ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

Laboratory Investigation

Volumn 82, Issue 3, 2002, Pages 273-283

  Wellington, Cheryl L ^a   Walker, Elizabeth K Y ^a   Suarez, Agripina ^a   Kwok, Anita ^a   Bissada, Nagat ^a   Singaraja, Roshni ^a   Yang, Yu Zhou ^a   Zhang, Lin Hua ^a   James, Erick ^a   Wilson, Janet E ^a   Francone, Omar ^b   McManus, Bruce M ^a   Hayden, Michael R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; BLADDER EPITHELIUM; CELL SPECIFICITY; CONTROLLED STUDY; DIGESTIVE SYSTEM; FAMILIAL DISEASE; GENE MUTATION; HYPOLIPOPROTEINEMIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY PROXIMAL TUBULE; LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PURKINJE CELL; PYRAMIDAL NERVE CELL; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TANGIER DISEASE; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; WESTERN BLOTTING;

ADRENAL GLANDS; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, WESTERN; CELLS, CULTURED; CHOLESTEROL, DIETARY; HUMANS; IN SITU HYBRIDIZATION; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; TESTIS; UP-REGULATION;

EID: 0036127574     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780421     Document Type: Article

References (37)

1. Characterization of apolipoprotein-mediated HDL generation induced by cAMP in a murine macrophage cell line
2. Direct interactions of Coxsackivirus B3 with immune cells in the splenic compartment of mice susceptible or resistant to myocarditis
3. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier Disease
4. The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines
5. The ABCA subclass of mammalian transporters
6. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
7. Regulation and activity of the human ABCA1 gene in transgenic mice
8. Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency
9. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
10. Brain lipoprotein metabolism and its relation to neurodegenerative disease
11. The pregnant patient with partial lipodystrophy developing acute renal failure - Onset of de novo membranoproliferative glomerulonephritis
12. Correlation between protein and mRNA abundance in yeast
13. Short-term feeding of an atherogenic diet to mice results in reduction of HDL and paraoxonase that may be mediated by an immune mechanism
14. Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)
15. An inventory of the human ABC proteins
16. Detection of mRNA in tissue sections using DIG-labeled RNA and oligonucleotide probes
17. Lipoproteins in the central nervous system
18. Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): Evidence for sterol-dependent regulation in macrophages
19. Localization of human ATP-Binding cassette transporter 1 (ABC1) in normal and atherosclerotic tissues
20. Partial lipodystrophy, mesangiocapillary glomerulonephritis, and complement dysregulation. An autoimmune phenomenon
21. Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux
22. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1
23. ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages
24. ABCA1-mediated transport of cellular cholesterol and phosopholipids to HDL apoplipoproteins
25. Membranoproliferative glomerulonephritis, type II and partial lipodystrophy in an adult
26. Familial incidence of C3 nephritic factor, partial lipodystrophy and membranoproliferative glomerulonephritis
27. Analysis of hABC1 Gene 5′ End: Additional peptide sequence, promoter region, and four polymorphisms
28. Apoplipoprotein specificity for lipid efflux by the human ABCA1 transporter
29. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
30. Tangier Disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
31. ABC transporters in cellular lipid trafficking
32. ABC1 gene expression and ApoA-1-mediated cholesterol efflux are regulated by LXR
33. Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAl-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1
34. Glomerulosclerosis in adriamycin-induced nephrosis is accelerated by a lipid-rich diet
35. Sphingomyelin and cholesterol modulate sodium coupled uptake in proximal tubular cells
36. Plasma membrane cholesterol: A critical determinant of cellular energetics and tubular resistance to attack
37. Increased proximal tubular cholesterol content: Implications for cell injury and "acquired cytoresistance"