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Volumn 339, Issue 17, 1998, Pages 1217-1227

Mechanisms of disease: Molecular pathogenesis of cholestasis

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; BILE SALT; CARRIER PROTEIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; URSODEOXYCHOLIC ACID;

EID: 0032558588     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199810223391707     Document Type: Review
Times cited : (695)

References (95)
  • 2
    • 0026072857 scopus 로고
    • Mechanisms and regulation of bile secretion
    • Nathanson MH, Boyer JL. Mechanisms and regulation of bile secretion. Hepatology 1991;14:551-66.
    • (1991) Hepatology , vol.14 , pp. 551-566
    • Nathanson, M.H.1    Boyer, J.L.2
  • 3
    • 0030020196 scopus 로고    scopus 로고
    • Bile duct epithelium: Frontiers in transport physiology
    • Boyer JL. Bile duct epithelium: frontiers in transport physiology. Am J Physiol 1996;270:G1-G5.
    • (1996) Am J Physiol , vol.270
    • Boyer, J.L.1
  • 4
    • 0029893370 scopus 로고    scopus 로고
    • Sinusoidal (basolateral) bile salt uptake systems of hepatocytes
    • Hagenbuch B, Meier PJ. Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin Liver Dis 1996;16:129-36.
    • (1996) Semin Liver Dis , vol.16 , pp. 129-136
    • Hagenbuch, B.1    Meier, P.J.2
  • 5
    • 0028231206 scopus 로고
    • Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter
    • Idem. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. J Clin Invest 1994;93:1326-31.
    • (1994) J Clin Invest , vol.93 , pp. 1326-1331
    • Hagenbuch, B.1    Meier, P.J.2
  • 6
    • 0029091022 scopus 로고
    • Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
    • Kullak-Ublick GA, Hagenbuch B, Stieger B, et al. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 1995;109:1274-82.
    • (1995) Gastroenterology , vol.109 , pp. 1274-1282
    • Kullak-Ublick, G.A.1    Hagenbuch, B.2    Stieger, B.3
  • 8
    • 0024371025 scopus 로고
    • The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles
    • Kamimoto Y, Gatmaitan Z, Hsu J, Arias IM. The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J Biol Chem 1989;264:11693-8.
    • (1989) J Biol Chem , vol.264 , pp. 11693-11698
    • Kamimoto, Y.1    Gatmaitan, Z.2    Hsu, J.3    Arias, I.M.4
  • 9
    • 0002650888 scopus 로고    scopus 로고
    • Hepatic canalicular membrane 1: The role of mdr2 P-glycoprotein in hepatobiliary lipid transport
    • Elferink RPJ, Tytgat GNJ, Groen AK. Hepatic canalicular membrane 1: the role of mdr2 P-glycoprotein in hepatobiliary lipid transport. FASEB J 1997;11:19-28.
    • (1997) FASEB J , vol.11 , pp. 19-28
    • Elferink, R.P.J.1    Tytgat, G.N.J.2    Groen, A.K.3
  • 10
    • 0029981430 scopus 로고    scopus 로고
    • Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
    • Paulusma CC, Bosma PJ, Zaman GJR, et al. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 1996;271:1126-8.
    • (1996) Science , vol.271 , pp. 1126-1128
    • Paulusma, C.C.1    Bosma, P.J.2    Zaman, G.J.R.3
  • 11
    • 0040761368 scopus 로고    scopus 로고
    • CDNa cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
    • Buchler M, Konig J, Brom M, et al. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 1996;271:15091-8.
    • (1996) J Biol Chem , vol.271 , pp. 15091-15098
    • Buchler, M.1    Konig, J.2    Brom, M.3
  • 12
    • 0031160517 scopus 로고    scopus 로고
    • Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2(cMRP/ cMOAT) gene in liver
    • Keppler D, Konig J. Hepatic canalicular membrane 5: expression and localization of the conjugate export pump encoded by the MRP2(cMRP/ cMOAT) gene in liver. FASEB J 1997;11:509-16.
    • (1997) FASEB J , vol.11 , pp. 509-516
    • Keppler, D.1    Konig, J.2
  • 13
    • 0028070766 scopus 로고
    • Bile acid transport by the rat liver canalicular bile acid transport/ecto-ATPase protein is dependent on ATP but not on its own ecto-ATPase activity
    • Sippel CJ, McCollum MJ, Perlmutter DH. Bile acid transport by the rat liver canalicular bile acid transport/ecto-ATPase protein is dependent on ATP but not on its own ecto-ATPase activity. J Biol Chem 1994;269: 2820-6.
