Hepatic disposition of fexofenadine: Influence of the transport inhibitors erythromycin and dibromosulphothalein

Pharmaceutical Research

Volumn 17, Issue 12, 2000, Pages 1511-1515

  Milne, Robert W ^a   Larsen, Linda A ^a   Jørgensen, Klaus L ^a   Bastlund, Jesper ^a   Stretch, Graham R ^a   Evans, Allan M ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Dibromosulphothalein; Erythromycin; Fexofenadine; Hepatic transport; Inhibition

Indexed keywords

DIBROMOSULFOPHTHALEIN; ERYTHROMYCIN; FEXOFENADINE;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BILE LEVEL; DRUG DISPOSITION; DRUG INHIBITION; DRUG LIVER LEVEL; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; AREA UNDER CURVE; BILE; BIOLOGICAL TRANSPORT, ACTIVE; ERYTHROMYCIN; HISTAMINE H1 ANTAGONISTS; LIVER; MALE; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SULFOBROMOPHTHALEIN; TERFENADINE;

EID: 0034466892     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007609225851     Document Type: Article

References (28)

1. Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers
2. Cardiovascular safety of fexofenadine HCl
3. Mass balance and pharmacokinetics of MDL 16,455A in healthy male volunteers
4. Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences
5. Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics
6. The effect of fluconazole on the steady-state pharmacokinetics and electrocardiac pharmacodynamics of terfenadine in humans
7. Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco- 2 cells
8. Interrelationship between substrates and inhibitors of human CYP 3A and Pglycoprotein
9. Grapefruit juice exerts stimulatory effects on P-glycoprotein
10. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
11. Molecular aspects of hepatobiliary transport
12. Mechanistic aspects of uptake and sinusoidal efflux of dibromosulfophthalein in the isolated perfused rat liver
13. The disposition of morphine and its metabolites in the in-situ rat isolated perfused liver
14. Bioavailability of terfenadine in man
15. Pharmacokinetics and biotransformation studies of terfenadine in man
16. Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin
17. Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences
18. Hepatic disposition of phenoldibromphthalein disulfonate and sulfobromophthalein
19. Uptake of organic anions by isolated rat hepatocytes. A classification in terms of ATP-dependency
20. Characterization of the transport properties of organic anion transporting polypeptide 1 (oatpl) and Na+/taurocholate cotransporting polypeptide (Ntcp): Comparative studies on the inhibitory effects of their possible substrates in hepatocytes and cDNA-transfected COS- 7 cells
21. Multiple transport systems for organic anions across bile canalicular membrane
22. Hepatic drug transport in the rat. A comparison between isolated hepatocytes, the isolated perfused liver and the liver in vivo
23. The drug transporter Pglycoprotein limits oral absorption and brain entry of HIV- 1 protease inhibitors
24. Fexofenadine (Fex) disposition in the isolated perfused rat liver (IPL): Effects of ketoconazole (Ket) and erythromycin (Ery)
25. Human MDR1 and mouse mdrl P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid and benzo(a)pyrene
26. Single dose pharmacokinetics of erythromycin and roxithromycin and the effects of chronic dosing
27. Biochemistry of multidrug resistance mediated by the multidrug transporter