Nephrotoxicity of beta-lactam antibiotics: Mechanisms and strategies for prevention

Pediatric Nephrology

Volumn 11, Issue 6, 1997, Pages 768-772

  Tune, Bruce M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Beta lactam antibiotics; Nephrotoxicity; Prevention

Indexed keywords

BETA LACTAM ANTIBIOTIC; CEFALEXIN; CEFALOGLYCIN; CEFALORIDINE; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; IMIPENEM; PANIPENEM; PENEM DERIVATIVE; PENICILLIN DERIVATIVE;

ACYLATION; CONFERENCE PAPER; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE NECROSIS; LIPID PEROXIDATION; NEPHROTOXICITY; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE;

ANIMALS; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; HUMANS; KIDNEY DISEASES;

EID: 0030726054     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004670050386     Document Type: Conference Paper

References (33)

1. Waxman DJ, Strominger JL (1983) Penicillin binding proteins and the mechanism of action of beta-lactam antibiotics. Annu Rev Biochem 52: 825-869
2. Hoover JRE (1983) Beta-lactam antibiotics: structure-activity relationships. In: Demain AL, Solomon NA (eds) Handbook of experimental pharmacology, vol 67/II. Beta-lactam antibiotics. Springer, Berlin Heidelberg New York, pp 119-245
3. Birnbaum J, Kahan FM, Kropp H, MacDonald JS (1985) Carbapenems. A new class of beta-lactam antibiotics. Discovery and improvement of imipenem/cilastatin. Am J Med 78 [Suppl 6A]: 3-21
4. Tune BM (1993) The nephrotoxicity of beta-lactam antibiotics. In: Hook JB, Goldstein RS (eds) Toxicology of the kidney. Raven, New York, pp 257-281
5. Topham JC, Murgatroyd LB, Jones DV, Goonetilleke UR, Wright J (1989) Safety evaluation of meropenem in animals: studies on the kidney. J Antimicrob Chemother 24 [Suppl A]: 287-306
6. Brughera M, Scampini G, Ferrari ML, Nava A, Mazué G (1989) Toxicologic profile of FCE 22101 and its orally available ester FCE 22891. J Antimicrob Chemother 23 [Suppl C]: 129-135
7. Hirouchi Y, Naganuma H, Kawahara Y, Okada R, Kamiya A, Inui K, Hori R (1994) Preventive effect of betamipron on nephrotoxicity and uptake of carbapenems in rabbit renal cortex. Jpn J Pharmacol 66: 1-6
8. Tune BM, Fernholt M, Schwartz A (1974) Mechanism of cephaloridine transport in the kidney. J Pharmacol Exp Ther 191: 311-317
9. Tune BM, Fravert D (1980) Cephalosporin nephrotoxicity. Transport, cytotoxicity and mitochondrial toxicity of cephaloglycin. J Pharmacol Exp Ther 215: 186-190
10. Kuo C-H, Maita K, Slieght SD, Hook JB (1983) Lipid peroxidation: a possible mechanism of cephaloridine-induced nephrotoxicity. Toxicol Appl Pharmacol 67: 78-88
11. Tune BM, Fravert D, Hsu C-Y (1989) The oxidative and mitochondrial toxic effects of cephalosporin antibiotics in the kidney. A comparative study of cephaloridine and cephaloglycin. Biochem Pharmacol 38: 795-802
12. Browning MC, Tune BM (1983) The reactivity and binding of beta-lactam antibiotics in rabbit renal cortex. J Pharmacol Exp Ther 226: 640-644
13. Tune BM, Fravert D, Hsu C-Y (1989) Thienamycin nephrotoxicity: mitochondrial injury and oxidative effects of imipenem in the rabbit kidney. Biochem Pharmacol 38: 3779-3783
14. Beyer KH, Russo HF, Tillson EK, Miller AK, Verwey WF, Gass SR (1951) 'Benemid', p-(di-n-propylsulfamyl)-benzoic acid: its renal affinity and its elimination. Am J Physiol 166: 625-640
15. Tune BM (1994) The renal tubular transport and nephrotoxicity of beta-lactam antibiotics: structure-activity relationships. Miner Electrolyte Metab 20: 221-231