    • (1994) J Biol Chem , vol.269 , pp. 2820-2826
    • Sippel, C.J.1    McCollum, M.J.2    Perlmutter, D.H.3
  • 14
    • 0030950640 scopus 로고    scopus 로고
    • A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport
    • Ortiz DF, St Pierre MV, Abdulmessih A, Arias IM. A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport. J Biol Chem 1997;272:15358-65.
    • (1997) J Biol Chem , vol.272 , pp. 15358-15365
    • Ortiz, D.F.1    St Pierre, M.V.2    Abdulmessih, A.3    Arias, I.M.4
  • 15
    • 0032540277 scopus 로고    scopus 로고
    • The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
    • Gerloff T, Stieger B, Hagenbuch B, et al. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 1998;273:10046-50.
    • (1998) J Biol Chem , vol.273 , pp. 10046-10050
    • Gerloff, T.1    Stieger, B.2    Hagenbuch, B.3
  • 16
    • 0029022589 scopus 로고
    • Identification of a sister gene to P-glycoprotein
    • Childs S, Yeh RL, Georges E, Ling V. Identification of a sister gene to P-glycoprotein. Cancer Res 1995;55:2029-34.
    • (1995) Cancer Res , vol.55 , pp. 2029-2034
    • Childs, S.1    Yeh, R.L.2    Georges, E.3    Ling, V.4
  • 17
    • 0031020196 scopus 로고    scopus 로고
    • Ectonucleotidases, purine nucleoside transporter, and function of the bile canalicular plasma membrane of the hepatocyte
    • Che M, Gatmaitan Z, Arias IM. Ectonucleotidases, purine nucleoside transporter, and function of the bile canalicular plasma membrane of the hepatocyte. FASEB J 1997;11:101-8.
    • (1997) FASEB J , vol.11 , pp. 101-108
    • Che, M.1    Gatmaitan, Z.2    Arias, I.M.3
  • 19
    • 0029993983 scopus 로고    scopus 로고
    • Regulation of intracellular pH in the hepatocyte: Mechanisms and physiological implications
    • Strazzabosco M, Boyer JL. Regulation of intracellular pH in the hepatocyte: mechanisms and physiological implications. J Hepatol 1996;24: 631-44.
    • (1996) J Hepatol , vol.24 , pp. 631-644
    • Strazzabosco, M.1    Boyer, J.L.2
  • 20
    • 84989554808 scopus 로고
    • Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver
    • Martinez-Anso E, Castillo JE, Diez J, Medina JF, Prieto J. Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver. Hepatology 1994;19:1400-6.
    • (1994) Hepatology , vol.19 , pp. 1400-1406
    • Martinez-Anso, E.1    Castillo, J.E.2    Diez, J.3    Medina, J.F.4    Prieto, J.5
  • 21
    • 0027134853 scopus 로고
    • Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells
    • Cohn JA, Strong TV, Picciotto MR, Nairn AC, Collins FS, Fitz JG. Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells. Gastroenterology 1993;105:1857-64.
    • (1993) Gastroenterology , vol.105 , pp. 1857-1864
    • Cohn, J.A.1    Strong, T.V.2    Picciotto, M.R.3    Nairn, A.C.4    Collins, F.S.5    Fitz, J.G.6
  • 22
    • 0031035237 scopus 로고    scopus 로고
    • Sepsis-associated cholestasis
    • Moseley RH. Sepsis-associated cholestasis. Gastroenterology 1997; 112:302-6.
    • (1997) Gastroenterology , vol.112 , pp. 302-306
    • Moseley, R.H.1
  • 23
    • 0027225501 scopus 로고
    • Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver
    • Bossard R, Stieger B, O'Neill B, Fricker G, Meier PJ. Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver. J Clin Invest 1993;91:2714-20.
    • (1993) J Clin Invest , vol.91 , pp. 2714-2720
    • Bossard, R.1    Stieger, B.2    O'Neill, B.3    Fricker, G.4    Meier, P.J.5
  • 24
    • 0030027622 scopus 로고    scopus 로고
    • Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis
    • Gartung C, Ananthanarayanan M, Rahman MA, et al. Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 1996;110:199-209.
    • (1996) Gastroenterology , vol.110 , pp. 199-209
    • Gartung, C.1    Ananthanarayanan, M.2    Rahman, M.A.3
  • 25
    • 0029737476 scopus 로고    scopus 로고
    • Effect of endotoxin on bile acid transport in rat liver: A potential model for sepsis-associated cholestasis
    • Moseley RH, Wang W, Takeda H, et al. Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis. Am J Physiol 1996;271:G137-G146.
