메뉴 건너뛰기




Volumn 78, Issue 3, 2005, Pages 260-277

Transporters and drug therapy: Implications for drug disposition and disease

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR; ANTIVIRUS AGENT; BOSENTAN; CARRIER PROTEIN; CEFALORIDINE; CIDOFOVIR; CIMETIDINE; CLARITHROMYCIN; CYCLOSPORIN; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOFETILIDE; ERYTHROMYCIN; ESTROGEN; FEXOFENADINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEVOFLOXACIN; LOPERAMIDE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PENICILLIN G; PROBENECID; PROCAINAMIDE; QUINIDINE; RIFAMPICIN; TALINOLOL; TROGLITAZONE; UNINDEXED DRUG; VERAPAMIL; XENOBIOTIC AGENT;

EID: 24344439264     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2005.05.011     Document Type: Review
Times cited : (436)

References (147)
  • 1
    • 0002485410 scopus 로고    scopus 로고
    • Pharmacokinetics: The dynamics of drug absorption, distribution, and elimination
    • J.G. Hardman L.E. Limbird A.G. Gilman McGraw-Hill New York
    • G. Wilkinson Pharmacokinetics the dynamics of drug absorption, distribution, and elimination J.G. Hardman L.E. Limbird A.G. Gilman Goodman & Gilman's the pharmacological basis of therapeutics 2001 McGraw-Hill New York 3 29
    • (2001) Goodman & Gilman's the Pharmacological Basis of Therapeutics , pp. 3-29
    • Wilkinson, G.1
  • 2
    • 0002822638 scopus 로고    scopus 로고
    • Pharmacodynamics: Mechanisms of drug action and the relationship between drug concentration and effect
    • J.G. Hardman L.E. Limbird A.G. Gilman McGraw-Hill New York
    • E.M. Ross, T.P. Kenakin Pharmacodynamics mechanisms of drug action and the relationship between drug concentration and effect J.G. Hardman L.E. Limbird A.G. Gilman Goodman & Gilman's the pharmacological basis of therapeutics 2001 McGraw-Hill New York 31 43
    • (2001) Goodman & Gilman's the Pharmacological Basis of Therapeutics , pp. 31-43
    • Ross, E.M.1    Kenakin, T.P.2
  • 5
    • 0037427972 scopus 로고    scopus 로고
    • The superfamily of organic anion transporting polypeptides
    • B. Hagenbuch, P.J. Meier The superfamily of organic anion transporting polypeptides Biochim Biophys Acta 1609 2003 1 18
    • (2003) Biochim Biophys Acta , vol.1609 , pp. 1-18
    • Hagenbuch, B.1    Meier, P.J.2
  • 6
    • 0030724010 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide mediates organic anion/HCO3-exchange
    • L.M. Satlin, V. Amin, A.W. Wolkoff Organic anion transporting polypeptide mediates organic anion/HCO3-exchange J Biol Chem 272 1997 26340 26345
    • (1997) J Biol Chem , vol.272 , pp. 26340-26345
    • Satlin, L.M.1    Amin, V.2    Wolkoff, A.W.3
  • 7
    • 0032568838 scopus 로고    scopus 로고
    • Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter
    • L. Li, T.K. Lee, P.J. Meier, N. Ballatori Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter J Biol Chem 273 1998 16184 16191
    • (1998) J Biol Chem , vol.273 , pp. 16184-16191
    • Li, L.1    Lee, T.K.2    Meier, P.J.3    Ballatori, N.4
  • 8
    • 0032859340 scopus 로고    scopus 로고
    • Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain
    • B. Gao, B. Stieger, B. Noe, J.M. Fritschy, P.J. Meier Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain J Histochem Cytochem 47 1999 1255 1264
    • (1999) J Histochem Cytochem , vol.47 , pp. 1255-1264
    • Gao, B.1    Stieger, B.2    Noe, B.3    Fritschy, J.M.4    Meier, P.J.5
  • 9
    • 0033943874 scopus 로고    scopus 로고
    • Oatp2 mediates bidirectional organic solute transport: A role for intracellular glutathione
    • L. Li, P.J. Meier, N. Ballatori Oatp2 mediates bidirectional organic solute transport a role for intracellular glutathione Mol Pharmacol 58 2000 335 340
    • (2000) Mol Pharmacol , vol.58 , pp. 335-340
    • Li, L.1    Meier, P.J.2    Ballatori, N.3
  • 10
    • 0028229150 scopus 로고
    • Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
    • A.H. Schinkel, J.J. Smit, O. van Tellingen, J.H. Beijnen, E. Wagenaar, L. van Deemter Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs Cell 77 1994 491 502
    • (1994) Cell , vol.77 , pp. 491-502
    • Schinkel, A.H.1    Smit, J.J.2    Van Tellingen, O.3    Beijnen, J.H.4    Wagenaar, E.5    Van Deemter, L.6
  • 11
    • 12644278301 scopus 로고    scopus 로고
    • Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
    • A. Sparreboom, J. van Asperen, U. Mayer, A.H. Schinkel, J.W. Smit, D.K. Meijer Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine Proc Natl Acad Sci U S A 94 1997 2031 2035
    • (1997) Proc Natl Acad Sci U S a , vol.94 , pp. 2031-2035
    • Sparreboom, A.1    Van Asperen, J.2    Mayer, U.3    Schinkel, A.H.4    Smit, J.W.5    Meijer, D.K.6
  • 12
    • 0028825399 scopus 로고
    • Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin a
    • A.H. Schinkel, E. Wagenaar, L. van Deemter, C.A. Mol, P. Borst Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A J Clin Invest 96 1995 1698 1705
    • (1995) J Clin Invest , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1    Wagenaar, E.2    Van Deemter, L.3    Mol, C.A.4    Borst, P.5
  • 13
    • 0032518290 scopus 로고    scopus 로고
    • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
    • R.B. Kim, M.F. Fromm, C. Wandel, B. Leake, A.J. Wood, D.M. Roden The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors J Clin Invest 101 1998 289 294
    • (1998) J Clin Invest , vol.101 , pp. 289-294
    • Kim, R.B.1    Fromm, M.F.2    Wandel, C.3    Leake, B.4    Wood, A.J.5    Roden, D.M.6
  • 14
    • 12644272784 scopus 로고    scopus 로고
    • Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine
    • K.S. Lown, R.R. Mayo, A.B. Leichtman, H.L. Hsiao, D.K. Turgeon, P. Schmiedlin-Ren Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine Clin Pharmacol Ther 62 1997 248 260
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 248-260
    • Lown, K.S.1    Mayo, R.R.2    Leichtman, A.B.3    Hsiao, H.L.4    Turgeon, D.K.5    Schmiedlin-Ren, P.6
  • 16
    • 0035012075 scopus 로고    scopus 로고
    • Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes
    • D. Nakai, R. Nakagomi, Y. Furuta, T. Tokui, T. Abe, T. Ikeda Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes J Pharmacol Exp Ther 297 2001 861 867
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 861-867
    • Nakai, D.1    Nakagomi, R.2    Furuta, Y.3    Tokui, T.4    Abe, T.5    Ikeda, T.6
  • 17
    • 0030753176 scopus 로고    scopus 로고
    • Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats
