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Volumn 54, Issue 10, 2002, Pages 1343-1352

Pharmacogenomics of organic anion-transporting polypeptides (OATP)

Author keywords

Drug disposition; Drug transporter; Single nucleotide polymorphism

Indexed keywords

BRAIN; DRUG PRODUCTS; NEGATIVE IONS; POLYPEPTIDES;

EID: 0037131885     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(02)00077-7     Document Type: Article
Times cited : (98)

References (56)
  • 2
    • 0036083485 scopus 로고    scopus 로고
    • An evolutionarily ancient Oatp: Insights into conserved functional domains of these proteins
    • Cai S.-Y., Wang W., Soroka C.J., Ballatori N., Boyer J.L. An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins. Am. J. Physiol. 282:2002;G702-G710.
    • (2002) Am. J. Physiol. , vol.282
    • Cai, S.-Y.1    Wang, W.2    Soroka, C.J.3    Ballatori, N.4    Boyer, J.L.5
  • 3
    • 85080851473 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides, cholestasis, and nuclear receptors (letter)
    • Kullak-Ublick G.A., Jung D., Hagenbuch B., Meier P.J. Organic anion transporting polypeptides, cholestasis, and nuclear receptors (letter). Hepatology. 35:2002;733.
    • (2002) Hepatology , vol.35 , pp. 733
    • Kullak-Ublick, G.A.1    Jung, D.2    Hagenbuch, B.3    Meier, P.J.4
  • 4
    • 0034709561 scopus 로고    scopus 로고
    • Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
    • Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M., Tsuji A. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem. Biophys. Res. Commun. 273:2000;251-260.
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , pp. 251-260
    • Tamai, I.1    Nezu, J.2    Uchino, H.3    Sai, Y.4    Oku, A.5    Shimane, M.6    Tsuji, A.7
  • 6
    • 0034753042 scopus 로고    scopus 로고
    • Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2
    • Cui Y., König J., Keppler D. Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol. Pharmacol. 60:2001;934-943.
    • (2001) Mol. Pharmacol. , vol.60 , pp. 934-943
    • Cui, Y.1    König, J.2    Keppler, D.3
  • 7
    • 0037155204 scopus 로고    scopus 로고
    • Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2)
    • Sasaki M., Suzuki H., Ito K., Abe T., Sugiyama Y. Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2). J. Biol. Chem. 277:2002;6497-6508.
    • (2002) J. Biol. Chem. , vol.277 , pp. 6497-6508
    • Sasaki, M.1    Suzuki, H.2    Ito, K.3    Abe, T.4    Sugiyama, Y.5
  • 9
    • 0033638544 scopus 로고    scopus 로고
    • Expression, transport properties, and chromosomal location of organic anion transporter subtype 3
    • Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A. Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Am. J. Physiol. 279:2000;G1188-G1200.
    • (2000) Am. J. Physiol. , vol.279
    • Walters, H.C.1    Craddock, A.L.2    Fusegawa, H.3    Willingham, M.C.4    Dawson, P.A.5
  • 10
    • 0032859340 scopus 로고    scopus 로고
    • Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroids plexus epithelium of rat brain
    • Gao B., Stieger B., Noé B., Fritschy J.-M., Meier P.J. Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroids plexus epithelium of rat brain. J. Histochem. Cytochem. 47:1999;1255-1263.
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 1255-1263
    • Gao, B.1    Stieger, B.2    Noé, B.3    Fritschy, J.-M.4    Meier, P.J.5
  • 16
    • 0034916717 scopus 로고    scopus 로고
    • Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis
    • Oswald M., Kullak-Ublick G.A., Paumgartner G., Beuers U. Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis. Liver. 21:2001;247-253.
    • (2001) Liver , vol.21 , pp. 247-253
    • Oswald, M.1    Kullak-Ublick, G.A.2    Paumgartner, G.3    Beuers, U.4