    • (1996) Am J Physiol , vol.271
    • Moseley, R.H.1    Wang, W.2    Takeda, H.3
  • 26
    • 0030470648 scopus 로고    scopus 로고
    • Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters
    • Simon FR, Fortune J, Iwahashi M, Gartung C, Wolkoff A, Sutherland E. Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters. Am J Physiol 1996;271:G1043-G1052.
    • (1996) Am J Physiol , vol.271
    • Simon, F.R.1    Fortune, J.2    Iwahashi, M.3    Gartung, C.4    Wolkoff, A.5    Sutherland, E.6
  • 27
    • 0031013566 scopus 로고    scopus 로고
    • Hepatocyte transport of bile acids and organic anions in endotoxemic rats: Impaired uptake and secretion
    • Bolder U, Ton-Nu HT, Schteingart CD, Frick E, Hofmann AF. Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion. Gastroenterology 1997;112:214-25.
    • (1997) Gastroenterology , vol.112 , pp. 214-225
    • Bolder, U.1    Ton-Nu, H.T.2    Schteingart, C.D.3    Frick, E.4    Hofmann, A.F.5
  • 28
    • 0029038668 scopus 로고
    • Mapping of a locus for progressive familial intrahepatic cholestasis (Byler disease) to 18q21-q22, the benign recurrent intrahepatic cholestasis region
    • Carlton VEH, Knisely AS, Freimer NB. Mapping of a locus for progressive familial intrahepatic cholestasis (Byler disease) to 18q21-q22, the benign recurrent intrahepatic cholestasis region. Hum Mol Genet 1995;4: 1049-53.
    • (1995) Hum Mol Genet , vol.4 , pp. 1049-1053
    • Carlton, V.E.H.1    Knisely, A.S.2    Freimer, N.B.3
  • 29
    • 0031907132 scopus 로고    scopus 로고
    • A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis
    • Bull LN, van Eijk MJT, Pawlikowska L, et al. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet 1998;18:219-24.
    • (1998) Nat Genet , vol.18 , pp. 219-224
    • Bull, L.N.1    Van Eijk, M.J.T.2    Pawlikowska, L.3
  • 30
    • 0030869696 scopus 로고    scopus 로고
    • Identification of a locus for progressive familial intrahepatic cholestasis PFIC2 on chromosome 2q24
    • Strautnieks SS, Kagalwalla AF, Tanner MS, et al. Identification of a locus for progressive familial intrahepatic cholestasis PFIC2 on chromosome 2q24. Am J Hum Genet 1997;61:630-3.
    • (1997) Am J Hum Genet , vol.61 , pp. 630-633
    • Strautnieks, S.S.1    Kagalwalla, A.F.2    Tanner, M.S.3
  • 31
    • 0029990296 scopus 로고    scopus 로고
    • Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis
    • Deleuze JF, Jacquemin E, Dubuisson C, et al. Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis. Hepatology 1996;23:904-8.
    • (1996) Hepatology , vol.23 , pp. 904-908
    • Deleuze, J.F.1    Jacquemin, E.2    Dubuisson, C.3
  • 32
    • 0040284751 scopus 로고    scopus 로고
    • Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis
    • de Vree JML, Jacquemin E, Sturm E, et al. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. Proc Natl Acad Sci USA 1998;95:282-7.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 282-287
    • De Vree, J.M.L.1    Jacquemin, E.2    Sturm, E.3
  • 33
    • 0027942323 scopus 로고
    • Genome screening by searching for shared segments: Mapping a gene for benign recurrent intrahepatic cholestasis
    • Houwen RHJ, Baharloo S, Blankenship K, et al. Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis. Nat Genet 1994;8:380-6.
    • (1994) Nat Genet , vol.8 , pp. 380-386
    • Houwen, R.H.J.1    Baharloo, S.2    Blankenship, K.3
  • 34
    • 0030941882 scopus 로고    scopus 로고
    • Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia
    • Shneider BL, Fox VL, Schwarz KB, et al. Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia. Hepatology 1997;25:1176-83.
    • (1997) Hepatology , vol.25 , pp. 1176-1183
    • Shneider, B.L.1    Fox, V.L.2    Schwarz, K.B.3
  • 35
    • 0030880647 scopus 로고    scopus 로고
    • Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene
    • Kullak-Ublick G, Beuers U, Fahney C, Hagenbuch B, Meier PJ, Paumgartner G. Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene. Hepatology 1997;26:991-7.
