Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats

Cancer Research

Volumn 57, Issue 16, 1997, Pages 3506-3510

  Masuda, Masayuki ^a   I'izuka, Yuji ^a   Yamazaki, Masayo ^a   Nishigaki, Ryuichiro ^a   Kato, Yukio ^b   Ni'inuma, Kayoko ^b   Suzuki, Hiroshi ^b   Sugiyama, Yuichi ^b  

^a TOHO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; GLUTATHIONE; METHOTREXATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANION TRANSPORT; ARTICLE; BILIARY EXCRETION; BOLUS INJECTION; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; INTRAVENOUS DRUG ADMINISTRATION; ISOMER; MALE; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANION TRANSPORT PROTEINS; ANTIMETABOLITES, ANTINEOPLASTIC; BILE; BILE CANALICULI; CARRIER PROTEINS; MALE; METHOTREXATE; RATS;

EID: 0030753176     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Jackson, R. L. Biological effects of folic acid antagonists with antineoplasmic activity. Pharmacol. Ther., 25: 61-82, 1984.
2. Schnabel, A., and Gross, W. L. Low-dose methotrexate in rheumatic diseases: efficacy, side effects, and risk factors for side effects. Semin. Arthritis Rheum., 23: 310-327, 1994.
3. Bremnes, R. M., Sløodal, L., Wist, E., and Aarbakke, J. Dose-dependent pharmacokinetics of methotrexate and 7-hydroxymethotrexate in the rat in vivo. Cancer Res., 49: 6359-6364, 1989.
4. Hillman, R. S., and Steinberg, S. E. The effects of alcohol on folate metabolism. Annu. Rev. Med., 33: 345-354, 1982.
5. Williams, R. T., Millburn, P., and Smith, R. L. The influence of enterohepatic circulation on toxicity of drugs. Ann. NY Acad. Sci., 123: 110-124, 1965.
6. Kates, R. E., and Tozer, T. N. Biliary secretion of methotrexate in rats and its inhibition by probenecid. J. Pharm. Sci., 65: 1348-1352, 1976.
7. Gatmaitan, Z. C., and Arias, I. M. ATP-dependent transport systems in the canalicular membrane of the hepatocytes. Physiol. Rev., 75: 261-275, 1995.
8. Yamazaki, M., Suzuki, H., and Sugiyama, Y. Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm. Res. (NY), 13: 497-513, 1996.
9. Inoue, M., Kinno, R., Tran, T., Biempida, L., and Arias, I. M. Taurocholate transport by rat liver canalicular membrane vesicles. J. Biol. Chem., 258: 5183-5188, 1983.
10. Meier, P. J., Sztul, E. S., Reuben, A., and Boyer, J. L. Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. J. Cell Biol., 98: 991-1000, 1984.
11. Jansen, P. L. M., Peters, W. H. M., and Lamers, W. H. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology, 5: 573-579, 1985.
12. Mikami, T., Nozaki, T., Tagaya, O., Hosokawa, S., Nakura, T., Mori, H., and Kondou, S. The characters of a new mutant in rats with hyperbilirubinuria syndrome. Congenital Anom., 26: 250-251, 1986.
13. Fernandez-Checa, J. C., Takikawa, H., Horie, T., Ookhtens, M., and Kaplowitz, N. Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. J. Biol. Chem., 267: 1667-1673, 1992.
14. Paulusma, C. C., Bosma, P. J., Zaman, G. J. R., Bakker, C. T. M., Otter, M., Scheffer, G. L., Scheper, R. S. J., Borst, P., and Elferink, P. J. O. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science (Washington DC), 271: 1126-1128, 1996.
15. Ito, K., Suzuki, H., Hirohashi, T., Kume, K., Shimizu, T., and Sugiyama, Y. Expression of a putative ATP-binding cassette region, homologous to that in multidrug resistance-associated protein (MRP), is hereditary defective in Eisai hyperbilirubinemic rats (EHBR). Int. Hepatol. Commun., 4: 291-298, 1996.
