Mexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na+ channel

Journal of Physiology

Volumn 537, Issue 3, 2001, Pages 701-714

  Takahashi, Masanori P ^a   Cannon, Stephen C ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOCAL ANESTHETIC AGENT; MEXILETINE; SODIUM CHANNEL; SODIUM ION;

ADULT; ALPHA CHAIN; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SIMULATION; DISSOCIATION CONSTANT; DRUG EFFECT; DRUG PROTEIN BINDING; EMBRYO; HOMEOSTASIS; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MISSENSE MUTATION; MOLECULAR MODEL; MUTANT; MYOPATHY; MYOTONIA; PATHOGENESIS; PERIODIC PARALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SODIUM CURRENT; DRUG MECHANISM; GENETIC ASSOCIATION; HEK293 CELL LINE; HUMAN TISSUE; REST; SKELETAL MUSCLE; TRANSIENT EXPRESSION; WHOLE CELL; WHOLE CELL PATCH CLAMP; WILD TYPE;

BINDING, COMPETITIVE; CELL LINE; COMPUTER SIMULATION; ELECTRIC STIMULATION; HUMANS; ION CHANNEL GATING; MEXILETINE; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; MUTATION, MISSENSE; MYOTONIA; PARALYSES, FAMILIAL PERIODIC; SODIUM CHANNELS;

EID: 0035893884     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2001.012541     Document Type: Article

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