C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance

Molecular Cancer Therapeutics

Volumn 1, Issue 8, 2002, Pages 611-616

  Imai, Yasuo ^a   Nakane, Minoru ^a   Kage, Kumie ^a   Tsukahara, Satomi ^a   Ishikawa, Etsuko ^a   Tsuruo, Takashi ^a,c   Miki, Yoshio ^b   Sugimoto, Yoshikazu ^a  

^a CANCER CHEMOTHERAPY CENTER   (Japan)

^b CANCER INSTITUTE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7-ETHYL-10-HYDROXYCAMPTOTHECIN; ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; COMPLEMENTARY DNA; DRUG DERIVATIVE; IRINOTECAN; MESSENGER RNA; MITOXANTRONE; TOPOTECAN; TUMOR PROTEIN;

ALTERNATIVE RNA SPLICING; ANIMAL; ARTICLE; CELL CULTURE; DNA SEQUENCE; DOSE RESPONSE; DRUG RESISTANCE; FIBROBLAST; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENETICS; HETEROZYGOTE; HOMOZYGOTE; METABOLISM; MOLECULAR GENETICS; MOUSE; MUTATION; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; WESTERN BLOTTING;

ALTERNATIVE SPLICING; ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CAMPTOTHECIN; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; FIBROBLASTS; HETEROZYGOTE; HOMOZYGOTE; MICE; MITOXANTRONE; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM PROTEINS; POLYMORPHISM, GENETIC; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; TOPOTECAN; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036598543     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Gottesman, M. M., Hrycyna, C. A., Schoenlein, P. V., Germann, U. A., and Pastan, I. Genetic analysis of the multidrug transporter. Annu. Rev. Genet., 29: 607-649, 1995. (Pubitemid 26005354)
2. Chen, C. J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., and Roninson, I. B. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrugresistant human cells. Cell, 47: 381-389, 1986. (Pubitemid 17210152)
3. Ueda, K., Clark, D. P., Chen, C. J., Roninson, I. B., Gottesman, M. M., and Pastan, I. The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation. J. Biol. Chem., 262: 505-508, 1987. (Pubitemid 17005205)
4. Miyake, K., Mickley, L., Litman, T., Zhan, Z., Robey, R., Cristensen, B., Brangi, M., Greenberger, L., Dean, M., Fojo, T., and Bates, S. E. Molecular cloning of cDNAs which is highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. Cancer Res., 59: 8-13, 1999. (Pubitemid 29062946)
5. Doyle, L. A., Yang, W., Abruzzo, L. V., Krogmann, T., Gao, Y., Rishi, A. K., and Ross, D. D. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc. Natl. Acad. Sci. USA, 95: 15665-15670, 1998. (Pubitemid 29018757)
6. Allikmets, R., Schriml, L., Hutchinson, A., Romano-Spica, V., and Dean, M. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res., 58: 5337-5339, 1998. (Pubitemid 28551112)
7. Maliepaard, M., van Gastelen, M. A., de Jong, L. A., Pluim, D., van Waardenburg, R. C., Ruevekamp-Helmers, M. C., Floot, B. G., and Schellens, J. H. Overexpression of the BCRP/MXR/ABCP gene in a topotecanselected ovarian tumor cell line. Cancer Res., 59: 4559-4563, 1999. (Pubitemid 29428958)
8. Kawabata, S., Oka, M., Shiozawa, K., Tsukamoto, K., Nakatomi, K., Soda, H., Fukuda, M., Ikegami, Y., Sugahara, K., Yamada, Y., Kamihira, S., Doyle, L. A., Ross, D. D., and Kohno, S. Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells. Biochem. Biophys. Res. Commun., 280: 1216-1223, 2001. (Pubitemid 32917772)
9. Imai, Y., Tsukahara, S., Ishikawa, E., Tsuruo, T., and Sugimoto, Y. Estrone and 17β-estradiol reverse breast cancer resistance proteinmediated multidrug resistance. Jpn. J. Cancer Res., 93: 231-235, 2002. (Pubitemid 34464356)
10. Hoffmeyer, S., Burk, O., von Richter, O., Arnold, H. P., Brockmoeller, J., Johne, A., Cascorbi, I., Gerloff, T., Roots, I., Eichelbaum, M., and Brinkmann, U. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc. Natl. Acad. Sci. USA, 97: 3473-3478, 2000. (Pubitemid 30183327)
11. O'Connor, P. M., Jackman, J., Bae, I., Myers, T. G., Fan, S., Mutoh, M., Scudiero, D. A., Monks, A., Sausville, E. A., Weinstein, J. N., Friend, S., Fornace, Jr., A. J., and Kohn, K. W. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res., 57: 4285-4300, 1997. (Pubitemid 27413438)
12. Kage, K., Tsukahara, S., Sugiyama, T., Asada, S., Ishikawa, E., Tsuruo, T., and Sugimoto, Y. Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization. Int. J. Cancer, 97: 626-630, 2002. (Pubitemid 34087801)
13. Bailey-Dell, K. J., Hassel, B., Doyle, L. A., and Ross, D. D. Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene. Biochim. Biophys. Acta, 1520: 234-241, 2001. (Pubitemid 32868794)
14. Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., and Sorrentino, B. P. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the sidepopulation phenotype. Nat. Med., 7: 1028-1034, 2001. (Pubitemid 32937383)
15. Fukuoka, M., Niitani, H., Suzuki, A., Motomiya, M., Hasegawa, K., Nishiwaki, Y., Kuriyama, T., Ariyoshi, Y., Negoro, S., Masuda, N., Nakajima, S., and the CPT-11 Lung Cancer Study Group. A Phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer. J. Clin. Oncol., 10: 16-20, 1992.
16. WHO. WHO handbook for reporting results of cancer treatment. In: WHO Offset Publication No. 48. Geneva: WHO, 1979.