    • (1997) Hepatology , vol.26 , pp. 991-997
    • Kullak-Ublick, G.1    Beuers, U.2    Fahney, C.3    Hagenbuch, B.4    Meier, P.J.5    Paumgartner, G.6
  • 36
    • 0027325467 scopus 로고
    • Abnormal expression of anion exchanger genes in primary biliary cirrhosis
    • Prieto J, Qian C, Garcia N, Diez J, Medina JF. Abnormal expression of anion exchanger genes in primary biliary cirrhosis. Gastroenterology 1993;105:572-8.
    • (1993) Gastroenterology , vol.105 , pp. 572-578
    • Prieto, J.1    Qian, C.2    Garcia, N.3    Diez, J.4    Medina, J.F.5
  • 37
    • 0031021891 scopus 로고    scopus 로고
    • Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis
    • Medina JF, Martinez-Anso E, Vazquez JJ, Prieto J. Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis. Hepatology 1997;25:12-7.
    • (1997) Hepatology , vol.25 , pp. 12-17
    • Medina, J.F.1    Martinez-Anso, E.2    Vazquez, J.J.3    Prieto, J.4
  • 38
    • 0001600657 scopus 로고    scopus 로고
    • Human MDR1 and MDR3 gene expression in the liver with obstructive jaundice
    • abstract
    • Nozawa S, Miyazaki M, Itou H, et al. Human MDR1 and MDR3 gene expression in the liver with obstructive jaundice. Gastroenterology 1997;112:Suppl:A1349. abstract.
    • (1997) Gastroenterology , vol.112 , Issue.SUPPL.
    • Nozawa, S.1    Miyazaki, M.2    Itou, H.3
  • 39
    • 12644268207 scopus 로고    scopus 로고
    • Genetic and morphological findings in progressive familial intrahepatic cholestasis (Byler disease [PFIC-1] and Byler syndrome): Evidence for heterogeneity
    • Bull LN, Carlton VEH, Stricker NL, et al. Genetic and morphological findings in progressive familial intrahepatic cholestasis (Byler disease [PFIC-1] and Byler syndrome): evidence for heterogeneity. Hepatology 1997;26:155-64.
    • (1997) Hepatology , vol.26 , pp. 155-164
    • Bull, L.N.1    Carlton, V.E.H.2    Stricker, N.L.3
  • 40
    • 0030447135 scopus 로고    scopus 로고
    • In search of a gene for hereditary cholestasis
    • Sela-Herman S, Bull L, Lomri N, et al. In search of a gene for hereditary cholestasis. Biochem Mol Med 1996;59:98-103.
    • (1996) Biochem Mol Med , vol.59 , pp. 98-103
    • Sela-Herman, S.1    Bull, L.2    Lomri, N.3
  • 41
    • 0030946427 scopus 로고    scopus 로고
    • Semiquantitation of intrahepatic MDR3 mRNA levels by reverse transcription/competitive polymerase chain reaction
    • Dumoulin FL, Reichel C, Sauerbruch T, Spengler U. Semiquantitation of intrahepatic MDR3 mRNA levels by reverse transcription/competitive polymerase chain reaction. J Hepatol 1997;26:852-6.
    • (1997) J Hepatol , vol.26 , pp. 852-856
    • Dumoulin, F.L.1    Reichel, C.2    Sauerbruch, T.3    Spengler, U.4
  • 42
    • 0027320960 scopus 로고
    • Inhibition by cyclosporin a of adenosine triphosphate-dependent transport from the hepatocyte into bile
    • Kadmon M, Klünemann C, Böhme M, et al. Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. Gastroenterology 1993;104:1507-14.
    • (1993) Gastroenterology , vol.104 , pp. 1507-1514
    • Kadmon, M.1    Klünemann, C.2    Böhme, M.3
  • 43
    • 0028284238 scopus 로고
    • Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver
    • Bohme M, Muller M, Leier I, Jedlitschky G, Keppler D. Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology 1994;107:255-65.
    • (1994) Gastroenterology , vol.107 , pp. 255-265
    • Bohme, M.1    Muller, M.2    Leier, I.3    Jedlitschky, G.4    Keppler, D.5
  • 44
    • 0029986408 scopus 로고    scopus 로고
    • Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
    • Kartenbeck J, Leuschner U, Mayer R, Keppler D. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology 1996;23:1061-6.