  • 17
    • 0036159433 scopus 로고    scopus 로고
    • Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
    • Dresser G.K., Bailey D.G., Leake B.F., Schwarz U.I., Dawson P.A., Freeman D.J., Kim R.B. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin. Pharmacol. Ther. 71:2002;11-20.
    • (2002) Clin. Pharmacol. Ther. , vol.71 , pp. 11-20
    • Dresser, G.K.1    Bailey, D.G.2    Leake, B.F.3    Schwarz, U.I.4    Dawson, P.A.5    Freeman, D.J.6    Kim, R.B.7
  • 18
    • 0030724010 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide mediates organic anion/HCO3-exchange
    • Satlin L.M., Amin V., Wolkoff A.W. Organic anion transporting polypeptide mediates organic anion/HCO3-exchange. J. Biol. Chem. 272:(42):1997;26340-26345.
    • (1997) J. Biol. Chem. , vol.272 , Issue.42 , pp. 26340-26345
    • Satlin, L.M.1    Amin, V.2    Wolkoff, A.W.3
  • 19
    • 0032568838 scopus 로고    scopus 로고
    • Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter
    • Li L., Lee T.K., Meier P.J., Ballatori N. Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. J. Biol. Chem. 273:1998;16184-16191.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16184-16191
    • Li, L.1    Lee, T.K.2    Meier, P.J.3    Ballatori, N.4
  • 20
    • 0033943874 scopus 로고    scopus 로고
    • Oatp2 mediates bidirectional organic solute transport: A role for intracellular glutathione
    • Li L., Meier P.J., Ballatori N. Oatp2 mediates bidirectional organic solute transport: a role for intracellular glutathione. Mol. Pharmacol. 58:2000;335-340.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 335-340
    • Li, L.1    Meier, P.J.2    Ballatori, N.3
  • 21
    • 0036158009 scopus 로고    scopus 로고
    • The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane
    • Mittur A., Wolkoff A.W., Kaplowitz N. The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane. Mol. Pharmacol. 61:2002;425-435.
    • (2002) Mol. Pharmacol. , vol.61 , pp. 425-435
    • Mittur, A.1    Wolkoff, A.W.2    Kaplowitz, N.3
  • 22
    • 0033968255 scopus 로고    scopus 로고
    • Down-regulation by extracellular ATP of rat hepatocyte organic anion transport is mediated by serine phosphorylation of Oatp1
    • Glavy J.S., Wu S.M., Wang P.J., Orr G.A., Wolkoff A.W. Down-regulation by extracellular ATP of rat hepatocyte organic anion transport is mediated by serine phosphorylation of Oatp1. J. Biol. Chem. 275:2000;1479-1484.
    • (2000) J. Biol. Chem. , vol.275 , pp. 1479-1484
    • Glavy, J.S.1    Wu, S.M.2    Wang, P.J.3    Orr, G.A.4    Wolkoff, A.W.5
  • 23
    • 0034767938 scopus 로고    scopus 로고
    • Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake
    • Guo G.L., Klaassen C.D. Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake. J. Pharmacol. Exp. Ther. 299:2001;551-557.
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 551-557
    • Guo, G.L.1    Klaassen, C.D.2
  • 24
    • 0036138199 scopus 로고    scopus 로고
    • Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways
    • Guo G.L., Choudhuri C., Klaassen C.D. Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. J. Pharmacol. Exp. Ther. 300:2002;206-212.
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 206-212
    • Guo, G.L.1    Choudhuri, C.2    Klaassen, C.D.3
  • 25
    • 0034982907 scopus 로고    scopus 로고
    • Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2
    • Rausch-Derra L.C., Hartley D.P., Meier P.J., Klaassen C.D. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2. Hepatology. 33:2001;1469-1478.
    • (2001) Hepatology , vol.33 , pp. 1469-1478
    • Rausch-Derra, L.C.1    Hartley, D.P.2    Meier, P.J.3    Klaassen, C.D.4
  • 27
    • 0035813209 scopus 로고    scopus 로고
    • Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1α
    • Jung D., Hagenbuch B., Gresh L., Pontoglio M., Meier P.J., Kullak-Ublick G.A. Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1α J. Biol. Chem. 276:2001;37206-37214.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37206-37214
    • Jung, D.1    Hagenbuch, B.2    Gresh, L.3    Pontoglio, M.4    Meier, P.J.5    Kullak-Ublick, G.A.6
  • 32
  • 34
    • 0030296680 scopus 로고    scopus 로고
    • Multispecific amphipathic substrate transport by an organic anion transporter of human liver
    • Bossuyt X., Muller M., Meier P.J. Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J. Hepatol. 25:1996;733-738.
    • (1996) J. Hepatol. , vol.25 , pp. 733-738
    • Bossuyt, X.1    Muller, M.2    Meier, P.J.3
  • 36
    • 0034968246 scopus 로고    scopus 로고
    • Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides
    • van Montfoort J.E., Muller M., Groothuis G.M., Meijer D.K., Koepsell H., Meier P.J. Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J. Pharmacol. Exp. Ther. 298:2001;110-115.
    • (2001) J. Pharmacol. Exp. Ther. , vol.298 , pp. 110-115
    • Van Montfoort, J.E.1    Muller, M.2    Groothuis, G.M.3    Meijer, D.K.4    Koepsell, H.5    Meier, P.J.6
  • 37
    • 0032793959 scopus 로고    scopus 로고
    • OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
    • Cvetkovic M., Leake B., Fromm M.F., Wilkinson G.R., Kim R.B. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab. Dispos. 27:1999;866-871.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 866-871
    • Cvetkovic, M.1    Leake, B.2    Fromm, M.F.3    Wilkinson, G.R.4    Kim, R.B.5
  • 38
    • 0035211396 scopus 로고    scopus 로고
    • Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptide, and three NADH:ubiquinone oxidoreductase flavoproteins
    • Iida A., Saito S., Sekine A., Mishima C., Kondo K., Kitamura Y., Harigae S., Osawa S., Nakamura Y. Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptide, and three NADH:ubiquinone oxidoreductase flavoproteins. J. Hum. Genet. 46:2001;668-683.
    • (2001) J. Hum. Genet. , vol.46 , pp. 668-683
    • Iida, A.1    Saito, S.2    Sekine, A.3    Mishima, C.4    Kondo, K.5    Kitamura, Y.6    Harigae, S.7    Osawa, S.8    Nakamura, Y.9
  • 39
    • 0030880647 scopus 로고    scopus 로고
    • Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene
    • Kullak-Ublick G.A., Beuers U., Fahney C., Hagenbuch B., Meier P.J., Paumgartner G. Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene. Hepatology. 26:1997;991-997.
    • (1997) Hepatology , vol.26 , pp. 991-997
    • Kullak-Ublick, G.A.1    Beuers, U.2    Fahney, C.3    Hagenbuch, B.4    Meier, P.J.5    Paumgartner, G.6
  • 40
    • 0033601257 scopus 로고    scopus 로고
    • A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
    • Hsiang B., Zhu Y., Wang Z., Wu Y., Sasseville V., Yang W.P., Kirchgessner T.G. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J. Biol. Chem. 274:1999;37161-37168.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37161-37168
    • Hsiang, B.1    Zhu, Y.2    Wang, Z.3    Wu, Y.4    Sasseville, V.5    Yang, W.P.6    Kirchgessner, T.G.7
  • 41
    • 0037733365 scopus 로고    scopus 로고
    • A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
    • König J., Cui Y., Nies A.T., Keppler D. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. 278:2000;G156-G164.
    • (2000) Am. J. Physiol. , vol.278
    • König, J.1    Cui, Y.2    Nies, A.T.3    Keppler, D.4
  • 42
    • 0035012075 scopus 로고    scopus 로고
    • Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes
    • Nakai D., Nakagomi R., Furuta Y., Tokui T., Abe T., Ikeda T., Nishimura K. Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes. J. Pharmacol. Exp. Ther. 297:2001;861-867.