16. Tune BM (1993) The renal tubular transport and nephrotoxicity of beta-tactam antibiotics. In: Anders MW, Dekant W, Henschler D, Oberleithner H, Silbernagl S (eds) Renal disposition and nephrotoxicity of xenobiotics. Academic Press, Orlando, pp 249-267
17. Tune BM (1975) Relationship between the transport and toxicity of cephalosporins in the kidney. J Infect Dis 132: 189-194
18. Inui K-I, Okano T, Takano M, Kitazawa S, Hori R (1983) Carrier-mediated transport of aminocephalosporins by brush border membrane vesicles isolated from rat kidney cortex. Biochem Pharmacol 32: 621-626
19. Tune BM (1986) The nephrotoxicity of cephalosporin antibiotics. Structure-activity relationships. Comments in Toxicology 1: 145-170
20. Indelicato JM, Dinner A, Peters LR, Wilham WL (1977) Hydrolysis of 3-chloro-3-cephems. Intramolecular nucleophilic attack in cefaclor. J Med Chem 20: 961-963
21. Bendirdjian J-P, Prime DJ, Browning MC, Tune BM (1982) The mitochondrial respiratory toxicity of cephalosporins. Molecular properties and pathogenic significance. In: Fillastre J-P (ed) Nephrotoxicity, ototoxicity of drugs. Editions INSERM, Rouen, pp 303-319
22. Tune BM, Sibley RK, Hsu C-Y (1988) The mitochondrial respiratory toxicity of cephalosporin antibiotics. An inhibitory effect on substrate uptake. J Pharmacol Exp Ther 245: 1054-1059
23. Tune BM, Hsu C-Y (1990) The renal mitochondrial toxicity of cephalosporins: specificity of the effect on anionic substrate uptake. J Pharmacol Exp Ther 252: 65-69
24. Cojocel C, Laeschke KH, Inselmann G, Baumann K (1985) Inhibition of cephaloridine-induced lipid peroxidation. Toxicology 35: 295-305
25. Cojocel C, Hannemann J, Baumann K (1985) Cephaloridine-induced lipid peroxidation by reactive oxygen species as a possible mechanism of cephaloridine nephrotoxicity. Biochim Biophys Acta 834: 402-410
26. Tune B (1995) Effects of nephrotoxic beta-lactam antibiotics on the mitochondrial metabolism of monocarboxylic substrates. J Pharmacol Exp Ther 274: 194-199
27. Tune BM, Wu KY, Longerbeam D, Holtzman D (1978) Renal transport and toxicity of cephalosporins, including effects on tubular and mitochondrial respiration. In: Lemieux G (ed) Proceedings of the Seventh International Congress of Nephrology. Karger, Basel, pp 279-287
28. Nakashima M, Uematsu T, Ueno K, Nagashima S, Inaba H, Nakano M, Kosuge K, Kitamura M, Sasaki T (1993) Phase 1 study of L-627, biapenem, a new parenteral carbapenem antibiotic. Int J Clin Pharmacol Ther Toxicol 31: 70-76
29. Tune BM, Hsu C-Y (1991) Prevention of nephrotoxicity of beta-lactam antibiotics. In: De Broe ME, Verpooten GA (eds) Prevention in nephrology. Klüwer, Dordrecht, pp 39-49
30. Schliamser SE, Cars O, Norrby SR (1991) Neurotoxicity of beta-lactam antibiotics: predisposing factors and pathogenesis. J Antimicrob Chemother 27: 405-425
31. Tune BM, Browning MC, Hsu C-Y, Fravert D (1982) Prevention of cephalosporin nephrotoxicity by other cephalosporins and by penicillins without significant inhibition of renal cortical uptake. J Infect Dis 145: 174-180
32. Blaszczak L, Brown R, Cook G, Hornback W, Hoying R, Indelicato J, Jordan C, Katner A, Kinnick M, McDonald JI, Morin JM, Munroe JE, Pasini CE (1990) Comparative reactivity of 1-carba-1-dethiacephalosporins with cephalosporins. J Med Chem 33. 1656-1662
33. Tune BM, Hsu C-Y, Fravert D (1996) Cephalosporin and carbacephem nephrotoxicity: roles of tubular cell uptake and acylating potential. Biochem Pharmacol 51: 557-561