    • (1996) Hepatology , vol.23 , pp. 1061-1066
    • Kartenbeck, J.1    Leuschner, U.2    Mayer, R.3    Keppler, D.4
  • 45
    • 0030994468 scopus 로고    scopus 로고
    • A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
    • Paulusma CC, Kool M, Bosma PJ, et al. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology 1997;25:1539-42.
    • (1997) Hepatology , vol.25 , pp. 1539-1542
    • Paulusma, C.C.1    Kool, M.2    Bosma, P.J.3
  • 47
    • 0029849789 scopus 로고    scopus 로고
    • The canalicular conjugate export pump encoded by the cmrp/cmoat gene
    • Boyer JL, Ockner RK, eds. Philadelphia: W.B. Saunders
    • Keppler D, Kartenbeck J. The canalicular conjugate export pump encoded by the cmrp/cmoat gene. In: Boyer JL, Ockner RK, eds. Progress in liver diseases. Vol. 14. Philadelphia: W.B. Saunders, 1996:55-67.
    • (1996) Progress in Liver Diseases , vol.14 , pp. 55-67
    • Keppler, D.1    Kartenbeck, J.2
  • 48
    • 0028793417 scopus 로고
    • Regulation of liver-specific gene expression
    • Boyer JL, Ockner RK, eds. Philadelphia: W.B. Saunders
    • Chojkier M. Regulation of liver-specific gene expression. In: Boyer JL, Ockner RK, eds. Progress in liver diseases. Vol. 13. Philadelphia: W.B. Saunders, 1995:37-61.
    • (1995) Progress in Liver Diseases , vol.13 , pp. 37-61
    • Chojkier, M.1
  • 49
    • 15844426563 scopus 로고    scopus 로고
    • Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter
    • Karpen SJ, Sun AQ, Kudish B, et al. Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter. J Biol Chem 1996;271:15211-21.
    • (1996) J Biol Chem , vol.271 , pp. 15211-15221
    • Karpen, S.J.1    Sun, A.Q.2    Kudish, B.3
  • 50
    • 0032524012 scopus 로고    scopus 로고
    • Endotoxin down-regulates hepatic ntcp gene expression via decreased activity of critical transcription factors
    • Trauner M, Arrese M, Lee H, Boyer JL, Karpen SJ. Endotoxin down-regulates hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest 1998;101:2092-100.
    • (1998) J Clin Invest , vol.101 , pp. 2092-2100
    • Trauner, M.1    Arrese, M.2    Lee, H.3    Boyer, J.L.4    Karpen, S.J.5
  • 52
    • 0030963906 scopus 로고    scopus 로고
    • The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
    • Trauner M, Arrese M, Soroka CJ, et al. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997;113:255-64.
    • (1997) Gastroenterology , vol.113 , pp. 255-264
    • Trauner, M.1    Arrese, M.2    Soroka, C.J.3
  • 53
    • 0029030458 scopus 로고
    • Anion exchanger immuno-reactivity in human salivary glands in health and Sjogren's syndrome
    • Vazquez JJ, Vazquez M, Idoate MA, et al. Anion exchanger immuno-reactivity in human salivary glands in health and Sjogren's syndrome. Am J Pathol 1995;146:1422-32.
    • (1995) Am J Pathol , vol.146 , pp. 1422-1432
    • Vazquez, J.J.1    Vazquez, M.2    Idoate, M.A.3
  • 54
    • 0031014582 scopus 로고    scopus 로고
    • +/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion
    • +/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion. Hepatology 1997;25:284-90.
    • (1997) Hepatology , vol.25 , pp. 284-290
    • Gartung, C.1    Schuele, S.2    Schlosser, S.F.3    Boyer, J.L.4
  • 56
    • 0029888189 scopus 로고    scopus 로고
    • Experimental Mallory body formation is accompanied by modulation of the expression of multidrug-resistance genes and their products
    • Preisegger K-H, Stumptner C, Riegelnegg D, et al. Experimental Mallory body formation is accompanied by modulation of the expression of multidrug-resistance genes and their products. Hepatology 1996;24:248-52.
    • (1996) Hepatology , vol.24 , pp. 248-252
    • Preisegger, K.-H.1    Stumptner, C.2    Riegelnegg, D.3
  • 57
    • 0029886277 scopus 로고    scopus 로고
    • Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents
    • Green RM, Beier D, Gollan JL. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 1996;111:193-8.
    • (1996) Gastroenterology , vol.111 , pp. 193-198
    • Green, R.M.1    Beier, D.2    Gollan, J.L.3
  • 58
    • 0030859655 scopus 로고    scopus 로고
    • +-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation
    • +-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation. J Hepatol 1997;27:1051-6.
