Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Aβ secretion. Role for altered lysosomal hydrolase distribution in β-amyloidogenesis

Journal of Biological Chemistry

Volumn 277, Issue 7, 2002, Pages 5299-5307

  Mathews, Paul M ^a   Guerra, Carolyn B ^a   Jiang, Ying ^a   Grbovic, Olivera M ^a   Kao, Benjamin H ^a   Schmidt, Stephen D ^a   Dinakar, Ravi ^a   Mercken, Marc ^a   Hille Rehfeld, Annette ^a   Rohrer, Jack ^a   Mehta, Pankaj ^a   Cataldo, Anne M ^a   Nixon, Ralph A ^a  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; ENZYMES; MUTAGENESIS; POSITIVE IONS;

AMYLOIDOGENESIS; NEURONS;

DISEASES;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CATHEPSIN D; HYDROLASE; LYSOSOME ENZYME; SOMATOMEDIN B RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; ENDOSOME; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LOCALIZATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; LYSOSOME; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BLOTTING, WESTERN; BRAIN; CATHEPSIN D; CATIONS; CELL LINE; CELL MEMBRANE; DNA, COMPLEMENTARY; ENDOSOMES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LYSOSOMES; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MUTATION; RECEPTOR, IGF TYPE 2; SUBCELLULAR FRACTIONS;

ANIMALIA; MURINAE;

EID: 0037085458     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M108161200     Document Type: Article

References (64)