16. Ito, K., Suzuki, H., Hirohashi, T., Kume, K., Shimizu, T., and Sugiyama, Y. Molecular cloning of canalicular multispecific organic anion transporter (cMOAT) whose expression is defective in mutant rats with hereditary conjugated hyperbilirubinemia (EHBR). Am. J. Physiol., 272: G16-G22, 1997.
17. Kobayashi, K., Sogame, Y., Hara, H., and Hayashi, K. Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J. Biol. Chem., 265: 7737-7741, 1990.
18. Lowson, G. J., and Dixon, P. F. Rapid and simple method for the measurement of methotrexate and 7-hydroxymethotrexate in serum by high-performance liquid chromatography, J. Chromatogr., 223: 225-231, 1981.
19. Brimmell, P. A., and Sams, D. J. Rapid and simple assay for the measurement of methotrexate in serum, urine and red blood cells by reversed-phase high-performance liquid chromatography, J. Chromatogr., 413: 320-325, 1987.
20. +-stimulated hydrolysis of adenosine triphosphate. Eur. J. Biochem., 1: 334-343, 1967.
21. Yachi, K., Sugiyama, Y., Sawada, Y., Iga, T., Ikeda, Y., Toga, G., and Hanano, M. Characterization of rose bengal binding to sinusoidal and canalicular plasma membrane from rat liver. Biochim. Biophys. Acta. 978: 1-7, 1989.
22. Bradford, M. M. A rapid and sensitive method for the quantitation of microsomal quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254, 1976.
23. Sathirakul, K., Suzuki, H., Yamada, T., Hanano, M., and Sugiyama, Y. Multiple transport systems for organic anions across the bile canalicular membrane. J. Pharmacol. Exp. Ther., 268: 65-73, 1994.
24. Takenaka, O., Horie, T., Suzuki, H., Kobayashi, K., and Sugiyama, Y. Kinetic analysis of hepatobiliary transport for conjugative metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugative hyperbilirubinemia. Pharm. Res. (NY), 12: 1746-1755, 1995.
25. Yamaoka, K., Tanigawara, Y., Nakagawa, T., and Uno, T. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharm. Dyn., 4: 879-885, 1981.
26. Yamaoka, K., Nakagawa, T., and Uno, T. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. J. Pharmacokinet. Biopharm., 6: 165-175, 1978.
27. Elferink, P. J. O., and Jansen, P. L. M. The role of the canalicular multispecific organic anion transporter in the disposal of endo-and xenobiotics. Pharmacol. Ther., 64: 77-97, 1994.
28. Jansen, P. L. M., Groothuis, G. M. M., Peters, W. H. M,. and Meijer, D. K. F. Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary-conjugated hyperbilirubinemia. Hepatology, 7: 71-76, 1987.
29. Jansen, P. L. M., Peters, W. H. M., and Meijer, D. K. F. Hepatobiliary excretion of organic anions in double-mutant rats with a combination of defective canalicular transport and uridine 5′-diphosphate glucronyl-transferase deficiency. Gastroenterology, 93: 1094-1103, 1987.
30. Kitamura, T., Jansen, P., Hardenbrook, C., Kamimoto, Y., Gatmaitan, Z., and Arias, I. M. Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia. Proc. Natl. Acad. Sci. USA, 87: 3557-3561, 1990.
31. Nishida, T., Roy Chowdhry, J., and Arias, I. M. Two distinct mechanisms for bilirubin glucuronide transport by rat bile canalicular membrane vesicles. J. Clin. Invest., 90: 2130-2135, 1992.
32. Nishida, T., Hardenbrook, C., Gatmaitan, Z., and Arias, I. M. ATP-dependent organic anion transport system in normal and TR-rat liver canalicular membranes. Am. J. Physiol., 262: G629-G635, 1992.
33. Sathirakul, K., Suzuki, H., Yasuda, K., Hanano, M., Tagaya, H., Horie, T., and Sugiyama, Y. Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats. J. Pharmacol. Exp. Ther., 265: 1301-1312, 1993.
34. Buchler, M., Konig, J., Brom, M., Kartenbeck, J., Spring, H., Horie, T., and Keppler, D. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J. Biol. Chem., 271: 15091-15098, 1996.