    • (1997) J Hepatol , vol.27 , pp. 1051-1056
    • Dumont, M.1    Jacquemin, E.2    D'Hont, C.3
  • 59
    • 0027162649 scopus 로고
    • Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
    • Welsh MJ, Smith AE. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell 1993;73:1251-4.
    • (1993) Cell , vol.73 , pp. 1251-1254
    • Welsh, M.J.1    Smith, A.E.2
  • 61
    • 0029981999 scopus 로고    scopus 로고
    • Leaky junctions and cholestasis: A tight correlation
    • Anderson JM. Leaky junctions and cholestasis: a tight correlation. Gastroenterology 1996;110:1662-5.
    • (1996) Gastroenterology , vol.110 , pp. 1662-1665
    • Anderson, J.M.1
  • 62
    • 0019521476 scopus 로고
    • Severe familial cholestasis in North American Indian children: A clinical model of microfilament dysfunction
    • Weber AM, Tuchweber B, Yousef I, et al. Severe familial cholestasis in North American Indian children: a clinical model of microfilament dysfunction. Gastroenterology 1981;81:653-62.
    • (1981) Gastroenterology , vol.81 , pp. 653-662
    • Weber, A.M.1    Tuchweber, B.2    Yousef, I.3
  • 63
    • 0029913760 scopus 로고    scopus 로고
    • Structure-function correlation of tight junctional impairment after intrahepatic and extrahepatic cholestasis in rat liver
    • Rahner C, Stieger B, Landmann L. Structure-function correlation of tight junctional impairment after intrahepatic and extrahepatic cholestasis in rat liver. Gastroenterology 1996;110:1564-78.
    • (1996) Gastroenterology , vol.110 , pp. 1564-1578
    • Rahner, C.1    Stieger, B.2    Landmann, L.3
  • 64
    • 0024412436 scopus 로고
    • Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis
    • Anderson JM, Glade JL, Stevenson BR, Boyer JL, Mooseker MS. Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis. Am J Pathol 1989;134:1055-62.
    • (1989) Am J Pathol , vol.134 , pp. 1055-1062
    • Anderson, J.M.1    Glade, J.L.2    Stevenson, B.R.3    Boyer, J.L.4    Mooseker, M.S.5
  • 65
    • 0027215387 scopus 로고
    • Altered expression and localization of the tight junction protein ZO-1 after common bile duct ligation
    • Fallon MB, Mennone A, Anderson JM. Altered expression and localization of the tight junction protein ZO-1 after common bile duct ligation. Am J Physiol 1993;264:C1439-C1447.
    • (1993) Am J Physiol , vol.264
    • Fallon, M.B.1    Mennone, A.2    Anderson, J.M.3
  • 66
    • 0028819684 scopus 로고
    • Altered hepatic localization and expression of occludin after common bile duct ligation
    • Fallon MB, Brecher AR, Balda MS, Matter K, Anderson JM. Altered hepatic localization and expression of occludin after common bile duct ligation. Am J Physiol 1995;269:C1057-C1062.
    • (1995) Am J Physiol , vol.269
    • Fallon, M.B.1    Brecher, A.R.2    Balda, M.S.3    Matter, K.4    Anderson, J.M.5
  • 67
    • 0027160599 scopus 로고
    • Newly synthesized hepatocyte plasma membrane proteins are transported in transcytotic vesicles in the bile duct-ligated rat
    • Barr VA, Hubbard AL. Newly synthesized hepatocyte plasma membrane proteins are transported in transcytotic vesicles in the bile duct-ligated rat. Gastroenterology 1993;105:554-71.
    • (1993) Gastroenterology , vol.105 , pp. 554-571
    • Barr, V.A.1    Hubbard, A.L.2
  • 68
    • 0029881783 scopus 로고    scopus 로고
    • Effects of cholestasis on membrane flow and surface polarity in hepatocytes
    • Stieger B, Landmann L. Effects of cholestasis on membrane flow and surface polarity in hepatocytes. J Hepatol 1996;24:Suppl 1:128-34.
    • (1996) J Hepatol , vol.24 , Issue.1 SUPPL. , pp. 128-134
    • Stieger, B.1    Landmann, L.2
  • 69
    • 84989558299 scopus 로고
    • Effect of obstructive cholestasis on membrane traffic and domain-specific expression of plasma membrane proteins in rat liver parenchymal cells
    • Erratum, Hepatology 1994;20:772
    • Stieger B, Meier PJ, Landmann L. Effect of obstructive cholestasis on membrane traffic and domain-specific expression of plasma membrane proteins in rat liver parenchymal cells. Hepatology 1994;20:201-12. [Erratum, Hepatology 1994;20:772.]
