Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 10, 2003, Pages 5902-5907

  Shu, Yan ^a   Leabman, Maya K ^a   Feng, Bo ^a   Mangravite, Lara M ^a   Huang, Conrad C ^a   Stryke, Doug ^a   Kawamoto, Michiko ^a   Johns, Susan J ^a   DeYoung, Joseph ^a   Carlson, Elaine ^a   Ferrin, Thomas E ^a   Herskowitz, Ira ^a,b   Giacomini, Kathleen M ^a   Benet, Leslie Z ^a   Brett, Claire M ^a   Burchard, Esteban G ^a   Castro, Richard ^a   De la Cruz, Melanie ^a   Edwards, Robert H ^b   Gitschier, Jane ^b   Glatt, Charles E ^c   Ho, Chesi ^a   Kroetz, Deanna L ^a   Lin, Emil T ^a   Reus, Victor I ^a   Sadee, Wolfgang ^a   Salazar, Michael ^a   Schaefer, Catherine ^d   Sheiner, Lewis B ^a   Tran, Cindy ^b   Urban, Thomas J ^a   Vulpe, Christopher ^e   Wright, Ernest M ^f   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d DIVISION OF RESEARCH   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATION; ORGANIC CATION TRANSPORTER; PYRIDINIUM DERIVATIVE; XENOBIOTIC AGENT;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BILE SECRETION; CATION TRANSPORT; GENE FUNCTION; GENETIC CONSERVATION; GENETIC VARIABILITY; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; XENOBIOTIC METABOLISM; XENOPUS;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CONSERVED SEQUENCE; DOGS; EVOLUTION, MOLECULAR; GENE FREQUENCY; HUMANS; KIDNEY; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; ORGANIC CATION TRANSPORTER 1; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; TRANSFECTION; VARIATION (GENETICS);

ANIMALIA; MAMMALIA;

EID: 0038184179     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0730858100     Document Type: Article

References (24)

1. Evans, W. E. & Relling, M. V. (1999) Science 286, 487-491.
2. Zhang, L., Schaner, M. E. & Giacomini, K. M. (1998) J. Pharmacol. Exp. Ther. 286, 354-361.
3. Zhang, L., Brett, C. M. & Giacomini, K. M. (1998) Annu. Rev. Pharmacol. Toxicol. 38, 431-460.
4. Zhang, L., Dresser, M. J., Gray, A. T., Yost, S. C., Terashita, S. & Giacomini, K. M. (1997) Mol. Pharmacol. 51, 913-921.
5. Gorboulev, V., Ulzheimer, J. C., Akhoundova, A., Ulzheimer-Teuber, I., Karbach, U., Quester, S., Baumann, C., Lang, F., Busch, A. E. & Koepsell, H. (1997) DNA Cell Biol. 16, 871-881.
6. Dresser, M. J., Leabman, M. K. & Giacomini, K. M. (2001) J. Pharm. Sci. 90, 397-421.
7. Strautnieks, S. S., Bull, L. N., Knisely, A. S., Kocoshis, S. A., Dahl, N., Arnell, H., Sokal, E., Dahan, K., Childs, S., Ling, V., et al. (1998) Nat. Genet. 20, 233-238.
8. Bull, L. N., van Eijk, M. J., Pawlikowska, L., DeYoung, J. A., Juijn, J. A., Liao, M., Klomp, L. W., Lomri, N., Berger, R., Scharschmidt, B. F., et al. (1998) Nat. Genet. 18, 219-224.
9. Toh, S., Wada, M., Uchiumi, T., Inokuchi, A., Makino, Y., Horie, Y., Adachi, Y., Sakisaka, S. & Kuwano, M. (1999) Am. J. Hum. Genet. 64, 739-746.
10. Leabman, M. K., Huang, C. C., DeYoung, J., Carlson, E. J., Taylor, T. R., de la Cruz, M., Johns, S. J., Stryke, D., Kawamoto, M., Urban, T. J., et al. (2003) Proc. Natl. Acad. Sci. 100, 5896-5901.
11. Mangravite, L. M., Lipschutz, J. H., Mostov, K. E. & Giacomini, K. M. (2001) Am. J. Physiol. 280, F879-F885.
12. Kerb, R., Brinkmann, U., Chatskaia, N., Gorbunov, D., Gorboulev, V., Mornhinweg, E., Keil, A., Eichelbaum, M. & Koepsell, H. (2002) Pharmacogenetics 12, 591-595.
13. Meyer-Wentrup, F., Karbach, U., Gorboulev, V., Arndt, P. & Koepsell, H. (1998) Biochem. Biophys. Res. Commun. 248, 673-678.
14. Stephens, M., Smith, N. J. & Donnelly, P. (2001) Am. J. Hum. Genet. 68, 978-989.
15. Dresser, M. J., Gray, A. T. & Giacomini, K. M. (2000) J. Pharmacol. Exp. Ther. 292, 1146-1152.
16. Ng, P. C. & Henikoff, S. (2001) Genome Res. 11, 863-874.
17. Henikoff, S. & Henikoff, J. G. (1992) Proc. Natl. Acad. Sci. USA 89, 10915-10919.
18. Grantham, R. (1974) Science 185, 862-864.
19. Cargill, M., Altshuler, D., Ireland, J., Sklar, P., Ardlie, K., Patil, N., Shaw, N., Lane, C. R., Lim, E. P., Kalyanaraman, N., et al. (1999) Nat. Genet. 22, 231-238.
20. Leabman, M. K., Huang, C. C., Kawamoto, M., Johns, S. J., Stryke, D., Ferrin, T. E., DeYoung, J., Taylor, T., Clark, A. G., Herskowitz, I. & Giacomini, K. M. (2002) Pharmacogenetics 12, 395-405.
21. Langston, J. W., Ballard, P., Tetrud, J. W. & Irwin, I. (1983) Science 219, 979-980.
22. Yang, M. C., McLean, A. J. & Le Couteur, D. G. (2001) Biochem. Biophys. Res. Commun. 289, 130-136.
23. Jonker, J. W., Wagenaar, E., Mol, C. A., Buitelaar, M., Koepsell, H., Smit, J. W. & Schinkel, A. H. (2001) Mol. Cell. Biol. 21, 5471-5477.
24. Wang, D. S., Jonker, J. W., Kato, Y., Kusuhara, H., Schinkel, A. H. & Sugiyama, Y. (2002) J. Pharmacol. Exp. Ther. 302, 510-515.