    • M. Masuda, Y. I'izuka, M. Yamazaki, R. Nishigaki, Y. Kato, K. Ni'inuma Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats Cancer Res 57 1997 3506 3510
    • (1997) Cancer Res , vol.57 , pp. 3506-3510
    • Masuda, M.1    I'Izuka, Y.2    Yamazaki, M.3    Nishigaki, R.4    Kato, Y.5    Ni'Inuma, K.6
  • 18
    • 0030906434 scopus 로고    scopus 로고
    • Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats
    • X.Y. Chu, Y. Kato, Y. Sugiyama Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats Cancer Res 57 1997 1934 1938
    • (1997) Cancer Res , vol.57 , pp. 1934-1938
    • Chu, X.Y.1    Kato, Y.2    Sugiyama, Y.3
  • 19
    • 0037155204 scopus 로고    scopus 로고
    • Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2)
    • M. Sasaki, H. Suzuki, K. Ito, T. Abe, Y. Sugiyama Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2) J Biol Chem 277 2002 6497 6503
    • (2002) J Biol Chem , vol.277 , pp. 6497-6503
    • Sasaki, M.1    Suzuki, H.2    Ito, K.3    Abe, T.4    Sugiyama, Y.5
  • 20
    • 0036842911 scopus 로고    scopus 로고
    • Structure, function, and regulation of renal organic anion transporters
    • G. You Structure, function, and regulation of renal organic anion transporters Med Res Rev 22 2002 602 616
    • (2002) Med Res Rev , vol.22 , pp. 602-616
    • You, G.1
  • 21
    • 0035212257 scopus 로고    scopus 로고
    • Drug transporters in the central nervous system: Brain barriers and brain parenchyma considerations
    • G. Lee, S. Dallas, M. Hong, R. Bendayan Drug transporters in the central nervous system brain barriers and brain parenchyma considerations Pharmacol Rev 53 2001 569 596
    • (2001) Pharmacol Rev , vol.53 , pp. 569-596
    • Lee, G.1    Dallas, S.2    Hong, M.3    Bendayan, R.4
  • 23
    • 0033514320 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine
    • M.F. Fromm, R.B. Kim, C.M. Stein, G.R. Wilkinson, D.M. Roden Inhibition of P-glycoprotein-mediated drug transport a unifying mechanism to explain the interaction between digoxin and quinidine Circulation 99 1999 552 557
    • (1999) Circulation , vol.99 , pp. 552-557
    • Fromm, M.F.1    Kim, R.B.2    Stein, C.M.3    Wilkinson, G.R.4    Roden, D.M.5
  • 24
    • 0032807119 scopus 로고    scopus 로고
    • P-glycoprotein-dependent disposition kinetics of tacrolimus: Studies in mdr1a knockout mice
    • K. Yokogawa, M. Takahashi, I. Tamai, H. Konishi, M. Nomura, S. Moritani P-glycoprotein-dependent disposition kinetics of tacrolimus studies in mdr1a knockout mice Pharm Res 16 1999 1213 1218
    • (1999) Pharm Res , vol.16 , pp. 1213-1218
    • Yokogawa, K.1    Takahashi, M.2    Tamai, I.3    Konishi, H.4    Nomura, M.5    Moritani, S.6
  • 25
    • 0027327987 scopus 로고
    • Epidemiology of drug-drug interactions as a cause of hospital admissions
    • C.A. Jankel, L.K. Fitterman Epidemiology of drug-drug interactions as a cause of hospital admissions Drug Saf 9 1993 51 59
    • (1993) Drug Saf , vol.9 , pp. 51-59
    • Jankel, C.A.1    Fitterman, L.K.2
  • 26
    • 0032907322 scopus 로고    scopus 로고
    • Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein
    • R.B. Kim, C. Wandel, B. Leake, M. Cvetkovic, M.F. Fromm, P.J. Dempsey Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein Pharm Res 16 1999 408 414
    • (1999) Pharm Res , vol.16 , pp. 408-414
    • Kim, R.B.1    Wandel, C.2    Leake, B.3    Cvetkovic, M.4    Fromm, M.F.5    Dempsey, P.J.6
  • 27
    • 0344740559 scopus 로고    scopus 로고
    • Induction of drug metabolism: The role of nuclear receptors
    • C. Handschin, U.A. Meyer Induction of drug metabolism the role of nuclear receptors Pharmacol Rev 55 2003 649 673
    • (2003) Pharmacol Rev , vol.55 , pp. 649-673
    • Handschin, C.1    Meyer, U.A.2
  • 28
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • D.J. Mangelsdorf, R.M. Evans The RXR heterodimers and orphan receptors Cell 83 1995 841 850
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 30
    • 0032702726 scopus 로고    scopus 로고
    • The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
    • B. Goodwin, E. Hodgson, C. Liddle The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module Mol Pharmacol 56 1999 1329 1339
    • (1999) Mol Pharmacol , vol.56 , pp. 1329-1339
    • Goodwin, B.1    Hodgson, E.2    Liddle, C.3
  • 31
    • 0037515661 scopus 로고    scopus 로고
    • A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression
    • H. Wang, S. Faucette, T. Sueyoshi, R. Moore, S. Ferguson, M. Negishi A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression J Biol Chem 278 2003 14146 14152
    • (2003) J Biol Chem , vol.278 , pp. 14146-14152
    • Wang, H.1    Faucette, S.2    Sueyoshi, T.3    Moore, R.4    Ferguson, S.5    Negishi, M.6
  • 32
    • 1642498178 scopus 로고    scopus 로고
    • Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor
    • Y. Chen, S.S. Ferguson, M. Negishi, J.A. Goldstein Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor J Pharmacol Exp Ther 308 2004 495 501
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 495-501
    • Chen, Y.1    Ferguson, S.S.2    Negishi, M.3    Goldstein, J.A.4
  • 33
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    • A. Geick, M. Eichelbaum, O. Burk Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin J Biol Chem 276 2001 14581 14587
    • (2001) J Biol Chem , vol.276 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 34
    • 21344439074 scopus 로고    scopus 로고
    • Nuclear receptors and drug disposition gene regulation
    • R.G. Tirona, R.B. Kim Nuclear receptors and drug disposition gene regulation J Pharm Sci 94 2005 1169 1186
    • (2005) J Pharm Sci , vol.94 , pp. 1169-1186
    • Tirona, R.G.1    Kim, R.B.2
  • 35
    • 9944247695 scopus 로고    scopus 로고
    • Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism
    • J.J. Eloranta, G.A. Kullak-Ublick Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism Arch Biochem Biophys 433 2005 397 412
    • (2005) Arch Biochem Biophys , vol.433 , pp. 397-412
    • Eloranta, J.J.1    Kullak-Ublick, G.A.2
  • 36
    • 0031845356 scopus 로고    scopus 로고
    • Effect of clarithromycin on renal excretion of digoxin: Interaction with P-glycoprotein
    • H. Wakasugi, I. Yano, T. Ito, T. Hashida, T. Futami, R. Nohara Effect of clarithromycin on renal excretion of digoxin interaction with P-glycoprotein Clin Pharmacol Ther 64 1998 123 128
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 123-128
