmacology

Volumn 63, Issue 6, 2003, Pages 1398-1406

  Nau, Carla ^a   Wang, Sho Ya ^b   Wang, Ging Kuo ^c  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; DRUG RESIDUE; LOCAL ANESTHETIC AGENT; MEMBRANE PROTEIN; MUTANT PROTEIN; SODIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG POTENCY; ELECTROPHYSIOLOGY; ENANTIOMER; GENETIC TRANSFECTION; ION CONDUCTANCE; NONHUMAN; PHYSICAL CHEMISTRY; POINT MUTATION; PRIORITY JOURNAL; RAT; SITE DIRECTED MUTAGENESIS; SKELETAL MUSCLE; STEREOCHEMISTRY;

AMINO ACID SUBSTITUTION; ANESTHETICS, LOCAL; ANIMALS; ASPARAGINE; BUPIVACAINE; CELLS, CULTURED; GLUTAMIC ACID; GLUTAMINE; HUMANS; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STEREOISOMERISM;

EID: 0038102242     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.6.1398     Document Type: Article

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