    • (1994) Hepatology , vol.20 , pp. 201-212
    • Stieger, B.1    Meier, P.J.2    Landmann, L.3
  • 71
    • 0025975766 scopus 로고
    • Transcytotic vesicular carriers for polymeric IgA receptors accumulate in rat hepatocytes after bile duct ligation
    • Larkin JM, Palade GE. Transcytotic vesicular carriers for polymeric IgA receptors accumulate in rat hepatocytes after bile duct ligation. J Cell Sci 1991;98:205-16.
    • (1991) J Cell Sci , vol.98 , pp. 205-216
    • Larkin, J.M.1    Palade, G.E.2
  • 72
    • 0028926092 scopus 로고
    • Isolation of the microtubulevesicle motor kinesin from rat liver: Selective inhibition by cholestatic bile acids
    • Marks DL, LaRusso NF, McNiven MA. Isolation of the microtubulevesicle motor kinesin from rat liver: selective inhibition by cholestatic bile acids. Gastroenterology 1995;108:824-33.
    • (1995) Gastroenterology , vol.108 , pp. 824-833
    • Marks, D.L.1    LaRusso, N.F.2    McNiven, M.A.3
  • 73
    • 0028789248 scopus 로고
    • Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets
    • Boyer JL, Soroka CJ. Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets. Gastroenterology 1995;109:1600-11.
    • (1995) Gastroenterology , vol.109 , pp. 1600-1611
    • Boyer, J.L.1    Soroka, C.J.2
  • 74
    • 0027141467 scopus 로고
    • Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis
    • Beuers U, Nathanson MH, Isales CM, Boyer JL. Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis. J Clin Invest 1993;92:2984-93.
    • (1993) J Clin Invest , vol.92 , pp. 2984-2993
    • Beuers, U.1    Nathanson, M.H.2    Isales, C.M.3    Boyer, J.L.4
  • 76
    • 0029838285 scopus 로고    scopus 로고
    • Calcium signaling mechanisms in liver in health and disease
    • Boyer JL, Ockner RK, eds. Philadelphia: W.B. Saunders
    • Nathanson MH, Schlosser SF. Calcium signaling mechanisms in liver in health and disease. In: Boyer JL, Ockner RK, eds. Progress in liver disease. Vol. 14. Philadelphia: W.B. Saunders, 1996:1-27.
    • (1996) Progress in Liver Disease. , vol.14 , pp. 1-27
    • Nathanson, M.H.1    Schlosser, S.F.2
  • 77
    • 0027484375 scopus 로고
    • Distribution of adenylate cyclase and GTP-binding proteins in hepatic plasma membranes
    • Dixon BS, Sutherland E, Alexander A, Nibel D, Simon FR. Distribution of adenylate cyclase and GTP-binding proteins in hepatic plasma membranes. Am J Physiol 1993;265:G686-G698.
    • (1993) Am J Physiol , vol.265
    • Dixon, B.S.1    Sutherland, E.2    Alexander, A.3    Nibel, D.4    Simon, F.R.5
  • 78
    • 0028030734 scopus 로고
    • G proteins in rat liver proliferation during cholestasis
    • Rodriguez-Henche N, Guijarro LG, Couvineau A, et al. G proteins in rat liver proliferation during cholestasis. Hepatology 1994;20:1041-7.
    • (1994) Hepatology , vol.20 , pp. 1041-1047
    • Rodriguez-Henche, N.1    Guijarro, L.G.2    Couvineau, A.3
  • 81
    • 0028933933 scopus 로고
    • Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children
    • Poupon R, Poupon RE. Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children. Pharmacol Ther 1995;66:1-15.
    • (1995) Pharmacol Ther , vol.66 , pp. 1-15
    • Poupon, R.1    Poupon, R.E.2
  • 82
    • 0031047361 scopus 로고    scopus 로고
    • Ursodiol for primary sclerosing cholangitis
    • Lindor KD. Ursodiol for primary sclerosing cholangitis. N Engl J Med 1997;336:691-5.
    • (1997) N Engl J Med , vol.336 , pp. 691-695
    • Lindor, K.D.1
  • 83
    • 0031024075 scopus 로고    scopus 로고
    • Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei
    • Setchell KDR, Rodrigues CMP, Clerici C, et al. Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei. Gastroenterology 1997;112:226-35.