    • Wakasugi, H.1    Yano, I.2    Ito, T.3    Hashida, T.4    Futami, T.5    Nohara, R.6
  • 37
    • 0033865280 scopus 로고    scopus 로고
    • Oral bioavailability of digoxin is enhanced by talinolol: Evidence for involvement of intestinal P-glycoprotein
    • K. Westphal, A. Weinbrenner, T. Giessmann, M. Stuhr, G. Franke, M. Zschiesche Oral bioavailability of digoxin is enhanced by talinolol evidence for involvement of intestinal P-glycoprotein Clin Pharmacol Ther 68 2000 6 12
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 6-12
    • Westphal, K.1    Weinbrenner, A.2    Giessmann, T.3    Stuhr, M.4    Franke, G.5    Zschiesche, M.6
  • 38
    • 0033678688 scopus 로고    scopus 로고
    • Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion
    • R.A. Boyd, R.H. Stern, B.H. Stewart, X. Wu, E.L. Reyner, E.A. Zegarac Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion J Clin Pharmacol 40 2000 91 98
    • (2000) J Clin Pharmacol , vol.40 , pp. 91-98
    • Boyd, R.A.1    Stern, R.H.2    Stewart, B.H.3    Wu, X.4    Reyner, E.L.5    Zegarac, E.A.6
  • 40
    • 0029892497 scopus 로고    scopus 로고
    • P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
    • A.H. Schinkel, E. Wagenaar, C.A. Mol, L. van Deemter P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs J Clin Invest 97 1996 2517 2524
    • (1996) J Clin Invest , vol.97 , pp. 2517-2524
    • Schinkel, A.H.1    Wagenaar, E.2    Mol, C.A.3    Van Deemter, L.4
  • 41
  • 42
    • 0036229852 scopus 로고    scopus 로고
    • Drugs as P-glycoprotein substrates, inhibitors, and inducers
    • R.B. Kim Drugs as P-glycoprotein substrates, inhibitors, and inducers Drug Metab Rev 34 2002 47 54
    • (2002) Drug Metab Rev , vol.34 , pp. 47-54
    • Kim, R.B.1
  • 43
    • 24344442157 scopus 로고
    • Effectiveness of a new compound, benemid, in elevating serum penicillin concentrations
    • J.M. Burnell, W.M.M. Kirby Effectiveness of a new compound, benemid, in elevating serum penicillin concentrations J Clin Invest 30 1951 697 700
    • (1951) J Clin Invest , vol.30 , pp. 697-700
    • Burnell, J.M.1    Kirby, W.M.M.2
  • 44
    • 0032780906 scopus 로고    scopus 로고
    • The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1
    • S. Jariyawat, T. Sekine, M. Takeda, N. Apiwattanakul, Y. Kanai, S. Sophasan The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1 J Pharmacol Exp Ther 290 1999 672 677
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 672-677
    • Jariyawat, S.1    Sekine, T.2    Takeda, M.3    Apiwattanakul, N.4    Kanai, Y.5    Sophasan, S.6
  • 45
    • 0034821939 scopus 로고    scopus 로고
    • Role of transport proteins in drug absorption, distribution, and excretion
    • A. Ayrton, P. Morgan Role of transport proteins in drug absorption, distribution, and excretion Xenobiotica 31 2001 469 497
    • (2001) Xenobiotica , vol.31 , pp. 469-497
    • Ayrton, A.1    Morgan, P.2
  • 46
    • 0017862739 scopus 로고
    • Clinical pharmacokinetics of methotrexate
    • D.D. Shen, D.L. Azarnoff Clinical pharmacokinetics of methotrexate Clin Pharmacokinet 3 1978 1 13
    • (1978) Clin Pharmacokinet , vol.3 , pp. 1-13
    • Shen, D.D.1    Azarnoff, D.L.2
  • 47
    • 0025891161 scopus 로고
    • Severe pancytopenia in a patient taking low dose methotrexate and probenecid
    • K.S. Basin, A. Escalante, T.D. Beardmore Severe pancytopenia in a patient taking low dose methotrexate and probenecid J Rheumatol 18 1991 609 610
    • (1991) J Rheumatol , vol.18 , pp. 609-610
    • Basin, K.S.1    Escalante, A.2    Beardmore, T.D.3
  • 48
    • 0021875876 scopus 로고
    • Acute renal failure and death following sequential intermediate-dose methotrexate and 5-FU: A possible adverse effect due to concomitant indomethacin administration
    • N.M. Ellison, R.J. Servi Acute renal failure and death following sequential intermediate-dose methotrexate and 5-FU a possible adverse effect due to concomitant indomethacin administration Cancer Treat Rep 69 1985 342 343
    • (1985) Cancer Treat Rep , vol.69 , pp. 342-343
    • Ellison, N.M.1    Servi, R.J.2
  • 49
    • 0022613399 scopus 로고
    • Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen
    • A. Thyss, G. Milano, J. Kubar, M. Namer, M. Schneider Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen Lancet 1 1986 256 258
    • (1986) Lancet , vol.1 , pp. 256-258
    • Thyss, A.1    Milano, G.2    Kubar, J.3    Namer, M.4    Schneider, M.5
  • 50
    • 0036076780 scopus 로고    scopus 로고
    • Characterization of methotrexate transport and its drug interactions with human organic anion transporters
    • M. Takeda, S. Khamdang, S. Narikawa, H. Kimura, M. Hosoyamada, S.H. Cha Characterization of methotrexate transport and its drug interactions with human organic anion transporters J Pharmacol Exp Ther 302 2002 666 671
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 666-671
    • Takeda, M.1    Khamdang, S.2    Narikawa, S.3    Kimura, H.4    Hosoyamada, M.5    Cha, S.H.6
  • 51
    • 0032522873 scopus 로고    scopus 로고
    • Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies
    • J. Lazarou, B.H. Pomeranz, P.N. Corey Incidence of adverse drug reactions in hospitalized patients a meta-analysis of prospective studies JAMA 279 1998 1200 1205
    • (1998) JAMA , vol.279 , pp. 1200-1205
    • Lazarou, J.1    Pomeranz, B.H.2    Corey, P.N.3
  • 52
    • 0027227827 scopus 로고
    • Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium
    • J.R. Spivey, S.F. Bronk, G.J. Gores Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium J Clin Invest 92 1993 17 24
    • (1993) J Clin Invest , vol.92 , pp. 17-24
    • Spivey, J.R.1    Bronk, S.F.2    Gores, G.J.3
  • 53
    • 0032540277 scopus 로고    scopus 로고
    • The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
    • T. Gerloff, B. Stieger, B. Hagenbuch, J. Madon, L. Landmann, J. Roth The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver J Biol Chem 273 1998 10046 10050
    • (1998) J Biol Chem , vol.273 , pp. 10046-10050
    • Gerloff, T.1    Stieger, B.2    Hagenbuch, B.3    Madon, J.4    Landmann, L.5    Roth, J.6
  • 54
    • 0033991960 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the murine bile salt export pump
    • R.M. Green, F. Hoda, K.L. Ward Molecular cloning and characterization of the murine bile salt export pump Gene 241 2000 117 123
    • (2000) Gene , vol.241 , pp. 117-123
    • Green, R.M.1    Hoda, F.2    Ward, K.L.3
  • 55
    • 0033984873 scopus 로고    scopus 로고
    • Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
    • B. Stieger, K. Fattinger, J. Madon, G.A. Kullak-Ublick, P.J. Meier Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver Gastroenterology 118 2000 422 430
    • (2000) Gastroenterology , vol.118 , pp. 422-430
    • Stieger, B.1    Fattinger, K.2    Madon, J.3    Kullak-Ublick, G.A.4    Meier, P.J.5
  • 56
    • 0035036050 scopus 로고    scopus 로고
    • The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions
    • K. Fattinger, C. Funk, M. Pantze, C. Weber, J. Reichen, B. Stieger The endothelin antagonist bosentan inhibits the canalicular bile salt export pump a potential mechanism for hepatic adverse reactions Clin Pharmacol Ther 69 2001 223 231
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 223-231
    • Fattinger, K.1    Funk, C.2    Pantze, M.3    Weber, C.4    Reichen, J.5    Stieger, B.6
  • 57
    • 0035126136 scopus 로고    scopus 로고
    • Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: In vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat
    • C. Funk, C. Ponelle, G. Scheuermann, M. Pantze Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat Mol Pharmacol 59 2001 627 635
    • (2001) Mol Pharmacol , vol.59 , pp. 627-635
    • Funk, C.1    Ponelle, C.2    Scheuermann, G.3    Pantze, M.4
  • 58
    • 0034008388 scopus 로고    scopus 로고
    • Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1
    • E.S. Ho, D.C. Lin, D.B. Mendel, T. Cihlar Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1 J Am Soc Nephrol 11 2000 383 393
    • (2000) J Am Soc Nephrol , vol.11 , pp. 383-393
    • Ho, E.S.1    Lin, D.C.2    Mendel, D.B.3    Cihlar, T.4
  • 59
    • 0031716603 scopus 로고    scopus 로고
    • Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys
    • S.A. Lacy, M.J. Hitchcock, W.A. Lee, P. Tellier, K.C. Cundy Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys Toxicol Sci 44 1998 97 106
    • (1998) Toxicol Sci , vol.44 , pp. 97-106
    • Lacy, S.A.1    Hitchcock, M.J.2    Lee, W.A.3    Tellier, P.4    Cundy, K.C.5
  • 60
    • 0033815816 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1
    • A.S. Mulato, E.S. Ho, T. Cihlar Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1 J Pharmacol Exp Ther 295 2000 10 15
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 10-15
    • Mulato, A.S.1    Ho, E.S.2    Cihlar, T.3
  • 61
    • 0030726054 scopus 로고    scopus 로고
    • Nephrotoxicity of beta-lactam antibiotics: Mechanisms and strategies for prevention
    • B.M. Tune Nephrotoxicity of beta-lactam antibiotics mechanisms and strategies for prevention Pediatr Nephrol 11 1997 768 772
    • (1997) Pediatr Nephrol , vol.11 , pp. 768-772
    • Tune, B.M.1
  • 62
    • 0034638766 scopus 로고    scopus 로고
    • Pharmacogenetics and adverse drug reactions
    • U.A. Meyer Pharmacogenetics and adverse drug reactions Lancet 356 2000 1667 1671
    • (2000) Lancet , vol.356 , pp. 1667-1671
    • Meyer, U.A.1
  • 63
    • 0024362996 scopus 로고
    • P-glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance
    • N. Kioka, J. Tsubota, Y. Kakehi, T. Komano, M.M. Gottesman, I. Pastan P-glycoprotein gene (MDR1) cDNA from human adrenal normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance Biochem Biophys Res Commun 162 1989 224 231
    • (1989) Biochem Biophys Res Commun , vol.162 , pp. 224-231
    • Kioka, N.1    Tsubota, J.2    Kakehi, Y.3    Komano, T.4    Gottesman, M.M.5    Pastan, I.6
  • 64
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • S. Hoffmeyer, O. Burk, O. von Richter, H.P. Arnold, J. Brockmoller, A. Johne Functional polymorphisms of the human multidrug-resistance gene multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo Proc Natl Acad Sci U S A 97 2000 3473 3478
    • (2000) Proc Natl Acad Sci U S a , vol.97 , pp. 3473-3478
    • Hoffmeyer, S.1    Burk, O.2    Von Richter, O.3    Arnold, H.P.4    Brockmoller, J.5    Johne, A.6
  • 65
    • 18444404305 scopus 로고    scopus 로고
    • Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors
    • M. Siegsmund, U. Brinkmann, E. Schaffeler, G. Weirich, M. Schwab, M. Eichelbaum Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors J Am Soc Nephrol 13 2002 1847 1854
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1847-1854
    • Siegsmund, M.1    Brinkmann, U.2    Schaffeler, E.3    Weirich, G.4    Schwab, M.5    Eichelbaum, M.6
  • 66
    • 0038241171 scopus 로고    scopus 로고
    • Polymorphism in the P-glycoprotein drug transporter MDR1 gene: A possible link between environmental and genetic factors in Parkinson's disease
    • M. Drozdzik, M. Bialecka, K. Mysliwiec, K. Honczarenko, J. Stankiewicz, Z. Sych Polymorphism in the P-glycoprotein drug transporter MDR1 gene a possible link between environmental and genetic factors in Parkinson's disease Pharmacogenetics 13 2003 259 263
    • (2003) Pharmacogenetics , vol.13 , pp. 259-263
    • Drozdzik, M.1    Bialecka, M.2    Mysliwiec, K.3    Honczarenko, K.4    Stankiewicz, J.5    Sych, Z.6
  • 67
    • 0037223561 scopus 로고    scopus 로고
    • Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis
    • M. Schwab, E. Schaeffeler, C. Marx, M.F. Fromm, B. Kaskas, J. Metzler Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis Gastroenterology 124 2003 26 33
    • (2003) Gastroenterology , vol.124 , pp. 26-33
    • Schwab, M.1    Schaeffeler, E.2    Marx, C.3    Fromm, M.F.4    Kaskas, B.5    Metzler, J.6
  • 68
    • 0037431040 scopus 로고    scopus 로고
    • Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
    • A. Siddiqui, R. Kerb, M.E. Weale, U. Brinkmann, A. Smith, D.B. Goldstein Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1 N Engl J Med 348 2003 1442 1448
    • (2003) N Engl J Med , vol.348 , pp. 1442-1448
    • Siddiqui, A.1    Kerb, R.2    Weale, M.E.3    Brinkmann, U.4    Smith, A.5    Goldstein, D.B.6
  • 69
    • 0037022006 scopus 로고    scopus 로고
    • Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: A pharmacogenetics study
    • J. Fellay, C. Marzolini, E.R. Meaden, D.J. Back, T. Buclin, J.P. Chave Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1 a pharmacogenetics study Lancet 359 2002 30 36
    • (2002) Lancet , vol.359 , pp. 30-36
    • Fellay, J.1    Marzolini, C.2    Meaden, E.R.3    Back, D.J.4    Buclin, T.5    Chave, J.P.6
  • 70
    • 0037131885 scopus 로고    scopus 로고
    • Pharmacogenomics of organic anion-transporting polypeptides (OATP)