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 861-867
    • Nakai, D.1    Nakagomi, R.2    Furuta, Y.3    Tokui, T.4    Abe, T.5    Ikeda, T.6    Nishimura, K.7
  • 44
    • 0035929574 scopus 로고    scopus 로고
    • Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans
    • Tirona R.G., Leake B.F., Merino G., Kim R.B. Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. J. Biol. Chem. 276:2001;35669-35675.
    • (2001) J. Biol. Chem. , vol.276 , pp. 35669-35675
    • Tirona, R.G.1    Leake, B.F.2    Merino, G.3    Kim, R.B.4
  • 45
    • 0035971239 scopus 로고    scopus 로고
    • Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6
    • Cui Y., König J., Leier I., Buchholz U., Keppler D. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J. Biol. Chem. 276:2001;9626-9630.
    • (2001) J. Biol. Chem. , vol.276 , pp. 9626-9630
    • Cui, Y.1    König, J.2    Leier, I.3    Buchholz, U.4    Keppler, D.5
  • 47
    • 0034725617 scopus 로고    scopus 로고
    • Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
    • König J., Cui Y., Nies A.T., Keppler D. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J. Biol. Chem. 275:2000;23161-23168.
    • (2000) J. Biol. Chem. , vol.275 , pp. 23161-23168
    • König, J.1    Cui, Y.2    Nies, A.T.3    Keppler, D.4
  • 48
    • 0000869658 scopus 로고    scopus 로고
    • Polymorphisms in the digoxin uptake transporter OATP-8, among Japanese, African-, and European-American subjects (Abstract)
    • Suzuki A., Tirona R.G., Leake B.F., Miyake F., Echizen H., Takahashi H., Kim R.B. Polymorphisms in the digoxin uptake transporter OATP-8, among Japanese, African-, and European-American subjects (Abstract). Clin. Pharmacol. Ther. 71:2002;P104.
    • (2002) Clin. Pharmacol. Ther. , vol.71
    • Suzuki, A.1    Tirona, R.G.2    Leake, B.F.3    Miyake, F.4    Echizen, H.5    Takahashi, H.6    Kim, R.B.7
  • 49
    • 0034754481 scopus 로고    scopus 로고
    • Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver
    • Ismair M.G., Stieger B., Cattori V., Hagenbuch B., Fried M., Meier P.J., Kullak-Ublick G.A. Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Gastroenterology. 121:2001;1185-1190.
    • (2001) Gastroenterology , vol.121 , pp. 1185-1190
    • Ismair, M.G.1    Stieger, B.2    Cattori, V.3    Hagenbuch, B.4    Fried, M.5    Meier, P.J.6    Kullak-Ublick, G.A.7
  • 53
    • 0034935038 scopus 로고    scopus 로고
    • Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene
    • Jonker J.W., Wagenaar E., Mol C.A., Buitelaar M M., Koepsell H., Smit J.W., Schinkel A.H. Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene. Mol. Cell. Biol. 21:2001;5471-5477.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5471-5477
    • Jonker, J.W.1    Wagenaar, E.2    Mol, C.A.3    Buitelaar M, M.4    Koepsell, H.5    Smit, J.W.6    Schinkel, A.H.7
  • 54
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • Hoffmeyer S., Burk O., von Richter O., Arnold H.P., Brockmoller J., Johne A., Cascorbi I., Gerloff T., Roots I., Eichelbaum M. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc. Natl. Acad. Sci. USA. 97:2000;3473-3478.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3473-3478
    • Hoffmeyer, S.1    Burk, O.2    Von Richter, O.3    Arnold, H.P.4    Brockmoller, J.5    Johne, A.6    Cascorbi, I.7    Gerloff, T.8    Roots, I.9    Eichelbaum, M.10
  • 56
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans W.E., Relling M.V. Pharmacogenomics: translating functional genomics into rational therapeutics. Science. 286:1999;487-491.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2


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