    • (1997) Gastroenterology , vol.112 , pp. 226-235
    • Setchell, K.D.R.1    Rodrigues, C.M.P.2    Clerici, C.3
  • 85
    • 0030012966 scopus 로고    scopus 로고
    • Effects of ursodeoxycholate and cholate feeding on liver diseases in FVB mice with a disrupted mdr2 P-glycoprotein gene
    • Van Nieuwkerk CMJ, Elferink RPJ, Groen AK, et al. Effects of ursodeoxycholate and cholate feeding on liver diseases in FVB mice with a disrupted mdr2 P-glycoprotein gene. Gastroenterology 1996;111:165-71.
    • (1996) Gastroenterology , vol.111 , pp. 165-171
    • Van Nieuwkerk, C.M.J.1    Elferink, R.P.J.2    Groen, A.K.3
  • 86
    • 0025098908 scopus 로고
    • Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: Effect of ursodeoxycholic acid
    • Calmus Y, Gane P, Rouger P, Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990;11:12-5.
    • (1990) Hepatology , vol.11 , pp. 12-15
    • Calmus, Y.1    Gane, P.2    Rouger, P.3    Poupon, R.4
  • 87
    • 0026642157 scopus 로고
    • Immunomodulatory effects of ursodeoxycholic acid on immune responses
    • Yoshikawa M, Tsujii T, Matsumura K, et al. Immunomodulatory effects of ursodeoxycholic acid on immune responses. Hepatology 1992;16: 358-64.
    • (1992) Hepatology , vol.16 , pp. 358-364
    • Yoshikawa, M.1    Tsujii, T.2    Matsumura, K.3
  • 88
    • 0027932658 scopus 로고
    • Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes
    • Hillaire S, Boucher E, Calmus Y, et al. Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes. Gastroenterology 1994;107:781-8.
    • (1994) Gastroenterology , vol.107 , pp. 781-788
    • Hillaire, S.1    Boucher, E.2    Calmus, Y.3
  • 89
    • 0027510926 scopus 로고
    • Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes
    • Beuers U, Nathanson MH, Boyer JL. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology 1993;104:604-12.
    • (1993) Gastroenterology , vol.104 , pp. 604-612
    • Beuers, U.1    Nathanson, M.H.2    Boyer, J.L.3
  • 90
    • 0029863466 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes
    • Beuers U, Throckmorton DC, Anderson MS, et al. Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. Gastroenterology 1996;110:1553-63.
    • (1996) Gastroenterology , vol.110 , pp. 1553-1563
    • Beuers, U.1    Throckmorton, D.C.2    Anderson, M.S.3
  • 91
    • 0028084463 scopus 로고
    • Kinetics of hepatic bile acid handling in cholestatic liver disease: Effect of ursodeoxycholic acid
    • Jazrawi RP, de Caestecker JS, Goggin PM, et al. Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid. Gastroenterology 1994;106:134-42.
    • (1994) Gastroenterology , vol.106 , pp. 134-142
    • Jazrawi, R.P.1    De Caestecker, J.S.2    Goggin, P.M.3
  • 93
    • 0027196615 scopus 로고
    • An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer
    • Yang Y, Raper SE, Cohn JA, Engelhardt JF, Wilson JM. An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer. Proc Natl Acad Sci U S A 1993;90:4601-5.
    • (1993) Proc Natl Acad Sci U S a , vol.90 , pp. 4601-4605
    • Yang, Y.1    Raper, S.E.2    Cohn, J.A.3    Engelhardt, J.F.4    Wilson, J.M.5
  • 94
    • 0028921605 scopus 로고
    • Correction of the cystic fibrosis defect by gene complementation in human intrahepatic biliary epithelial cell lines
    • Grubman SA, Fang SL, Mulberg AE, et al. Correction of the cystic fibrosis defect by gene complementation in human intrahepatic biliary epithelial cell lines. Gastroenterology 1995;108:584-92.
    • (1995) Gastroenterology , vol.108 , pp. 584-592
    • Grubman, S.A.1    Fang, S.L.2    Mulberg, A.E.3
  • 95
    • 0028350767 scopus 로고
    • Gene therapy: Applications to the treatment of gastrointestinal and liver diseases
    • Chang AGY, Wu GY. Gene therapy: applications to the treatment of gastrointestinal and liver diseases. Gastroenterology 1994;106:1076-84.
    • (1994) Gastroenterology , vol.106 , pp. 1076-1084
    • Agy, C.1    Wu, G.Y.2


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