    • R.G. Tirona, R.B. Kim Pharmacogenomics of organic anion-transporting polypeptides (OATP) Adv Drug Deliv Rev 54 2002 1343 1352
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1343-1352
    • Tirona, R.G.1    Kim, R.B.2
  • 71
    • 0038106665 scopus 로고    scopus 로고
    • Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs
    • T. Sakaeda, T. Nakamura, K. Okumura Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs Pharmacogenomics 4 2003 397 410
    • (2003) Pharmacogenomics , vol.4 , pp. 397-410
    • Sakaeda, T.1    Nakamura, T.2    Okumura, K.3
  • 72
    • 0038523918 scopus 로고    scopus 로고
    • Pharmacogenetics of hepatocellular transporters
    • C. Pauli-Magnus, P.J. Meier Pharmacogenetics of hepatocellular transporters Pharmacogenetics 13 2003 189 198
    • (2003) Pharmacogenetics , vol.13 , pp. 189-198
    • Pauli-Magnus, C.1    Meier, P.J.2
  • 73
    • 0036256463 scopus 로고    scopus 로고
    • Mechanisms of hepatic transport of drugs: Implications for cholestatic drug reactions
    • A. Bohan, J.L. Boyer Mechanisms of hepatic transport of drugs implications for cholestatic drug reactions Semin Liver Dis 22 2002 123 136
    • (2002) Semin Liver Dis , vol.22 , pp. 123-136
    • Bohan, A.1    Boyer, J.L.2
  • 74
    • 2142799057 scopus 로고    scopus 로고
    • Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy
    • A.C. Lockhart, R.G. Tirona, R.B. Kim Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy Mol Cancer Ther 2 2003 685 698
    • (2003) Mol Cancer Ther , vol.2 , pp. 685-698
    • Lockhart, A.C.1    Tirona, R.G.2    Kim, R.B.3
  • 75
    • 0037131880 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): Its impact on drug disposition
    • H. Suzuki, Y. Sugiyama Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2) its impact on drug disposition Adv Drug Deliv Rev 54 2002 1311 1331
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1311-1331
    • Suzuki, H.1    Sugiyama, Y.2
  • 76
    • 0038184179 scopus 로고    scopus 로고
    • Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1
    • Y. Shu, M.K. Leabman, B. Feng, L.M. Mangravite, C.C. Huang, D. Stryke Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1 Proc Natl Acad Sci U S A 100 2003 5902 5907
    • (2003) Proc Natl Acad Sci U S a , vol.100 , pp. 5902-5907
    • Shu, Y.1    Leabman, M.K.2    Feng, B.3    Mangravite, L.M.4    Huang, C.C.5    Stryke, D.6
  • 77
    • 0036865724 scopus 로고    scopus 로고
    • Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences
    • R. Kerb, U. Brinkmann, N. Chatskaia, D. Gorbunov, V. Gorboulev, E. Mornhinweg Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences Pharmacogenetics 12 2002 591 595
    • (2002) Pharmacogenetics , vol.12 , pp. 591-595
    • Kerb, R.1    Brinkmann, U.2    Chatskaia, N.3    Gorbunov, D.4    Gorboulev, V.5    Mornhinweg, E.6
  • 78
    • 0035929574 scopus 로고    scopus 로고
    • Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans
    • R.G. Tirona, B.F. Leake, G. Merino, R.B. Kim Polymorphisms in OATP-C identification of multiple allelic variants associated with altered transport activity among European- and African-Americans J Biol Chem 276 2001 35669 35675
    • (2001) J Biol Chem , vol.276 , pp. 35669-35675
    • Tirona, R.G.1    Leake, B.F.2    Merino, G.3    Kim, R.B.4
  • 79
    • 0038209381 scopus 로고    scopus 로고
    • Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
    • Y. Nishizato, I. Ieiri, H. Suzuki, M. Kimura, K. Kawabata, T. Hirota Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes consequences for pravastatin pharmacokinetics Clin Pharmacol Ther 73 2003 554 565
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 554-565
    • Nishizato, Y.1    Ieiri, I.2    Suzuki, H.3    Kimura, M.4    Kawabata, K.5    Hirota, T.6
  • 80
    • 0036073404 scopus 로고    scopus 로고
    • Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): Allele frequencies in the Japanese population and functional analysis
    • T. Nozawa, M. Nakajima, I. Tamai, K. Noda, J. Nezu, Y. Sai Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9) allele frequencies in the Japanese population and functional analysis J Pharmacol Exp Ther 302 2002 804 813
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 804-813
    • Nozawa, T.1    Nakajima, M.2    Tamai, I.3    Noda, K.4    Nezu, J.5    Sai, Y.6
  • 81
    • 0033361943 scopus 로고    scopus 로고
    • Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome
    • S. Toh, M. Wada, T. Uchiumi, A. Inokuchi, Y. Makino, Y. Horie Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome Am J Hum Genet 64 1999 739 746
    • (1999) Am J Hum Genet , vol.64 , pp. 739-746
    • Toh, S.1    Wada, M.2    Uchiumi, T.3    Inokuchi, A.4    Makino, Y.5    Horie, Y.6
  • 82
    • 0040761368 scopus 로고    scopus 로고
    • CDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
    • M. Buchler, J. Konig, M. Brom, J. Kartenbeck, H. Spring, T. Horie cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats J Biol Chem 271 1996 15091 15098
    • (1996) J Biol Chem , vol.271 , pp. 15091-15098
    • Buchler, M.1    Konig, J.2    Brom, M.3    Kartenbeck, J.4    Spring, H.5    Horie, T.6
  • 83
    • 0029986408 scopus 로고    scopus 로고
    • Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
    • J. Kartenbeck, U. Leuschner, R. Mayer, D. Keppler Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome Hepatology 23 1996 1061 1066
    • (1996) Hepatology , vol.23 , pp. 1061-1066
    • Kartenbeck, J.1    Leuschner, U.2    Mayer, R.3    Keppler, D.4
  • 84
    • 0030994468 scopus 로고    scopus 로고
    • A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
    • C.C. Paulusma, M. Kool, P.J. Bosma, G.L. Scheffer, F. ter Borg, R.J. Scheper A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome Hepatology 25 1997 1539 1542
    • (1997) Hepatology , vol.25 , pp. 1539-1542
    • Paulusma, C.C.1    Kool, M.2    Bosma, P.J.3    Scheffer, G.L.4    Ter Borg, F.5    Scheper, R.J.6
  • 85
    • 6844250107 scopus 로고    scopus 로고
    • Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome
    • M. Wada, S. Toh, K. Taniguchi, T. Nakamura, T. Uchiumi, K. Kohno Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome Hum Mol Genet 7 1998 203 207
    • (1998) Hum Mol Genet , vol.7 , pp. 203-207
    • Wada, M.1    Toh, S.2    Taniguchi, K.3    Nakamura, T.4    Uchiumi, T.5    Kohno, K.6
  • 87
    • 0033652766 scopus 로고    scopus 로고
    • Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome
    • V. Keitel, J. Kartenbeck, A.T. Nies, H. Spring, M. Brom, D. Keppler Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome Hepatology 32 2000 1317 1328
    • (2000) Hepatology , vol.32 , pp. 1317-1328
    • Keitel, V.1    Kartenbeck, J.2    Nies, A.T.3    Spring, H.4    Brom, M.5    Keppler, D.6
  • 88
    • 0036830243 scopus 로고    scopus 로고
    • Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome
    • K. Hashimoto, T. Uchiumi, T. Konno, T. Ebihara, T. Nakamura, M. Wada Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome Hepatology 36 2002 1236 1245
    • (2002) Hepatology , vol.36 , pp. 1236-1245
    • Hashimoto, K.1    Uchiumi, T.2    Konno, T.3    Ebihara, T.4    Nakamura, T.5    Wada, M.6
  • 89
    • 0035813178 scopus 로고    scopus 로고
    • Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome
    • R. Mor-Cohen, A. Zivelin, N. Rosenberg, M. Shani, S. Muallem, U. Seligsohn Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome J Biol Chem 276 2001 36923 36930
    • (2001) J Biol Chem , vol.276 , pp. 36923-36930
    • Mor-Cohen, R.1    Zivelin, A.2    Rosenberg, N.3    Shani, M.4    Muallem, S.5    Seligsohn, U.6
  • 90
    • 0032558588 scopus 로고    scopus 로고
    • Molecular pathogenesis of cholestasis
    • M. Trauner, P.J. Meier, J.L. Boyer Molecular pathogenesis of cholestasis N Engl J Med 339 1998 1217 1227
    • (1998) N Engl J Med , vol.339 , pp. 1217-1227
    • Trauner, M.1    Meier, P.J.2    Boyer, J.L.3
  • 91
    • 0025991571 scopus 로고
    • Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system
    • T. Nishida, Z. Gatmaitan, M. Che, I.M. Arias Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system Proc Natl Acad Sci U S A 88 1991 6590 6594
    • (1991) Proc Natl Acad Sci U S a , vol.88 , pp. 6590-6594
    • Nishida, T.1    Gatmaitan, Z.2    Che, M.3    Arias, I.M.4
  • 92
    • 0000627095 scopus 로고    scopus 로고
    • Familial hepatocellular cholestasis
    • F.J. Suchy R.J. Sokol W.F. Balistreri Lippincott, Williams & Wilkins Philadelphia
    • P.F. Whitington, K.M. Emerick, F.J. Suchy Familial hepatocellular cholestasis F.J. Suchy R.J. Sokol W.F. Balistreri Liver disease in children 2001 Lippincott, Williams & Wilkins Philadelphia 315 325
    • (2001) Liver Disease in Children , pp. 315-325
    • Whitington, P.F.1    Emerick, K.M.2    Suchy, F.J.3
  • 93
    • 0035203879 scopus 로고    scopus 로고
    • BSEP: Function and role in progressive familial intrahepatic cholestasis
    • R. Thompson, S. Strautnieks BSEP function and role in progressive familial intrahepatic cholestasis Semin Liver Dis 21 2001 545 550
    • (2001) Semin Liver Dis , vol.21 , pp. 545-550
    • Thompson, R.1    Strautnieks, S.2
  • 94
  • 95
    • 17344366172 scopus 로고    scopus 로고
    • A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis
    • S.S. Strautnieks, L.N. Bull, A.S. Knisely, S.A. Kocoshis, N. Dahl, H. Arnell A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis Nat Genet 20 1998 233 238
    • (1998) Nat Genet , vol.20 , pp. 233-238
    • Strautnieks, S.S.1    Bull, L.N.2    Knisely, A.S.3    Kocoshis, S.A.4    Dahl, N.5    Arnell, H.6
  • 96
    • 0036828271 scopus 로고    scopus 로고
    • Functional expression of the canalicular bile salt export pump of human liver
    • J. Noe, B. Stieger, P.J. Meier Functional expression of the canalicular bile salt export pump of human liver Gastroenterology 123 2002 1659 1666
    • (2002) Gastroenterology , vol.123 , pp. 1659-1666
    • Noe, J.1    Stieger, B.2    Meier, P.J.3
  • 98
    • 0032711405 scopus 로고    scopus 로고
    • Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis
    • P.L. Jansen, S.S. Strautnieks, E. Jacquemin, M. Hadchouel, E.M. Sokal, G.J. Hooiveld Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis Gastroenterology 117 1999 1370 1379
    • (1999) Gastroenterology , vol.117 , pp. 1370-1379
    • Jansen, P.L.1    Strautnieks, S.S.2    Jacquemin, E.3    Hadchouel, M.4    Sokal, E.M.5    Hooiveld, G.J.6
  • 99
    • 0029990296 scopus 로고    scopus 로고
    • Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis
    • J.F. Deleuze, E. Jacquemin, C. Dubuisson, D. Cresteil, M. Dumont, S. Erlinger Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis Hepatology 23 1996 904 908
    • (1996) Hepatology , vol.23 , pp. 904-908
    • Deleuze, J.F.1    Jacquemin, E.2    Dubuisson, C.3    Cresteil, D.4    Dumont, M.5    Erlinger, S.6
  • 101
    • 0027363563 scopus 로고
    • Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
    • J.J. Smit, A.H. Schinkel, R.P. Oude Elferink, A.K. Groen, E. Wagenaar, L. van Deemter Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease Cell 75 1993 451 462
    • (1993) Cell , vol.75 , pp. 451-462
    • Smit, J.J.1    Schinkel, A.H.2    Oude Elferink, R.P.3    Groen, A.K.4    Wagenaar, E.5    Van Deemter, L.6
  • 103
    • 0035045719 scopus 로고    scopus 로고
    • The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood
    • E. Jacquemin, J.M. de Vree, D. Cresteil, E.M. Sokal, E. Sturm, M. Dumont The wide spectrum of multidrug resistance 3 deficiency from neonatal cholestasis to cirrhosis of adulthood Gastroenterology 120 2001 1448 1458
    • (2001) Gastroenterology , vol.120 , pp. 1448-1458
    • Jacquemin, E.1    De Vree, J.M.2    Cresteil, D.3    Sokal, E.M.4    Sturm, E.5    Dumont, M.6
  • 105
    • 0033023251 scopus 로고    scopus 로고
    • Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy
    • E. Jacquemin, D. Cresteil, S. Manouvrier, O. Boute, M. Hadchouel Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy Lancet 353 1999 210 211
    • (1999) Lancet , vol.353 , pp. 210-211
    • Jacquemin, E.1    Cresteil, D.2    Manouvrier, S.3    Boute, O.4    Hadchouel, M.5
  • 106
    • 0034604707 scopus 로고    scopus 로고
    • MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping
    • A.J. Smith, A. van Helvoort, G. van Meer, K. Szabo, E. Welker, G. Szakacs MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping J Biol Chem 275 2000 23530 23539
    • (2000) J Biol Chem , vol.275 , pp. 23530-23539
    • Smith, A.J.1    Van Helvoort, A.2    Van Meer, G.3    Szabo, K.4    Welker, E.5    Szakacs, G.6
  • 107
    • 0014264541 scopus 로고
    • The plasma lecithins:cholesterol acyltransferase reaction
    • J.A. Glomset The plasma lecithins:cholesterol acyltransferase reaction J Lipid Res 9 1968 155 167
    • (1968) J Lipid Res , vol.9 , pp. 155-167
    • Glomset, J.A.1
  • 108
    • 0032813808 scopus 로고    scopus 로고
    • Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
    • A. Brooks-Wilson, M. Marcil, S.M. Clee, L.H. Zhang, K. Roomp, M. van Dam Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency Nat Genet 22 1999 336 345
    • (1999) Nat Genet , vol.22 , pp. 336-345
    • Brooks-Wilson, A.1    Marcil, M.2    Clee, S.M.3    Zhang, L.H.4    Roomp, K.5    Van Dam, M.6
  • 109
    • 0032813809 scopus 로고    scopus 로고
    • The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
    • M. Bodzioch, E. Orso, J. Klucken, T. Langmann, A. Bottcher, W. Diederich The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease Nat Genet 22 1999 347 351
    • (1999) Nat Genet , vol.22 , pp. 347-351
    • Bodzioch, M.1    Orso, E.2    Klucken, J.3    Langmann, T.4    Bottcher, A.5    Diederich, W.6
  • 110
    • 0032813660 scopus 로고    scopus 로고
    • Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
    • S. Rust, M. Rosier, H. Funke, J. Real, Z. Amoura, J.C. Piette Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1 Nat Genet 22 1999 352 355
    • (1999) Nat Genet , vol.22 , pp. 352-355
    • Rust, S.1    Rosier, M.2    Funke, H.3    Real, J.4    Amoura, Z.5    Piette, J.C.6
  • 111
    • 0032725185 scopus 로고    scopus 로고
    • The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
    • R.M. Lawn, D.P. Wade, M.R. Garvin, X. Wang, K. Schwartz, J.G. Porter The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway J Clin Invest 104 1999 R25 R31
    • (1999) J Clin Invest , vol.104
    • Lawn, R.M.1    Wade, D.P.2    Garvin, M.R.3    Wang, X.4    Schwartz, K.5    Porter, J.G.6
  • 112
    • 0033962086 scopus 로고    scopus 로고
    • Transport of lipids from golgi to plasma membrane is defective in Tangier disease patients and Abc1-deficient mice
    • E. Orso, C. Broccardo, W.E. Kaminski, A. Bottcher, G. Liebisch, W. Drobnik Transport of lipids from golgi to plasma membrane is defective in Tangier disease patients and Abc1-deficient mice Nat Genet 24 2000 192 196
    • (2000) Nat Genet , vol.24 , pp. 192-196
    • Orso, E.1    Broccardo, C.2    Kaminski, W.E.3    Bottcher, A.4    Liebisch, G.5    Drobnik, W.6
  • 113
    • 0343717914 scopus 로고    scopus 로고
    • High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1
    • J. McNeish, R.J. Aiello, D. Guyot, T. Turi, C. Gabel, C. Aldinger High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1 Proc Natl Acad Sci U S A 97 2000 4245 4250
    • (2000) Proc Natl Acad Sci U S a , vol.97 , pp. 4245-4250
    • McNeish, J.1    Aiello, R.J.2    Guyot, D.3    Turi, T.4    Gabel, C.5    Aldinger, C.6
  • 114
    • 0036127574 scopus 로고    scopus 로고
    • ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation
    • C.L. Wellington, E.K. Walker, A. Suarez, A. Kwok, N. Bissada, R. Singaraja ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation Lab Invest 82 2002 273 283
    • (2002) Lab Invest , vol.82 , pp. 273-283
    • Wellington, C.L.1    Walker, E.K.2    Suarez, A.3    Kwok, A.4    Bissada, N.5    Singaraja, R.6
  • 115
    • 0034693064 scopus 로고    scopus 로고
    • Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1
    • N. Wang, D.L. Silver, P. Costet, A.R. Tall Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1 J Biol Chem 275 2000 33053 33058
    • (2000) J Biol Chem , vol.275 , pp. 33053-33058
    • Wang, N.1    Silver, D.L.2    Costet, P.3    Tall, A.R.4
  • 116
    • 0034602387 scopus 로고    scopus 로고
    • ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages
    • J.F. Oram, R.M. Lawn, M.R. Garvin, D.P. Wade ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages J Biol Chem 275 2000 34508 34511
    • (2000) J Biol Chem , vol.275 , pp. 34508-34511
    • Oram, J.F.1    Lawn, R.M.2    Garvin, M.R.3    Wade, D.P.4
  • 117
    • 0034666311 scopus 로고    scopus 로고
    • The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines
    • A.E. Bortnick, G.H. Rothblat, G. Stoudt, K.L. Hoppe, L.J. Royer, J. McNeish The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines J Biol Chem 275 2000 28634 28640
    • (2000) J Biol Chem , vol.275 , pp. 28634-28640
    • Bortnick, A.E.1    Rothblat, G.H.2    Stoudt, G.3    Hoppe, K.L.4    Royer, L.J.5    McNeish, J.6
  • 119
    • 0037031835 scopus 로고    scopus 로고
    • Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I
    • M.L. Fitzgerald, A.L. Morris, J.S. Rhee, L.P. Andersson, A.J. Mendez, M.W. Freeman Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I J Biol Chem 277 2002 33178 33187
    • (2002) J Biol Chem , vol.277 , pp. 33178-33187
    • Fitzgerald, M.L.1    Morris, A.L.2    Rhee, J.S.3    Andersson, L.P.4    Mendez, A.J.5    Freeman, M.W.6
  • 120
    • 0037424367 scopus 로고    scopus 로고
    • Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis
    • A.R. Tanaka, S. Abe-Dohmae, T. Ohnishi, R. Aoki, G. Morinaga, K.I. Okuhira Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis J Biol Chem 278 2002 8815 8819
    • (2002) J Biol Chem , vol.278 , pp. 8815-8819
    • Tanaka, A.R.1    Abe-Dohmae, S.2    Ohnishi, T.3    Aoki, R.4    Morinaga, G.5    Okuhira, K.I.6
  • 122
    • 0035814958 scopus 로고    scopus 로고
    • Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease
    • S.M. Clee, A.H. Zwinderman, J.C. Engert, K.Y. Zwarts, H.O. Molhuizen, K. Roomp Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease Circulation 103 2001 1198 1205
    • (2001) Circulation , vol.103 , pp. 1198-1205
    • Clee, S.M.1    Zwinderman, A.H.2    Engert, J.C.3    Zwarts, K.Y.4    Molhuizen, H.O.5    Roomp, K.6
  • 123
    • 0035864677 scopus 로고    scopus 로고
    • Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease
    • M.E. Brousseau, M. Bodzioch, E.J. Schaefer, A.L. Goldkamp, D. Kielar, M. Probst Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease Atherosclerosis 154 2001 607 611
    • (2001) Atherosclerosis , vol.154 , pp. 607-611
    • Brousseau, M.E.1    Bodzioch, M.2    Schaefer, E.J.3    Goldkamp, A.L.4    Kielar, D.5    Probst, M.6
  • 124
    • 14644420598 scopus 로고    scopus 로고
    • Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population
    • R. Frikke-Schmidt, B.G. Nordestgaard, G.B. Jensen, A. Tybjaerg-Hansen Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population J Clin Invest 114 2004 1343 1353
    • (2004) J Clin Invest , vol.114 , pp. 1343-1353
    • Frikke-Schmidt, R.1    Nordestgaard, B.G.2    Jensen, G.B.3    Tybjaerg-Hansen, A.4
  • 126
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
    • B. Hagenbuch, P.J. Meier Organic anion transporting polypeptides of the OATP/SLC21 family phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties Pflugers Arch 447 2004 653 665
    • (2004) Pflugers Arch , vol.447 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.J.2
  • 127
    • 0035066252 scopus 로고    scopus 로고
    • Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
    • M.J. Dresser, M.K. Leabman, K.M. Giacomini Transporters involved in the elimination of drugs in the kidney organic anion transporters and organic cation transporters J Pharm Sci 90 2001 397 421
    • (2001) J Pharm Sci , vol.90 , pp. 397-421
    • Dresser, M.J.1    Leabman, M.K.2    Giacomini, K.M.3
  • 129
    • 0001744641 scopus 로고    scopus 로고
    • Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2)
    • J.D. Allen, A.H. Schinkel Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2) Mol Cancer Ther 1 2002 427 434
    • (2002) Mol Cancer Ther , vol.1 , pp. 427-434
    • Allen, J.D.1    Schinkel, A.H.2
  • 130
    • 0036159433 scopus 로고    scopus 로고
    • Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
    • G.K. Dresser, D.G. Bailey, B.F. Leake, U.I. Schwarz, P.A. Dawson, D.J. Freeman Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine Clin Pharmacol Ther 71 2002 11 20
    • (2002) Clin Pharmacol Ther , vol.71 , pp. 11-20
    • Dresser, G.K.1    Bailey, D.G.2    Leake, B.F.3    Schwarz, U.I.4    Dawson, P.A.5    Freeman, D.J.6
  • 132
    • 0034466892 scopus 로고    scopus 로고
    • Hepatic disposition of fexofenadine: Influence of the transport inhibitors erythromycin and dibromosulphothalein
    • R.W. Milne, L.A. Larsen, K.L. Jorgensen, J. Bastlund, G.R. Stretch, A.M. Evans Hepatic disposition of fexofenadine influence of the transport inhibitors erythromycin and dibromosulphothalein Pharm Res 17 2000 1511 1515
    • (2000) Pharm Res , vol.17 , pp. 1511-1515
    • Milne, R.W.1    Larsen, L.A.2    Jorgensen, K.L.3    Bastlund, J.4    Stretch, G.R.5    Evans, A.M.6
  • 135
    • 0036731995 scopus 로고    scopus 로고
    • MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients
    • T. Illmer, U.S. Schuler, C. Thiede, U.I. Schwarz, R.B. Kim, S. Gotthard MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients Cancer Res 62 2002 4955 4962
    • (2002) Cancer Res , vol.62 , pp. 4955-4962
    • Illmer, T.1    Schuler, U.S.2    Thiede, C.3    Schwarz, U.I.4    Kim, R.B.5    Gotthard, S.6
  • 136
    • 1942532906 scopus 로고    scopus 로고
    • Functional C3435T polymorphism of MDR1 gene: An impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia
    • K. Jamroziak, W. Mlynarski, E. Balcerczak, M. Mistygacz, J. Trelinska, M. Mirowski Functional C3435T polymorphism of MDR1 gene an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia Eur J Haematol 72 2004 314 321
    • (2004) Eur J Haematol , vol.72 , pp. 314-321
    • Jamroziak, K.1    Mlynarski, W.2    Balcerczak, E.3    Mistygacz, M.4    Trelinska, J.5    Mirowski, M.6
  • 137
    • 0037906108 scopus 로고    scopus 로고
    • The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients
    • C.R. Yates, W. Zhang, P. Song, S. Li, A.O. Gaber, M. Kotb The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients J Clin Pharmacol 43 2003 555 564
    • (2003) J Clin Pharmacol , vol.43 , pp. 555-564
    • Yates, C.R.1    Zhang, W.2    Song, P.3    Li, S.4    Gaber, A.O.5    Kotb, M.6
  • 138
    • 1842637753 scopus 로고    scopus 로고
    • Polymorphisms in the multidrug resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-specific manner
    • K. Kajinami, M.E. Brousseau, J.M. Ordovas, E.J. Schaefer Polymorphisms in the multidrug resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-specific manner Am J Cardiol 93 2004 1046 1050
    • (2004) Am J Cardiol , vol.93 , pp. 1046-1050
    • Kajinami, K.1    Brousseau, M.E.2    Ordovas, J.M.3    Schaefer, E.J.4
  • 139
    • 3042772026 scopus 로고    scopus 로고
    • Identification of functionally variant MDR1 alleles among European Americans and African Americans
    • R.B. Kim, B.F. Leake, E.F. Choo, G.K. Dresser, S.V. Kubba, U.I. Schwarz Identification of functionally variant MDR1 alleles among European Americans and African Americans Clin Pharmacol Ther 70 2001 189 199
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 189-199
    • Kim, R.B.1    Leake, B.F.2    Choo, E.F.3    Dresser, G.K.4    Kubba, S.V.5    Schwarz, U.I.6
  • 140
    • 1542373607 scopus 로고    scopus 로고
    • Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors
    • M.F. Hebert, A.L. Dowling, C. Gierwatowski, Y.S. Lin, K.L. Edwards, C.L. Davis Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors Pharmacogenetics 13 2003 661 674
    • (2003) Pharmacogenetics , vol.13 , pp. 661-674
    • Hebert, M.F.1    Dowling, A.L.2    Gierwatowski, C.3    Lin, Y.S.4    Edwards, K.L.5    Davis, C.L.6
  • 142
    • 0036598543 scopus 로고    scopus 로고
    • C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance
    • Y. Imai, M. Nakane, K. Kage, S. Tsukahara, E. Ishikawa, T. Tsuruo C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance Mol Cancer Ther 1 2002 611 616
    • (2002) Mol Cancer Ther , vol.1 , pp. 611-616
    • Imai, Y.1    Nakane, M.2    Kage, K.3    Tsukahara, S.4    Ishikawa, E.5    Tsuruo, T.6
  • 145
    • 2042469487 scopus 로고    scopus 로고
    • Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics
    • J. Mwinyi, A. Johne, S. Bauer, I. Roots, T. Gerloff Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics Clin Pharmacol Ther 75 2004 415 421
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 415-421
    • Mwinyi, J.1    Johne, A.2    Bauer, S.3    Roots, I.4    Gerloff, T.5
  • 146
    • 3242808852 scopus 로고    scopus 로고
    • High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)
    • M. Niemi, E. Schaeffeler, T. Lang, M.F. Fromm, M. Neuvonen, C. Kyrklund High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1) Pharmacogenetics 14 2004 429 440
    • (2004) Pharmacogenetics , vol.14 , pp. 429-440
    • Niemi, M.1    Schaeffeler, E.2    Lang, T.3    Fromm, M.F.4    Neuvonen, M.5    Kyrklund, C.6
  • 147
    • 3242765929 scopus 로고    scopus 로고
    • Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8)
    • K. Letschert, D. Keppler, J. Konig Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8) Pharmacogenetics 14 2004 441 452
    • (2004) Pharmacogenetics , vol.14 , pp. 441-452
    • Letschert, K.1    Keppler, D.2    Konig, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.